role of stem cells in the pathogenesis of copd and pulmonary emphysema
The role of b cells in the pathogenesis of atherosclerosis 1
... lipoprotein (oxLDL) has been reported in clinical and experimental atherosclerosis, implying the involvement of humoral B cell responses However, the understanding of the mechanism(s) by which B cells ... atherosclerosis Of interest, B cells and their involvement in atherosclerosis will be discussed 1.4.1 Localization of B cells in Atherosclerosis In apoE-/- mice, it was demonstrated that the localization of ... from T cells (Ait-Oufella et al., 2010) Therefore, these observations suggest that the disagreement in assigning the role of B cells in atherosclerosis may be due to differing roles carrying out...
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The role of b cells in the pathogenesis of atherosclerosis 2
... accumulation of plasma cells in the bone marrow of apoE-/- mice Because we maintained the mice on BrdU in drinking water for one month, the result is also indicative that these plasma cells accumulated in ... 2006), we included the non-proliferative state of plasma cells as an additional parameter when examining plasma cells in the bone marrow To begin our investigation into ASCs in the bone marrow of apoE-/- ... affected in the apoE-/- mice In addition, our preliminary data suggests that although B1a cells did not expand in the spleen of apoE-/- mice, we did detect increased differentiation of B1a cells into...
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The role of b cells in the pathogenesis of atherosclerosis
... fall into the state of anergy However, it remains to be determined if APOE protein is crucial in maintaining the anergy state of B cells 4.7 Role of B cell subpopulations However, it remains unclear ... mice had an increase accumulation of apoptotic cells in the plaque (Bhatia et al., 2007; Lewis et al., 2009) In these aspects, the understanding of the generation and maintenance of modified ... frequency of oxLDL-specific IgM ASCs in the bone marrow 157 Chapter Discussions 158 Chapter Discussion 4.1 Summary of findings Our investigations on the role of B cells in the pathogenesis of...
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Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis" pps
... cytokine for Tregs, and plays a key role in the control of self-antigen-reactive T cells in vivo [38] The upregulation of IL-10 is in line with the induction of Tregs in vitro and in vivo in our ... addition of UC-MSCs maintained such inhibitory effects, suggesting that the transplantation of these cells is practicable and effective for treatment of RA Interestingly, the invasive behavior of FLSs ... both inflammation and tissue damage One of the critical mediators of inflammation in RA is the proinflammatory cytokine IL-6 Interestingly, the UC-MSCs could downregulate the IL-6 production in the...
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Báo cáo y học: "Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2" potx
... predominantly the tunica intima consisting of the endothelial layer and the basement membrane, and αSMA (e, f) staining predominantly the tunica media consisting of the muscular layer of the arteriole ... [47] The use of FGF-2 may therefore be of particular benefit in increasing the production of matrix in cartilage tissue-engineered in vitro The inhibition of actin stress fibres by FGF-2 in adult ... higher yield of stem cells and there is reduced pain and morbidity associated with the harvest of cells [8] In preliminary work, we identified perivascular cells in the IPFP tissue which stained with...
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Báo cáo y học: "Stem cells in the genomic age" docx
... into an oocyte or fused with an ES cell, the underlying mechanisms remain obscure Using the ES fusion system, Smith has found an unexpected role for the homeodomain-containing protein Nanog in ... developed in his group This, he told us, is just the beginning of an ambitious and far-reaching transcriptional profiling project As other labs around the world develop reporter lines for their favorite ... process By boosting levels of Nanog it is possible to increase the efficiency of nuclear reprogramming up to 100-fold in cell fusions between ES cells and neural stem cells, and further experiments...
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Stem Cells in Human Reproduction Basic Science and Therapeutic Potential Second Edition pot
... eIF4E, the cap-binding factor The binding of maskin to eIF4E precludes the binding of eIF4G to eIF4E, thus inhibiting the formation of the translation initiation complex Following stimulation, the ... another role in translation by binding the cap-binding complex (Fig 3) This complex consists of the cap-binding protein eIF4E, the RNA Molecular Biology of the Gamete 25 Figure (A) Cap-binding ... ball, which introduces the clinical and the ethical views of the gamete generation from stem cells, probably one of the main key points of the stem cell field in reproductive medicine, is by two...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; ... whether VEGF-signaling is involved in recruiting CD68-positive cells, such as OPCs, in GCTs We investigated the effects of GCTCM on the biological phenotypes of OPCs To examine the VEGF protein ... monocyte-like cells may induce the tyrosine phosphorylation of FAK in cells within GCTs Correlation between the clinical stage and pY-Flt-1 and pY-FAK expression in GCTs To determine the biological...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; ... whether VEGF-signaling is involved in recruiting CD68-positive cells, such as OPCs, in GCTs We investigated the effects of GCTCM on the biological phenotypes of OPCs To examine the VEGF protein ... monocyte-like cells may induce the tyrosine phosphorylation of FAK in cells within GCTs Correlation between the clinical stage and pY-Flt-1 and pY-FAK expression in GCTs To determine the biological...
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Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx
... protein; matrilin-1) Matrilin-3 CILP (cartilage intermediate layer protein) Fibronectin PRELP (proline/arginine-rich and leucine-rich repeat protein) Chondroadherin Fibrillin Tenascin-C Elastin MGP (matrix ... during childhood, and OA of the knees in adulthood A complex splicing defect of exon and/ or exon 10 in the COL9A1 gene has been identified in other families [59] Consistent with these findings, ... severity of the OA disorder may be influenced by multiple environmental, hormonal, and intrinsic and extrinsic factors, with multiple genes in any given individual The identification of the genetic...
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Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... result in an increase in the gene expression of the aggrecanase ADAMTS4 in cells derived from degenerate NP In vivo, the NP contains the highest concentration of aggrecan in the IVD The response of ... presence of IL-1Ra immunopositive cells in every disc, with high proportions of cells of up to 40% showing immunoposiR737 tivity in the NP and IAF; and high numbers of cells in the NP and IAF ... IL-1 in such systems, one using ovine IVD cells [25] and the other, rabbit IVD cells [28] This is the first reported study to investigate the effects of IL-1 on human disc cells cultured in 3D...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... through the regulation of FcRs much like the instructive role of the innate immune system for the adaptive response [56] The production of autoantibodies as a result of the failure of the immune system’s ... contributions of either complement or FcγRs in the inflammatory response, especially in Arthus reaction mice models, have resulted in a better understanding of the role of the complement system and FcγRs, ... at the same time and, for B cells, on the very same cell Both FcRs and complement receptors are involved in the binding of ICs and phagocytosis; they deliver signals leading to the activation and...
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Báo cáo y học: "The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis" potx
... implicating osteoclasts in the pathogenesis of the peri-implant osteolysis associated with prosthetic implant wear debris The findings of TRAP and cathepsin K expression in macrophages and foreign ... neither the β3 integrin nor the CTR are expressed by osteoclast precursors The expression of these genes increases during the late stages of osteoclast differentiation [42], after induction of the ... is indicated by the resorptive defect in osteoclast-mediated bone resorption in mice in which either of these genes has been deleted [36,37] In humans, inactivating mutations in the cathepsin...
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Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt
... participated in the design of the study, performed the majority of the laboratory work and analysis, and drafted the manuscript AJF participated in the design of the study and interpretation of data ... block of tissue (incorporating AF and NP in continuity) was fixed in 10% neutral buffered formalin and processed to paraffin wax Sections were taken for haematoxylin and eosin staining to score the ... inability to withstand load [3,4] Because matrix changes largely reflect alterations in the biology of the cells, it is not surprising to find that during ageing and degeneration, the cells of...
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Báo cáo y học: "Hypoxic conditions increase hypoxia-inducible transcription factor 2α and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients" pps
... The GAG content reflected proteoglycan biosynthesis and accumulation in the matrix, and under hypoxic conditions there was a 1.9-fold increase in the total GAG per aggregate In spite of the increased ... Multilineage potential of adult human mesenchymal stem cells Science 1999, 284:143-147 Khan WS, Andrews JG, Hardingham TE: The role of FGF-2 in the proliferation and chondrogenic potential of infrapatellar ... temperature in streptavidin–peroxidase complex (1:500 in DPBS; Dako), rinsed in distilled water and incubated in fast-DAB (3,3'-diaminobenzidine) peroxidase substrate (Sigma) for minutes and counterstained...
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Báo cáo y học: "Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer" pps
... formation, of 541.3 ± 166.3 μm2 in the center and 386.1 ± 108.7 μm2 the periphery of the Ad.BMP-2 transduced aggregates, and of 307.8 ± 75.6 μm2 in the center and 248.7 ± 65.4 μm2 the periphery of the ... to the joint space and the bone Page 10 of 15 (page number not for citation purposes) respectively, alignment of the chondrocytes along the arcades of Benninghoff [29] and by the appearance of ... chondrocytes and in osteoarthritic cartilage [17], we were next interested in the appearance of live and apoptotic cells within our aggregate system after 10 and 21 days, which was visualized using the...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... [1,2], B cells are considered to play important roles in the pathogenesis of RA In this regard, the synovial tissue of RA patients shows abundant accumulation of inflammatory cells, including T cells, ... Comparison of the migratory effects of the chemokines on peripheral blood CD27- and CD27+ B cells in each individual showed that for each of the chemokines, the chemotactic response of CD27+ B cells ... was supported in part by grants -in- aid from the Ministry of Health, Labor and Welfare, and the Ministry of Education, Science, Sports and Culture, Japan, and the Japanese Ministry of Education,...
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Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx
... for errors in trypsin specificity Carbamidomethylation of cysteines was taken as fixed modifications, and methionine oxidation and formylation of lysine, arginine and N-terminal amino acids as ... and SCLC, 93 in the overlap only between LCNEC and LCC, and 453 in the overlap among three groups; SCLC contained a total of 1,096 including 362 unique, 100 in the overlap only between SCLC and ... AK1C1, AK1C3, brain-type fatty acid-binding protein (FABP) and b-enolase On the other hand, those in SCLC were brain acid soluble protein (BASP), secretagogin (SEGN), fascin and neural cell adhesion...
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báo cáo khoa học: " Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling" doc
... mimicking the one of resident cells in the host tissue Insults trigger the release of chemokines from the endothelium inducing adhesion and migration of circulation BMDC into the liver parenchyma The ... development of HCC seems to be the abnormal regulation of the transcription factor b-catenin, a key component of the Wnt signaling pathway [58] In the normal state, the binding of members of a family of ... addressed regard the surface antigens used for MSCs purification, the route of delivery, the amount of infused cells and the timing of infusions[79] Conclusions In conclusion, the present findings demonstrate...
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Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot
... polymorphisms in MRL-lpr lupus mice and that enhanced expression of α-actinin may determine the extent of antibody deposition [10] These observations, together with the demonstration that α-actinin immunization ... anti-α-actinin antibodies in lupus patients was associated with a 2.5-fold increase in the prevalence of LN [14] Finally, levels of anti-α-actinin antibodies correlated with those of anti-DNA ... anti-α-actinin antibodies How can the discrepancies between these disappointing results and the previous studies be explained? No doubt, a longitudinal design is important, although the number of patients...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose