protein folding disulfide bond formation in the er can lead to formation of h2o2 and er generated oxidative stress
Disulfide Bond Formation of Heterodimer and Heterotrimer of Human Laminin332 Coiledcoil Domains
... that interchain interactions of LCC domains of β3 and γ2 at the N-terminus were not strong enough or incomplete to support the disulfide bond formation Therefore, interchain hydrophobic interactions ... by a disulfide bond at the Cterminus of LCC domains When α3 chain interacts with β3-γ2 heterodimer, the interaction of three chains at the N-terminus of LCC domains can make their cysteine residues ... by binding to cysteine residues of LM chains These factors could be any molecular chaperones involving in interchain and intrachain disulfide bond formation of proteins (27) Further researche...
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Báo cáo khoa học: "Luminal concentrations of L- and D-lactate in the rectum may relate to severity of disease and outcome in septic patients" ppt
... including both the correlation between them and their relation to clinical parameters Therefore, the present study was undertaken to assess concentrations of L- and Dlactate in the rectal lumen and ... suggesting a hypoxic origin of hyperlactataemia in these patients On the other hand, non-hypoxic causes of hyperlactatemia can be observed Studies of raised systemic lactate in human endotoxaemia and ... producer of L- and D-lactate in sepsis The plasma concentrations of D-lactate observed in the present study are within the range observed by others [9,10,19,20] In contrast to our study, Poeze and...
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Báo cáo y học: " Indications that "codon boundaries" are physico-chemically defined and that protein-folding information is contained in the redundant exon bases" pot
... external sources of additional and specific protein folding information: (a) the chaperons (other proteins that assist in the folding of proteins and nucleic acids [4]; and (b) the protein- coding ... specificity in protein- protein interactions Part II: The complementary coding of some proteins as the possible source of specificity in protein- protein interactions Med Hypotheses 1981, 7:981-993 Segersteen ... the average free energy, dG, of the RNA and the magnitude of change is proportional to the number of base pair formations Therefore the free folding energy (FFE) is used to characterize the local...
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Báo cáo khoa học: "Nutrient concentrations in Pinus radiata D Don needles in the Basque Country (Spain): preliminary classification of parameters and sites" pptx
... November 1989 and November 1990 The sites lrún and Lezama were not sampled in 1990 because both of them were victims of fire and abusive pruning In 1990 the site Odiaga was added to increase the information ... biochemical parameters and nutrient levels in the soil in southwestern Germany and in southern California In: IUFRO Semin Manage Water and Nutrient Relations to Increased Forest Growth Canberra, Australia, ... (Zöttl and Mies, 1983; Hüettl et al, 1987) the study of the nutrient concentration of pine needles is of great importance In order to determine the effect of air on the plantations of Pinus radiata...
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Báo cáo y học: "Retention of foreign body in the gut can be a sign of congenital obstructive anomaly: a case report" potx
... intramural width of small intestine of cm or less is considered abnormal An abdominal CT scan is of great help in diagnosing and detecting the etiology of intestinal obstruction in 73–95% of cases [1012] ... of this journal Competing interests The authors declare that they have no competing interests Authors' contributions SPS assessed and interpreted the patient's gastrointestinal symptoms and the ... Duodenoduodenostomy or duodenojejunostomy should be performed after removal of the foreign object(s) However, in spite of the persistence of the radio-opaque foreign body on plain X-rays of the abdomen, the...
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Báo cáo y học: "Resilience of refugees displaced in the developing world: a qualitative analysis of strengths and struggles of urban refugees in Nepal" docx
... request, and a number of interviews and the Somali focus group were conducted in the TPONepal office The interview topic guide broadly covered personal experiences of being a refugee in Kathmandu, perceived ... in Kathmandu, we were interested in providing a study with policy relevance Other than country of origin, minimum age and gender mix, there were no specific criteria and instead we preferred an ... depiction of the inter-subjectivity of the elements in Honneth’s theory In the present context, this type of framework is intended to guide the research and inform the research findings Such...
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Study of the morphological and functional alterations of high endothelial venules in the regional lymph nodes to tongue cancer patients and its clinico pathological correlations
... attributed to the higher incidence of young people picking up smoking and the increasing incidence of HPV infection in young adults In the United States, an increase in the tongue cancer mortality ... effects of cancer therapy by characterizing biochemical changes in the cancer These scans can be performed on the whole body or can be localized to the head and neck A PET scan demonstrates the biological ... essential to understand the pattern of spread of cancer in the neck About a third of all the lymph nodes in the body are in the head and neck region Most squamous cell carcinomas of the head and neck...
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Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt
... that cannot be predicted from the amino acid sequence, we were very interested in analyzing whether ILT2 nitration affected the Tyr residues in the hydrophobic interdomain that binds HLA-G To address ... using an antibody against b-actin, which produced a band at 42 kDa The data indicate the intensity of the HLA-G band related to the b-actin band and are representative of three different experiments ... Identification of nitration site in the extracellular domain of ILT2 In the extracellular domain of ILT2, there are several Tyr residues that participate in the interaction with HLA-G [3,19] Because protein...
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Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio) pptx
... (1972) A binding protein for fatty acids in cytosol of intestinal mucosa, liver, myocardium, and other tissues Science 177, 56–58 Haunerland NH & Spener F (2004) Fatty acid-binding proteins – insights ... distribution and binding activities of FABPs and regulation of FABP genes, including FABP gene knock-out experiments [8], our understanding of the physiological function(s) of these proteins remains limited ... and pig [16] Over the years, FABP6 has been given a variety of names, such as ileal lipid-binding protein, intestinal 15 kDa protein, ileal bile acid-binding protein and gastrotropin, reflecting...
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Báo cáo khoa học: Protein folding includes oligomerization – examples from the endoplasmic reticulum and cytosol doc
... to lack interactions that may retain it in the ER, and (b) the protein needs to be recognized by the export machinery of the ER The retention of folding intermediates can be the consequence of ... with the on–off cycle of chaperone-mediated protein folding One of the intriguing questions in heteromer formation is how a rare protein finds its partner In the ER, all folding membrane proteins ... reactions in the ER, in principle, are mediated through protein protein interactions Considering the high intracellular concentration of glutathione and its Protein folding and oligomerization – ER and...
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Báo cáo khoa học: Retention of the duplicated cellular retinoic acid-binding protein 1 genes (crabp1a and crabp1b) in the zebrafish genome by subfunctionalization of tissue-specific expression doc
... development (24 hpf and thereafter) Together, the expression patterns of the zebrafish crabp1a and crabp1b generally sum to the expression of their mammalian orthologs in the developing nervous system ... transcripts were abundantly distributed in the posterior hindbrain and anterior spinal cord in which the signal was restricted to the dorsal spinal cord and gradually diminished along the length of the ... crabp1a mRNA were observed in the nucleus of the diencephalon, the ventricular zone of the developing optic tectum and the dorsal retina, the epidermis of the tail tip in addition to neurohypophysis...
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The Microstructure of the Bond Market in the 20th Century∗ docx
... explains that in the bond corner” trading in foreign bonds and Liberty Bonds was conducted in the two smaller booths, while the other bonds were traded in the third, and largest, bond booth For the ... Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured Insured ... to the historical costs The underlying costs to the intermediating institutions are costs of identifying and matching counter parties (communication costs) and of managing and tracking inventory...
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Báo cáo khoa học: The heat shock protein 70 molecular chaperone network in the pancreatic endoplasmic reticulum ) a quantitative approach potx
... ATP-binding cleft Owing to their additional domains, the Hsp40s ERj3, ERj4 and ERj5 may be able to bind polypeptide substrates and deliver them to peptide-binding domains of BiP in the course of their ... activity by the GST–J-domain hybrid was due to a BiP–substrate rather than a BiP–cochaperone interaction In the case of ERj1, ERj3, and ERj4, the stimulatory effects of the ERjs correlated with their ... case of the membrane proteins ERj1, ERj 2, and ERj4, the transmembrane domains were absent form the GST hybrids (Table 1) Thus, only the ER- luminal domains were analyzed in these cases In the...
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Báo cáo khoa học: Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates potx
... present in brain, but not in PBL (Fig 3A, lanes and 3) To examine whether the CbD4 variants were expressed in different parts of the brain as well as in fetal brain, PCR was carried out using the ... as inducing a CRE-regulated promoter regulating a luciferase reporter gene Together, these results suggest that lack of the exon induces a structural change in the catalytic cleft, rendering the ... variants in the brain of other species Rhesus monkey brain and mouse brain cDNAs were PCR amplified using the human and mouse Cb common primers (Table 1), respectively The resulting DNA fragments were...
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Báo cáo khoa học: Selenium affects biosilica formation in the demosponge Suberites domuncula Effect on gene expression and spicule formation pot
... 150 200 250 the amino acids glutamine, lysine and histidine at the N-terminus and the nonpolar amino acid proline and the hydroxy amino acids serine and threonine at the C-terminal border 3842 Fig ... These data interestingly show that the expression pattern of the different selenoproteins in the fish is region-specific To obtain an insight into the potential function of selenoprotein M in S domuncula, ... sponges and in turn skeleton formation in these animals The final interesting finding for the biotechnological application of silicatein, especially with respect to the understanding of biosilica formation...
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Báo cáo y học: "Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity" ppt
... other CA residues Therefore, it is possible to speculate that the E98A mutation may rather be involved in inter-molecular CA-CA interaction or with other possible cellular factors involved in ... and Western blot analysis of capsid mutants Structural view and Western blot analysis of capsid mutants A close view of the structure of the cyclophilin A binding loop in the N-terminal (A) and ... against Tat and then tested for the infectivity (Fig 3C) However, we were unable to inhibit the subtle amount of Tat-induced luciferase activity seen in these cells and subsequently explain this...
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Báo cáo y học: " Mathematical model of blunt injury to the vascular wall via formation of rouleaux and changes in local hemodynamic and rheological factors. Implications for the mechanism of traumatic myocardial infarction" pot
... since there is no breaking force at zero shear and yield velocity A certain number of rouleaux can then enter the arterial branching zone, where the shear velocity and shear stress on the internal ... due to the attachment of rouleaux to the vessel wall This may decrease the permeability of the endothelium [16] and decrease the rate of removal of lipids and lipoproteins, which in turn can lead ... data and indicates that the main source of rouleaux is the erythrocytes themselves The higher the erythrocyte concentration, the more rouleaux remain in the blood despite an increase in the forces...
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Báo cáo y học: "Novel G-protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe grisea" pot
... was used to build the tree (the amino-terminal CFEM domain seen in a few proteins was not included), the 13 CFEM domain-containing proteins occurred together in one clade, indicating that the sequences ... in N crassa compared to 12, including PTH11, in M grisea It remains to be determined whether other members of this expanded class of PTH11-related proteins are involved in different aspects of ... domains that are conserved with respect to other receptors of the same class Known Pfam domains or domains conserved between the M grisea protein and other members of the class, as shown in Figure...
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TEACHING READING ESP IN INTEGRATION WITH THE OTHER LANGUAGE SKILLS TO STUDENTS OF LINGUSTICS AT UNIVERSITY OF SOCIAL SCIENCES AND HUMANITIES, VIETNAM NATIONAL UNIVERSITY, HANOI
... divided into two chapters − Chapter I presents an overall view of reading and reading in ESP teaching and learning; − Chapter II introduces the advantages of skill-integration in teaching and learning ... points and weak points of the teaching and learning of reading ESP in Department of Linguistics and Vietnamese Studies at USSH – VNU based on the two survey questionnaires and the observation The ... 4.2.1.5 Asking students to write a list of things they know and things they want to know about the topic ……………… 4.2.1.6 Asking students to fill in the blanks of a summary of the text ………………………………………………………...
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Tài liệu Managing Telecom Invoices & Service Contracts in the Enterprise:A Guide to Best Practices doc
... with existing inventory information about services installed, allow customers to create a detailed inventory of the services installed and associated charges This baseline of services can then be ... practice for invoice and service inventory development and management is: • Create an inventory of telecom invoices • Examine invoices and invoice source collateral, and create an inventory of services ... baseline of cost against which services and cost can be validated for contractual and service accuracy In addition to invoices, service providers offer customer service records (CSRs), circuit inventories,...
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- in the 19th century which two patterns of intergroup
- the auto industry in the united states is an example of
- why is the banking system in the united states referred to as a fractional reserve banking system
- what will happen in the end times according to the bible
- are we living in the end times according to the bible
- are we in the end times according to the bible
- the description of the workmen in the reading passage is an example of which of these literary terms
- ca2 imaging in the er
- ca2 dynamics in the er and in
- ca2 buffering in the er lumen
- ca2 binding proteins in the er lumen
- ca2 buffering in the er
- conditions of the skin soft tissue in the er
- 4 6 interior view of an intestinal bulb at 7 dpf this image is an expanded focus of 32 8 µm of z depth 320 stacks with a z stack size of 0 1 µm the intestinal folding has been started in the ventral side of the intestinal to shape the int
- 2δire1 displays conditional lethality and retains endogenous proteins in the er
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25