genetic abnormalities in non hodgkin s lymphoma as revealed by conventional and molecular cytogenetics methods of analyses
báo cáo khoa học: " Diffuse large B-cell non Hodgkin’s lymphoma in a 65-year-old woman presenting with hypopituitarism and recovering after chemotherapy: a case report" pptx
... had sufficient evidence of lymphomatous infiltration of the pituitary based on clinical findings, histology from liver and lymph nodes and PET scan results Pituitary lymphomas are described as ... the ultrasound findings as well as identifying involvement of the base of her skull She underwent a biopsy from a right groin Figure T1-weighted MRI of her pituitary with contrast showing normal ... after successful treatment of the lymphoma An early report of complete resolution of non Hodgkin s lymphoma involving the pituitary was based on 67 gallium scintigraphy and the patient remained...
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Báo cáo y học: " Large cell non-Hodgkin’s lymphoma masquerading as renal carcinoma with inferior vena cava thrombosis: a case report" docx
... also be caused by lymphomas, as well as by breast, esophageal, thyroid, thymus and testicular cancer A very small percentage of cases of superior vena cava syndrome are associated with actual intravascular ... published instance of a renal lymphoma Intravascular extension of lymphoma is a rare clinical finding An atypical pattern of intra-abdominal spread of metastases and liver invasion was an important ... 90% of all cases of superior vena cava syndrome are caused by Page of Figure Anterior abdominal subcutaneous tumor Subcutaneous abdominal mass (source of diagnostic biopsy) (A) Subcutaneous mass...
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báo cáo khoa học: " Hypercalcemia and huge splenomegaly presenting in an elderly patient with B-cell non-Hodgkin’s lymphoma: a case report" potx
... Table shows the clinical and laboratory data of 10 such patients, including ours As shown in Table 2, the hypercalcemia was severe and life-threatening and immediate therapeutic modalities such as ... for some fibrotic changes compatible with her age No mediastinal lymphadenopathy was seen In her abdominal CT scan, it was noted that her spleen was large and that it contained a definite mass ... occupying about two thirds of the splenic space No abdominal or para-aortic lymph nodes were seen (Figure 1) Her serum calcium was gradually corrected by the use of intravenous saline and furosemide...
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Báo cáo y học: "Non-Hodgkin''''s lymphoma presenting as a primary bladder tumor: a case report" ppsx
... useful and in fact superior to CT for primary staging and assessment of disease extension in both Hodgkin' s disease and NHL The technique is reported to have sensitivities of 82% to 99% and specificities ... identified using PET (P < 0.05) [16] With regard to staging, FDG-PET is more sensitive and specific than conventional staging methods in FDG avid lymphomas such as Hodgkin' s lymphoma and most aggressive ... test was normal, as were his direct and indirect Coombs tests, serum protein counts, and plasma serum immunoglobulins His β2microglobulin was 2.79 mg/dL (normal range =
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Báo cáo y học: " Non-Hodgkin''''s lymphoma in a woman with adult-onset Still''''s disease: a case report" pptx
... and necessitating in most instances a biopsy to rule out lymphoma We describe a woman who was diagnosed with AOSD and developed non- hodgkin' s lymphoma (NHL) 10 months after the onset of her symptoms ... case of such an association Our patient was the youngest among the three reported cases and her lymphoma was diagnosed 10 months after the onset of AOSD Although the association between AOSD and ... Nakamura S, Miyawaki S, Yashiro K, Oyama T, Itoh H, Sakata N, Sugihara S, Masawa N: Lymph node lesion in adultonset Still 's disease resembling peripheral T-cell lymphoma: a report of three cases Int...
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Báo cáo khoa học: "Radiation-induced cancer after radiotherapy for non-Hodgkin''''s lymphoma of the head and neck: a retrospective study" ppsx
... benign diseases such as tuberculous lymphadenitis, skin diseases, thyroid diseases and spondylitis, however, at present, RT is mainly used to treat malignancies The limitation of the prior disease ... cycles of CHOP) The pathological diagnosis of the second HNC in all the cases (2 cases of cancer of the gum, case of tongue cancer, and case of maxillary sinus cancer) was SCC (fig 2) The median interval ... decrease in the incidence at higher doses is that the number of surviving cells decreases at these doses A similar relationship was suggested between sarcoma induction and the radiation dose employed,...
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báo cáo khoa học: "Synchronous perforation of non-Hodgkin’s lymphoma of the small intestine and colon: a case report" ppsx
... simultaneous small and large bowel non- Hodgkin s lymphoma with synchronous perforation Tumors of the small intestine are infrequent; only 3% to 6% of gastrointestinal tumors and 1% of gastrointestinal ... exists Some patients remain asymptomatic until intestinal perforation At diagnosis the lymphoma was bulky in 65% of patients, reaching over 10 cm in 45% of cases, implying a delay in diagnosis ... habits She underwent extensive investigation for non- specific abdominal pain and no pathology was found This investigation included blood tests, esophagogastroduodunoscopy, colonoscopy, and a...
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Tài liệu Báo cáo khoa học: Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X-ray crystallographic analyses pdf
... a combination of these mutations strikingly increases the stability of So-RNase HI to a level similar to that of Ec-RNase HI These results suggest that Asn29, Asp39, Met76 and Lys90 are not optimal ... corresponding positions of at least one of the amino acid sequences of its mesophilic and thermophilic counterparts Lys29 is conserved as Arg27 in Ec-RNase HI and Arg31 in Thermus thermophilus RNase ... determined [11] This structure strongly resembles that of Ec-RNase HI Nevertheless, So-RNase HI is less stable than Ec-RNase HI by 22.4 °C in Tm and 12.5 kJÆmol)1 in DG(H2O) [11] We used So-RNase...
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Báo cáo khoa học: Diversity of metallothioneins in the American oyster, Crassostrea virginica, revealed by transcriptomic and proteomic approaches potx
... pattern of expression reflects prior exposure to metals or other stresses that may induce MT expression, or is representative of basal expression associated with normal metals homeostasis Diversity of ... acid) and the mass was determined by MALDI-TOF MS (Voyager-DE STR BioSpectrometry Workstation; Applied Biosystems) Cysteine content was determined by subtracting the mass of the native protein from ... metalsdetoxification and metals-resistance, as proposed for high molecular mass isoforms of MTs and other cysteine-rich proteins present in other species [27,40] Acknowledgements The authors would...
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Báo cáo y học: " Hodgkin’s lymphoma masquerading as vertebral osteomyelitis in a man with diabetes: a case report" pptx
... presented simultaneously in an osseous and a non- osseous site, 25% of such cases were initially misdiagnosed as osteomyelitis by histopathology [2] Fine needle aspirates revealing lymphoma cells ... aureus accounts for nearly half of all cases of HVO and most commonly presents with back pain (89%) and fever (>60%) [4] Initial characteristics of CT and MRI scans in our case raised suspicion ... inflammation increases sensitivity and specificity for HVO, but atypical organisms, such as mycobacteria, often lack paraspinal inflammation and are also more likely to demonstrate multi-level disease and...
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Báo cáo khoa học: " Radiotherapy of large target volumes in Hodgkin''''s lymphoma: normal tissue sparing capability of forward IMRT versus conventional techniques" docx
... cent increase in MUs was 15.6%, that is, considering a dose rate of 200 MU/min, just less than 10 seconds of machine treatment increment Discussion Radiation treatment of Hodgkin' s lymphoma is an ... OARs, the comparison was made considering normal tissue sparing capabilities Dose volume constrains and NTCPs were the main focus of the evaluation Indeed, in the past few years, the FPIMRT has ... of dose distribution of FPIMRT (a) vs conventional (b) plans showing 110% (yellow line) and 95% (cyan line) isodoses in axial, sagittal and coronal sections the basis of either a large mediastinal...
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Báo cáo khoa học: " A comparison of mantle versus involved-field radiotherapy for Hodgkin''''s lymphoma: reduction in normal tissue dose and second cancer risk" docx
... has long been established that Hodgkin' s lymphoma (HL) survivors experience increased risks of secondary cancer (SC), in particular breast and lung cancer, and cardiac disease attributable in ... reduction in SC risk with RT doses greater than 5–10 Gy, which is clearly contrary to the results of large studies of HL survivors demonstrating increasing risks with escalating doses beyond 20 ... consideration Firstly, the biologic model applied [19] has inherent limitations, and is based on four assumptions [see Additional file 1] These assumptions include those regarding estimating risks...
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báo cáo khoa học: "Lenalidomide induced good clinical response in a patient with multiple relapsed and refractory Hodgkin''''s lymphoma" pptx
... Despite evidence of disease progression, the patient feels well, enjoys a good quality of life, is maintaining her university studies, and was able to go on vacation She remains on continuous ... lenalidomide and her disease progression is expected to remain limited in the immediate future Conclusions The lenalidomide dose selected for this patient was based on the standard dose used in multiple ... has been ongoing for 18 months The observed efficacy is consistent with data reported from two small studies [3,4] Further clinical studies are needed to assess the clinical Table 1: Results of...
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báo cáo khoa học: "An osseous lesion in a 10-year-old boy with Hodgkin’s lymphoma: a case report" ppsx
... rare and must be distinguished from systemic HL with diffuse bone and bone marrow involvement and from osseous metastases in advanced stage of disease Due to the nature of HL, most cases are associated ... multiple sites, particularly in cases of hereditary multiple exostoses syndrome (HMES) with an autosomal dominant inheritance Most children are asymptomatic OC usually presents as a solitary mass, as ... metastasis, and the most frequent (histopathologic and radiographic) misdiagnosis, osteomyelitis In general, routine bone scintigraphy seems to be of limited value in the clinical assessment of...
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Hodgkin''''s Lymphoma Edited by Nima Rezaei potx
... was associated with overexpression of genes involved in apoptotic induction and cell signaling pathways, including cytokines, whereas bad outcome was associated with overexpression of genes associated ... disease was later recognized as Hodgkin s disease (Wilks, S. , 1859) Wilks had to put the term Hodgkin s disease” in the title of his paper to make the point (Wilks, S. , 1865) Most of the cases ... is possible the other cases were also HL but no tissue was available for histology or immunohistochemistry at the time of Poston s study 4 Hodgkin' s Lymphoma Hodgkin s description of his cases...
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HODGKIN''''S LYMPHOMA potx
... was associated with overexpression of genes involved in apoptotic induction and cell signaling pathways, including cytokines, whereas bad outcome was associated with overexpression of genes associated ... disease was later recognized as Hodgkin s disease (Wilks, S. , 1859) Wilks had to put the term Hodgkin s disease” in the title of his paper to make the point (Wilks, S. , 1865) Most of the cases ... is possible the other cases were also HL but no tissue was available for histology or immunohistochemistry at the time of Poston s study 4 Hodgkin' s Lymphoma Hodgkin s description of his cases...
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Hodgkin''''s lymphoma potx
... khoảng s ng quanh nhân, lưới nhân thô Yếu tố nguy cơ: - Tỷ lệ mắc bệnh nam giới gấp đôi nữ giới - Một s virus: EBV (Epstein-Barr virus), HIV làm tăng nguy phát triển u lympho Hodgkin - Suy yếu ... Một s xét nghiệm cần tiến hành như: - Sinh thiết hạch cho chẩn đoán xác định bệnh - Xét nghiệm máu - X-quang lồng ngực, cần chụp CT MRI - Sinh thiết tuỷ xương - Có thể đề nghị nội soi để quan s t ... lympho Hodgkin Tuy nhiên, có nhiều trường hợp bị Hodgkin mà không thấy có yếu tố nguy Triệu chứng lâm s ng Các triệu chứng thường không giống người bệnh: - Nổi hay nhiều hạch cổ, nách bẹn, hay s u...
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Báo cáo y học: "Hodgkin''''s lymphoma presenting with markedly elevated IgE: a case report" potx
... was no history of allergic rhinitis (seasonal or perennial), asthma, sinusitis, otitis or other allergic disease Her physical examination was entirely normal Skin tests were positive to trees, ... mediastinal lymph node biopsy was consistent with Hodgkin' s lymphoma, nodular sclerosing subtype, grade I/II She was reassessed by Hematology and treatment with ABVD (adriamycin, bleomycin, vinblastine ... immunoglobulins, and rarely, cases have been reported of both B- and T-cell lymphomas associated with elevated IgE [6-8] S zary 's syndrome (a peripheral T-cell neoplasm) has been associated with...
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Báo cáo khoa học: "Primary multifocal osseous Hodgkin''''s lymphoma" ppt
... It does not include patients who presented with disease at non osseous and osseous sites, or those patients in whom hodgkins disease disseminated to the bone At least of these cases were reported ... lumbar spine Investigation undertaken weeks after presentation showing loss of height of L1 with surrounding soft tissue mass and impingement on the conus vey Guidelines) for Hodgkin' s disease, and ... T12 and L2 There was a soft tissue mass anterior and posterior to L1 causing spinal stenosis and impingement on the conus Radiologically this was thought to resemble Potts disease and the macroscopic...
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Báo cáo khoa học: " Clinical outcome of breast cancer occurring after treatment for Hodgkin''''s lymphoma: case-control analysis" pdf
... (months) 10* 11 DCIS Invasive DCIS Invasive Invasive Invasive Invasive Invasive DCIS Unknown Invasive Invasive DCIS Invasive DCIS Invasive Invasive Invasive Invasive Invasive DCIS DCIS 0.0 0.0 1.4 ... RT dose, RT field, and CT regimens], as well as the mode of presentation of the index breast cancers Pathological characteristics of breast cancers as well as tumor location within the breast were ... Abbreviations: DCIS, ductal carcinoma in situ * Patient was not treated for her first breast cancer at Massachusetts General Hospital - Synchronous disease: second breast cancer diagnosed within six...
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