... thought of as the manufacturing end of the life sciences industry.”—University of Michigan, School of Medicine“Body of methods and techniques that employ as tools the living cells of organisms ... the influence of ethnicity of the genomics of organisms. Ethnicity refers to organismswith origins from different parts of the world. Most scientists focus onthe ethnogenomics of humans. This ... chain of command of genes in embryonic de-velopment, the development of stem cells in adult and fetal tissues, andthe mechanisms of gene activation in cancer. Biotechnology makes use of epigenomics...
... malonyl-CoA and CPT1c in the treatment of obesity Michael J. Wolfgang and M. Daniel LaneDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USAIntroductionAll ... malonyl-CoA;neurometabolism; nutrient sensing; obesity CorrespondenceM. J. Wolfgang, Department of BiologicalChemistry, Johns Hopkins University School of Medicine, Center for Metabolism and Obesity Research, 475 Rangos ... major user of long-chain fattyacids making a brain-specific isoform intriguing.CPT1c was identified and cloned from in silicosequences as a highly homologous member of theCPT1 class of enzymes...
... emerging targets for treatment of obesity and related metabolic diseasesTsuyoshi Kadomatsu, Mitsuhisa Tabata and Yuichi OikeDepartment of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto ... metabolism;insulin resistance; metabolic syndrome; obesity; obesity- related metabolic diseaseCorrespondenceY. Oike, Department of Molecular Genetics,Graduate School of Medical Sciences,Kumamoto University, ... roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity andrelated metabolic diseases, and discuss the possibility that both could func-tion as molecular targets for the prevention and treatment of obesity...
... most prevalent form of MetS isassociated with abdominal (visceral) obesity and thatthis type ofobesity contributes to insulin resistance(IR) and the increased release of cytokines, as well ... risk of T2DM, hypertension and CVD;however, the exact underlying pathophysiologicalmechanisms by which obesity increases the risk of VD remains the subject of intensive investigation [20]. Obesity ... deficiencyand hypogonadism-induced obesity remain the subject of intense investigation.Several hypotheses have discussed the relationship of androgen deficiency and obesity. That obesity iscommonly associated...
... "The Nature of Affixing in Written English," an algorithm for the structural definitionof affixes was developed and applied to data consisting of all the words of the form CVCVC ... two-vowel-string words. This paper summarizes the results of applying a modified form of the operational definition to data consisting of all the four-, five-, six-, and seven-vowel-string words ... classification of the weak suffixes by degree of weakness as a means of approaching the suffix-in- context problem. Table 2, which reviews the prefixes and suffixes de- fined by Resnikoff and Dolby,...
... mode of action of RMI1 in the regulation of energy homeostasis might be based on the regulation of adipocyte hyperplasia. Studies have shown that siRNAknockdown of RMI1 resulted in suppression of ... cause of adult obesity, and hyperplasia of adipocytes in obese adults some-times occurs secondary to adipocyte hypertrophy, pos-sibly due to an increased number of adipocytescapable of secreting ... escalating prevalence ofobesity is one of the most pressing healthconcerns of the modern era, yet existing medicines to combat this globalpandemic are disappointingly limited in terms of safety and...
... ambulatory (ANPEG) of the Institute of Geriatrics and Gerontology of the Catholic University of the state of Rio Grande do Sul(PUCRS). Collaborating Center for the Prevention of Pathologic Aging ... Diseases of the WHO/PAHO. Porto Alegre, RS,Brazil. bDepartment of Psychiatry of the Paulista Medical School, Federal University of São Paulo. São Paulo, SP, Brazil. cDepartment of Psychiatry of ... ‘as the components of the quality of life are personal, the most adequate procedureto measure it seems to be the use of the individual definitions of each interviewed.’The aim of this study was...
... use of drugs to counteract obesity risk factors or simply to the latency of the effect. This analysis does not take account of the impact of childhood obesity. The health consequences of overweight ... prevalence of obesity THE DETERMINANTS • 132. The determinants of obesity Main messages• The simultaneous presence of physical inactivity and poor diet to a large extent explains the obesity ... sense of fatalism about their health. Lower socioeconomic status not only increases the risk ofobesity but may result from obesity. Several stud-ies have noted that obesity increases time off...
... of obesity. The guideline addresses:primary prevention ofobesity in children, young people and adults treatment of overweight /obesity by diet and lifestyle interventions treatment ofobesity ... MANAGEMENT OF OBESITY A Cochrane systematic review examined the effectiveness of interventions to improve health professionals’ management of obesity. Interventions included training and provision of ... slowing the rate of eating reinforcement of changes relapse prevention strategies for dealing with weight regain. 73 OBESITY IN ADULTS3 Obesity in adults3.1 PREVALENCE OFOBESITY IN ADULTSThe...
... 2001/20/EC1. A clear understanding of the definitionof an IMP requires knowledge of the definitions of a medicinal product and of a clinical trial; these two definitions are provided in Annex ... (IMP) is linked to (a) the definition of a “medicinal product”, (b) the intended use of a medicinal product and (c) the definitionof a “clinical trial” for the purposes of Directive 2001/20/EC1. ... General definitions useful for this guidance Medicinal Product Article 1.1 of Directive 2004/27/EC provides the definitionof "medicinal product" which applies for the purposes of Directive...
... frame of reference (Taylor & Tversky, 1996). A frame of reference includes an origin, a coordinate system, apoint of view, referenceterms, and a reference object. Threekinds offramesof reference ... REPRESENTATIONS 51SITUATION MODELS AND LEVELS OF COHERENCEToward a Definitionof ComprehensionIsabelle TapieroUniversity of LyonUniversity of Lyon IILAWRENCE ERLBAUM ASSOCIATES, PUBLISHERS2007 ... theConstruction-IntegrationModel is a significantexample of themodels developed in the second generation of research. It offers a new way of investigating the contribution of knowledge to the reading comprehen-sion...
... "Status of this Memo" section that identify the document as the product of the IRTF. The current text is defined in [RFC5741].3. Rules for Submission and Use of Material The goals of the ... guarantee of publication. In particular, the IRTF Chair may question the appropriateness of a "no derivative works" restriction requested by an author. The appropriateness of such ... publication by the IRSG are not a candidate for any level of Internet Standard; see Section 2 of RFC 5741. Information about the current status of this document, any errata, and how to provide feedback...
... acids into fat cells in the form of triglycerides, leads to thedevelopment of obesity. Despite the pivotal role ofobesity and dyslipide-mia in the development of the metabolic syndrome and heart ... Journal compilation ª 2009 FEBSMINIREVIEWMechanisms ofobesity and related pathologies: Role of apolipoprotein E in the development of obesity Kyriakos E. Kypreos1, Iordanes Karagiannides2, ... a direct correlation between obesity andthe development of cardiovascular disease [36,37].Despite the pivotal role ofobesity and dyslipidemia inthe development of the metabolic syndrome and...
... expansion of adi-pose depots accompanying obesity is central to the development of appropriate therapeutic strategies. This minireview focuses on a discussion of the recent identification of molecular ... arole in directing the formation of WAT and BAT duringdevelopment. The most notable of these adipogeniceffectors are members of the BMP family of transform-Control of adipose tissue development ... discovery of BAT in adult humanspresents investigators with the new challenge of howto increase its mass and ⁄ or activity as a part of ananti -obesity therapy. Additional knowledge of themolecular...