blood brain barrier permeability and brain edema formation
báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... aminoacid, 1% sodium pyruvate and 1% antibiotic penicillin and streptomycin (all from Gibco, Scotland, UK) and were maintained under standard cell culture conditions at 37°C and 5% CO2 One hour before ... acetoxymethyl ester (AM) (5 μM) (Sigma-Aldrich Inc, St Louis, MO, USA) were allowed to Blood brain barrier model Blood brain barrier model was performed as described previously [30] with modifications Briefly, ... Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood- brain barrier model for drug uptake and transport studies Brain Res 2003, 990:95-112 28 Yang...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... the blood- brain barrier properties in a serum free cell culture system Biochemical and Biophysical Research Communications 1998, 217:312-315 Mayhan WG, Heistad DD: Permeability of blood- brain barrier ... Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and Its Manipulation, Volume 2: Clinical Aspects Edited by Neuwelt ... into the brain because of blood- brain barrier (BBB) efflux transporters so that the brain serves as a reservoir for HIV-1 [2] and a source for viral escape [3] Therefore, HIV-1 in the brain can...
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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot
... W A and Erickson, M A.: The blood- brain barrier and immune function and dysfunction Neurobiol.Dis 2010, 37:26-32 44 Quan, N.: Immune-to -brain signaling: how important are the blood- brain barrierindependent ... S., Jacobson, S., Connolly, R., Tutor, D., and Theoharides, T C.: Corticotropin-releasing hormone (CRH) and brain mast cells regulate blood- brain- barrier permeability induced by acute stress J Pharmacol ... endings and regulate blood- brain barrier permeability Upon stimulation by allergic and non-immune triggers (e.g, CRH, neurotensin, mercury, mitochondrial (mt) DNA), mast cells release vasodilatory and...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... breakdown of the blood- brain barrier, reducing cerebral and pituitary edema formation, as assessed by extravasation of albumin and EB (Figure 1) hours anti-C5a IgG treated sham animals and experimental ... Anti-C5a ameliorates impairment of the blood- brain barrier after caecal ligation and puncture (CLP) (a-e) Brains were surgically removed, snap-fro(CLP) zen and tissue sections (10 μm) were obtained ... regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic substances During sepsis, however, blood- borne proinflammatory mediators are...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... INTRODUCTION 1.1 BLOOD BRAIN BARRIER 1.1.1 History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS ... delivery [34], and receptor/vector mediated drug delivery [35-39] Disturbing the blood brain barrier includes osmotic blood brain barrier disruption [40-44] and biochemical blood brain barrier disruption ... PENETRATE THE 30 BLOOD BRAIN BARRIER 2.5.1 Ideal Properties of Nanoparticles across the Blood Brain Barrier 30 2.5.2 Possible Mechanism of Nanoparticles to Penetrate the Blood Brain Barrier 31 2.5.3...
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the blood – brain barrier
... (2001) Molecular and cellular permeability control at the blood- brain barrier Brain Res Rev 36, 258–264 106 Rubin, L L., and Staddon, J M (1999) The cell biology of the blood- brain barrier Annu Rev ... factor in blood- brain barrier breakdown and angiogenesis in brain trauma J Neuropathol Exp Neurol 56, 912–921 33 Risau, W (1994) Molecular biology of blood- brain barrier ontogenesis and function ... blood- brain barrier permeability to protein Acta Neuropathol (Berl) 90, 454–460 Nag S (1998) Blood- brain barrier permeability measured with histochemistry In Introduction to the Blood- Brain Barrier...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
... dendrimer surface and disruption of the blood- brain barrier Conclusion In this study, we identified the precise physiologic upper limit of blood- brain tumor barrier pore size, and demonstrated ... impermeable to the BBTB and remain within brain tumor microvasculature (Figure 2H and Figure 3) Effect of Gd-dendrimer dose and blood half-life on particle accumulation within brain tumor tissue At ... compromised blood- brain tumor barrier Gd-G7 dendrimers are impermeable to the BBTB of the smallest RG-2 gliomas and remain intravascular Gd-G8 dendrimers continue to be impermeable to the blood- brain...
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Hình thái và chức năng của hàng rào máu não (blood brain barrier)
... dụ: nhồi máu não, xuất huyết não chấn thương sọ não ), có chứng tượng mở hàng rào máu não (Brain- Blood Barrier opening) bù trừ có tính chọn lọc phá hủy mặt cấu trúc giải phẫu cách đơn (Lee et ... máu não 5.2.1.Phù não (Brain edema) Theo Klatzo, phù não phân thành hai loại khác khác dựa vào đặc điểm hình thái chúng 34 - Phù não có nguồn gốc mạch máu (vasogenic edema) : hay phù “ướt”, phù ... ngoại trừ não Vào thời điểm đó, Ehrlich đơn giản cho não không nhận chất nhuộm màu Năm 1900, Lewandowsky nêu lên ý niệm hàng rào máu não nghiên cứu hạn chế vận chuyển ferrocya-nate kali vào não...
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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx
... of brain edema and 27 did not The mean age for patients with edema was 80.29 years (SD: 4.16), and 77.3 (SD: 7.67) for those without edema (difference not significant) Among patients with edema ... understanding of the elevation of CRP and NT-PBNP in the acute phase of stroke both CRP and NT-PBNP are markers of brain edema in stroke at baseline and after 48 hours respectively Given that brain ... new brain CT and determined again the CRP and NT-PBNP in the serum because the edema tends to be more evident after this elapse of time By edema in ischemic stroke we mean mass-effect and sulcal...
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Báo cáo y học: "Minocycline-induced hypersensitivity syndrome presenting with meningitis and brain edema: a case report'''' doc
... erythematous, oedematous and coalescing plaques on the upper trunk, and on proximal segments of the limbs Her palms and soles were erythematous She also had injection of the sclera, and edema of the ... cause serious adverse events such as hepatitis, autoimmune syndrome and HS [1,5] To our knowledge, lymphocytic meningitis and brain edema associated with minocycline-induced HS have not been reported ... multiform); facial edema is evocative and intense pruritus is common; and (3) multivisceral involvement [3,5,10] The most common visceral signs are enlargement of the lymph nodes, hepatomegaly and splenomegaly...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
... the formation of edema It is not known whether edema formation is related to BBB breakdown or other factors in sepsis The exact mechanism and the relation between BBB breakdown and edema formation ... on brain edema and blood brain barrier breakdown after experimental traumatic brain injury in rats J Neurosurg Anesthesiol 2003, 15:119-125 Heath DL, Vink R: Neuroprotective effects of MgSO4 and ... experimental sepsis attenuated BBB permeability and the extent of brain edema formation Alterations of BBB permeability with subsequent brain edema formation are common features of septic encephalopathy...
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Application of biologically active micelles in drug delivery across the blood brain barrier
... system (CNS) is to overcome the barrier preventing the drugs moving into the brain parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits ... the bloodstream to the brain parenchyma or spinal cord (Pardridge, 1997; Rubin and Staddon, 1999), due to the existence of the blood brain barrier (BBB) or the blood cerebral spinal fluid barrier ... from the blood to the brain (Brightman and Reese, 1969; Reese and Karnovsky, 1967; Rubin and Staddon, 1999) The tight junction consists of tight junctional strands between adjacent brain capillary...
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Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
... position and with wearing noseclips The best results for FVC and FEV1 were taken and percent predicted values were calculated according Quanjer et al [18] Blood pressure, medication and other ... high blood pressure regardless of its medical treatment - B HBP or medication: high blood pressure or the use of antihypertensive medication - C HBP and medication: high blood pressure and the ... between the abovementioned classes of high blood pressure and antihypertensive medication and lung function outcomes Additionally, high blood pressure and antihypertensive medication were used...
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Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"
... and serve as antioxidants and anti-inflammatory agents [12, 13] as well as hepatoprotectants [14] and neuroprotectants [15] However, the effects of naringin and hesperidin on metabolic rate and ... effects of p-synephrine alone and in combination with different amounts of hesperidin and naringin on: (1) resting metabolism, (2) blood pressure, (3) resting heart-rate, and (4) self-reported mood/energy ... hesperidin and 600 mg naringin Group 4: Advantra Z® with 100 mg hesperidin and 600 mg naringin Group 5: Advantra Z® with 1,000 mg hesperidin and 600 mg naringin After remaining seated and resting...
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Báo cáo khoa học: Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies pot
... both a-helix and b-sheet) that can serve as the nucleating core of amyloid fibril formation The algorithm betascan [35] calculates likelihood scores for potential b-strands and strand-pairs based ... primary structures The method predicts local conformational changes, usually associated with protein aggregation and amyloid fibril formation, and can quantitatively estimate the mutational effect ... ‘conformational switches’ in sequences – regions with a high predicted tendency to form both a-helices and b-strands – using the consensus secondary structure prediction program secstr [27] and...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
... between the L-arginine transport systems y+L and y+ and NO formation The effects of N-ethylmaleimide and L-leucine on L-arginine uptake and on NOx formation were closely correlated (y ¼ 0.284404x ... N-ethylmaleimide treatment decreased cGMP formation by 35% and L-leucine reduced cGMP production by 60% The effects of N-ethylmaleimide or L-leucine on NOx formation and on cGMP levels were strictly correlated ... L-arginine in human platelets and described a stimulatory effect of N-ethylmaleimide on this system, incubated Fig Effect of N-ethylmaleimide and L-leucine on NO formation and cGMP levels in platelets...
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Báo cáo khoa học: a-Fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation docx
... caspase 3, c-IAP-2 and AFP To study further the interaction between AFP, cIAP-2 and caspases and 3, we precipitated pure recombinant active caspases and (His-tagged) with nickel resin and then incubated ... Apaf-1 and p53, and simultaneous overexpression of the antiapoptotic proteins Hsp70, Bcl-2 and Bcl-xL, resulting in tumor-specific suppression of apoptosis and enhancement of the malignance and therapy ... caspase and AcIETD-AMC for caspases and [33] as described above Fractions were then concentrated 20-fold with mL centrifugal concentrators (Centricon YM-10; Amicon) and analyzed by PAGE and immunoblotting...
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Báo cáo khoa học: Intrinsic disorder and coiled-coil formation in prostate apoptosis response factor 4 pptx
... · F1) and spectral widths of 8389.2 and 2128.9 Hz for F2 and F1, respectively; rrPar-4DLZ: 20 transients, 2048 · 128 points (F2 · F1) and spectral widths of 8389.2 and 2128.9 Hz for F2 and F1, ... F1) and spectral widths of 8389.2 and 2128.9 Hz for F2 and F1, respectively All data sets were linear predicted and zero-filled once in the indirect dimension before Fourier transformation and ... the RS measured for rrPar-4FL, rrPar-4DLZ and rrPar-4SAC correspond to MWs of 8.9 · 103, 64.1 and 18.7 kDa, respectively, and are much larger (713, 129 and 141%) than what would be expected for...
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Báo cáo khoa học: Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation pdf
... distinct band with slow mobility, a fainter band with intermediate mobility, and a diffuse, rapidly migrating band (Fig 2A) This pattern of complex formation over time varied between wild-type and ... at different time points up to 60 and analyzed by both SDS ⁄ PAGE and native PAGE Separation by SDS ⁄ PAGE and visualization by phosphorimaging showed a single band of 42 kDa with similar intensity ... analysis of the mobility shift of this band by native PAGE and radiography (Fig 2C) DNase I binds the actin monomer and condenses the smear to a distinct band of characteristic mobility The smear...
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