the role of oxidative stress in the pathogenesis of polycystic ovary syndrome
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... utility of anti-inflammatory drug therapies in the treatment of AD Microglia are the principle immune effector cells in the brain and represent approximately 5–10% of all glia found in the brain The ... use of vitamin E and vitamin C in combination reduced the prevalence and incidence of AD in an elderly population; however, the use of either of these vitamins alone had no effect [110] Finally, ... gp91phox and an increase in p47phox protein expression in monocytes primed with INFγ [59] Figure Activation of the Rac GTPase Activation of the Rac GTPase GTP-binding of the Rac protein confers an...
- 12
- 413
- 0
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... for the present biological evaluation The second evaluation was carried out in the morning, hour after the last intake of nifedipine The study was approved by the local Ethics Committee (Cochin ... endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1 Endothelium injury is critical in SSc and is suspected to occur early in the ... transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress also promotes angiogenesis [13] The link between oxidative stress and angiogenesis is emphasised in SSc...
- 6
- 518
- 0
Báo cáo khoa học: " The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise" doc
... The exercise-induced increase in LPO content was reverted by supplementation with MSM, pointing to an improvement in the oxidative status of the cells, according to the MSM-induced increase of ... mechanism for the exercise-related increase in oxidative stress Our finding of increased horse's plasma LPO content after jumping exercise supports the hypothesis of augmented oxidative stress with ... combined with vitamin C (Vit C), on training -induced increase of lipid Effect of methyl (LPO) levels Effect of methyl sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training...
- 9
- 296
- 0
Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... Oxidative stress after status epilepticus in rats inefficiency of the electron-carrying components of the mitochondrial transport chain, monoamine degradation, xanthine oxidase reaction, ... determined by analysis of variance markedly increased in this model compared with corresponding values for the control group After pilocarpine-induced SE, there was a significant (77%) increase in ... activity only changes during the initiation of seizures [14] When studying this epilepsy model, we found increased catalase activity in the hippocampus, indicating that this enzyme, in association with...
- 6
- 480
- 0
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the flow of electrons in the respiratory chain inducing overreduction of the complexes, favouring the generation of ROS [16,17,22]; ... continuous load of calcium to the neuron The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in ... Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence of PTP in situ has not gained wide acceptance among investigators and results published in the literature...
- 18
- 549
- 0
Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... apoptosis In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidative stress is involved in the ... generation of ROS Blocking the formation of ROS could sufficiently inhibit the effects of NSC741909, including JNK activation, cell growth suppression, and apoptosis These results indicate that the oxidative ... evaluated the effects on NSC-741909's antitumor cell activity of several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein),...
- 10
- 576
- 0
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... oxidative stress and inflammation are indeed functionally relevant in the development of the phenotype of these animals However, we also provide new information on the critical issue of the in ... receiving indomethacin plus vitamin E Representative pictures of brain sections from mice on placebo or receiving indomethacin plus vitamin E underlie the effect of this compound in vivo, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16] This finding suggests that...
- 9
- 490
- 0
Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... Western Blotting The lower shows the ratio of Nrf2/actin using calculatging by densitometor In the cell treated with PM2.5, the level of Nrf2 was much highly increased than in the cell treated ... suggesting that PM2.5 induced more oxidative stress than PM10 In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form Comparative study of PM2.5 ... (P
- 8
- 442
- 1
Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... increased in response to O3 in both groups of seedlings (Figs 5E5H) during the growing season The level of activity decreased in the neoformed ush of the episodic seedlings when the O3 concentration ... grown in the absence of O3 decreased more than two-fold during the growing season In the truncated seedlings there was no change in the NR activity under O3 (Figs 6A6C) On day 85, the rst ush of the ... produced during the day [4] and may use the NADPH produced by G6PDH In the neoformed ush of the episodic seedlings, stimulation of G6PDH activity was not maintained until the end of the season (day...
- 11
- 392
- 0
Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... and the Japan Rheumatism Foundation References Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced ... clarify the role of oxidative damage in the pathogenesis of OA, we looked for the presence of oxidative damage in degenerated cartilage from OA patients and examined whether chemical oxidative stress ... cartilage increase the risk for joint deterioration that causes the clinical syndrome of OA However, the exact mechanism of chondrocyte senescence remains unclear Our findings, demonstrating the oxidative...
- 12
- 407
- 0
Báo cáo khoa hoc:" Lack of association between mutations of gene-encoding mitochondrial D310 (displacement loop) mononucleotide repeat and oxidative stress in chronic dialysis patients in Taiwan" ppsx
... in many types of tumors [13] The number of cytosines in the first stretch of the D310 region can vary from to in normal individuals The homopolymeric C-stretch is part of CSBII, located within ... and oxidative stress in chronic renal failure References Competing interests The authors declare that they have no competing interests Authors' contributions J-BC participated in the design of the ... collected clinical data of subjects C-WL performed measurement of oxidative stress biomarkers P-WW assisted in the design of the study M-MT assisted in the drafting of the manuscript S-CL performed...
- 7
- 352
- 0
Báo cáo y học: "Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure" potx
... inhibited by increasing amounts of SOD in the homogenate, was monitored spectrophotometrically at 480 nm The amount of enzyme that inhibited 50% of epinephrine auto-oxidation was defined as U of SOD ... an apnea index of 60 per hour The SIH group was housed in an adjacent cage and underwent the same fan activity as the IH group, but no Page of gas was introduced in the cage during the hypoxia ... eosin appear to be increased in individuals with OSA, is due to the conversion of xanthine dehydrogenase (type D) into its oxidase (type O) form in hypoxia, followed by the activation of the...
- 7
- 281
- 0
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... Ca2+ influx (41) The increased activity of NOS and the increased formation of NO in brain in anoxia as observed by increase in NOx concentration in this study support the earlier findings of NO involvement ... brain regions significantly in anoxia suggesting an increased utilization of citrulline for the production of arginine in anoxia In reperfusion group the activities of these enzymes were increased ... continuous supply of arginine at the site of synthesis Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circulating arginine and (b) recycling...
- 8
- 622
- 0
Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... domain, containing an iron-binding domain, which is involved in ADH activity The integrity of both domains and that of the iron-binding domain are required for ALDH activity [16] Moreover, the enzyme ... probably involved An explanation for the protective effect of the coenzymes against oxidative stress in EhPFOR is that they bind close to the FeS clusters, blocking the access of ROS In this regard, ... Fermenting enzymes and oxidative stress in Entamoeba E Pineda et al hypothesized that the formation of the TPP free radical induced by pyruvate binding may promote greater exposure of the FeS...
- 14
- 420
- 0
Báo cáo khoa học: Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice pdf
... approval of the Heinrich-Heine-University Institutional Animal Care and Use Committee The care of the animals was in accordance with the Heinrich-Heine-University Medical Center and Institutional ... mice (Fig 3A) Interestingly, the MCT diet also induced AOX gene expression in WT mice After 24 h of fasting, both genotypes showed a significant increase in the expression of AOX with the MCT diet ... of AOX expression at the mRNA level in the nonfasted state, and a further increase after fasting Very similar results were obtained for the expression of CYP4A1, with a significant induction of...
- 10
- 381
- 0
Báo cáo khoa học: A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus ppt
... shown in Fig 6D Both A fumigatus 293.1 and Dpes1 strains showed an increase in the diameter of the inhibition zone as the dose of H2O2 increased, but the effect was stronger in the case of the ... coverage of the N-terminal and C-terminal domains, respectively, of Pes1) Furthermore, using MALDI LIFT-TOF ⁄ TOF MS, the sequence of four peptides derived from Pes1 was determined Deletion of pes1 ... resulting in the loss of microbial properties However, the effect of HOCl is directly related to the presence of protein on the surface or in the surrounding environment [35], and higher amounts of...
- 16
- 361
- 0
Báo cáo y học: " Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilag" pps
... due to the presence in the OA joint of proinflammatory catabolic cytokines such as IL-1β, which has been shown to induce GLUT-1 expression both in the present study (Figure 2) and in other studies, ... Gruzman A, Sasson S: The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes Arch Physiol ... undergoing total knee replacement surgery at the Orthopedic Department of the University Hospital of Coimbra The Ethics Committee of the University Hospital of Coimbra approved all of the procedures...
- 11
- 431
- 0
Báo cáo y học: "Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticu" docx
... canonically implicated in the inflammatory response, other factors, including members of the S100 protein family [45,46], act to sustain the inflammatory response or to determine direct effects on ... (pg/ml) Discussion The main result of the present study is the finding PETL and GABA protected animals from KA-induced brain injury MDA and apoptosis were significantly reduced in the GABA and PETL-treated ... scavenging of free radicals Therefore, the aim of this study was to investigate the protective mechanisms of GABA and Pu-erh tea leaf extract on KA-induced injury in neuronal cells in vivo and in vitro...
- 10
- 366
- 0
Báo cáo y học: "EGb761 protects motoneurons against avulsion-induced oxidative stress in rats Research article" ppsx
... removed The level of NO in spinal cord and serum was determined using a NO kit (Nanjing Jiancheng Institute of Biology and Engineering, Nanjing, China) Briefly, the method involved measuring the ... avulsion injury The effect of EGb761 was estimated according to the survival of injured motoneurons The investigation of the protective mechanism of EGb761 was focused on the production of NO, and the ... removed The C7 spinal segment was defined as the region between the uppermost root and lowermost root of the C7 nerve of the contralateral spinal cord The C7 segment of the spinal cord of each...
- 7
- 331
- 0
Báo cáo y học: "TNF-α and IL-10 downregulation and marked oxidative stress in Neuromyelitis Optica" pptx
... conditions in the brain during TNF- treatment, including experimentally induced brain trauma [13] and a murine model of multiple sclerosis [14,15] No clinical efficacy or worsening of the symptoms ... one of the etio-pathogenic mechanisms of NMO Oxidative stress is defined as an imbalance in the generation of reactive oxygen species (ROS) and plays a major role in disease pathogenesis The ... oligodendrocytes leading to a delay in the generation of these cells, showing an unexpected role for TNF- and TNFR2 in repair of the CNS [17] In humans, beneficial effects of anti-TNF- treatments in patients...
- 9
- 241
- 0
Tìm thêm: xác định các mục tiêu của chương trình khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25