which hormone is responsible for regulating blood glucose levels
Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... of carnitine: mm (for standard comparison with other published data), and a concentration equal to the Km for carnitine of each enzyme (for comparison between mutants) In this article, we show ... been dissected in the N-terminal region of this enzyme, which is less malonyl-CoA sensitive than human CPT1B The IC50 for malonyl-CoA inhibition of human CPT1B (IC50 = 0.096 lm) [7,22,23] is ... sequence as being responsible for the peculiar kinetic characteristics of this enzyme, acting as a negative determinant for malonyl-CoA sensitivity Asp17 may account, at least in part, for the high...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... the active conformation, Val371 forms contacts with neighboring residues that are important for stabilizing the active state (e.g Asp189, which is part of the S1 pocket responsible for the binding ... sequence identity of 3045%), this position is occupied solely by a valine This conserved amino acid is replaced by isoleucine in the Val371Ile FXI mutant Interestingly, an isoleucine residue naturally ... levels and hemorrhagic episodes are usually associated with injury or surgery, but may be so severe as to demand replacement therapy [16] The genetic basis of this rare coagulation disorder is...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... However, this proteolysis is much slower in vitro, because of a lack of chaperone machinery The in vitro proteolysis requires ATP [14] We examined the proteolysis of purified r32-C-his (1.2 lm) ... several membrane-associated substrates, for which the mechanism of proteolysis is probably somewhat different [21] Whether kCIII would act as an inhibitor for such substrates (e.g SecY, YccA, Foa) ... CIII on proteolysis of the heat shock sigma factor r32, another substrate of HflB Like proteolysis of CII, r32 proteolysis requires ATP Both CIII and CIIIC inhibit this proteolysis, with CIIIC exhibiting...
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
... synthesis, it might be involved in the stearic acid incorporation after the de novo synthesis of this lipid (i.e the second hypothesis) According to this hypothesis, previously raised for mammals ... throughout eukaryotes, and the biosynthetic pathway for PI synthesis is well documented [14] PI is synthesized from phosphatidic acid (PA), which is further used as substrate by a cytidine diphosphate-diacylglycerol ... regulation [1–5] The fatty acid composition of this phospholipid is quite distinctive in living organisms because, in comparison with other phospholipids, PI is by far the most saturated In bovine heart,...
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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc
... o-quinone) the values obtained are not very precise (150 mV for Dopa and 195 mV for compound 1), but indicate that the formation of the phosphonic o-quinone is not favored Thus, two other factors drive ... solution What distinguishes our case from other redox 4104 B Gasowska et al (Eur J Biochem 269) ˛ interactions in this system is the decomposition of the phosphonic o-quinone This decomposition ... mushroom (Agaricus bisporus) tyrosinase isoforms by tropolone J Agric Food Chem 47, 2638–2644 Kahn, V & Andrawis, A (1985) Inhibition of mushroom tyrosinase by tropolone Phytochemistry 24, 905–908...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... ABCG2R482G remains in a conformation that contains a low-affinity binding site for [3H]daunomycin immediately post-nucleotide hydrolysis Discussion A precise molecular mechanism for substrate translocation ... low-affinity conformation of drug binding sites in ABC multidrug efflux pumps is assumed to correspond to the outward-facing conformation The energy produced by the hydrolysis of ATP is harnessed for the ... binding affinity for [a32P]azido-ATP as KD = 201 ± 80 lm This affinity is similar to the value obtained for ATP binding to ABCB1 [29] The ability of nucleotides to displace binding is shown in Fig...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... hydrolysis), corresponding to that expected for the F variant This result is the first evidence for the heterozygous status (M/F) of the individual goat milk analysed In addition to this, the ... first one is an ACRS-PCR technique [26], the principle of which is to create a TaqI restriction site (TCGA) by using a mismatching primer (C9LM*) which allows both the F and M alleles to be discriminated ... subsequently distinguished after a second amplification which allows discrimination between the alleles on the basis of the fragment sizes (Fig 8, Step IIA) In the first step, a 266-bp (265 bp for the...
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Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
... TA isoforms act similarly to p53, inducing apoptosis In comparison, ΔN isoforms have little transactivation activity and play a role blocking target genes of p53 and their respective TAp73 isoforms ... their respective TAp73 isoforms [6] Therefore, the TA isoforms may be expected to have functions in tumor suppression while ΔN isoforms might be oncogenic For the first time in 2006, Dominguez et ... curve analysis Western Blot Analysis For protein analysis, 7.5 × 105 cells were seeded, and after treatment, harvested, washed in ml of cold PBS and lysed in EBC lysis buffer (50 mM Tris pH8, 120...
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Báo cáo khoa học: " Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells" pot
... USA) Statistical analysis Results are shown as mean ± SE Statistical analyses were performed following analysis of variance (ANOVA) for multiple comparisons or Students t-test when data consisted ... timedependent study with Annexin V and propidium iodide (PI), which is an important marker for distinguishing early apoptosis and necrosis Untreated cells were not stained with Annexin V and PI, ... apoptosis, probably reflecting that Apaf-1 is required for initial steps of apoptosis [25] Taken together with above results, our data strongly suggest that IRES-dependent protein translation is responsible...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" ppsx
... 'butterfly') rash; 2, discoid rash; 3, sensitivity to light, or photosensitivity; 4, oral ulcers; 5, arthritis; 6, serositis; 7, kidney disorder; 8, neurologic disorder; 9, blood abnormalities; ... 'butterfly') rash; 2, discoid rash; 3, sensitivity to light, or photosensitivity; 4, oral ulcers; 5, arthritis; 6, serositis; 7, kidney disorder; 8, neurologic disorder; 9, blood abnormalities; ... that in healthy controls after a single standardised dose of UVB [16] Apoptotic cells are formed in several tissues as part of normal tissue homeostasis or are induced by influences from the environment...
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