rtog 95 17 phase ii apbi trial
Báo cáo khoa học: "A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer" potx
... an update of radiation therapy oncology group trial (RTOG) 90-01 J Clin Oncol 2004, 22(5):872-80 Pearcey R, Brundage M, Drouin P, et al: Phase III trial comparing radical radiotherapy with and ... uterine cervix Clin Oncol (R Coll Radiol) 2005, 17( 6):412-7 doi:10.1186 /174 8-717X-5-84 Cite this article as: Geara et al.: A phase II randomized trial comparing radiotherapy with concurrent weekly ... significantly lower in the Page of cisplatin-alone arm [53] A phase III randomized trial testing this combination for definitive CTRT in stages IIB to IVA disease, has completed accrual but results are...
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
... immunizations were supported by the addition of high-dose bolus IL-2 Methods Patients This phase II trial was an open label study of MVA-5T4 vaccine in patients with metastatic clear cell or ... region Study design A dose of × 108 pfu (1 ml) MVA-5T4 was established as safe in a Phase I trial [11] In this trial, the first dose was given by intramuscular injection alone and booster vaccination ... tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I /II trial Clin Cancer Res 2006, 12:3416-3424 Harrop R, Ryan MG, Myers KA, Redchenko I, Kingsman...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
... clinically important difference Control Clin Trials 1989, 10:407-415 doi:10.1186/1479-5876-8-20 Cite this article as: DiPaola et al.: A randomized phase II trial of mitoxantrone, estramustine and ... S, Rao KV, Kane M, Dave N, Capanna T, Doyle-Lindrud S, Engle E, Jin L, Todd M, DiPaola RS: A phase II trial of docetaxel and vinorelbine in patients with hormone-refractory prostate cancer Cancer ... Pharmacol 2005, 56:199-204 Hussain A, Dipaola RS, Baron AD, Higano CS, Tchekmedyian NS, Johri AR: Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer Ann Oncol...
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Báo cáo sinh học: "Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety" ppt
... Human Use (ICH)-Good Clinical Practice (GCP)-registered phase I /II clinical trial of rh-HGF As this application is the first clinical trial to administer rh-HGF to humans, we performed additional ... to evaluate renal involvement, including serum creatinine and histological findings A phase I /II clinical trial for patients with acute liver failure Overview This single-arm, open-labeled, and ... recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I /II clinical trial, following preclinical studies to ensure safety Journal of Translational Medicine...
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Báo cáo khoa học: "Surgical treatment for locally advanced lower third rectal cancer after neoadjuvent chemoradiation with capecitabine: prospective phase II trial" pptx
... occurred Hematological toxicity was mild with grade II anemia in patients (9.3%, 95% CI 3–23), and grade II leucopenia in patients (4.7%, 95% CI 0.8 17) Regarding non hematological toxicity; hand-foot ... two large, randomized phase III trials including over 1200 patients showed that oral capecitabine was more active than bolus 5-FU/LV in terms of tumor response (26% versus 17% ), and produced at ... rectal cancer: a multicentric phase II study Ann Oncol 2006, 17: 246-51 Dunst J, Reese T, Debuse J, Hoelscher T, Budach W, Rudat V, Wulf J, Mose S, Hinke A: Phase II study of preoperative chemoradiation...
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Báo cáo khoa học: "Long-term results from a randomized phase II trial of neoadjuvant combined-modality therapy for locally advanced rectal cancer" ppt
... multicentric phase II study Ann Oncol 2006, 17: 246-251 27 Desai SP, El-Rayes BF, Ben-Josef E, Greenson JK, Knol JA, Huang EH, Griffith KA, Philip PA, McGinn CJ, Zalupski MM: A phase II study of ... GERCOR phase II study Oncology 2007, 73:169 -176 30 Freedman GM, Meropol NJ, Sigurdson ER, Hoffman J, Callahan E, Price R, Cheng J, Cohen S, Lewis N, Watkins-Bruner D, Rogatko A, Konski A: Phase I trial ... Oncol Biol Phys 2006, 66:1378-1383 doi:10.1186 /174 8-717X-5-88 Cite this article as: Velenik et al.: Long-term results from a randomized phase II trial of neoadjuvant combined-modality therapy...
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Báo cáo y học: "A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis" ppsx
... suppressed by CCII [17, 18] These experiments in rodents have provided the basis for human clinical trials In a randomized, double-blind, multicenter, and controlled phase II clinical trial involving ... giving their written informed consent [20] There are no patients in the phase II study who were enrolled in this phase III trial Table defines the study population Admission criteria also included ... patients with RA In this phase III trial, CCII at 0.1 mg daily and MTX at 10 mg once weekly effectively alleviated signs and symptoms of active RA However, the efficacy of CCII did not exceed that...
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Tài liệu WWEI phase II pdf
... lng c bn - other salary Cụng tỏc xõy lp thuc nhúm II: 1.062 group II of construction of work Cụng tỏc xõy lp thuc nhúm III: 1 .171 group III of construction of work Legal holiday, public holiday ... 380 CII 300 CIII TCVN 1651 - 85 Tensile strength CI Standard Yeild strength 400 Grade Bendable Inside diameter 25 180o 0,5d 500 19 180o 3d 600 14 90o 3d 180o 3d 16 (d < 25 mm) SD 295A 295 400 ... JIS A5528 1998 bn c lý Mechanical Properties Gii hn chy Yeild Point (N/mm2) Gii hn t Tensile Strength (N/mm2) gión di Elongation (%) SY 295 295 490 17 SY 390 390 540 15 Thnh phn húa hc Steel bars...
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MARTA 2012 Management Audit PHASE II DRAFT pdf
... long-term In 2011, MARTA commissioned Phase I of the KPMG study in an effort to determine if efficiencies could be obtained This report, representing Phase II of KPMG’s work represents p p g p ... i ti key business areas 2012 Management Audit – Focused on Strategic Transformation Phase 2011 Phase 2012 Phase 2013 Capital, Operations & Maintenance Gap Assessment Process Strategic Transformation ... reserved Final Phase Sc P cope The Scope consisted of required tasks and a commitment to assess other high priority tasks Required tasks, also referred to as Fixed tasks, were identified in Phase project...
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Child Health Action Plan Phase II Impacting on Child Health Outcomes 2012 - 2017 pptx
... May 2011 Stage II of Phase I involves utilising rheumatic fever, respiratory disease and serious skin infection resources across other high needs areas in the district; and • Phase II: covering ... developed for the purposes of identifying the key issues, and prioritised areas for action for Phase II The Phase II document has been developed effectively as “five plans in one” The CCDHB Child Health ... Project involves developing a phased approach to child protection service development: • Phase I - building a multi-disciplinary team approach within CCDHB; • Phase II - a strategy to support a...
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FACILITY SURVEY (Under Reproductive and Child Health Project) Phase – II, 2003 ppt
... Acknowledgements………………………………………………………………………… iii List of Tables …………………………………………………………………………… iv-v List of Figures ………………………………………………………………………… vi-vii Acronyms………………………………………………………………………………… viii Definition of Selected ... specific facilities……………… xxii Percentage of ISM & H Hospital with specific facilities………… xxiii Percentage of ISM & H Dispensary with specific facilities…………… xxiii CHAPTER I INTRODUCTION Table ... Territories (UTs were fully covered in Phase I) were again covered under the Facility Survey during Phase – II, in 2003, after a gap of five years During Phase – II in 2003, in seven districts of...
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Phase II: Estimating Health and Economic Damages (ILLNESS COSTS OF AIR POLLUTION) pdf
... H Economic Losses Due to Premature Mortality vii Appendix I Quality of Life Damages Appendix J Lost Productivity Damages Appendix K ICAP Results viii List of Tables Table 5.1 Comparative Human ... namely: i) the value of reduced risk of premature mortality ii) the cost of reduced health care resource utilization (e.g., hospital care) iii) the value of avoided lost productive time (e.g., lost ... requirements are: i) current and future air quality conditions, ii) current and future size, distribution and composition of the exposed population, iii) E/RFs for key air pollutants, and iv) economic coefficients...
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The National Study Report- Phase II of The National Study of Business Strategy and Workforce Development docx
... resource management responsibilities A total of 578 organizations provided information during Phase I and Phase II Although this was not a random sample, all analyses (unless noted otherwise) used proportional ... can be found online at: http://agingandwork.bc.edu/documents/RH03_BenchmarkStudy_12-06_001.pdf Phase II was the National Study Non-governmental organizations with 50 or more employees were invited ... Report The National Study of Business Strategy and Workforce Development was implemented in two phases Phase I was “The Benchmark Study.” This study focused on employers who were “early adaptors”...
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Natural Resource Accounting in Goa Phase II: Integrated Research and Action for Development, New Delhi doc
... Nadu 20326 2174 0 23358 25965 Karnataka 18091 1957 8 21238 23945 22497 West Bengal 174 99 18494 20548 Andhra Pradesh 179 32 19087 21372 23153 Arunachal Pradesh 15577 16916 19029 19724 1957 2 Meghalaya ... 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Goa 51073 60787 57369 58184 30701 Punjab 25868 26 395 28607 Maharashtra 24044 26858 28848 3 2170 32712 Haryana 24883 26818 2950 4 Himachal ... - waste 7000 175 00 0 .17 - 1 0950 3650 0.08 100.3 NA 0.01 5.9 2432 NA 0.03 10.2 14600 NA 0.19 7.4 36711 21150 0.48 123.8 Municipal Council Marmugao Municipal Council Ponda Municipal 172 9 Council...
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báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx
... multicenter phase II trial J Clin Oncol 1999, 17: 914-920 Rebattu P, Quantin X, Ardiet C, Morere JF, Azarian MR, Schuller-Lebeau MP, Pujol JL: Dose-finding, pharmacokinetic and phase II study of ... weeks (95% CI 12 – 21) and 14 weeks (95% CI – 27) in arm B (Figure 1A) Median survival in arms A and B was 32 weeks (95% CI 27 – 49) and 33 weeks (95% CI 24 – 54), and 1year survival was 33% (95% ... randomized phase III trial of paclitaxel plus cisplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small cell lung cancer: a Southwest Oncology Group trial J...
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Báo cáo hóa học: " Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100derived epitope peptide " pot
... enrolled in this trial are listed in Table Grade III non-hematological adverse events were observed in P1 (CNS hemorrhage at the brain metastasis) and P4 (hypoxia), and grade III hematological ... gp100:209- 217 peptide as well as the melanoma cells positive for HLA-A*0201 and gp100 [19] In other clinical trials, HLA-A*0201positive melanoma patients were vaccinated with gp100:209- 217( 210M) ... peptides derived from gp100 to treat HLA-A*2402-positive melanoma patients We have conducted a phase I clinical trial to treat the HLA-A*2402-positive patients with stage IV melanoma by vaccination with...
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Báo cáo hóa học: "Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma" potx
... y M1a Surgery CR 30 # 095- 050 Female/70 y IIIc Surgery-ILP PR 33+ # 095- 200 Male/46 y M1a Surgery/Interferon PR 35+ # 095- 020 Female/44 y M1b Surgery-ILP SD/NED 30+ # 095- 060 Female/69 y M1b ... treatment initiation 23 70% 1 3% 3% IIIB - N2c 13% IIIC - N3 16% IV - M1a 16 42% IV - M1b 10 26% IV - M1c 3% (5%) (8%) (53%) had received prior immunotherapy and 17 patients (45%) had received prior ... firstline treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG Ann Oncol 2006, 17: 563-570 12 Wolchok JD, Hoos A, O’Day S, Weber JS, Hamid O,...
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Báo cáo khoa học: " Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study" docx
... and colleagues [16] Recently, two phase III trials, the large National Surgical Adjuvant Breast and Bowel Project (NSABP) R-04 Intergroup study [17] and a German trial [18], have confirmed that ... German CAO/ARO/AIO-04 randomized phase III trial J Clin Oncol 2011, 29(suppl):Abst LBA3505 23 Mohiuddin M, Winter K, Mitchell E, Hanna N, Yuen A, et al: Randomized phase II study of neoadjuvant combined-modality ... of a randomised phase III study J Clin Oncol 2001, 19:2282-2292 Page of 11 Twelves C, Wong A, Nowacki MP, Abt M, Burris H, et al: Capecitabine as adjuvant treatment for stage III colon cancer...
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- annex 4 scope of work for phase ii data collect
- phase i and phase ii
- phase ii and phase iii
- fast track combined phase i and phase ii
- content and format combined phase i and phase ii application
- i phase ii funding commitment commercial contribution optional
- e provide annual pro formas for the next five years two years of the fast track phase ii effort 3 years post phase ii income statements are required cash flow and balance sheets may be included if they are considered critical for your strateg
- simon¡¯s two stage phase ii design
- phase ii studies in solid tumors
- phase ii studies in myelodysplastic syndrome mds
- phase ii studies in chronic myeloid leukemia cml patients
- box 4 1 phase 2b clinical trial data of onabotulinumtoxin a dmochowski et al 2010
- overview of phase ii clinical trials
- phase ii trials using time to event endpoints
- phase ii selection designs
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