... and SB participated inthe acquisition ofthe data and performed DNA testing AC conducted data analyses and interpreted the results COL participated inthe study design, acquisition of data and ... sponsorship TAP participated inthe acquisition, analysis and interpretation of data CGM participated inthe design ofthe study, carried out DNA testing and participated inthe writing ofthe manuscript ... hours inthe hospital, andthe dose and pattern of administration were in accordance with current standards Failure of organs was evaluated using the Sequential Organ Failure Assessment (SOFA) scale...
... GCTCAGTGGTGGA-3 and 5-CTGAGGGAAGCAAG AATGGA-3, OXI1 (At3g25250): 5-GACGAGATTATC AGATTTTACGC-3 and 5-AACTGGTGAAGCGGAAG AGAC-3, PTI1-4 (At2g47060): 5-CCCCAAAGAAAATG AGTTGCT-3 and 5-GCATCATTTCCTGGAGGAAAG-3 ... variety of external stimuli and consist of three sequentially acting protein kinases: a MAPK kinase kinase, a MAPK kinase (MAPKK) and finally a MAPK [19] However, little is known about the function and ... Matsuoka D, Nanmori T, Sato K, Fukami Y, Kikkawa U & Yasuda T (2002) Activation of AtMEK1, an Arabidopsis mitogen-activated protein kinase kinase, in vitro andin vivo: analysis of active mutants...
... screen We are grateful to Nicola Minshall and Nancy Standart forthe tethering assay constructs, and to Marvin Wickens and Labib Rouhana forthe gifts of HA-MS2-XGld2 and HAMS2-XGld2 D24 2A, respectively ... mRNA The molecular mechanism underlying XRbm9-dependent translational activation is unclear and awaits further investigations The subcellular localization of mammalian Rbm9 is unclear andis ... suggesting an acceleration ofthe G2 ⁄ M transition in meiosis I This hastening of maturation was correlated with a precocious synthesis of Mos and AuroraA proteins, and with the activation ofthe mitogen-activated...
... adhesion and activation Three such molecules, LAPP (an approximately 13 kDa leech antiplatelet protein isolated from Haementeria of cinalis) and calin and saratin (approximately 65 kDa and 12 kDa proteins, ... alimentary habit of hematophagy The presence of anticoagulants inthe salivary glands ofthe leech, Hirudo medicinalis, was originally discovered by Haycraft in 1884 and led to the isolation of hirudin, ... significant implications forthe use of saratin as a tool to inhibit platelet–collagen interactions, and may provide the basis forthe therapeutic use of saratin as a potent antithrombotic agent...
... within the 56-amino-acid MADS box at their N-termini and within an adjacent 29-amino-acid region referred to as the MEF2 domain The MADS box is essential for DNA binding and dimerization, andthe ... throughout the brain lobes and at the midline inthe subesophageal ganglion (SG) (Fig 1A) The axons emanating from the somata ofthe two pairs of lateral cells extend towards the pars intercerebral with ... gene The axon emanating from the somata (light blue arrowheads and enlarged image shown in E) runs towards the midline ofthe brain with some arborization (boxed area in A) , contralateral after...
... stimulation of glycogen synthesis by inactivation of phosphorylase is associated with both activation and translocation of glycogen synthase, and that the former mechanism alone cannot explain the ... phosphatase This reverses the inhibition of synthase phosphatase by phosphorylase a There isa long-standing debate as to whether inactivation of phosphorylase isa component ofthe mechanism by ... GSK-3 inhibitors indicates that insulin activates glycogen synthase by mechanisms additional to inactivation of GSK-3 This can be explained, at least in part, by the inactivation of phosphorylase...
... karikara, vivara, achobya, vivaha, utsanga, bahula, nagabala, titilambha, vyavaithanaprajnapti (! that's 1031), and so through the alluring samaptalambha (1037) andthe tongue-twisting visandjnagati ... in endless space; and each Indra lives 71 eons, andthe lives of 28 Indras are a day anda night inthe life of Brahma, which is made up of 108 years of such days and nights; and before and after ... ever further from individuals and instances, lunging always toward generalities and abbreviating the singularity of things to an Escher array, an orchard seen from the air rather than this gnarled...
... participated inthe design ofthe study and performed the statistical analysis YD, MAH, CM conceived ofthe study, and participated in its design and coordination and helped to draft the manuscript All authors ... Gautschi O, Mack PC, Davies AM, Lara PN, Gandara DR: Aurora kinase inhibitors: a new class of targeted drugs in cancer Clin Lung Cancer 2006, 8:93-98 Page 10 of 10 37 Mazzino A, Muratore-Ginanneschi ... the vendor The majority ofthe cell lines were used within months of acquisition and no re-authentication was performed Forthe DSMZ cell bank STR DNA typing is performed for authentication and...
... participated inthe design ofthe study and performed the statistical analysis YD, MAH, CM conceived ofthe study, and participated in its design and coordination and helped to draft the manuscript All authors ... Gautschi O, Mack PC, Davies AM, Lara PN, Gandara DR: Aurora kinase inhibitors: a new class of targeted drugs in cancer Clin Lung Cancer 2006, 8:93-98 Page 10 of 10 37 Mazzino A, Muratore-Ginanneschi ... the vendor The majority ofthe cell lines were used within months of acquisition and no re-authentication was performed Forthe DSMZ cell bank STR DNA typing is performed for authentication and...
... alleles We also show that current genetic mapping indicates that the P2RX7 gene is located within the region defined as lbw3 andisa therefore a strong candidate for being the product of this ... PS and associated proteins are major targets of autoantibodies in SLE [8], cells stimulated via the P2X7 receptor may be a significant source of autoantigen in this disease An allelic variation ... to the design of experiments and drafting ofthe manuscript All authors read and approved the final manuscript Acknowledgements This work was supported by the Medical Research Council of Great...
... NRP -A and NRP-B, an ubiquitin-associated (UBA) protein homolog and NAC (NAM, ATAF1, ATAF2 and CUC2) domaincontaining proteins NAC proteins are plant specific transcriptional factors that are involved ... activate an osmotic- and ER-stress integrating pathway, also called the integrated pathway The enhanced accumulation of membrane-associated NRPs activates a cascade to induce the expression of ... Federal de Viçosa, 36570.000, Viçosa, Minas Gerais, Brazil Authors’ contributions JAQA carried out the experiments, the statistical analysis ofthe data and drafted the manuscript MTBR and PABR assisted...
... biophysical studies and neutralization assays, and drafted the manuscript DT participated to the neutralization and binding assays AA participated inthe design ofthe study and writing ofthe manuscript ... explain how P5 exhibited an antiviral activity against the T20-resistant viruses ENF-1 and that lack this GIV motif P5 also comprises a lipid-binding domain (666–673) essential for maintaining the ... HIV-1HXB2 The N-ter of T20 (aa 638) located within the calcium-binding site and that of P1 (a. a 649) are indicated (grey arrow head) The calcium-binding site in P5 and P5 (L) are underlined Chemically...
... stable cell lines, and performed luciferase and β-galactosidase assays AS, SW, and NC performed western blots All authors read and approved the final manuscript RNA purification and qRT-PCR analyses ... Additional data files 13 The following additional data are available with the online version of this paper Additional data file isa table listing the G1/S associated mRNAs predicted to be targets ... standard deviations away from what was seen for random sampling of similar sized sets of targets The complete list of G1/S-phase related predictions is detailed in Additional data file This analysis...
... superfamily small G protein Ras Rho ARF ClassI:ARF1, ARF2, ARF3 ClassII: ARF4, ARF5 Rab ARF Arl Arl1, Arl2, Arl3, Arl4, Arl5, Arl6, Arl7, ARFRP1, ARD1 ClassIII: ARF6 Fig Classification of mammalian ... understanding ofthe cell 1.2 ARF family GTPases and their classification The small GTPases of ARF family are classified into the Sar, ARF and Arl subfamilies The Sar subfamily consists of only ... divergences ofthe mammalian ARF and Arl subfamily of small GTPases The alignment was assembled by clustal W method using DNA Star software The prefixes “h” and “r” indicate human and rat species...
... coefficient and linear regression analysis was performed after logarithmic transformation of Ang-2 values (logAng-2) The primary outcome studied was 30-day survival and was calculated from the day of ... optimal cut-off values Data are displayed as median and range (minimum to maximum) unless otherwise stated All statistical analyses were performed with the SPSS Page of (page number not for citation ... be statistically significant at a 10% level inthe univariate analysis and subjected to multivariate Cox regression analysis: lactate, APACHE II score, SOFA score and circulating Ang-2 (Table...
... work KA and IK drafted the manuscript and participated inthe acquisition of data andthe study design JB participated inthe acquisition of data NM helped to draft the manuscript, and participated ... Morocco Acta Anaesthesiol Scand 2007, 51:189-197 A ssaoui Y, Zeggwagh AA, Zekraoui A, Abidi K, Abouqal R: Validation ofa behavioral pain scale in critically ill, sedated, and mechanically ventilated ... participated inthe acquisi- Page of 10 (page number not for citation purposes) tion of data AZ participated inthe coordination ofthe study AAZ participated inthe design ofthe study, and performed the...
... Graduate Management Admission Test, which isa standardized exam given at various locations inthe United States and Canada and around the world Throughout North America andin many international ... a margin as any candidate inthe state’s history (C) having been reelected with as wide a margin as any candidate inthe state’s history (D) she was reelected with as wide a margin as any candidate ... as wide ofa margin as any candidate inthe state’s history (A) she was reelected with as wide ofa margin as any candidate inthe state’s history (B) she had been reelected with as wide of a...
... ―Mapping Against Standards‖ isthe percentage of companies that map against relevant external standards and programs, including AA1000 andthe Global Reporting Initiative, as an element inthe ... percentage of governance mechanisms in Panel A that a firm has adopted ―High Sustainability‖ is an indicator variable that takes thevalueof one if a firm is included inthe High Sustainability ... percentage of stakeholder engagement mechanisms in Panel A that a firm has adopted ―High Sustainability‖ is an indicator variable that takes thevalueof one if a firm is included inthe High Sustainability...