intracellular uptake of macromolecular drugs drug release rate from the complex and drug resistance
Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... accumulation and increasing release of these drugs (ADR and VCR) [5] PrPC-mediated multidrug resistance (MDR) was thought to be related to upregulation of P-glycoprotein (P-gp) [6] and inhibition of apoptosis ... cellular drug resistance is mediated by various mechanisms operating at various steps in the cytotoxic activity of the drug, from a decrease of drug accumulation in the cell to abrogation of apoptosis ... 25% of the tumor cells exhibiting IR; 2, 25–50% of the tumor cells exhibiting IR; 3, 50–75% of the tumor cells exhibiting IR; 4, > 75% of the tumor cells exhibiting IR The overall score was the...
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Báo cáo khoa học: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138 pot
... interface The availability of a range of structures of NNRTIresistant RTs drugs will provide greater understanding of the molecular basis of drug resistance mechanisms Such data will contribute to the ... structure, of key importance in understanding the interaction of the drug with these residues There are some similarities in the structural changes seen in the nevirapine complexes for both the RT(Glu138Lys) ... towards the surface of the drug pocket are also known sites of drug resistance mutations Indeed, Lys103Asn is the mutation most frequently observed in clinical use of NNRTIs Other NNRTI resistance...
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báo cáo hóa học: " Uniform comparison of several drugs which provide protection from noise induced hearing loss" docx
... rapid screening of threshold in a large number of animals) and the times of threshold assessment (before the noise exposure and one week after) were the same for all drugs tested The drugs administered ... The results of these experiments can lead to possible treatment strategies and, in addition, based on knowledge of the presumed mode of action of the different drugs, it was hoped that they could ... injection) and the anti-oxidants each provide more or less the same degree of protection, coupled with the result that the administration of both types of drugs to the same animals (the loop diuretic...
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Báo cáo y học: "The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains" ppt
... HIV-1 virus and whether the C-terminal region of RT played a role in the emergence of the Q151M MDR complex The emergence and presence of mutations in DNA pol domain, connection subdomain and RNase ... initiation of therapy, even though the viral load had been relatively high at earlier time points This raises the possibility of suboptimal use of the drugs contributing to the emergence of the Q151M ... mutations and the sequential acquisition of the Q151M MDR mutations suggested that they could be facilitating the emergence of the Q151M MDR complex This notion is further supported by the observation...
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Aerobic Uptake of Cholesterol by Ergosterol Auxotrophic Strains in Candidaglabrata & Random and Site-Directed Mutagenesis of ERG25 in Saccharomyces cerevisiae
... antifungal drugs These azole drugs target the ERG11 gene product by preventing the C-14 demethylation of the first sterol intermediate, lanosterol, thereby inhibiting the production of the pathways ... new drugs for improved treatments and/ or potential improvements in preventative methods of the spread of said disease Of the Candida species, C albicans is the leading causative species of candidasis, ... scheme of random mutagenesis “vector” creation .29 3.1 GC profile of wild type Candida glabrata 39 3.2 GC profile of ERG1 in Candida glabrata 40 3.3 GC profile of ERG7 in Candida...
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Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"
... Ministry of Social Affairs and the Ministry of Education DWECS was conducted in 1990, and featured a random sample drawn from the Central Population Register of Denmark of 9653 people aged 18-59 Of these, ... exposure contrast and reduce the generalizability of the results, and the findings may therefore not apply to the general population The present study and the study by Gjesdal and Bratberg [10] ... of equal size: Q1 included the part of the population with least (0) absence (35% of the population), Q2 included 17% of the population, Q3 23%, and Q4 consisted of the 25% with most absence (see...
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The Art Of Creating A Successful Blog – Tips From The Pros
... throughout the interview – was actually rather simple His secret to success is teamwork The two people that founded the site were myself and Marty Moe We kind of cooked up the idea and cofounded the ... Nation, and then Polygon, which is a games site that we launched in the middle of 2012.” Joshua told me that Jim Bankof f , the CEO of SB Nation, decided to f und the f ounding of T he Verge, and ... in the middle of the desert And, you know, the reaction to that was huge People really got it, and the video was really intense That was the first week we launched I think, and when I saw the...
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Tài liệu Báo cáo khoa học: Identification, sequencing, and localization of a new carbonic anhydrase transcript from the hydrothermal vent tubeworm Riftia pachyptila docx
... expressed in tissues of the worm These sequences are also compared with other CA sequences from vertebrates and nonvertebrates Results CA sequences from the SSH libraries From the body wall-subtracted ... amplifications of RpCAbr and RpCAtr with 18S amplification The number of cycles on the y-axis is the difference between the number of cycles required to amplify each transcript and the number of cycles ... values, we believe that the isolation of clade I from the rest of nonvertebrate sequences is well supported because the group consisting of clade I, vertebrate cytosolic, and vertebrate mitochondrial...
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Tài liệu Báo cáo khoa học: Three-dimensional structures of thermophilic b-1,4-xylanases from Chaetomium thermophilum and Nonomuraea flexuosa Comparison of twelve xylanases in relation to their thermal stability pdf
... studies and helps us to understand the molecular basis of the thermostability of these industrially relevant enzymes Materials and methods Protein purification The catalytic domains of C thermophilum ... right hand: two b-sheets and the a-helix form fingers and a palm, a long loop between the B7 and B8 strands forms a thumb, and a loop between the B6 and B9 strands forms a cord (Fig 1A) The final ... N-acetyl-glucosamines and two mannoses were attached (Fig 2B) Carbohydrates are orientated in the same way as the backbone of b-strand B1 and therefore they are almost like an extension of the b-strand N-glycans...
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Tài liệu Báo cáo Y học: Kinetic study of sn-glycerol-1-phosphate dehydrogenase from the aerobic hyperthermophilic archaeon, Aeropyrum pernix K1 potx
... denaturation of the enzyme With the exception of the temperatureactivity profile, the characteristics of the enzyme were determined from initial velocity measurements in the direction of the NADH-dependent ... varied at the nonsaturated level of dihydroxyacetone phosphate because the family of lines did not share a common intersection on the ordinate (see B-1 and B-2 of Figs and 6) Within the range of experimental ... obtained from the inhibition effect of NAD(P)+ ([P] ¼ 0) The Kip (dissociation constant for Gro1P) and the Kp/Kq values were obtained from product inhibition studies of Gro1P (Q ¼ 0) The Kp and Kq...
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RKesneaorcwh arlteiclde ge and perception of pulmonary tuberculosis in pastoral communities in the middle and Lower Awash Valley of Afar region, Ethiopia docx
... Knowledge of the Mode of Transmission and Prevention of PTB Table depicts the communities' knowledge about the mode of transmission and preventive methods of PTB The majority (95%) of the participants ... study of the prevalence of latent and active TB in pastoralists and their livestock However, prior to the implementation of a survey on the prevalence of the disease, we attempted to assess the ... total of 424 participants were included from each of the selected districts The participants were eligible if they were the member of that kebele, a husband/wife (or the responsible person) in the...
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Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis Recommendations from the National Tuberculosis Controllers Association and CDC pptx
... set on the basis of the characteristics of the index patient, the duration and circumstances of exposure, and the vulnerability or susceptibility of the contact to disease progression from M ... 306 and 308(d) of the Public Health Service Act; the Freedom of Information Act of 1966; the Privacy Act of 1974, which restricts the use of Social Security numbers; the Privacy Protection Act of ... durations and proximities of exposure The potential is great for controversies among public health officials, school officials, and the guardians of the children The presence of TB in schools often...
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Báo cáo Y học: Characterization of a low redox potential laccase from the basidiomycete C30 pptx
... that of the binuclear T3 pair was indicated by a shoulder at 333 nm in the UV/visible spectrum (data not shown) Values of the constants extracted from the X band EPR spectrum for the T1 and the ... On the other hand, when tested at their respective optimum pH values, the two isoforms are the most active at the same temperature of 55 °C The amino acid sequences deduced from lac1, the gene ... the differences in kinetics observed may be the consequence of the variability of certain of the amino acids involved in the substrates channel in specific enzymes A substantial variation in the...
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OVERVIEW OF FINAL AMENDMENTS TO AIR REGULATIONS FOR THE OIL AND NATURAL GAS INDUSTRY ppt
... cut emissions of smog-forming volatile organic compound (VOC) emissions and air toxics from several segments of the oil and gas industry The final rules are the result of the review of four air ... gas exploration and production that protect public health and the environment In 2011, for example, the Agency signed a memorandum of understanding with the departments of Interior and Agriculture ... Guardians and the San Juan Citizens Alliance sued EPA, alleging that the Agency had failed to review the new source performance standards and the major source air toxic standards for the oil and natural...
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Báo cáo khoa học: Molecular characterization of a blood-induced serine carboxypeptidase from the ixodid tick Haemaphysalis longicornis docx
... the host is the only source of energy Elucidation of the function of HlSCP1 in the hard tick may contribute a better understanding of the physiology of blood digestion and development, and thus ... Japan) The densities of stained bands were measured using image j 1.36b (National Institutes of Health) and the ratio of the density divided by that of the control was determined Acknowledgements The ... molecular mass of 53 kDa and a pI of 7.5 (Fig 2A), corresponding to the predicted size of the putative protein calculated from the HlSCP1 amino acid sequence To detect the localization of endogenous...
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Báo cáo khoa học: Production and characterization of a thermostable L-threonine dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus docx
... substrate in the standard oxidation reaction and acetoin in the reduction reaction The activity of Pf-TDH was significantly increased by the addition of mm CoCl2 (relative activity to that of the ... standard reaction 170%) and not by the addition of mm ZnCl2 or one of the other metals ⁄ salts tested The enzyme was inhibited by the addition of mm dithiothreitol (relative activity to that of ... estimate the molecular mass of the proteins Activity assays Rates of alcohol oxidation and aldehyde reduction were determined at 70 °C, unless stated otherwise, by following either the reduction of...
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The Determinants of Bank Net Interest Margin: Evidence from the Lebanese Banking Sector ppt
... LBP and foreign currency deposit and lending rates Consequently, the central bank and the ministry of finance started to offer lower returns on treasury bills and certificates of deposit and ... discount rates, interbank rates, and the dollarization of loans and deposits were taken from the central bank of Lebanon database Finally, the macroeconomic variables (GDP growth, inflation rate, ... between 1996 (3.95%) and 2009 (1.97%) This was due to the increase competition on one hand, and the decrease in lending rates (following the decrease of sovereign rates) on the other Domestic bank...
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ASSESSMENT OF THE BENEFITS OF EXTENDING THE TROPICAL RAINFALL MEASURING MISSION A PERSPECTIVE FROM THE RESEARCH AND OPERATIONS COMMUNITIES doc
... Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members ... to the protection of life and property of an extension of the TRMM mission Extension of the mission to at least late 2005 will provide time for further examination of the relevant issues • There ... of the unique aspects of TRMM’s orbit and sensor suite This reflects their professional judgment of the value of doing so based on their experiences of improvements in such things as fixing the...
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Báo cáo khoa học: Expression and characterization of recombinant 2¢,5¢-oligoadenylate synthetase from the marine sponge Geodia cydonium ppt
... Experimental procedures of the porcine 2-5A synthetase (data not shown) Figure demonstrates the results of the purification of the recombinant proteins The occurrence of dominant bands of the recombinant ... distant from humans The general significance of the study of 2-5A synthetase as one of the key components of the mammalian 2-5A system will be its contribution to our understanding of the evolution of ... that the addition of the nuclease caused the precipitation of the material in a concentration-dependent manner Formation of the precipitate in the solution containing the highest amount of the...
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Báo cáo khoa học: Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus pptx
... with the native state of the protein We then carried out the characterization of the thermal properties of the mutant in comparison with those of PfPNP The results obtained indicate that the substitution ... integrated peak areas In all of the kinetic and purification studies the amounts of the protein was adjusted so that no more than 10% of the substrate was converted to product and the reaction rate ... oxidation-reduction to rescue the possible damage of the other two disulfide bonds The presence of a low percentage of the protein with Cys254 and Cys256 in the reduced form further supports this hypothesis It has...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25