báo cáo khoa học: " Trust and the regulation of pharmaceuticals: South Asia in a globalised world" ppt

... in data collection, and helped draft the manuscript. NR and MS were partners in the data collection in Nepal. SMR was a partner in the data collection and analysis of material from India. All authors ... overcounterfeit, fake, substandard and spurious medicines, and quality standards in Indian generic companies, lookingparticularly at the role played by the US FDA; and (iii) the implications of lack of trust ... RESEARCH Open Access Trust and the regulation of pharmaceuticals: South Asia in a globalised worldPetra Brhlikova1†, Ian Harper1†, Roger Jeffery1*†, Nabin Rawal2, Madhusudhan Subedi2and...

Báo cáo khoa học: MicroRNAs and the regulation of ﬁbrosis potx

... thereforeappears that although miRNAs predominately represstranslation through binding within the 3¢-UTR of tar-get mRNA, individual miRNAs might also increasemRNA translation and bind regions within the 5¢-UTR.There ... several organs, including heart, lung, kidney and liver (Fig. 1).miRNA and cardiac fibrosisCardiac fibroblasts are the most numerous cell type in the heart and are central to the regulation of cardiacECM ... thatmiR-133 and miR-590 are down-regulated in a caninemodel of nicotine-induced atrial interstitial fibrosis[28,29]. Interestingly, mechanistic studies in the caninemodels and in cultured atrial fibroblasts...

Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

... DNA damage facilitates activation of the DNA damage-activated protein kinases ATM and ATR. ATR and ATM in turn phosphorylation-dependently activate the downstream check-point kinases Chk1 and ... the DNA damage-acti-vated kinase homeodomain-interacting protein kinase 2 (HIPK2).AbbreviationsATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; Bak, Bcl-2 homologous antagonist ... ataxia-telangiectasia mutated(ATM); ataxia-telangiectasia mutated and Rad3-related (ATR); DNA damage;homeodomain-interacting proteinkinase 2 (HIPK2); nuclear bodies; p53;p73; promyelocytic leukaemia(PML)CorrespondenceT....

Báo cáo khoa học: "Evaporation and surface conductance of three temperate forests in the Netherlands" pdf

... most of this paperboth the average and the maximum values of variables are shown. This gives an indi-cation of the statistical variation in the data, and allows a qualitative ... and as a maximum value.There is not always an equal number of points used in the calculation of the aver-age. This limits the approach to showing a general seasonal ... explain the difference in early spring transpirationbetween the stands. The relatively highevaporation rates of the poplar stand in the spring are caused by undergrowth of nettles...

Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx

... be a feature of the way in which stability was measured. Attachment of an amino-ter-minal GFPS tag to a protein in the global protein stabilityassay may interfere with cellular localization and ... mRNA decay rates, microRNA (miRNA)targeting and ubiquitination have critical roles in the degradation and disposal of human proteins and transcripts. Here, we describe a study examining these ... predicted miRNA targets and proteindisorder in a general way.Mono-ubiquitination rather than polyubiquitination is the prevalent signal in intranuclear trafficking and triggers the first step of endocytosis...

Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt

... following primers: F133N-fw (5¢-GATTTTTGTGGCTGGAACAGGAAACCCATATTTTACAACTGATTCG) and F133N-rv (5¢-CGAATCAGTTGTAAAATATGGGTTTCCTGTTCCAGCCACAAAAAT), with the alterednucleotides shown in bold and ... underlined. The F13 3A mutation was created using the following primers: F13 3A- fw (5¢-GTGGCTGGAACAGGAGCGCCATATTTTACAACTGATTCG) and F13 3A- rv (5¢-CGAATCAGTTGTAAAATATGGCGCTCCTGTTCCAGCCAC). The ... and part of the His-tag was observed in the B chain. A fewamino acid residues are found in disallowed regions in the Ramachandran plot; these are A4 , A1 65, A1 67, B3, B4 and F165, all of which are...

Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

... Kaneko1, Yuanying Ding1, Kazuhiro Ogawa2,*,Miki Yoshizawa1, Masaki Kawamura1, Kazuhisa Takeda1, Tadashi Yoshida3 and Shigeki Shibahara11 Department of Molecular Biology and Applied ... Takahashi K, Takeda K, FuruyamaK, Kaneko K, Takahashi S, Tamai M & Shibahara S(2004) Expression of heme oxygenase-1 is repressed byinterferon-gamma and induced by hypoxia in humanretinal ... norm-oxia (Fig. 6A, C), and was shortened to 6 h under hyp-oxia. The decreased levels of HO-2 mRNA may be in part due to the enhanced degradation of the HO-2mRNA.Functional analysis of the HO-1 and...

Báo cáo khoa học: Protein and mRNA content of TcDHH1-containing mRNPs in Trypanosoma cruzi pdf

... proteins, mRNA-binding proteins, initiation and elongation translationfactors, ribosomal proteins and metabolic proteins.Abundant proteins, such as heat shock proteins and elongation factor 1a, ... 78(Tc00.1047053506585.40),F,5¢-TGGCGGTAAGAAGAAGCAGT-3¢;R,5¢-CCGAGGTCAAACACAAGGAT-3¢;putative (H+)-ATPase G subunit (Tc00.1047053510993.10),F,5¢-ACAACGTGCAAAGGCTTCTT-3 ¢;R,5¢-CTCGTGCCAACTCCAAGTTT-3¢.PCR, using a Bio-Cycler ... v.3.5.2program (Kodak, Rochester, NY, USA). The ratio of the densitometric values of the bands containing ampliﬁedcDNA between IP and SP samples was determined.AcknowledgementsWe thank Andreia Dallabona,...

Báo cáo khoa học: " Ecophysiology and field performance of black spruce (Picea mariana): a review" ppsx

... seedlings. In addition to carbo-hydrate and amino-acid accumulation in response to water stress, Zwiazek and Blake(199 0a) also observed an increase in majororganic acids in ... of osmoregulation in expandedleaves of many species with sugars beingapparently dominant in black spruce(Zwiazek and Blake, 199 0a; Tan et al,199 2a, b). Concentrations of ... of Picea mariana and Larix laricinafrom drained and undrained peatlands. Can J ForRes 20, 995-1000Maliondo SM, Krause HH (1985) Genotype and soil fer-tility interaction...

báo cáo khoa học: "Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients" potx

... carcinoma followed by cervical carcinoma and bladder carcinoma. (Table 1).Clinicopathological analysis of cervical carcinoma thatdeveloped after a renal transplant The mean age at the time of ... included in the study. According to a retrospective review of the medical charts of these patients, 36 of them had malig-nancy. The incidence of carcinoma was analyzedaccording to the type of carcinoma. ... malignant carcinomas in female patients who had received a renal transplant at a single hospital, to analyze the clinicopathological features of patients with cervical cancer and to analyze whether...

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