... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... thymus, involution, aging, microarray, AGEMAP, thymocytes, caloric restriction Introduction The aging immune system is often characterized by a general decline in the ability to resist infection ... delay age-associated thymic involution through directly affecting the thymocytes. Endocrinology 2004;145: 2392-2401 22. Dominguez-Gerpe L and Rey-Mendez M. Evolution of the thymus size in...