... rate and differentiation of F9 cells were not affected by the over-expression of Hsp105a, the sensitivity of cells to oxidativestress wasenhanced by the over-expression of Hsp105a,andthesefindings ... over-expression of Hsp105a seemed toenhance the release of cytochrome c from mitochondria inF9 cells by hydrogen peroxide.Fig. 3. Enhancement ofoxidative stress- induced apoptosis by over-expression of ... apoptosis at orupstream of cytochrome c release from mitochondria.Furthermore, the transmission of signals from externalstresses is accompanied by the activation of a family of stress- activated protein...
... Agarwal A, Krajcir N, Alvarez JG: Roleofoxidativestress inendometriosis. Reprod Biomed Online 2006, 13:126–134.22. Agarwal A, Gupta S, Sharma RK: Roleofoxidativestress in femalereproduction. ... toxins: pervasive theme of oxidative stress and electron transfer. Curr Med Chem 2001, 8:863–892.323. Kovacic P, Sacman A, Wu-Weis M: Nephrotoxins: widespread role of oxidativestress and electron ... CM, Gupta S, Agarwal A: Could oxidativestress influence thein-vitro maturation of oocytes? Reprod Biomed Online 2009, 18:864–880.383. Sikka SC: Roleofoxidativestress response elements and...
... 1997:190). 27 The pattern ofstress in this sentence is stressed – unstressed – stressed – unstressed – stressed – unstressed, with equal number of alternating stressed and unstressed syllables. ... frequency usage of English sentence stress The chart below shows 13 of them (32.5%) indicate that they never use sentence stress while speaking. Some of them about 12.5% often use sentence stress in ... Misunderstanding of meaning caused by wrong placement ofstress 49 2.2. Misunderstanding of meaning caused by changes in sentence stress. 50 2.3. Communication breakdown caused by wrong use of stress...
... boxes.Ó FEBS 2003 Roleof 3,4-dihydrocoumarin hydrolase of Acinetobacter (Eur. J. Biochem. 270) 491 Role of Acinetobacter calcoaceticus3,4-dihydrocoumarin hydrolasein oxidativestress defence ... probe.Ó FEBS 2003 Roleof 3,4-dihydrocoumarin hydrolase of Acinetobacter (Eur. J. Biochem. 270) 489deduced amino acid sequence of DCH exhibited highsimilarity to those of the esterases of Pseudomonas ... ability of dch to catalyse the peroxidation of organic acids, which could be an intermediary reaction of halogenation, and it is assumed that the roleof DCH in vivois the degradation of peroxoacids.Peroxoacids...
... and fragmentation of theirnuclei. The percentage of apoptotic cells was calculated asthe number of apoptotic cells divided by the total number of cells counted. A minimum of 500 cells were ... beensuggested to play an important role in precondition-ing, a phenomenon of protection of a heart fromstrong ischaemic insult by prior exposure to mildischaemia or other mild stresses. In the presentstudy, ... additional protection against oxidant stress (Fig. 4D). Therefore, Hsp70-transfected cells with ahigher level of nucleolin ⁄ C23 protein become moreresistant to oxidativestress and less susceptible...
... [2]. Concentrations of aldehydes alsoincrease with age and in diseases that are accompan-ied by oxidative stress. Oxidativestress causes lipidperoxidation and formation of aldehydes such asmalon(di)aldehyde, ... acidic pH (b-hydroxyacrolein).The following investigations focus on the effects of acetaldehyde and acrolein because of the relevance of these aldehydes for the biological effects of ingestedethanol ... andKeywordsacetaldehyde; acrolein; metallothionein; oxidative stress; zincCorrespondenceW. Maret, Division of Human Nutrition,Preventive Medicine and CommunityHealth, The University of Texas MedicalBranch,...
... presence of catalase, whereas superoxide anion waslikely to be of m inor importance i n formation of the radicalcations [166].Collectively, the drastic disruption of the C- andN -oxidative ... andN -oxidative biotransformation of aniline and its 4-chloroderivative [149,163] by the presence of catalase furnishesunequivocal e vidence f or a vital roleof autoxidativelyliberated H2O2in ... ring opening of an epoxide inter-mediate at either of its two C-O bonds [219,220].The sum of these findings strongly invokes the notion of oxygen activation during redox cycling of the diversedioxygenases...
... to oxidative stress affects c-Fos stability and BimEL expression by chang-ing the duration of the ERK signal. Therefore, theduration ofoxidativestress might be a fundamentaldeterminant of ... AP-1-dependent geneexpression occurred under the conditions of sustained oxidative stress. This idea is supported by data show-ing that transient oxidativestress for 3 or 6 h did notinduce apoptosis [38].In ... expression of BimEL, a major isoform among the bim geneproducts, leading to apoptosis in rat primary hepato-cytes [15].Bim is a member of the Bcl-2 family of proteins,which play a fundamental role...
... insights into the roles and mechan-isms of PM2.5-associated physiology and pathology.In summary, our data demonstrate the importanteffects of PM2.5exposure on oxidativestress and mito-chondrial ... number and area of mitochondria in the eWAT and iBAT. A-B. Representative TEM images of eWAT. C-D. Representative TEMimages of iBAT (Arrows point to mitochondria). E: The analysis of mitochondrial ... 8:20http://www.particleandfibretoxicology.com/content/8/1/20Page 14 of 14RESEARC H Open AccessAmbient particulate air pollution induces oxidative stress and alterations of mitochondriaand gene expression in brown...
... increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the flow of electrons in the respiratory chain inducing over-reduction of the complexes, favouring the generation of ROS [16,17,22]; ... the’Ca2+paradox’In spite of the widely accepted roleof [Ca2+]cderegula-tion in the manifestation of neurodegeneration, exactlyhow Ca2+ions mediate neural cell death is less clear[185]. One of the most ... to oxidativestress is dependent on activa-tion of poly (ADP-ribose) polymerase. Br J Pharma-col 143, 186–192.235 Balzer M, Lintschinger B & Groschner K (1999)Evidence for a roleof Trp...
... data-base of the aerobic hyperthermophilic archaeon Sulfolobus solfataricus. Its role in oxidativestress was investigated by transcriptional analysis of RNAisolated from cultures that had been stressed ... hydroperoxideFig. 4. Northern hybridization analysis of S. solfataricus P2 bcp2 transcripts: effect ofoxidativestress agents. Cultures of S. solfataricus P2were grown until the mid-exponential ... base of P. horikoshii nei-ther a homologue of A. pernix thioredoxin-like norother types of thioredoxins were found.In this study we examined the involvement of theperoxiredoxin Bcp2 in oxidative...
... thought to elicit oxidative stress, and it is recog-nized that this may have a role in the progression of the disease (for review, see [18]). Usually, the occur-rence ofoxidativestress is evaluated ... influence ofoxidativestress onthese processes. Our data clarify some of these aspects,and suggest that thiol-directed oxidativestress consider-ably influences the inter-organ exchange of cysteine ... long-lasting effects of thiol-directed oxidative stress, and, inparticular, its influence on the inter-organ exchange of LMM-SH.ResultsIn a first set of experiments, the kinetics of plasmathiols...
... Finkel T & Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239–247.3 Jamieson DJ (1998) Oxidativestress responses of theyeast Saccharomyces cerevisiae. ... response of cells with dysfunctional mitochondriato oxidative stress, we evaluated H2O2sensitivity of deletion mutants for the regulators most frequentlyassociated with oxidativestress response: ... oxi-dation of glutathione to the disulfide. Biochem BiophysRes Commun 37, 593–596.41 Garrido EO & Grant CM (2002) Roleof thioredoxinsin the response of Saccharomyces cerevisiae to oxidative stress...
... resulted in a decrease of 0.29 ± 0.19 nmolÆmg)1 of mitochondrial protein. The combination of 3.5 lmCa2+and H ⁄ R led to the substantial decrease in GSH of 1.27 ± 0.15 nmolÆmg)1 of mitochondrial ... conse-quences of stroke [3,4]. Moreover, the increase in lipidperoxidation after ischemia also points towards theinvolvement ofoxidativestress [5,6].Further investigations using animal models of strokemade ... radicals is com-plex I [14]. The degree of production of ROS by therespiratory chain depends on the type of tissue, thekind of substrates driving oxidative phosphorylation(either complex...
... residuesand some of them have been implicated in oxidative stress response. Thus, it is very likely that this redox system formsthe basis of annexin response to oxidativestress in that itreduces ... molecular basis for annexin functionin oxidativestress response.Keywords: calcium; cellulose synthase; cotton; oxidative stress response; plant annexin. Oxidative stress is a health-threatening phenomenon ... structure of Anx(Gh1) from cotton emphasizes thehigh conservation of the unique annexin fold even amongthe members of the plant subfamily of annexin proteins. Thefold is comprised of the arrangement...