simon¡¯s two stage phase ii design
báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx
... survival (OS) This randomized phase II trial can be considered as two simultaneous phase II studies: the sample size for each arm was calculated using Simon's one -stage design with a 5% α error and ... Giaccone G: Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-smallcell lung cancer: a phase III trial of the European Organization for ... group phase II study Cancer Chemother Pharmacol 2007, 60:725-732 Binder D, Sailer V, Schweigert M, Temmesfeld B, Wobst B, Schweisfurth H, Petri F, Kieslich C, Possinger K: A randomized phase II...
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Báo cáo toán học: " Two-stage source tracking method using a multiple linear regression model in the expanded phase domain" pdf
... proposed two- stage method The multiple linear regression model-based LS method for IPD estimation is proposed in the expanded phase domain, Ωd The proposed method is composed of two stages: the ... estimator (MVE) in the expanded phase domain The proposed TDE method is composed of two stages: an LS-based TDE method estimates an initial delay at the first stage, and the estimated delay is ... that the phase is linear and always starts from zero at zero frequency However, phase wrapping results in discontinuity due to the shifting phase term, ±2π given in Equation The purpose of phase...
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Báo cáo y học: " Two-stage procedure in the treatment of late chronic hip infections spacer"
... allografts in two- stage reconstruction after failure of hip replacement due to infection J Bone Joint Surg 1991;73A:1460-1468 Haddad FS, Muirhead-Allwood SK, Manktelow AR, Bacarese-Hamilton I Two- stage ... The outcome of two- stage arthroplasty using a custom-made interval spacer to treat the infected hip J Arthroplasty 1997;12(6):615-623 12 McKenna PB, O’Shea K, Masterson EL Two- stage revision ... complications associated with prolonged recumbency are also avoided due to early mobilisation [33] Two- stage revision arthroplasty using ALC but without long-term systemic antibiotic therapy has also...
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Let''''s go 1A - Ky II ( full )
... To encrease Ss interested in learning English II- Teaching aids: 1- Teachers: Teaching project, text book, 2- Pupils: Text book, notebook, pen, III- Activities for teaching and learning: 1- Organization: ... To encrease Ss interested in learning English II- Teaching aids: 1- Teachers: Teaching project, text book, 2- Pupils: Text book, notebook, pen, III- Activities for teaching and learning: 1- Organization: ... To encrease Ss interested in learning English II- Teaching aids: 1- Teachers: Teaching project, text book, 2- Pupils: Text book, notebook, pen, III- Activities for teaching and learning: 1- Organization:...
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Numerical investigation into premixed hydrogen combustion within two-stage porous media burner of 1 kW solid oxide fuel cell system
... system, the two- stage porous media after-burner plays a key role in ensuring the complete conversion of the SOFC off gases during nominal operation, supplying heat during the system start up phase, ... interest in the literature For example, Trimis and Durst [5] conducted two- section porous media zone experiments in which the two sections contained materials with different properties and porosities, ... study, numerical simulations are performed to analyze the premixed combustion problem within the two- stage porous media burner in the kW SOFC system developed by INER [4] In contrast to most previous...
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Tài liệu WWEI phase II pdf
... lng c bn - other salary Cụng tỏc xõy lp thuc nhúm II: 1.062 group II of construction of work Cụng tỏc xõy lp thuc nhúm III: 1.171 group III of construction of work Legal holiday, public holiday ... engineering design consists of (1) review of definitive plan: Phase II : IR, F/S Phase I : detailed design (detail drawing, main report and final report), ICB document (2) detailed engineering design: ... THUT XUT a) Basic Design Parameters - Design load for pavement: Axle load 12 ton Tire pressure Kg/cm2 Diameter of tire mark 36 cm - Design Traffic Volume (H10): 300 vehicle/Day - Design speed: 60...
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Tài liệu Báo cáo khoa học: "EXTENDING KIMMO''''S TWO-LEVEL MORPHOLOGY *" doc
... Kimmo's two- level model X: (+:0) We have implemented the extended two- level model using the standard method of representing phonological rules by deterministic finite state automata (Antworth, ... the two- level model is described in the next section EXTENDING CV* +:0 t : t {B,NAS}C +:0 Consider a fictional e x a m p l e - - ( l l ) below to illustrate how the extended model works (II) ... used in a general way without conflicts with the complete set of two- level rules applicable To avoid conflict we assign a subset of two- level rules, say P1, to morpheme which it applies between...
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MARTA 2012 Management Audit PHASE II DRAFT pdf
... commissioned Phase I of the KPMG study in an effort to determine if efficiencies could be obtained This report, representing Phase II of KPMG’s work represents p p g p the next stage of MARTA’s ... i ti key business areas 2012 Management Audit – Focused on Strategic Transformation Phase 2011 Phase 2012 Phase 2013 Capital, Operations & Maintenance Gap Assessment Process Strategic Transformation ... Draft Phase Deliverables to MARTA September 2012 Presented Final Phase Deliverables to MARTA © 2012 KPMG LLP, a Delaware limited liability partnership and the U.S member firm of the KPMG network...
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Child Health Action Plan Phase II Impacting on Child Health Outcomes 2012 - 2017 pptx
... May 2011 Stage II of Phase I involves utilising rheumatic fever, respiratory disease and serious skin infection resources across other high needs areas in the district; and • Phase II: covering ... Systems Service Design Project involves developing a phased approach to child protection service development: • Phase I - building a multi-disciplinary team approach within CCDHB; • Phase II - a strategy ... developed for the purposes of identifying the key issues, and prioritised areas for action for Phase II The Phase II document has been developed effectively as “five plans in one” The CCDHB Child Health...
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FACILITY SURVEY (Under Reproductive and Child Health Project) Phase – II, 2003 ppt
... Acknowledgements………………………………………………………………………… iii List of Tables …………………………………………………………………………… iv-v List of Figures ………………………………………………………………………… vi-vii Acronyms………………………………………………………………………………… viii Definition of Selected ... specific facilities……………… xxii Percentage of ISM & H Hospital with specific facilities………… xxiii Percentage of ISM & H Dispensary with specific facilities…………… xxiii CHAPTER I INTRODUCTION Table ... Territories (UTs were fully covered in Phase I) were again covered under the Facility Survey during Phase – II, in 2003, after a gap of five years During Phase – II in 2003, in seven districts of...
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Phase II: Estimating Health and Economic Damages (ILLNESS COSTS OF AIR POLLUTION) pdf
... H Economic Losses Due to Premature Mortality vii Appendix I Quality of Life Damages Appendix J Lost Productivity Damages Appendix K ICAP Results viii List of Tables Table 5.1 Comparative Human ... namely: i) the value of reduced risk of premature mortality ii) the cost of reduced health care resource utilization (e.g., hospital care) iii) the value of avoided lost productive time (e.g., lost ... requirements are: i) current and future air quality conditions, ii) current and future size, distribution and composition of the exposed population, iii) E/RFs for key air pollutants, and iv) economic coefficients...
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Philosophers in the "Republic": Plato's Two Paradigms
... Contents Acknowledgments ix Introduction: Two Paradigms 1 Philosophers by Nature 11 Philosophers by Design I: The Making of a Philosopher 49 Philosophers by Design II: The Making of a Ruler 85 Socratic ... pankalous—540b), the reader is in a position to know better because he has already seen better III Two Cities and Two Kinds of Philosopher-Ruler In Books 2–5 Socrates constructs for Glaucon (and, to a ... political or as psychological/moral The books I emphasize are and 7, where the two paradigms are developed The first of these two portrayals begins at 5.473c, continues on to 6.490d, and is revived and...
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The National Study Report- Phase II of The National Study of Business Strategy and Workforce Development docx
... Report The National Study of Business Strategy and Workforce Development was implemented in two phases Phase I was “The Benchmark Study.” This study focused on employers who were “early adaptors” ... resource management responsibilities A total of 578 organizations provided information during Phase I and Phase II Although this was not a random sample, all analyses (unless noted otherwise) used proportional ... skills, their professional networks, their client networks, and their desire to lead and supervise (See Figure 8.) Figure 8: Business-Related Attributes by Career Stage % respondent organizations...
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Báo cáo khoa học: "A Two-Stage Approach to Retrieving Answers for How-To Questions" pot
... Regression classification model) will be used for further experiments on the two- stage architecture Stage Two Stage One Figure A two- stage architecture We also tried to test how well query expansion could ... the goal to retrieve relevant documents (equivalent to the first stage in the two- stage architecture) We will also compare the two- stage approach with systems that applies automatic query expansion ... result of the first stage in the twostage architecture, one system that uses query expansion technique following the architecture in figure and two systems that apply the two6 IR Model For the...
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Natural Resource Accounting in Goa Phase II: Integrated Research and Action for Development, New Delhi doc
... Pilot Project on NRA (Phase I) ANNEX Municipal SWM ANNEX Municipal Workers Details ANNEX Air & Water Pollution ANNEX Forestry Details of Goa References 100 113 116 119 129 138 viii PR-IRADe-08-2007 ... environmental accounting and valuation Kindly give us your feedback Jyoti Parikh Executive Director, IRADe iii PR-IRADe-08-2007 Acknowledgements We express our sincere thanks to Central Statistical Organisation ... Natural Resource Accounting in Goa Phase II Project Report March 2008 Project Team Dr Jyoti Parikh, Team Leader Vinay Singh Saudamini...
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Báo cáo khoa học: "An Effective Two-Stage Model for Exploiting Non-Local Dependencies in Named Entity Recognition" pdf
... approach With our two- stage approach, we manage to get improvements on the F1 measure over existing approaches that model non-local dependencies At the same time, the simplicity of our two- stage ap1125 ... consistency information within a document using relatively ad hoc multi -stage labeling procedures Borth- 1127 wick (1999) used a two- stage approach similar to ours with CMM’s where Reference Resolution ... local feature weights and their non-local penalties to approximate inference We present a simple two- stage approach where our second CRF uses features derived from the output of the first CRF This...
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
... virus Ankara (MVA) encoding human 5T4 (MVA-5T4) was tested previously in a phase I clinical trial for patients with stage IV colorectal carcinoma [11] Vaccinated patients demonstrated few adverse ... patients with metastatic RCC In order to take advantage of IL-2 during the contraction phase of the immune response, we designed an exploratory trial in which an initial vaccination was administered ... booster immunizations were supported by the addition of high-dose bolus IL-2 Methods Patients This phase II trial was an open label study of MVA-5T4 vaccine in patients with metastatic clear cell or...
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Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot
... understand and target mechanisms of tumor resistance In the current study, two regimens are tested in a randomized phase II selection design study in an attempt to develop various approaches to abrogate ... Therefore, the results of this study using CRA/IFN with weekly paclitaxel (Arm B of this randomized phase II study) may be helpful to this area of drug development to determine the activity of the combination, ... study entry, no active angina pectoris, or known heart disease of New York Heart Association Class III-IV Patients must have had no history of myocardial infarction within months of study entry and...
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Báo cáo hóa học: "Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma" potx
... site were eligible Stage eligibility included non-resected in-transit (Stage IIIb-N2C or stage IIIC-N3), or distant skin, subcutaneous or lymph node (Stage IV-M1a), or pulmonary (Stage IV-M1b) metastases, ... anti-tumor effects Patients and Methods Study Design and Conduct This was a single-arm, two stage, open-label, multi-center phase II study In the first stage, 12 patients were enrolled, and since ... solid tumors [see comments] J Natl Cancer Inst 2000, 92:205-216 Simon R: Optimal two- stage designs for phase II clinical trials Control Clin Trials 1989, 10:1-10 10 Schultze JL, Grabbe S, von...
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Báo cáo sinh học: "A Practical Two Stage MMSE based MIMO detector for Interference Mitigation with Non-Cooperative Interferers" pdf
... system The performance of our two- stage algorithm approaches that of the infeasible MMSE solution The loss in performance is less than 0.5 dB We also note that the two- stage solution consistently ... alternatives available for the pre-filter are inferior to the proposed two- stage solution The SMI solution also fails to outperform the two- stage solution in this complex channel The bit error rate for ... improvement in performance from the two- stage approach The performance of the system without a pre-filter is not good enough to sustain reliable communications The two- stage approach provides performance...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 chỉ tiêu chất lượng 9 tr 25