... agency. The roles oftheThe roles ofthe state in the financial sector include those of a pro-state moter, owner, regulator, and overseer. The report focuses on areas that were highlighted by the ... and Professor of Economics at the Wharton School ofthe University of PennsylvaniaThorsten Beck Professor of Economics and Chairman ofthe European Banking Center, Tilburg University, NetherlandsCharles ... from around the world.Two building blocks underlie the report’s view oftheroleofthe state in finance. First, there are sound economic reasons for the state to play an active role in financial...
... must still be determined whetherits absence in the V79-G18 mutant is the result ofthe missingESSS subunit alone, or whether the absence of ESSS causes the f ailure of other integral membrane subunits ... and the effect of the absence of intact complex I, but the results are toopreliminary in this regard.Heterologous expression ofthe ESSS-HA subunit The localization ofthe ESSS subunit in the ... as a nother identification of the complex at the position o f the histochemical stain in the left panel. Antisera against the SDHC subunit of complex IIand against the Rieske protein of complex...
... required for efficientcleavage [11]. The solution structure ofthe SEA domain of the mouse homologue of MUC16 (which in the humanencodes the core protein ofthe ovarian cancer antigenCA125) was ... furtherinvestigate theroleofthe SEA domain in cleavage of membrane-tethered mucins we carried out site-directedmutagenesis ofthe FRPG ⁄ SVVV site and evaluatedhybrid mucins in which the ... ducts is of considerable significance in the pathology of a number of diseases including cystic fibrosis and cancer.Equally important is the fate ofthe cytoplasmic tail of the mucins once the extracellular...
... locks the enzyme in the active form for CTP synthesis andthereby stimulates the kcat of the reaction. Since GTP actually willactivate the uncoupled glutaminase reaction the structure of the monomer ... wassimilar to that ofthe overall CTP synthesis reaction. Itwas concluded that the effect of GTP was mainly toenhance the rate of chemical steps ofthe glutaminasereaction. The finding that the kcatvalue ... as the displacement ofthe baseline. The peaksobserved at each injection time are derived from the heat of dilution of glutamine into the reaction cell. (B) The heat generated by hydrolysisof...
... sense of group identity, in the eyes of its members and those outside the group. What is theroleofthe facilitator? The roleofthe facilitator is to make it easier for groups to work together ... 1. TheRoleofthe Facilitator – page 6What is theroleofthe facilitator?How do facilitators help groups achieve their goals?They do it by • Clarifying and reinforcing the purpose ofthe ... Facilitation - 1. TheRoleofthe Facilitator – page 11Group dynamicsFacilitators need to be aware both ofthe communication styles ofthe individuals who make up the group, and ofthe way the group...
... examine the dynamics of tobacco-related media interventions at each of these levels, within a systemic framework. The relationships among these levels and stakeholders on either side ofthe tobacco ... product ofthe mass media era; the art and science of mass communications and mass marketing were critical to the growth of tobacco use in the past century. At the same time, however, the media ... underestimate the effectiveness ofthe campaign.n Last, the all-pervasive nature ofthe media environment includes both messages of interest as well as background “noise.”Given these challenges,...
... analysis oftheroleofthe Healthy Waterways Partnership – Cottingham, Franz Delfau, Garde 25 as well as the risk to the assets under the current flow management strategies (Department ofthe ... increased by 71%, amounting to 23% ofthe State’s direct output from the industrial sector. Mining employed 3.2% ofthe local labour force during the period. The offices ofthe major mining companies ... what the key issues are in the region and how they have arisen. The second part ofthe report puts forward a critique of a program that targets one ofthe priority issues that emerged from the...
... possibleinterpretation ofthe data suggests that the indicatedbasic region of ic3 ofthe D2receptor and acidic region of the C-tail ofthe D1receptor might be involved in the interactions between the two ... on the number of Arg residues thatwere replaced by Ala in the Arg-rich region of ic3 (resi-dues 217–222) ofthe dopamine D2receptor. The effi-ciency of energy transfer in the wild-type ofthe ... localization of these proteins in the cell rather thanfrom the possible roleofthe D2R basic domain in the mechanism of D1–D2receptor heterodimerization. However, we find that the acidicepitope...
... cleavage ofthe c-phosphate does occur in the NBD with the mutation at the IC [36,38,39]. More-over, these and other studies suggest that the ICresidues are involved in the formation ofthe NBDdimer, ... sequence contacts the c-phosphate ofthe bound nucleotide across the dimer [15] and the aromatic residue ofthe A-loopstacks against the adenine moiety of boundnucleotide and provides further stabilization ... activates the attackingwater molecule that cleaves the terminal phosphate of bound ATP. In the latter model, the IC is part of acatalytic dyad, along with the histidine residue of the H-loop,...
... study the behavior ofthe Tyr110-loop in PAL in moredetail.Results and discussionModeling the active conformation of the essential Tyr110-loop of parsley PALBecause ofthe uncertainty ofthe ... subtilis [34], respectively. On the basis of the functional similarity of HAL and PAL, ofthe sameelectrophilic prosthetic group at the active sites, and of the sequence conservation over a ... interpreted bythis hypothesis. The hypothesis will also be extendedto the analysis ofthe possible roleof C-terminalmulti-helix domain in this process.Investigation of bacterial PAL structuresAs...
... family. One ofthe women told that she had been at the offices of the company and an officer showed her the papers related to the purchase of lands ofthe family. According to him, they had just ... from the existence of swamps. The Pampa ofthe South of Brazil, in the State of Rio Grande do Sul (RS) borders another two countries ofthe Pampa: Uruguay and Argentina. Due to a number of ... meet the needs ofthe communities. On the contrary, they were designed on the basis of an agro-export model geared to the countries ofthe North – and the European Union specifically in the...
... upstream of the GAF domain are the potential ligands of the Fe-S cluster. Consequently, the binding ofthe ATPanalog and the subsequent rearrangement ofthe inter-domain interaction affects the ... electronic condition of the Fe-S cluster through the protein scaffold, resultingin an alteration ofthe signal rhombicity ofthe EPRspectrum. The divergence ofthe g-value from that of the whole cell ... level ofthe lacZ gene immediately after the addition of o-phen to minimize the effect ofthe growthinhibition by o-phen on the transcriptional activity of VnfA. Figure 5 shows the time course of...
... discrepancies within the nursing profession with regard to specialist/advanced nursing titles, differing roles and the educational needs of these nurses.In the United Kingdom, the idea of advanced ... ongoing professional development, rather than a requirement of their job description. The implementation within the NHS ofthe Agenda for Change in 2005 aimed to evaluate nursing roles based ... participation in the research process. If the aim of clinical nurse specialists is to enhance patient care, then research must be part oftherole (Armstrong 1999). It will involve their awareness of current...
... implementedto help explain their importance to the specificity andcatalytic efficiency ofthe enzyme. The roleofthe Phe-Phe entranceway The fortuitous discovery of an unreacted molecule of the mechanism-based ... seen for the Phe triad in the structure ofthe mutant Exg:L3 complex. Neither of the two sugar residues interacting with the Trp triadoverlaps with the sugar seen in the Phe-Phe clamp of Exg.Structural ... solved the crystal structure of this GH5enzyme in the presence of two different mechanism-based inhibitors, thereby revealing the close network of interactions that hold the terminal glucose of the...
... interactions with the enzyme and therefore to considerably decrease the contribution ofthe second binding loop of cystatin A to the inhibition of target proteases. However, the flexibility of the second ... within the Leu73–Asn77 segment in the second binding loop of cystatin A. After each of these steps, the conformation of the second binding loop in the complex was refined byenergy minimization ofthe ... in the inhibition of papainand most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute 45% ofthe totalunitary free energy of binding of cystatin A to cathepsin...