HODGKIN'S LYMPHOMA Edited by Nima Rezaei           Hodgkin's Lymphoma Edited by Nima Rezaei Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Bojan Rafaj Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published March, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Hodgkin's Lymphoma, Edited by Nima Rezaei p. cm. ISBN 978-953-51-0402-5    Contents  Preface IX Part 1 Recent Insights into the Biology of Hodgkin's Lymphoma 1 Chapter 1 Recent Insights into the Biology of Hodgkin's Lymphoma 3 Diponkar Banerjee Part 2 Advances in Classical Hodgkin’s Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures 27 Chapter 2 Advances in Classical Hodgkin Lymphoma Biology: New Prognostic Factors and Outcome Prediction Using Gene Expression Signatures 29 Beatriz Sánchez-Espiridión, Juan F. García and Margarita Sánchez-Beato Part 3 Epidemiology of Hodgkin's Lymphoma 47 Chapter 3 Epidemiology of Hodgkin's Lymphoma 49 Youssef Al-Tonbary Part 4 Hodgkin’s Lymphoma: From Tumor Microenvironment to Immunotherapeutic Approach – Body’s Own Power Protection Challenges 61 Chapter 4 Hodgkin’s Lymphoma: From Tumor Microenvironment to Immunotherapeutic Approach – Body’s Own Power Protection Challenges 63 Marylène Lejeune, Luis de la Cruz-Merino and Tomás Álvaro Part 5 Treatment of Early Stage Hodgkin's Lymphoma 111 Chapter 5 Treatment of Early Stage Hodgkin Lymphoma 113 Samer A. Srour and Luis E. Fayad VI Contents Part 6 State of the Art Therapy of Advanced Hodgkin’s Lymphoma 145 Chapter 6 State of the Art Therapy of Advanced Hodgkin Lymphoma 147 Mark J. Fesler Part 7 Evolving Therapies in Relapsed and Refractory Hodgkin's Lymphoma 177 Chapter 7 Evolving Therapies in Relapsed and Refractory Hodgkin Lymphoma 179 Sulada Pukiat and Francisco J. Hernandez-Ilizaliturri Part 8 Therapy for Relapsed and Refractory Pediatric Hodgkin’s Lymphoma 201 Chapter 8 Therapy for Relapsed and Refractory Pediatric Hodgkin Lymphoma 203 Karen S. Fernández and Pedro A. de Alarcón Part 9 Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma 221 Chapter 9 Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma 223 Daisuke Niino and Koichi Ohshima Part 10 Toxic Effects of Hodgkin’s Lymphoma Treatment 233 Chapter 10 Toxic Effects of Hodgkin Lymphoma Treatment 235 Alma Sofo Hafizović Part 11 Survivorship in Hodgkin's Lymphoma 253 Chapter 11 Survivorship in Hodgkin Lymphoma 255 Matthew A. Lunning and Matthew J. Matasar    Preface  Hodgkin's lymphoma, previously known as Hodgkin's disease, is recognized as B cell derived cancer of lymphatic system. Although the disease had been described about 180 years ago, its exact causes and pathophysiology still remains unknown. However, there have been some progresses in identifying some genetic and environmental risk factors in development of lymphoma. Considering recent advances in treatment of patients with lymphoma during last two decades, the disease is considered as a curable disease, but it is still a controversial subject. The current book consists of 11 chapters. Recent insights into the biology of Hodgkin's lymphoma, including historical aspects, epidemiology, pathophysiology, genetic defects, and prognostic indicators are explained in the chapters 1-3. Chapter 4 is a translational chapter from tumor microenvironment to immunotherapeutic approach, followed by the chapters 5-9, explaining treatment of early stage, advanced, and refractory Hodgkin’s lymphoma as well as MALT lymphoma, respectively. The chapter 10 briefly explains some adverse effects of chemotherapy and radiotherapy in the affected patients, while the final chapter is focused on survivorship in Hodgkin's lymphoma. These chapters are intended to help physicians as well as medical students to learn and understand the pathophysiology of Hodgkin's lymphoma as well as practical approach to diagnosis and management in clinical practice. The book is the result of valuable contribution of 20 scientists in this field and I would like to acknowledge the expertise of all contributors, for generously giving their time and considerable effort in preparing their respective chapters. I hope the book will be welcomed by the physicians, who wish to learn more about Hodgkin's lymphoma. Nima Rezaei, MD, PhD Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran . HODGKIN'S LYMPHOMA Edited by Nima Rezaei           Hodgkin's Lymphoma Edited by Nima Rezaei Published by InTech Janeza Trdine 9, 51000 Rijeka,. Hodgkin's Lymphoma, Edited by Nima Rezaei p. cm. ISBN 978-953-51-0402-5    Contents  Preface IX Part 1 Recent Insights into the Biology of Hodgkin's Lymphoma 1 Chapter. respective chapters. I hope the book will be welcomed by the physicians, who wish to learn more about Hodgkin's lymphoma. Nima Rezaei, MD, PhD Research Center for Immunodeficiencies,