phase ii studies in solid tumors
Báo cáo y học: "A tumor cord model for Doxorubicin delivery and dose optimization in solid tumors Steffen Eikenberry" ppsx
... by increasing infusion time or dividing single large infusions into multiple smaller infusions For example, Greene et al [22] proposed that dividing a 15 minute infusion of 75 mg/m2 into infusions ... vessel wall during the plasma distribution phase and therefore aid transport into the tumor cord During the terminal phase the DOX gradient inverts and drug begins clearing back into the vasculature, ... DOX in the plasma inhibits delivery to the tumor cord, increasing binding to proteins in the extracellular space causes bound DOX to act as a reservoir that increases cellular exposure to DOX Increasing...
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Natural Resource Accounting in Goa Phase II: Integrated Research and Action for Development, New Delhi doc
... Accounting in Goa Phase II Project Report March 2008 Project Team Dr Jyoti Parikh, Team Leader Vinay Singh Saudamini Sharma Champak Buragohain Sponsored By Central Statistical Organization Ministry ... is expected to help in the revival of agriculture and increase in its contribution to GSDP in the State The value added from Forestry & Logging in GSDP has been declining in real terms This can ... Domestic tourist arrivals in 2003 In India, a total of 274215 foreign tourist arrived in India in January 2003, whereas the corresponding figure for Goa is 38236 (13% of India) In December, the foreign...
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oxford studies in metaethics volume ii jun 2007
... explanatory indispensability In section 5, I say more about what indispensability is, dividing the discussion into an account of what I call instrumental and intrinsic indispensability In the following ... remarks about the ‘shaping’ role of moral wrongness indicate, they could instead be reasons for thinking about what to in a certain way (a way that involves taking a certain view of which other ... is something like Field’s (1989: 59) distinction between being useful in, e.g., facilitating inferences on the one hand, and, on the other hand, being useful in being theoretically indispensable.²⁵...
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
... support determining the effector to regulatory ratio in future clinical trials In summary, this study provides safety and feasibility data supporting the combination of MVA-5T4 vaccine and IL2 ... altered morphology and increased motility suggesting that 5T4 plays a role in tumor progression and invasion [10] A recombinant modified vaccinia virus Ankara (MVA) encoding human 5T4 (MVA-5T4) ... protocol was approved by the Institutional Review Board Vaccine preparation 5T4-MVA vaccine was produced by homologous recombination of human 5T4 cDNA into deletion region III of MVA under the control...
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báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
... both brain tumors and peripheral tumors is much larger In the case of brain tumors, inter-endothelial cell gaps have been reported to range between 100 nm and 3000 nm in diameter[10,13] and in the ... topic RG-2 gliomas growing in brain tissue is approximately 12 nm Our present finding is in agreement with our previously reported finding that the upper limit of pore size in the BTB of orthotopic ... inoculated with 105 RG-2 glioma cells in μL of sterile PBS In each location, the cells were injected over minutes, using a 10 μL Hamilton syringe with a blunt tip 32-gauge needle for the brain...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
... cancer In addition, the 26-item Trial Outcome Index (TOI) was computed by combining the physical wellbeing, functional well-being, and PCS subscales Pain intensity and interference with functioning ... combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine in patients with CRPC One study demonstrated a potential clinical benefit ... receptor tyrosine kinase inhibitor ZD1839 in non-small cell lung cancer and other solid tumors Clin Cancer Res., 9: 2040-2048, 2003 Clin Cancer Res 2003, 9:1990-1994 Jaeschke R, Singer J, Guyatt...
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Báo cáo hóa học: "Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma" potx
... transferred to the clinical site with continuous temperature monitoring The vaccine was administered within one hour of thawing and reconstituting in mL of sterile saline Patients were scheduled to receive ... and Indoleamine 2,3-Dioxygenase in Patients with Melanoma Undergoing CTLA4 Blockade Clin Cancer Res 2009, 15:390-399 15 Marincola FM, Jaffee EM, Hicklin DJ, Ferrone S: Escape of human solid tumors ... or SD lasting at least eight weeks, following the Response Evaluation Criteria in Solid Tumors (RECIST) [8] Lesions in the skin and subcutaneous tissues, evaluable only by physical examination...
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Báo cáo khoa học: "A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer" potx
... encouraging results have been obtained in phase I studies using cisplatin-combination CTRT with either topotecan or tirapazamine [60-62] Several phase I /II studies are currently investigating the ... tested in phase I /II studies and some of them have shown promising results Perhaps the most promising and most studied drugs of this group are gemcitabine, tirapazamine, and topotecan In a phase II ... cisplatin (4/7 studies) or carboplatin (3/7 studies) but was never used alone for CTRT The majority of these studies was phase I (4/7 studies) , with one study being a combined phase I /II study...
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Báo cáo khoa học: " Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study" docx
... as well as in the adjuvant setting in colon cancers [8-14] Furthermore, capecitabine has been investigated in various protocols for rectal and other gastrointestinal cancers in combination with ... treatment for LARC [4] Phase II studies evaluating preoperative doublet chemotherapy of oxaliplatin or irinotecan plus 5-FU or capecitabine combined with concurrent radiotherapy in LARC have reported ... evaluating preoperative capecitabine and oxaliplatin reported a pCR rate of 10% while studies investigating preoperative capecitabine, oxaliplatin and bevacizumab found rates of 24-36% [32-34] In...
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Báo cáo y học: "Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors" pps
... profile of everolimus in Chinese patients is consistent with that of previous studies, including the pivotal global phase III metastatic RCC study [9,11,15] In the phase III study in RCC, the most ... Drug Administration to evaluate PK, safety, and antitumor activity of oral everolimus and 10 mg/day in Chinese patients with advanced solid tumors in part to support global phase III studies ... moderate in severity [11] Preclinical studies have shown that everolimus inhibits proliferation of a wide spectrum of human solid tumors in vitro and in vivo [12-14] Pharmacokinetic (PK) studies...
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Báo cáo y học: "A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis" ppsx
... controlled phase II clinical trial involving 236 patients with severe active RA, a decrease in the number of swollen joints and tender joints occurred in subjects fed CCII for months Meanwhile, CCII ... RA were entered into the study after giving their written informed consent [20] There are no patients in the phase II study who were enrolled in this phase III trial Table defines the study population ... doubleblind, multicenter, and controlled phase III clinical trial Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by pain, swelling, and stiffness of multiple joints It...
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Báo cáo khoa học: "Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study" docx
... conditioned in ampoules containing mg selenium as sodium selenite diluted in 48 ml saline and were administered intravenously by continuous infusion (2 ml/hour) at the following doses, expressed in selenium ... variables of fluid infused during the previous 24 hours bDopamine at any dose; dobutamine, epinephrine and norpinephrine at doses corresponding to the inclusion criteria Table Origin of sepsis and ... selenite may be interesting as they may temporarily reduce excessive inflammation by inhibiting NF-κB to DNA binding [32,33] or by inducing a proapoptotic effect on activated circulating cells [13,20,34]...
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Hydrodynamics studies in two and three phase bubble column
... TABLE OF CONTENTS Acknowledgements i Table of contents iii Summary vii Nomenclature viii List of Figures x List of Tables Chapter Introduction xiii 1.1 Objectives and Scope 1.2 Organization of thesis ... containing draught tube As a result, liquid flow velocity can be interpreted for determination of transition regime in bubble columns Also, attempt will be made to obtain information regarding ... associated with the gas phase including the bubble wake interaction with the continuous phase, bubble coalescence, and bubble breakup Thus, in any reactor design or modeling of bubble columns,...
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Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... “sugar pills” in the morning to protect blinding and two UC -II capsules in the evening accounting for a daily dose of 40 mg UC -II containing 10 mg of bioactive undenatured type II collagen Each ... capsules (providing 10 mg of undenatured collagen II) is based on efficacy demonstrated in earlier studies (8,9) Blinding In order to protect blinding, subjects were given bottles containing product ... Visit Randomization Clinical assessments as indicated; first dose in clinic Clinical assessments as indicated Clinical assessments as indicated Clinical assessments as indicated 30 60 Treatment...
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THE INFORMAL SECTOR IN SOLID WASTE MANAGEMENT IN DEVELOPING COUNTRIES SUSTAINABILITY EFFECTS OF FORMALISATION CONSIDERING HO CHI MINH CITY – VIETNAM AS AN EXAMPLE
... MANAGEMENT IN DEVELOPING COUNTRIES III The informal sector and the informal economy III.1 Definition The term ‘informal sector’ was first introduced by the International Labour Organisation (ILO) in ... III.5.1.1 III.5.1.2 III.5.1.3 III.5.1.4 III.5.2 III.5.3 III.5.4 Ecological dimension 23 Economical dimension 25 Social dimension 25 Institutional ... III.4.3 Problems of Informal Waste Management actors 21 III.5 FORMALIZING INFORMAL WASTE MANAGEMENT ACTIVITIES 22 III.5.1 Reasons for formalisation 22 III.5.1.1 III.5.1.2...
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Design and development of major balance of plant components in solid oxide fuel cell system
... reforming or partialoxidation reforming In the INER SOFC system, the reforming process is performed using a combination of these two methods by feeding both steam and an oxidant (air) into a ... research topics including: power plant, two phase flow, cold neutron source, and solid oxide fuel cell E-mail address: wthang@iner.gov.tw Tzu-Hsiang Yen obtained a PhD in Mechanical engineering from ... of Nuclear Energy Research He holds a PhD in environmental engineering, M.S and B.S in chemical engineering His research interests include biomass reforming, hydrogen generation and low level radwaste...
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Tài liệu STUDIES IN NUTRITION pptx
... the during the bean periods negative balance during the phaseolin period, but the unfavorable nitrogen balance during the feeding of pea globulin is presumably attributable to its inherent inadequacy ... produced brittle feces g ence ployed aa noted in the table t Forced feedIng necessary throughout l (4 days) FeedIng On 83.8 I the “indineatlble” in the remaining the was three period-no TABLE 94.5 I ... cent respectively Wintgen’s results are in accord with those obtained in an extensive investigation by Wait, in which a utilization of 77 to 78 per cent was obtained for bean protein, and 70 to 83...
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Tài liệu WWEI phase II pdf
... Js.Co Road engineer duty Detailed engineering design consists of (1) review of definitive plan: Phase II : IR, F/S Phase I : detailed design (detail drawing, main report and final report), ... nghin cu tin kh thi, bo co feasibility studies, and feasibility studies; nghin cu kh thi; b) Consultancies for project implementation, including b) Dch v t thc hin d n gm c kho st, surveying, ... function Phase I - In the International Competitive Bidding document INTERNATIONAL COMPETITIVE BIDDING FOR PACKAGE D CONVEYANCE AND EXISTING COMBINED SEWER VOLUMES: VOLUME 1: general and pricing...
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Tài liệu Studies in ornamental trees and shrubs docx
... branches inclined to be longitudinal or spreading: leaves narrowly linear, rigid, sharp-pointed, to in long, about y8 in wide, midrib and marginal ribs prominent, cross-nerves spreading nearly ... cross-veinlets: flowering spikes creamy white (varying to pink and purple in Australia), 1% to in long, in wide, at first terminal, the axis growing out only after flowering: stamens nearly ^ in long ... overlapping, narrowly linear, acute, % to % in long, y^ in wide, apparently nerveless: flowering spikes of a rich scarlet color, cylindric, about 21/) in long and 11/2 to 1% in in diameter, forming...
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