p selectin mutant mice prior to the onset of arthritis
Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
... JMP contributed to the study design JPP, CB, MB, JB, FM, CG and JMP performed the acquisition of data JPP, CB, FM, PR, DL and JMP analyzed and interpreted the data JPP, CB, PR, DL and JMP prepared ... necrosis factor-α [26], however, the capacity of licofelone to inhibit the synthesis of IL-1β [6-8] may explain, at least in part, the effect of the drug on the synthesis of cathepsin K R1097 Arthritis ... in the deep zones of cartilage) (×40; Leitz Diaplan) The superficial zone of cartilage corresponds to the superficial and to the upper intermediate layers The deep zone of cartilage corresponds...
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Senescence and Cell Cycle Control
... induction of p2 1Cip1 expression Therefore, p1 6INK4a and p1 4ARF are positive regulators of the Rb- and p5 3-dependent pathways, respectively Both proteins are upregulated during the senescence process ... in preventing malignant transformation While the proapoptotic function of p5 3 involves a number of genes, the only known mediator of its prosenescent function is Fig The p1 6INK4a -Rb and ARF -p5 3 ... from p5 3 converges to the Rb/E2F pathway This signaling crosstalk could result from p2 1Cip1 inhibition of Cdk2 and possibly Cdk4/6 Inactivation of these pocket binding proteins by the papillomavirus...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... atropine reduced the intensity to levels even below those displayed by the uncomplexed protein (Fig 1B) These results reinforce the hypothesis that atropine and ipratropium are bound to tryptophancontaining ... counting the number of colonies from appropriate dilutions of culture (in triplicate) spread on the surface of tryptic soy agar plates supplemented with 5% defibrinated sheep blood Micrographs of samples ... Adsorption to the column is favored entropically, as binding of the first DEAE group brings the C-LytA protein in close proximity to the resin and promotes the subsequent cooperative binding of the...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... Criteria for POP family members DNA sequence homology to prolyl endopeptidase (PEP ⁄ POP) Subclans of the POP family S9A Prolyl endopeptidase (PEP ⁄ POP) S9B Dipeptidyl peptidase IV (DPIV) S9C Acylaminoacyl ... peptidase S9D Glutamyl endopeptidase (plant) S9B subclan - DPIV gene family DPIV Fibroblast activation protein (FAP) DP8 DP9 Nonenzyme DPIV-related POP family members DP6 (DPX, DPL1) DP10 (DPY, ... attenuated in the presence of overexpressed DPIV [93] There has been some interest in the use of DP inhibitors for cancer therapy The nonselective DP inhibitor, PT100 (Val-boro-Pro), slows growth of syngeneic...
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Understanding the participatory news consumer - How internet and cell phone users have turned news into a social experience pdf
... before; whether they only follow news about specific topics; and whether they rely on people around them to keep them informed 19 Who are the 34% of respondents who most appreciate serendipitous encounters ... news participators, 19% have news alerts sent to their cell phones News participators are fond of social media: 76% of news participators use social networking sites; 34% of news participators ... Americans explore a wide variety of news topics online Internet users were asked how many, if any, of 12 specific news topics they explore online Of those 12 news topics, the most popular are weather...
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Báo cáo khoa học: Linking pseudouridine synthases to growth, development and cell competition potx
... death rather than reduced proliferation, indicating that apoptosis is a major component of the loss of function mutant phenotype As induction of apoptosis has been previously described in the ovaries ... ap–GAL4-silenced larvae (B) The domain of the expression of the ap–GAL4 driver, restricted to the D compartment, is GFP-labelled (green) The strong and localized depletion of Mfl in the D compartment ... black The black bar on the top shows the position of the DNA segment employed in the 16822 VDRC RNAi construct [25], which targets all mRNA isoforms, and the open bar shows the position of the...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... Wood MK, Ryseck RP, Walther S & Meyers CA (1999) Peptides corresponding to the N and C termini of IkappaB-alpha-beta, and -epsilon as probes of the two catalytic subunits of IkappaB kinase, IKK-1 ... (100 lmặwell)1 due to the : dilution factor) was dispensed into the wells of each plate prior to IL-1a addition A total of 48 ngặmL)1 (8 ngặmL)1 per well due to the : dilution factor for wells containing ... abscissa indicates the time the reactions were stopped with trichloroacetic acid and the plot shows the number of repeats Phosphorylation of tagged IjBa (d; A) and autophosphorylated rhIKK2 (j;...
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
... were present in 67% of mice injected with the parent HCT116 cells (P < 0.05) These data strongly support the importance of uPAR expression in colon cancer invasion and metastasis [13] To develop ... DNAzyme for anticancer therapy This paper describes the first step in the development of a potential therapeutic drug It would be interesting to perform further studies in other cancer cell lines ... attributed to uPAR, with other compensatory mechanisms allowing the cell invasion process to continue uPA binding to uPAR has been shown to induce the proliferation of Saos-2 cells, therefore...
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Anatomy, Histology, and Cell Biology PreTestTM Self-Assessment and Review pptx
... branching pattern of the developing airways The diaphragm forms from the septum transversum, the two pleuroperitoneal membranes, the dorsal mesentery of the esophagus (where the crura develop), and the ... cells appear in all portions of the respiratory system except the respiratory epithelium and move mucus and particulates toward the oropharynx (mucociliary escalator) Gas exchange in the lungs ... development, epithelial-mesenchymal interactions occur reciprocally between the epithelium of the ureteric bud and the mesenchyme of the metanephric cap (blastema) to convert the mesenchyme of the...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
... independently of the endogenous upstream apoptotic machinery Fig Immunoapoptotins specifically induce apoptosis of breast cancer cells Targeted Apoptosis in Breast Cancer Immunotherapy 33 Another ... domain-containing proteins, forming a complex comprising TRADD, TNF Receptor Associated Factor-2 (TRAF2), cellular inhibitor of apoptosis-1 (CIAP1), and the receptor-interacting protein-1 (RIP1) The complex then ... of pores in the mitochondria and the release of cytochrome C and other pro-apoptotic molecules from the intermembrane space The released cytochrome C interacts with Apaf-1 to recruit pro-caspase...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
... activity of the Bcl-2 family proteins that control the integrity of the mitochondrial membrane The release of proapoptotic factors from the mitochondria, such as cytochrome c, into the cytoplasm promotes ... induce apoptosis independently of p5 3 [24,35,36,41] Together, these data suggest that upregulation of the tumor suppressor p5 3 may be an important mechanism of Ras ⁄ Raf ⁄ ERK-induced apoptosis Other ... receptors, whereas phosphoserine ⁄ phosphothreonine phosphatases target the adapter protein Shc and MEK1 ⁄ Dual-specificity phosphatases [DUSP; also called MAPK phosphatases (MKP)], are able to...
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Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx
... interdependent Caspase-independent pathways can operate to promote apoptotic cell death and, conversely, cells dying through a nonapoptotic mode may recruit caspase-dependent pathways [5] In the ... recruits micro-RNA to promote PC12 cell survival by blocking the expression of the proapoptotic BH3-only protein Bcl2-interacting mediator of cell death (BIM) [32] Similarly, whether micro-RNA are ... death in several other models independently of caspase Thus, substance P and its receptor, neurokinin-1, mediate an alternative, nonapoptotic form of cell death in hippocampal, striatal and cortical...
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Báo cáo khoa học: ERK and cell death: ERK location and T cell selection pdf
... change depending of the nature of the selecting ligand In addition, the kinetics of the other MAPK important for negative selection are the same independent of the ligand Given their opposing function ... sequester the proapoptotic molecules Bax and Bak to prevent them from inducing apoptosis Once active, BIM is able to bind Bcl-2 or Bcl-xL, leading to the release and activation of Bax ⁄ Bak and apoptosis ... balance of proapoptotic and prosurvival proteins in the cytosol (reviewed in [52]) Apoptosis induced by negative selection does not involve classical death receptor pathways, rather it depends...
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Báo cáo khoa học: ERK and cell death: cadmium toxicity, sustained ERK activation and cell death pot
... restricted to a single process, but includes apoptosis, necrosis and autophagy, depending upon the context of the intoxication, such as cadmium concentration, as well as the inducing pathway (lipid peroxidation, ... the onset of apoptosis via the death receptor pathway, but are independent of the mitochondrial pathway In this system, P3 5 protects cells from apoptosis [46] Together, these results show that constitutive ... on the upper panel with an anti-ERK -P IgG, this treatment resulted in the appearance of the activated ⁄ phosphorylated forms of ERK Cells were also cotreated with 100 ngÆmL–1 PMA and cadmium (PMA...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... (2000) The platelet-derived-growth-factor receptor, not the epidermalgrowth-factor receptor, is used by lysophosphatidic acid to activate p4 2/44 mitogen-activated protein kinase and to induce prostaglandin ... that PI3K is located upstream of PAK in LPA signaling pathway of A2058 cells From a molecular point of view, two types of PI3Ks can be activated in response to LPA stimulation PI3Kc has the unique ... identified that the LPA-producing lysophospholipase D, autotaxin, can increase the levels of Cdc42-GTP and Rac1-GTP via the activation of PI3Kc [21] In the present study, direct pulldown assay...
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Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx
... in previous studies, using the promoterless LUC reporter gene plasmid pBLUC as the cloning vector [4,20,46] The catalytic subunit of PKA expression plasmid (PKAc), in which the expression of the ... ATP, mm MgCl2, 0.5 lCi [3 2P] ATP[cP], 200 ng PKA substrate, and the testing sample After an incubation at 30 °C for 60 min, the reaction was stopped and spotted on the P8 1 phosphor-cellulose paper ... treatment further indicated the complexity of the corresponding regulatory networks One may suggest that this discrepancy and the presence of negative feedback loops may partially explain why opposite...
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schaum's easy outline molecular and cell biology - william stansfield, raul j cano, jaime s. colome
... other During metaphase, the chromosomes line up in the center of the spindle At anaphase, the two chromatids of each replicated chromosome are pulled to opposite poles by depolymerization of the ... within the cristae of the mitochondria or the plasma membrane of prokaryotes These chains consist of series of proteins that first serve as electron acceptors, then donors to the next complex in the ... the cells grow, duplicate their genomes, separate their duplicated chromosome sets into nuclei at the opposite poles of the cell, and divide the cytoplasm to form progeny cells The eukaryotic cell...
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apoptosis and cell proliferation
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