thomas hematopoietic cell transplantation 4th edition
Chapter 108. Hematopoietic Cell Transplantation (Part 1) pps
... siblings. Chapter 108. Hematopoietic Cell Transplantation (Part 1) Harrison's Internal Medicine > Chapter 108. Hematopoietic Cell Transplantation Hematopoietic Cell Transplantation: ... of the patient with high-dose myelotoxic therapy. Categories of Hematopoietic Cell Transplantation Hematopoietic cell transplantation can be described according to the relationship between ... interaction of cell- surface molecules, termed selectins, on bone marrow endothelial cells with ligands, termed integrins, on early hematopoietic cells. Human hematopoietic stem cells can survive...
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Chapter 108. Hematopoietic Cell Transplantation (Part 2) ppt
... been the source of hematopoietic stem cells for transplantation. Typically, anywhere from 1.5 to 5 x 108 nucleated marrow cells per kilogram are collected for allogeneic transplantation. Several ... stem cells resulting in improved overall survival. Umbilical cord blood contains a high concentration of hematopoietic progenitor cells, allowing for its use as a source of stem cells for transplantation. ... adequate numbers of stem cells from the peripheral blood for transplantation. Donors are typically treated with 4 or 5 days of hematopoietic growth factor, following which stem cells are collected...
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Chapter 108. Hematopoietic Cell Transplantation (Part 3) pptx
... similar Chapter 108. Hematopoietic Cell Transplantation (Part 3) The Transplant Preparative Regimen The treatment regimen administered to patients immediately preceding transplantation is ... of red cells to prevent hemolysis in ABO-incompatible transplants, the removal of donor T cells to prevent GVHD, or attempts to remove possible contaminating tumor cells in autologous transplantation. ... HLA-matched. Peripheral blood stem cells are collected by leukophoresis after the donor has been treated with hematopoietic growth factors or, in the setting of autologous transplantation, sometimes...
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Chapter 108. Hematopoietic Cell Transplantation (Part 4) potx
... syndromes complicating marrow transplantation. VOD, venoocclusive disease; GVHD, graft-versus-host disease; HSV, herpes simplex virus; CMV, cytomegalovirus; VZV, varicella-zoster virus. The size...
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Chapter 108. Hematopoietic Cell Transplantation (Part 5) potx
... second general approach to GVHD prevention is removal of T cells from the stem cell inoculum. While effective in preventing GVHD, T cell depletion is associated with an increased incidence of ... receiving stem cells from unrelated donors. The disease is usually treated with glucocorticoids, antithymocyte globulin, or monoclonal antibodies targeted against T cells or T cell subsets. ... evidence suggests that T -cell depletion improves cure rates in any specific setting. Despite prophylaxis, significant acute GVHD will develop in ~30% of recipients of stem cells from matched siblings...
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Chapter 108. Hematopoietic Cell Transplantation (Part 6) pps
... common following use of less-immunosuppressive preparative regimens, in recipients of T cell depleted stem cell products, and in patients receiving grafts from HLA-mismatched donors. Treatment ... Posttransplant patients, particularly recipients of allogeneic transplantation, require unique approaches to the problem of infection. Early after transplantation, patients are profoundly neutropenic, ... 180 or off immunosuppression Viral Herpes simplex Acyclovir 800 mg PO bid to day 30 Varicella zoster Acyclovir 800 mg PO bid to day 365 Cytomegalovirus Ganciclovir 5 mg/kg IV bid...
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Chapter 108. Hematopoietic Cell Transplantation (Part 7) potx
... Using Hematopoietic Cell Transplantation Nonmalignant Diseases: Treatment Immunodeficiency Disorders By replacing abnormal stem cells with cells from a normal donor, hematopoietic cell transplantation ... 40 40 Hodgkin's disease First relapse/second remission 40 50 Chapter 108. Hematopoietic Cell Transplantation (Part 7) Pneumocystis jiroveci pneumonia, once seen in 5–10% of patients, ... haplotype-mismatched parents as donors (Table 108-3). Table 108-3 Estimated 5-Year Survival Rates Following Transplantation a Disease Allogeneic, % Autologous, % Chronic phase 70 ID Accelerated...
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Chapter 108. Hematopoietic Cell Transplantation (Part 8) doc
... compared to allogeneic transplantation. On balance, most experts recommend use of allogeneic stem cells if an appropriate donor is available. Theoretically, hematopoietic cell transplantation should ... malignancies have been cured of both with transplantation. Malignant Diseases: Treatment Chapter 108. Hematopoietic Cell Transplantation (Part 8) Aplastic Anemia Transplantation from matched siblings ... osteoclasts derive from the marrow, transplantation can cure this rare inherited disorder. Hematopoietic cell transplantation has been used as treatment for a number of storage diseases caused by...
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Chapter 108. Hematopoietic Cell Transplantation (Part 9) ppt
... Readings Appelbaum FR: Haematopoietic cell transplantation as immunotherapy. Nature 411:385, 2001 [PMID: 11357147] Baron F, Storb R: Hematopoietic stem cell transplantation after reduced-intensity ... stem- cell transplantation. N Engl J Med 354:1813, 2006 [PMID: 16641398] Petersdorf EW et al: Major-histocompatibility-complex class I alleles and antigens in hematopoietic- cell transplantation. ... function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA 291:2335, 2004 [PMID: 15150205] cancer have yielded mixed results. No role for autologous transplantation...
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VHDL Programming by Example 4th Edition
... semiconductor companies now known as Accellera.And when the ASIC industry needed a standard way to convey gate-level design data and timing information in VHDL, one of Accellera’sprogenitors (VHDL International) ... modern synthesistechnology and enabled the development of ASIC semiconductor compa-nies. The editions of Doug Perry’s books have served as the authoritativesource of practical information...
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