new insights into the role of chemokines and their receptors pdf
Click Here: The State of Online Advertising - New insights into the beliefs of consumers and professional marketers ppt
... magazines and while watching a favorite TV show are the two most preferred places to look at an ad Majority of respondents use social media; over half have liked on behalf of their favorite brands, ... Visit the product's website 11% Visit the product's social media page Other 6% Like' the product 5% 'Comment' on the product 4% Hide that person from your social media newsfeed 2% Recommend the ... popular form of online advertising Advertising/Marketing professionals considered in the bottom professions among consumers – along with actors and dancers; not highly regarded by marketing professionals...
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Báo cáo sinh học: "Making the jump: new insights into the mechanism of trans-translation" pdf
... RNA at the start of translation How then is the resume triplet properly positioned? And what mechanism allows the ribosome to take off from the damaged mRNA template and land precisely on the tmRNA’s ... permutations of the -1 triplet and determined their effect on survival in the kanamycin resistance assay They found that eight of the 18 codons that were prohibited according to the -1 hypothesis [12] ... structures of (a) tRNA, (b) mRNA and (c) tmRNA (a,c) The 3’ and 5’ termini, the amino acid acceptor stem (AC) and the anticodon (A), D and T arms are indicated (b,c) The Shine-Dalgarno sequence (SD), the...
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báo cáo khoa học: " Recent insights into the role of NF-κB in ovarian carcinogenesis" pot
... activation of the IKK complex, which then phosphorylates IκB Phosphorylated IκB is then ubiquitinated and degraded by the proteasome system, leading to the release of p65 and p50 The heterodimer then ... Figure The NF-κB pathway In unstimulated cells, the NF-κB subunits p65 and p50 are sequestered in the cytoplasm by IκB Ligand binding to receptors (such as TNFα and TLR4) leads to the activation of ... pathway involving other NF-κB family members Most of the studies on EOC have looked at the members of the canonical pathway the cancer stem cell marker CD44 and are in fact the ovarian cancer...
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Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx
... humidity of 48% Food and water were provided ad libitum with a standard rodent diet The weight of the rats was followed Page of 12 before and after the implant of a prednisone pellet for the first ... Suppression of osteoblast and osteoclast precursor production, increased apoptosis of osteoblasts and osteocytes, prolongation of the lifespan of osteoclasts and apoptosis of endothelial cells ... the same procedure at two and three months respectively The average dose release from the pellet was equivalent to 1.5 mg/kg/day for the period of six months The dose of corticosteroids and the...
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an investigation into the role of chemokines in haemopoietic stem cell quiescence
... 5-13 The numbers of HSC in the BM of WT and Cxcl4-/-animals 250 Figure 5-14 The numbers of progenitor cells in the BM of WT and Cxcl4-/-animals 251 Figure 5-15 The numbers of HSC in the spleen ... for the study of the stem cell behaviour at a single cell level The ability to identify and isolate HSC from their environment allows for their study and this approach has enabled us to understand ... plays important roles throughout development, with the migration of HSC to different sites of haemopoiesis and in the adult at basal levels In the adult, the egress of HSC into the periphery is...
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Molecular insights into the role of arginine on protein stabilization
... barriers to further the development of these proteinbased drugs Most of these barriers are related to the stability of the protein molecule (both, the stability of the folded structure and stability ... in the presence of M arginine and guanidine In order to understand the role of the guanidinium group (as well as those of the other segments) we consider the following objective: Compare and ... guanidinium group of arginine with the plane of the aromatic ring of the residues Such an alignment would cause the polar end of arginine to protrude into the solution and to aid in solvating the arginine-aromatic...
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Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs
... on toxicity rather than efficacy (7-9) In addition, the approach of MTD ignores the fact that the degree of synergy depends on the concentration and ratio of the combined drugs (9) Therefore, better ... to Fas receptors, a conformational change in the intracellular domains of the Fas receptors reveals the presence of a death domain (DD) The activation of DDs leads to the recruitment of adaptor ... activation of PARP-1 depletes NAD+ pool and ATP Therefore, in the event of extensive DNA damage, massive synthesis of poly(ADP-ribose) drives the cell to death by necrosis On the other hand, when...
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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx
... of the active-site residues of the 20 conformers of the solution structure of HtA Catalytic groups E66 and H113 are shown in red, and side chains of other residues in their vicinity are shown in ... should affect their pKa values, increasing the pKa of carboxylates and decreasing the pKa of histidines [24] Structurally, the architecture of the active site in HtA is unique among the ribotoxin ... decrease the pKa of the aspartic acid and increase the pKa of the histidine side chain groups Finally, E66 and R95 are in their canonical positions but establish different interactions to those in other...
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Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot
... sequenced Of these, 10 clones were found to encode the LC2 and LC1 subunits Others were found to encode other variants of the C-lectin-like venom proteins The amino acid sequences of both subunits ... peptide of 23 residues, and the predicted sequence for its mature protein matches that published previously [8] The amino acid sequences of LC1 and LC2, together with those of other homologues of ... HC, the light chains appear to confer the substrate specificities of RVV-X [12] Collectively, the primary sequences of the three subunits of RVV-X (Figs and 5) suggest the possible presence of...
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báo cáo khoa học: " Construction of a potato consensus map and QTL meta-analysis offer new insights into the genetic architecture of late blight resistance and plant maturity traits" pps
... is the number of hypothetic meta-QTLs of a model) “Delta” is the rescaled value of the criterion, it is the difference between the value of the given model and the value of the best model The ... onto the consensus map It is based on a scaling rule between the positions of the flanking markers of the QTLs on their original maps and the positions of these markers on the consensus map The ... one hand, and within maturity traits (Maturity, Vigour), on the other hand QTL names are written to the left of the bars QTL nomenclature is as follows: the name of the first author of the original...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... the A-chain and B-chain of nPS, and in the case of His37, the v1 torsion angle changes from 63.34° to )67.80° and )52.11° for the A-chain and B-chain of nPS, respectively The imidazole ring of ... back to the position of the Fig Superimposition of the A-chain of nPS (green), the B-chain of nPS (cyan), and the substrate-free protein (1IHO.pdb; magenta) The carbon and oxygen atoms of pantoate ... backbone u and w dihedral angles occupy allowed regions of the Ramachandran map [32,33] Comparison of the monomer of the substrate-free form of E coli PS [13] with the monomers of nPS in the pantoate-bound...
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Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt
... investigation of the catalytic mechanism and substrate specificity and to understand the differences therein for this class of enzymes In order to identify the subsites of the ervatamins and to understand ... ervatamin-B) at the bottom of the subsite is conserved in ervatamins Compared to a Ser in the equivalent position of papain, the role of Leu here is to restrict the size and depth of the S2 subsite The S2 ... backbone of residues 65–64 and is partly exposed to the solvent (Fig 2B) On the other hand, the P3 moiety of E-64 in each of the of the two ervatamin-C molecules in the asymmetric unit mainly...
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Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt
... [18], cowpea [19], and poppy [20,21] In the present study, the first insights into the secondary and tertiary structure of PLDa2 from cabbage are given The surface structure of the enzyme was investigated ... assistance with protein purification and for preparation of the PpNp The financial support of the Kultusministerium des Landes Sachsen-Anhalt and the Graduiertenkolleg 1026 of the Deutsche Forschungsgemeinschaft, ... at the two ends of the molecule (Fig 3) An assignment of these relaxed structures to sequence regions of PLDa2 has not yet been possible According to the volume estimation on the basis of the...
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Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf
... with antibodies to the subunits of the yeast bc1 complex indicated on the left side of the blots The Western blots are shown in panels A and B and the relative amounts of each of the subunits determined ... protein to insert into and be stable in the inner mitochondrial membrane or lack of detection of the truncated protein by the antibodies In the W303–1B q° strain the amounts of the other two catalytic ... the absence of subunit also resulted in an increase in the ratio of intermediate to mature cytochrome c1 and a disappearance of the intermediate form of the Rieske protein At the same time, the...
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Tài liệu Báo cáo khoa học: Insights into the interaction of human arginase II with substrate and manganese ions by site-directed mutagenesis and kinetic studies Alteration of substrate specificity by replacement of Asn149 with Asp docx
... consequence of the mutagenic replacements Effects of the His120Asn and His145Asn mutations on the affinity of metal binding to arginase II To further examine the effects of the His120fiAsn and His145fiAsn ... Selection of target residues (Asp149, His120 and His145) was based on the roles assigned to the equivalent residues in arginase I [1,24] and the crystal structure of the arginase II–BEC complex [9] The ... by His120 and His145, which are equivalent to the histidines at position 101 and 126 in the sequence of arginase I [10] However, they are clearly differentiated by the consequences of their replacements...
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Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc
... also the measurement of the rate of passive diffusion of the dye through the plasma membrane This cannot be done by the simple measurement of the increase of the fluorescence signal (Fcyto) of the ... presence of the pump, the free intracellular rhodamine concentration, the rate of their passive diffusion through the plasma membrane and then the kinetic parameters characteristic of their P-gp-mediated ... proportional to the amount of rhodamine free in the cytosol This observation allows the further determination of the concentration of drug free in the cytosol of resistant cells The determination of ka...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... in the wild-type PA c-551 and its quintuple mutant The mutated residues in the quintuple mutant, and the corresponding ones of the wild-type PA c-551 and HT c-552 are colored purple, green, and ... Fig 1), therefore their mainchain folding may be similar Furthermore, the optimal growth temperature greatly differs between H thermophilus and A aeolicus (70 °C and 95 °C, respectively) Therefore, ... c-552, but not in most of the others at the corresponding positions It is likely that some of them are the residues responsible for stability, and in fact Ala7, Met13, and Tyr43 in HT c-552 have...
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Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP ppt
... interactions in the presence and absence of the nucleotide According to our results, the absence of modulation of the oligomeric state of the enzyme by the nucleotide is in clear contrast with the behaviour ... sequencing Then, they were double digested with NdeI plus SalI and ligated into the corresponding sites of pCWori In all cases, the hexa-His was at the N-terminal end of the protein and the FLAG ... referred to as GAP1 and GAP2 (Fig 2A) Binding of GRIP to SR occurs through the direct interaction of the PDZ6 domain of GRIP and the final four amino acids of SR [12] We performed the recombinant...
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Báo cáo khoa học: Insights into the design of a hybrid system between Anabaena ferredoxin-NADP+ reductase and bovine adrenodoxin pot
... to the changes introduced in the redox cofactor environment upon complex formation They are therefore related to the specificity and the strength of the protein–protein interaction Therefore, the ... allowing the determination of a Kd value of 25 ± lM for the [FNRox:Adxox] complex and of 17 ± lM for the [FNRox:Adx(4–108)ox] complex (Table 1) Study of the kinetics of reduction of WT Adx by FNRrd Stopped-flow ... absorption band is consistent with the presence of FNRsq and it is already present at the very beginning of the reaction, indicating that its formation takes place within the dead time of the steady-state...
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Transformation of defects into fatigue cracks; the role of kt and defect scale on fatigue life of non pristine components
... 150 and 185 μm) and three root radii of 5, 25 and 50 μm The defect open angle was kept constant ( =60°) for all the specimens (see Table 2) Notches were introduced along the entire width of the ... of samples of mm 2024 T351 aluminium sheet scribed with notches between 25 and 185 μm deep show reductions in life of up to 95%, the extent of reduction depending on the scribe depth and on the ... initiation of fatigue cracks at notches Values of q vary between zero and unity; values of zero corresponding to complete notch insensitivity, and a value of meaning that K f = K t , and the elastic...
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