volume brain edema and cell death
Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
... Pathways and Cell Death in Breast Cancer, Edited by Rebecca L Aft p cm ISBN 978-953-51-0145-1 Contents Preface IX Part Breast Cancer Cell Death Chapter Estrogen-Induced Apoptosis in Breast Cancer Cells: ... and prostate cancers Targeting New Pathways and Cell Death in Breast Cancer was affiliated with significant systemic side effects, such as nausea, areola pigmentation, uterine bleeding, and edema ... glutamine, cysteine, and glycine It is the most abundant intracellular small molecule thiol present in mammalian cells and it serves as a potent intracellular antioxidant protecting cells from toxins...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
... Daniels MA (2009) ERK and cell death: ERK location and T cell selection FEBS J Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation and cell death FEBS J Taylor ... Journal compilation ª 2009 FEBS S Cagnol and J.-C Chambard ERK and cell death Table Continued Stimuli inducing cell death Duration of ERK activation promoting cell death Human melanoma C8161,WM164 Mel ... condensation PARP cleavage Cell viability Evidence implicating MEK-ERK in cell death Reference U0126 [36] U0126 PD98059 PD98059 [37] [38] U0126 [39] [43] [53] ERK and cell death S Cagnol and J.-C Chambard...
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Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx
... hand, in non-neuronal cells, cytoplasmic retention of ERK1 ⁄ is required for death- associated protein kinase-mediated cell death [35] Thus, ERK1 ⁄ might promote cell death depending upon the cell ... promote cell death As discussed above, in PC12 cells a sustained ERK1 ⁄ activation induced by NGF promotes differentiation and cell survival Thus, the decision by sustained ERK1 ⁄ to induce cell death ... neuronal death was mediated by ERK1 ⁄ [43] Together, these data suggest that ERK1 ⁄ 2-mediated features of neuronal death may differ depending on cell type and death stimulus, but in several cell death...
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Báo cáo khoa học: ERK and cell death: ERK location and T cell selection pdf
... negative selecting ligand Note the separate location of pJNK and pERK, and Ras-GRP1 ⁄ Grb2 ⁄ SOS ⁄ Ras ⁄ Raf at the plasma membrane lead to such distinct cell fates as survival and death Much is known ... problem Interestingly, JNK activity and subcellular location are the same regardless of the ligand strength, ERK location and T cell selection whereas ERK activity and location change depending of ... important for determining cell fate decisions in a diverse number of organisms and cell types (reviewed in [7,8]) In thymocytes, c-JunNH2-terminal kinase (JNK) [9], p38 [10] and extracellular signal-regulated...
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Báo cáo khoa học: ERK and cell death: cadmium toxicity, sustained ERK activation and cell death pot
... result of cell death and not due to an inhibition of cell proliferation, as determined by cell counting as well as quantification of loss of cell integrity [22] Although the ERK prodeath effect ... J & Lenormand P (2009) Total ERK1 ⁄ activity regulates cell proliferation Cell Cycle 8, 705–711 ´ Lefloch R, Pouyssegur J & Lenormand P (2008) Single and combined silencing of ERK1 and ERK2 reveals ... cells [40] and in astrocytes This increase in turn leads to an increase in ROS and to mitochondrial impairment [41] Pretreatment with a calcium chelator reduced ROS production and increased cell...
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TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER pot
... Pathways and Cell Death in Breast Cancer, Edited by Rebecca L Aft p cm ISBN 978-953-51-0145-1 Contents Preface IX Part Breast Cancer Cell Death Chapter Estrogen-Induced Apoptosis in Breast Cancer Cells: ... and prostate cancers Targeting New Pathways and Cell Death in Breast Cancer was affiliated with significant systemic side effects, such as nausea, areola pigmentation, uterine bleeding, and edema ... glutamine, cysteine, and glycine It is the most abundant intracellular small molecule thiol present in mammalian cells and it serves as a potent intracellular antioxidant protecting cells from toxins...
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báo cáo khoa học: " EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana" docx
... precursors stimulate cell death in plants and animals The mechanism by which sphingolipids promote cell death is unknown and may be indirect via their impact on the functioning of cell death effectors ... programmed cell death during the plant innate immune response Cell 2005, 121(4):567-577 Gilchrist DG: Mycotoxins reveal connections between plants and animals in apoptosis and ceramide signaling Cell Death ... causes cell death in both plants and animals and appears to target the same step in ceramide biosynthesis as fumonisin B1 [8,9] In addition, the acd5 and acd11 mutants, which exhibit constitutive cell...
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Roles of tuberous sclerosis complex proteins in autophagy and cell death
... autophagy and cell death in TSC2-/- cells 93 Figure 3.12 Nutrients supplementation further sensitizes TSC2-/cells to cell death 94 Figure 3.13 The involvement of TSC in the regulation of autophagy and ... “programmed cell death (PCD) is the most common term used in the study of cell death (Vaux, 2002), and was first coined by Lockshin and Williams (1965) to study developmental cell death in insects ... immunity, inflammation and tumourigenesis (Fuchs and Steller, 2011; Takeda et al., 2007) There are three types of cell death, which are apoptosis, necrosis and autophagic cell death (Clarke, 1990),...
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Báo cáo khoa học: Programmed cell death Apoptosis and alternative deathstyles pot
... with death domain (FADD) induced caspaseindependent cell death No DNA fragmentation was observed and dying cells showed neither condensation nor fragmentation of cells and nuclei, but the cells and ... autophagy and caspase-dependent cell death pathways Camougrand and coworkers [133] showed in yeast that the expression of Bax induces cell death with characteristics of both apoptosis and autophagy, ... inhibitors [94] Neuregulin (NRG; a ligand of ErbB), also activates ErbB-2/ErbB-3 heterodimers and induces cell death of prostate cancer LNCaP cells Neuregulin-induced cell death was not inhibited by broadspectrum...
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Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
... loss of ERK1 ⁄ and ⁄ or PKB signalling and, as a consequence, promote increased expression of BIM and BIM-dependent cell death in tumour cells Here we review recent advances in understanding BIM ... promote cell death [73] and there is now good evidence to indicate that (a) BIM is important in Myc-induced cell death and (b) that this may be an arbiter of tumour progression B-lymphoid cells ... Furthermore, NSCLC cell lines expressing the secondary T790M mutant EGFR were resistant to gefitinib and erlotinib and failed to upregulate BIM; in such cases, BIM induction and cell death were re-imposed...
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Báo cáo khoa học: Plant oxylipins: role of jasmonic acid during programmed cell death, defence and leaf senescence doc
... of EDS1 ⁄ PAD4 ⁄ SAG101 and BON1 ⁄ BAP1 + in cell death and plant pathogen resistance Whereas EDS1, PAD4 and SAG101 are positive regulators of cell death, BON1, BAP1 and BAP2 operate as negative ... C Reinbothe et al JA and cell death Fig Central role of JA in cell death regulation in plants Animals respond to many external factors with a plethora of different cell death pathways of which ... and JA-mediated cell death in irradiated flu plants is likely to be a form of programmed cell death (PCD) [29] In many aspects it resembles PCD and apoptosis in animals [95–99] This includes cell...
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Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death docx
... proteins Bax and Bak, caspase activation and cell death [2,3] In addition, the physiological platelet agonist thrombin also induces Bid, Bax and Bak translocation to the mitochondria and endogenous ... analysis showing the intracellular distribution of CD47 molecule in zymosan-treated cells (central panel) and OPZ-treated cells (right panel) (E) DIC (Nomarski) micrographs showing cell aggregates in ... annexin V and 0.05% trypan blue for 10 at room temperature, and analyzed by fluorescenceactivated cell sorting (FACS) in the FL1 and FL3 channels to determine the percentage of dead cells The...
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Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death potx
... L(1–2); loop between sheets b-1 and b-2; L(2–3), loop between sheets b-2 and b-3 Asp57, Glu197 and Glu201 are residues involved in chitosan substrate binding at )2, )1 and +2 subsite, respectively ... cell density We thus estimated the number of falsepositive colonies recovered on this medium by mixing various proportions of the V148T chitosanase-expressing cells and chitosanase-negative cells ... CsnN174 (GH46) C-end of a-1 helix b-1 strand E36 (alternative general base) D40b (general base) T45 (water positioning) Loop between b-1 and b2 strands b-2 strand Hen egg-white lysozyme (GH22) T japonica...
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Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer doc
... cancer cells, by either inducing cell death or preventing further proliferation; b) to explore the molecular mechanism of cell death by Ruta + Ca3(PO4)2 treatment of brain cancer cells in vitro; and ... 37˚C, and the cells were harvested after 72 h following the standard air-drying techniques Cell harvesting and cytological preparations All drugtreated and control MGR1 cell cultures, B-lymphoid and ... 3(PO4) could induce cell death in human (HL-60 and MGR1 glioma) and murine (K 1735 clone X-21) cancer cells and provide chemo-protection for normal human PBLs and B-lymphoid cells, by inducing...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death ppt
... shown to participate in cell death in response to various cytokine signals, including IFN-cinduced cell death [2], TNF-a and FAS-induced cell death [48], and TGF-b-induced cell death [10] There are ... source maintaining cell survival, it has been proposed that autophagy can contribute to cell death in a process DAPK and signal transduction termed autophagic (type II) cell death Disturbance ... control and cell metabolism [15] In mammalian cells, two structurally and functionally distinct mTOR-containing complexes have been identified, mTORC1 and mTORC2 [15] mTORC1 directly regulates cell...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death docx
... apoptotic cell death resemble those of ‘healthy’ cells Growth and retraction FEBS Journal 277 (2010) 58–65 ª 2009 The Authors Journal compilation ª 2009 FEBS 61 Blebbing in programmed cell death ... not been examined in blebs of cells undergoing cell death Although the proteins involved in the execution of blebbing appear similar in apoptotic and autophagic cell death, the upstream signals ... occurs as part of the normal cell growth process, and although blebbing is one of the characteristic hallmarks of programmed cell death, its exact contribution to cell death remains unclear It has...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... ANT1 and ANT2-silencing on ADF cells (A) Cell growth curves analyzed by crystal violet assay in nontransfected ADF cells, and in Scramble- and ANT1 siRNA and ANT2 siRNA ADF-transfected cells ... BA, ATR and ANT1 siRNA on cell viability and glucose consumption (A,B) Cell growth curves analyzed by crystal violet assay in BA and vehicle-treated (A) and in ATR and vehicle-treated (B) cells ... U-87-MG cells, 24 and 48 h after transfection (C) Cell growth curves analyzed by crystal violet assay in nontransfected U87-MG cells, and in Scramble- and ANT1 siRNA U87-MG-transfected cells Each...
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PROGRESS I N BRAIN RESEARCH VOLUME 36 BIOCHEMICAL AND PHARMACOLOGICAL MECHANISMS UNDERLYING BEHAVIOUR doc
... going and now I I think we can more with it and look for more specialized areas What we cannot quite understand ZONAL CENTRIFUGATION OF BRAIN SUBCELLULAR FRACTIONS 11 in this methodology, and I ... enzymes from pigeon and guinea-pig brains the enzymes from rat and cat brains were distributed over a rather broader pH range The enzymes from rat brain (Malthe-Ssrenssen and Fonnum, 1971a) were ... endings This fits in with observations of Lenard and Singer (1968) on the red cell membrane and those of Condrea and Rosenberg (1968) and Rosenberg and Condrea (1968) on the squid giant axon From...
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Báo cáo hóa học: " Role of protease-activated receptor-2 on cell death and DNA fragmentation in Helicobacter pylori-infected gastric epithelial cells" ppt
... augments H pyloriinduced cell death and DNA fragmentation in gastric epithelial cells To investigate the relations of PAR-2 expression, cell death, and DNA fragmentation, cells were transfected ... apoptotic cell death, the expression of PAR-2, and the activation of MAPK in H pylori-infected gastric epithelial cells, cell viability and DNA fragmentation were determined in the cells transfected ... the cells without transfection and cultured in the presence of H pylori Figure Inhibition of PAR-2 expression augments H pyloriinduced cell death and DNA fragmentation in AGS cells (A) AGS cells...
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Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
... avidity T cells, with excellent memory recall features, restricted migration and refractory to negative regulatory mechanisms => Expanding high avidity T cells, with broad functionality and widespread ... recombinant proteins, peptides, cells, or cell lysates), achieves alternating production of ‘central-memory’ low PD-1 cells and highly differentiated effector T cells, respectively Figure 4B is ... subsides, a minor subset of T cells down-regulate PD-1 and become memory cells, while the larger pool of effector cells extinguishes through a range of mechanisms leading to cellular apoptosis Conversely,...
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