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the role of mesenchymal stem cells in tumor microenvironment

báo cáo khoa học:

báo cáo khoa học: " Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling" doc

Báo cáo khoa học

... evaluating the tumor suppressive effects of MSCs on the in vivo progression of HCC, and to investigate the possible role of Wnt signaling in tumor tissues by assessing the gene expression profile of ... mimicking the one of resident cells in the host tissue Insults trigger the release of chemokines from the endothelium inducing adhesion and migration of circulation BMDC into the liver parenchyma The ... that link MSCs to the targeted inhibition of tumor cells Despite their distinct origins, stem cells and tumor cells share many characteristics[15,16] In particular, they have similar signaling...
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Báo cáo sinh học:

Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot

Điện - Điện tử

... measurement of the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells ... NK cells and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate ... in HSV-1 infected tissues just 24 hours post inoculation (p.i.; Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body...
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báo cáo hóa học:

báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot

Hóa học - Dầu khí

... measurement of the abundance of CD4+ T cells, CD8+ T cells, and CD3- CD49b+ NK cells in the spleens of BALB/c versus scid mice (n = 10 per group) "Other WBCs" refers to the fraction of spleen cells ... NK cells and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate ... in HSV-1 infected tissues just 24 hours post inoculation (p.i.; Fig of Ref [31]) T cells, NK cells, and professional antigen-presenting cells (APCs) are the primary IFN-γ-producers in the body...
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Báo cáo y học:

Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

Báo cáo khoa học

... proteoglycans are involved in rendering the disease chronic [16,17] Beyond the 100% incidence of arthritis, another major advantage of the AIA model is that the time point of induction of arthritis ... AIA is dominated by cells of the innate immune system [19], and the exacerbation of arthritis in CD25-depleted mice could be due to a lack of suppression of these cells by Treg cells In accordance ... is known, allowing manipulation of CD4+CD25+ Treg cell number in vivo at defined stages in the disease Using depletion of CD25-expressing cells or transfer of CD4+CD25+ cells, in the present study...
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báo cáo khoa học:

báo cáo khoa học: " The HPB-AML-I cell line possesses the properties of mesenchymal stem cells" ppt

Báo cáo khoa học

... observed in these cells [12] In view of these features, we further investigated the possibility of HPB-AML-I being a neoplasm of MSC origin Recently, some human MSC lines have been established from the ... which made them distinct from the undifferentiated cells Inverted microscopic examination demonstrated the presence of a number of vacuoles in the cytoplasm of differentiated HPB-AML-I cells (Figure ... consisted of cells with a flattened or spindle-like morphology and that the capability of differentiating toward adipocytes of the spindle-like MSCs was superior than that of the flattened cells Since...
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Báo cáo y học:

Báo cáo y học: " Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment" pdf

Báo cáo khoa học

... through the inhibition of IκB kinase Page of 15 [13,18] There is increasing interest in curcumin as a therapeutic option for OA and RA, with evidence that curcumin inhibits the IL-1β-induced ... levels of proinflammatory cytokines in the articular joint These are produced by synovial lining cells, macrophages and the chondrocytes themselves further exacerbating cartilage degrading and ... combination of both (1) lead to the production and accumulation of high levels of pro-inflammatory cytokines (2) in the joint These trigger the production of additional pro-inflammatory cytokines...
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Báo cáo y học:

Báo cáo y học: " Influence of hypoxia on the domiciliation of Mesenchymal Stem Cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies " doc

Báo cáo khoa học

... on the perspective of cellular therapy by intravenous stem cells infusion The participation of stem cells in several vascular diseases pathogenesis was first proved with haematopoietic stem cells ... and the adherent soft tissue was removed The proximal and distal ends of the femur were excised at a level just into the beginning of the marrow cavity Whole marrow plugs were obtained by flushing ... Figure Mesenchymal stem cells used during this study Mesenchymal stem cells used during this study Typical morphological aspects of mesenchymal stem cells observed through culture flask (A) Mesenchymal...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses

The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses

Y - Dược

... resulting in the killing of 39 Chapter 1: Introduction these infected cells Under these circumstances, the dying cells, CD8 T -cells and other APCs such as macrophages and DCs within the inflammatory ... containing large spherical mitochondria which, in the living state in vitro, are continually elongating, retracting, and reorienting themselves, leading to a wide variety of cell shapes (Steinman ... 1995) They then induce cytolysis of infected cells either by the granule exocytosis pathway through co-ordinated delivery of perforin and granzymes into target cells, or by upregulation of FasL...
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Characterization of the secretion of mesenchymal stem cells and its relevance to cardioprotection

Characterization of the secretion of mesenchymal stem cells and its relevance to cardioprotection

Cao đẳng - Đại học

... scattering F1 contained 4% of total protein input but contained ∼ 50% of the CD9 in the input (Fig 5B) Proteins were distributed among F2, F3, and F4 fractions according to the principle of size-exclusion ... third of the publications in the regenerative medicine field29 The rationale for the use of stem cells to repair cardiac tissues was based on the hypothesis that these cells could differentiate into ... that the mortality rate of AMI in Germany reduced from 16.2% in 1994 to 9.9% in 2002 in tandem with the increasing use of reperfusion therapy6 The efficacy of reperfusion therapy has led to increasing...
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Báo cáo y học:

Báo cáo y học: "An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue" pot

Báo cáo khoa học

... 3,3-diaminobenzidine disclosure) for aggrecan and the staining intensity increased with time post injection (Figures and 5b) Aggrecan matrix staining within the vicinity of the injected cells was ... fluorescent protein (GFP)-infected cells Following identification of the position of injection site and the presence of GFP-labelled cells, serial sections in the area of the injection site were ... following injection, and the intensity of the matrix staining increased with time in culture (Figures and 5b) Weak staining for type II collagen was observed within a small number of cells in monolayer...
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Báo cáo y học:

Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis" pps

Báo cáo khoa học

... T cells in vivo [38] The upregulation of IL-10 is in line with the induction of Tregs in vitro and in vivo in our study Moreover, in our experiments we did not find UC-MSCs in the joint of the ... damage [31] The MMPs are key mediators of the invasive phenotype of FLSs [32] Therefore, we further investigated the effect of UC-MSCs on the invasive behavior of FLSs by the Cell Migration/Invasion ... UC-MSCs maintained such inhibitory effects, suggesting that the transplantation of these cells is practicable and effective for treatment of RA Interestingly, the invasive behavior of FLSs was inhibited...
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Transplantation of mesenchymal stem cells for the treatment of parkinsons disease in a mouse model

Transplantation of mesenchymal stem cells for the treatment of parkinsons disease in a mouse model

Thạc sĩ - Cao học

... microglial cells in the SNc of MPTP-treated mice, real-time RT-PCR did not find mRNA expression of MBL in the brain parenchyma, suggesting the infiltration of MBL from the circulation into the brain ... from the blood into the brain parenchyma where they may then interact with microglia In addition to the presence of these inflammatory cytokines, other inflammatory mediators or ongoing inflammatory ... protein involved in the degradation of cytoplasmic proteins The function of α-synuclein is still not clear In the healthy brain, α-synuclein is present in the presynaptic terminals in the SN and locus...
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Applying macromolecular crowding to promote the expansion and adipogenic differentiation of human mesenchymal stem cells in vitro; an effect of matrix reciprocity

Applying macromolecular crowding to promote the expansion and adipogenic differentiation of human mesenchymal stem cells in vitro; an effect of matrix reciprocity

Cao đẳng - Đại học

... 2001;Function and interactions of integrins Cell Tissue Res (3):285-298 41 Mould AP, Askari JA, Aota SI, et al 1997;Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory ... 2007 ;In vitro enhancement of collagen matrix formation and crosslinking for applications in tissue engineering: a preliminary study Tissue Eng (2):385391 37 Qian L, Saltzman WM 2004;Improving the ... expansion Cytotherapy 75 Du F, Zhou Z, Mo ZY, et al 2006;Mixed macromolecular crowding accelerates the refolding of rabbit muscle creatine kinase: implications for protein folding in physiological...
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The role of kruppel like factors in embryonic stem cells

The role of kruppel like factors in embryonic stem cells

Cao đẳng - Đại học

... transcripts zinc finger protein 42 zinc finger protein 143 zinc finger protein of the cerebellum XI Introduction CHAPTER I INTRODUCTION Introduction CHAPTER I INTRODUCTION Stem cells can be identified ... MEF feeders in the presence of serum The conditioned medium can support the normal growth of ES cells in the absence of feeders indicating that fibroblasts are producing signals inhibiting ES cell ... depends on their binding to GTP or GDP Activated Ras leads to activation of a MAP kinase signaling cascade, including MAP kinase, MAP kinase kinase (MKK), and MAP kinase kinase kinase (MKKK) 16 Introduction...
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Báo cáo khoa học:

Báo cáo khoa học: "In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood" ppt

Báo cáo khoa học

... llec gnimrofrep dna esu lacinilc rof SBF gnisu tuohtiw oviv xe sCSM dnapxe ot sdohtem dnif ot deen ew dna ,hcraeser ruo rof SBF desu ew ,yduts tneserp ni ,revewoH noitarefilorp sCSM rof noitidnoc ... 001-X notirT %4.0 neht dna ,nim rof enoteca %001 ,nim 01 rof lonahtem %001 dloc eci htiw detaert neht erew yehT erutarepmet moor ta nim 01 rof SBP ni edyhedlamrof %7.3 htiw dexif neht dna SBP ... noitcudni cinegoetso na desu ew ,sCSM eht morf noitaitnereffid cinegoetso ecudni oT laitnetop cinegoetso tibihxe sCSM doolb droC )A2 giF( nitnemiv dna 2HS snegitna detaler -myhcnesem rof ytivitisop...
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Báo cáo khoa học:

Báo cáo khoa học: "Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs" pot

Báo cáo khoa học

... ytisrevinU lanoitaN luoeS fo ’slaminA yrotarobaL fo esU dna eraC eht rof ediuG‘ eht fo senilediug eht ot gnidrocca demrofrep saw noitagitsevni sihT yduts yrujni droc lanips latnemirepxe eht rof desu ... erew sgod ehT ICS eht retfa keew a demrofrep saw sCSM-BCU eninac fo noitatnalpsnarT :FSCGhmr fo noitcejni dna sCSM-BCU eninac fo noitatnalpsnarT noitcejni eht rof noitulos enilas fo lµ 051 ni 601 ... ilumits cinegotim cificepsnon ro ralullec yb decudni noitarefilorp etycohpmyl-T sserppus sllec lamorts worram enob namuH MA innaiG ,S itnasirG ,P iccuettaM ,DP inognoL ,M isenaliM ,M ingaM ,C...
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Báo cáo y học:

Báo cáo y học: "Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute" potx

Báo cáo khoa học

... among the most intriguing aspects of their biology [20] Francesco Dazzi reported, in a murine model, that MSCs inhibit the division of stimulated T cells by preventing their entry into the S ... persisting functional satellite cells; furthermore, they restore sarcolemmal dystrophin when they are injected into the muscles of the immunosuppressed myodystrophic mdx mouse From the clinical point ... making them attractive therapeutic agents in complex AD in which an admix of inflammatory and scarring tissue damage is often present On the other hand, MSCs may also actively participate in initiating...
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phosphatidylserine exposure in red blood cells: a suggestion for the active role of red blood cells in blood clot formation

phosphatidylserine exposure in red blood cells: a suggestion for the active role of red blood cells in blood clot formation

Tổng hợp

... Aquaporins are integral membrane proteins belonging to a larger family of major intrinsic proteins that form pores in the membrane of biological cells The threedimensional structure of aquaporin ... Methods F Investigation of the kinetics of PS exposure To investigate the kinetics of the PS exposure processes, the washed RBCs were put on a coverslip in physiological solution in the presence of ... important role in activating scramblases, thereby leading to the exposure of PS to outer leaflet of the cell membrane The activation of Ca2+-activated K+ channel (Gardos channel) by an increase of intracellular...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc

Tài liệu The Role of Public Regional Universities in Community and Economic Development doc

Cao đẳng - Đại học

... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... $28,000 in average annual salary) Preserving Value Continuing education is important to preserving the market value of specialized education – particularly in professional fields Continuing education ... Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best Practice Highlights...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf

Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf

Báo cáo khoa học

... Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic character of mutant W260K/A219N (as reflected by a threefold increase of the ... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... our incomplete understanding of the relation between enzyme properties and conformational flexibility limits the exploitation of the full potential of protein engineering in the redesign of psychrophilic...
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