... documented in detail It is evident fromthe rapid assessments carried outin Manipur that injecting drug users preferred OST [15] Having understood the need fromthe drug using populations inthe Northeastern ... first step in this advocacy process, the findings of this evaluation were reported to the joint meeting of the NACO and the partner NGOs working with IDUs in India with funding support from DFID ... afternoon in eight DICs, whilst the remaining five operate from morning through to the evening Six of the nine DICs in Manipur allow take home doses that are not exceeding three days save for in exceptional...
... bất quy tắc học thuộc lòng good/better /the best bad/worse /the worst many(much)/more /the most little/less /the least far/farther(further) /the farthest (the furthest) Double comparison(So sánh kép) ... hơn) Vd: The richer she is the more selfish she becomes The more intelligent he is the lazier he becomes Dạng khác(càng ) The + S + V + the + comparative + S + V Vd: the more we studythe more ... + adj Vd: The weather gets colder and colder His daughter becomes more and more intelligent + Different adj: The + comparative + S + V the + comparative + S + V (The + comparative the + từ dạng...
... analysis What you are learning in school is analysis You are being taught tools and techniques Analysis is just one of the ingredients inthe recipe You may have the best analysis inthe room ... with the best answers sit inthe back of the room while hacks run the show If you enjoy the view fromthe back, getting an MBA will not change anything A MBA degree only works if you are willing ... you? Einstein would have been a terrible manager There is a huge misconception among students that being smart is the way to be successful Let me break this to you It is not about being smart There...
... the individual works inthe collection are inthe public domaininthe United States If an individual work is inthe public domaininthe United States and you are located inthe United States, ... mind hasbeen much involved in dangerous apprehensions concerning an insurrection of the negroes in several of the adjoining counties Such a thing hasbeenin agitation by an ambitious and insidious ... inthe South and inthe West, and they continued to work on all the plantations There were, indeed, estates which had neither owners nor managers resident on them Some of these had been put in...
... Mars or the yellow of the star Sirius Why? The optic nerve linking the eyes to the brain connects directly behind the pupil In doing so, it displaces the lightsensitive cells that line the inside ... because the Earth is spinning us away from them, eventually taking us back into the blinding rays of the sun The stars are moving through outer space, and at incredible speeds But they are so vastly ... and sets inthe west, in an arc that heads south for the winter and returns north for the summer The Earth spins beneath the North Star, causing everything inthe sky to appear to turn from east...
... like to insist, however, that the improvement of the antinuclear antibody test substrate, which is the important diagnostic tool for SLE, is the foremost agenda to be dealt with Competing interests ... patents relating to the IT-1 cell line References Mahler M, Ngo JT, Schulte-Pelkum J, Luettich T, Fritzler MJ: Limited reliability of the indirect immunofluorescence technique for the detection ... is not found in SLE [abstract] Korean J Lab Med 1999, 19(Suppl):S366 Sung YK, Hur NW, Sinskey JL, Park D, Bae SC: Assessment of damage in Korean patients with systemic lupus erythematosus J Rheumatol...
... Arthritis Research & Therapy Vol 11 No Mahler and Fritzler the BioPlex 2200 ANA screen for the detection of antinuclear antibodies and comparison with conventional ... Goodner M, Boyes B, Hoy E: Detection and identification of significant ANAs in previously determined ANA negative samples Clin Lab 2005, 51:517-521 Page of (page number not for citation purposes)...
... customers, so marketing is increasingly valued and they always want find outthe most effective marketing methods Inthe near future thegroup would like to present some of the following methods: 1.To ... understand the importance of marketing but they can’t distinguish between marketing and advertising Marketing has vast boundaries and advertising is just a part of it All forms of marketing promote ... dollars in marketing just to maintain their reputation Marketing educates people on the latest market trends, helps boost sales and profit, and develops company reputation Competitive keeping in the...
... [WORDS AND THEIR STORIES] One is to play a song on a musical instrument by remembering the tune and not by reading the music "Play it by ear" also means to decide what to at the last minute instead ... last minute instead of making detailed plans (MUSIC) This VOA Special English program, WORDS AND THEIR STORIES, was written by Jill Moss I'm Faith Lapidus Falco | www.youtemplates.com Knowledge...
... others have inflammation of the urethra – the ‘so called’ urethral syndrome Antibiotics not hasten the clinical response in urethral syndrome In catheterised patients a positive dipstick urinalysis ... related to increased morbidity or mortality and giving antibiotics does not improve outcome Investigation and treatment will increase side-effects (including C.Diff infection) and medicalise the condition ... examination in hospital in or outpatients who are at higher risk of having a complicated or resistant infection and clinical assessment is also required UTI can only be proven bacteriologically in...
... unfolding of some protein substrates is initiated through productive binding to the substrate via two elements in ClpA, one inthe N -domain and the other inthe pore of the ClpA hexamer Inthe ... N -domain and two ATP-binding domains referred to as the D1 and D2 domains Interestingly, deletion of the N -domain from ClpA not only abolishes binding of the adaptor protein, ClpS, but additionally ... controls binding of ClpA to ClpP [14] Interestingly, there is also considerable debate regarding the role of the ClpB N -domain (which shares a common fold with the N -domain of ClpA) in substrate...
... seen in Fig 4, both proteins possess N-terminal AAA+ domains and C-terminal DNA binding domains (DBDs) In DnaA, the DBD contains a helix-turn-helix; inthe archaeal proteins, the DBD has a winged ... are shown in cyan with ADP indicated in red The helix-turn-helix (HTH)-containing DNA binding domain of DnaA is in green and the winged helix (WH)-containing domain of Orc1 ⁄ Cdc6 is in dark blue ... helix domain (reviewed in [62]) Interestingly, the relative position of the AAA+ domain and the winged helix domain of Aeropyrum pernix Orc1 ⁄ Cdc6 homolog was in uenced by the nature of the nucleotide...
... chain to the nucleotide-binding pocket [3] We describe the engineering, expression and purification of single-cysteine-containing proteins comprising either the C-terminal NBD or the N-terminal ... N-terminal NBD of P-glycoprotein contains only a single cysteine inthe Walker-A motif [43] Thus, MBP-NBD-Nter is a 75-kDa fusion protein containing a single cysteine residue located inthe ATP-binding ... on p[NH]ppA binding, in agreement with the results obtained here The nonidentical interaction of GTP may be related to another variation in sequence inthe vicinity of the ATP-binding pocket,...
... cysteine variants of VnfA The findings obtained inthe present study indicate that VnfA bears the 3Fe-4S cluster as the prosthetic groupThe involvement of some metal ion as a prosthetic group ... conformational change in a similar manner to NifA; the binding of the ATP analog induces the rearrangement of the GAF and possible AAA+ (the central domain) domains in VnfA Indeed, the limited protease ... participate in binding the cluster However, VnfA has additional three cysteine residues, namely at position 107, at position 134 inthe GAF domain and at position 267 inthe possible AAA+ domain Accordingly,...
... original NMR numbering for two -domain mammalian metallothionein (2, and are assigned to the three divalent metal ions inthe b domain) [10,11] The 11 cysteinyl sulfurs are labeled according to the ... nearly all the metallothionein species to be converted into the Cd5a form The ESI mass spectrum obtained for the purified Cd-coordinated a domain as isolated fromthe recombinant preparation in E coli ... identification of the binding site for the fifth Cd2+ ion inthe Cd5a-rhMT 1a cluster The indirect 2D 1H–113Cd NMR approach exploits the J scalar coupling between the cysteine b protons and the coordinated...
... the SH2 domain, while SOCS1, -5 and -7 contain PEST motifs inthe N-terminal domainThe PEST sequence inthe CIS SH2 domain is located eight residues downstream fromthe terminus of the predicted ... an insertion inthe true SOCS3 SH2 domain Murine SOCS3(D129–163) binds to a phosphotyrosine peptide from gp130 In order to determine whether deleting the PEST region would have an impact on the ... contain lysine, arginine or histidine The X-ray structures of several proteins containing PEST sequences have been determined, but in each case the electron density of the PEST sequence is missing...