mice are resistant to type ii collagen mab induced arthritis
Báo cáo y học: "Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvemen" doc
... Abbreviations AIA: antigen -induced arthritis; BSA: bovine serum albumin; CAIA: type II collagen mAb- induced arthritis; CII: type II collagen; CIA: collagen- induced arthritis; DMEM: Dulbecco’s ... important inflammatory and destructive mediators u-PA-/- mice are resistant to type II collagen mAb- induced arthritis We previously found [14] a reduced proliferative T-cell response to CII stimulation ... http:/ /arthritis- research.com/content/12/2/R37 Page of 13 Figure Urokinase -type plasminogen activator gene-deficient mice are resistant to T-cell-independent arthritis models (a) Type II collagen mAb- induced arthritis (CAIA) using Pam-3-Cys...
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Báo cáo y học: "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen" pot
... Induction of arthritis in B6 mice We first compared bovine, chicken, and mouse collagen type II for their ability to induce arthritis in B6 mice (Table 1) Only chicken collagen was able to induce arthritis ... of anti -collagen IgG isotypes in DBA/1 and B6 mice with collagen- induced arthritis Serum from naïve and arthritic mice were analysed B6 mice with collagen- induced arthritis for anti -collagen ... responses to collagen type II in B6 mice with collageninduced arthritis Inguinal lymph node cells were cultured from naïve mice or mice with early (up to weeks after onset) or late (6 to weeks...
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Báo cáo y học: "Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro" pps
... nonarthritogenic mAb to CII, CIIF4, and to an irrelevant mAb, GAD6, in the absence of inflammatory mediators known to dominate the effector phase of CIA Both arthritogenic and non-arthritogenic ... Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen- induced arthritis in the mouse Arthritis Rheum ... Immunisation against heterologous type II collagen induces arthritis in mice Nature 1980, 283:666-668 20 22 Stuart JM, Cremer MA, Townes AS, Kang AH: Type II collageninduced arthritis in rats Passive...
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Báo cáo y học: "Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium" ppt
... Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen- induced arthritis in the mouse Arthritis ... anti -type II collagen antibody -induced arthritis Arthritis Rheum 2004, 50:2347-2359 Taggart CC, Greene CM, McElvaney NG, O'Neill S: Secretory leucoprotease inhibitor prevents lipopolysaccharide -induced ... guidelines for the care and use of laboratory animals DBA1/J mice were obtained from the Jackson Laboratory (Bar Harbor, ME, USA) All mice were kept under standard conditions at the animal care facility...
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Báo cáo y học: "Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension" pptx
... response to challenges than WT mice To further explore the TSP-1-/- mice pulmonary vasculature decreased reaction to chronic hypoxia we investigated their response to acute pulmonary vasoconstrictors ... were bred and genotyped as previously described [1] TSP-1-/- mice have been found to be susceptible to lung infection with D Streptoccocus and Pasteurella pneumotropica [1] To help prevent this ... cardiac responses to vasoactive stress Matrix Biol 2009, 28(2):110-119 doi: 10.1186/1749-8090-5-32 Cite this article as: Ochoa et al., Thrombospondin-1 null mice are resistant to hypoxia -induced pulmonary...
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Báo cáo y học: "mPGES-1 null mice are resistant to bleomycininduced skin fibrosis" docx
... inflammatory diseases, including rheumatoid arthritis and osteoarthritis [10,11,16,17] mPGES-1 null mice are resistant to chronic inflammation of joints in the models of collagen- induced arthritis ... showed reduced collagen content in mPGES-1 null mice compared with wild -type (WT) mice in response to bleomycin treatment Data from four separate mice per group are shown (b, c) Immunohistochemistry ... null mice compared with PBS-treated mice +P < 0.05; bleomycin-treated mPGES-1 null mice compared with bleomycin-treated WT mice Representative data from four separate animals per group are shown...
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Báo cáo y học: "Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis" pps
... showed reduced collagen content in mPGES-1 null mice compared with wild -type (WT) mice in response to bleomycin treatment Data from four separate mice per group are shown (b, c) Immunohistochemistry ... per group are shown *P < 0.05; bleomycin-treated WT and mPGES-1 null mice compared with phosphate-buffered saline (PBS)-treated mice +P < 0.05; bleomycin-treated mPGES-1 null mice compared with ... anti-α-SMA antibody was performed mPGES-1 null mice showed a reduced number of α-SMA-expressing myofibroblasts compared with WT mice in response to bleomycin treatment (4-week treatment) Representative...
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Báo cáo y học: "Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis" pdf
... antibodies to type II collagen in rheumatoid arthritis Arthritis Rheum 1990, 33:1493-1500 Cook AD, Mackay IR, Cicuttini FM, Rowley MJ: IgG subclasses of antibodies to type II collagen in rheumatoid arthritis ... antibodies to type II collagen in early rheumatoid arthritis J Rheumatol 1994, 21:1186-1191 Cook AD, Rowley MJ, Mackay IR, Gough A, Emery P: Antibodies to type II collagen in early rheumatoid arthritis ... Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen- induced arthritis in the mouse Arthritis...
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Báo cáo y học: "Analog peptides of type II collagen can suppress arthritis in HLA-DR4" docx
... suggest that positions 263 and 266 in CII are critical for T-cell Figure type II collagen Proliferation of DR4-(DRB1*0401)-restricted T cells in response to type II collagen A panel of analog peptides ... with rheumatoid arthritis and osteoarthritis Arthritis Rheum 1985, 28:241-248 Watson WC, Cremer MA, Wooley PH, Townes AS: Assessment of the potential pathogenicity of type II collagen autoantibod- ... murine type II collagen- induced arthritis Arthritis Res 1999, 1:81-91 Kim SH, Kim S, Evans CH, Ghivizzani SC, Oligino T, Robbins PD: Effective treatment of established murine collagen- induced arthritis...
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Báo cáo y học: "A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis" ppsx
... laboratory found that collagen- induced arthritis (CIA) could be established in Wistar rats, Kunming mice, and DBA/1 mice with chicken type II collagen (CCII) [15,16] Feeding CCII to rats by oral administration ... T-cell tolerance epitopes of chicken type II collagen that suppresses collagen- induced arthritis Mol Immunol 2009, 46:729-737 26 Tanaka D, Kagari T, Doi H, Shimozato T: Administration of antitype II ... Juvenile arthritis and autoimmunity to type II collagen Arthritis Rheum 2001, 44:1775-1781 29 Choy EH, Scott DL, Kingsley GH, Thomas S: Control of rheumaArthritis Rheum 2001, toid arthritis by oral tolerance...
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Báo cáo y học: "Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice" docx
... macropinocytosis Available online http:/ /arthritis- research.com/content/8/4/R93 Figure type II collagen (CII) Confocal micrographs of dendritic cells and macrophages pulsed with type II collagen (CII) ... PH: Direct interactions of collagen II and Toll-like receptor depend upon the saccharide residue of collagen II: a potential mechanism for collagen- induced arthritis Arthritis Rheum 2005, 52:S477 ... degradation II collagen (CII) by macrophages The effect of inhibitors of uptake on the intracellular processing of type II collagen (CII) by macrophages Macrophages from HLA-DR1-tg mice were pulsed...
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Báo cáo y học: "Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development" ppsx
... dendritic cells; CAIA: collagen antibody induced arthritis; CII: collagen type II; CIA: collagen induced arthritis; CTLL: murine T cell line; DC: dendritic cells; DTH: Delayed -Type Hypersensitivity ... the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development Arthritis Research & Therapy 2011 13:R54 Submit your next manuscript to BioMed ... Titertec multiscan spectrophotormeter Induction and evaluation of CII antibody induced arthritis (CAIA) Arthritis was induced in three -to- five-month-old male mice with an anti-CII antibody cocktail containing...
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Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... disease; ochronosis; haemochromatosis; heritable arthritic disorder or collagen gene mutations or rheumatoid arthritis History of asthma, history of diabetes (Type I or Type II) Hyperuricemia (urate, ... compared to UC -II at every time point assessed From baseline to Day 30 a total of subjects (33.3%) on UC -II used rescue medication as compared to 23 subjects (88.5%) on 319 G+C From Day 30 to ... in UC -II induced pharmacological anti-arthritic effects in humans, dogs or horses is not clearly established Type II collagen is the primary form of collagen contained in cartilage Type II collagen...
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Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx
... subtypes in tolerized and nontolerized collagen- induced arthritis (CIA) mice When examined at 3, and weeks after primary immunization, mice that received oral type II collagen (CII) exhibited ... been shown to be significantly increased in DBA/1 mice with CIA [12,13] We investiga- Suppression of arthritis in mice that received oral type II collagen (CII) before arthritis induction Mice that ... EH, Townes AS, Kang AH: Incidence and specificity of antibodies to type I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic disease as measured by 125I-radioimmunoassay Arthritis...
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Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading" ppt
... of variance was used to control for the side factor and for the time factor The side factor was analyzed as the paired measure Post-hoc tests were also performed to compare time points Significant ... expression levels of osteoarthritis-relevant genes in femoral condyles at 48 weeks Group Anterior cruciate ligament transection Control Collagen type II YKL-40 Collagen type I Aggrecan TenascinC ... natural history of experimental osteoarthritis I Progressive discoordinate expression of aggrecan and type II procollagen messenger RNA in the articular cartilage of adult animals Arthritis Rheum...
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Báo cáo y học: "Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen" ppt
... Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen- induced arthritis in the mouse Arthritis ... or stochastic factor in the selection of the antibody response to specific CII epitopes However, links to the development of chronic relapsing arthritis are also indicated The total anti-CII response ... http:/ /arthritis- research.com/content/7/5/R1148 Figure Arthritis development in B10.Q mice and antibody response to CII-specific epitopes in individual mice (a) Arthritis course during 156 days of male mice B10.Q mice to 12 weeks old...
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Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... in the collagen- stimulated cultures The CD4+ phenotype of CI-specific T cells is consistent with murine studies showing that type II collagen- specific T cells in the collagen- induced arthritis ... Postlethwaite AE: Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen Arthritis Rheum 2000, 43:1054-1061 16 ... fibrosis: collagen- induced migration inhibition factor production and cytotoxicity mediated by lymphocytes J Clin Invest 1976, 58:1223-1232 25 Schrier DJ, Phan SH, Ward PA: Cellular sensitivity to collagen...
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Báo cáo y học: "Mesangial cells of lupus-prone mice are sensitive to chemokine production" pps
... DBA/W F1 mice are a nonautoimmune disease-prone strain with MHC class II molecules identical to those of NZB/W mice DBA/W mice not spontaneously develop autoimmune disease; mice were monitored throughout ... more responsive to LPS On the other hand, MCs also express Toll-like receptor-2 [41] and Toll-like receptor-3 [21] that caused secretion of proinflammatory cytokines C5a receptor activation in ... control; DBA/W mice are a nonautoimmune disease-prone strain with MHC class II molecules identical to those of NZB/W mice) , both in the baseline (normal culture) condition and in response to LPS stimulation...
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Báo cáo y học: "Arthrogenicity of type II collagen monoclonal antibodies associated with complement activation and antigen affinity" pps
... homologous type II collagens J Immunol 1992, 149:1045-1053 Watson WC, Townes AS: Genetic susceptibility to murine collagen II autoimmune arthritis Proposed relationship to the IgG2 autoantibody ... Seyer JM: Collagen- induced arthritis in mice: synergistic effect of E coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen ... C2B-16 to the mAbs (CII-6, CII-3, and C2B-14) to test the arthritogenicity We predicted that C2A-12 would exacerbate the arthritis because its ability to activate complement and bind to mouse CII...
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Báo cáo y học: "Arthrogenicity of type II collagen monoclonal antibodies associated with complement activation and antigen affini" doc
... homologous type II collagens J Immunol 1992, 149:1045-1053 Watson WC, Townes AS: Genetic susceptibility to murine collagen II autoimmune arthritis Proposed relationship to the IgG2 autoantibody ... Seyer JM: Collagen- induced arthritis in mice: synergistic effect of E coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen ... C2B-16 to the mAbs (CII-6, CII-3, and C2B-14) to test the arthritogenicity We predicted that C2A-12 would exacerbate the arthritis because its ability to activate complement and bind to mouse CII...
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