... our incomplete under-standing ofthe relation between enzyme properties and conformational flexibility limits the exploitation ofthe fullpotential of protein engineering inthe redesign of psychro-philic ... designed on the basis of side-chain packing criteriafrom a modelled structure ofthe enzyme resulted in restor-ation ofthe energy of activation to the levels ofthe nativeenzyme andin an increased ... designed with the aim of reducing the spatialconstraints originating from the side-chain interactionsbetween Tyr269 and Ala261 (Fig. 2C). The main differencebetween the G261A and G261A/Y269A...
... OS-fitness ofthe clone, the ratio ofthe specicabsorbance inthe presence of 10 lgặmL)1HEL to that in the absence of HEL was taken as an index.To analyze the effect ofthe type of each FR2 ... antigen in itself [7,20]. Atleast for these antibodies, theroleofthe VLdomainmight be to increase the affinity by supporting the VHdomain. The phenomenon may also be observed in the chain ... correlation between the antigen-binding affinity andthe VH⁄ VLinteraction, especially inthe presence of aset of particular VLresidues. The effect ofthe H39 mutation on the wild-type variable...
... mountain; (b) lava IS-PART of vol-cano, and moreover it is a part coming from the inside; and (c) fragments of lava have all the prop-erties of lava, the following question semantic TheRoleof ... example, inthe case of questionQ209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor. ... Iditarod ?”, since the definition of Word-Net sense 2 of noun harness contains the bigram“pull cart” and both sled and cart are forms of vehicles, the alternation ofthe pair of keywordspull,...
... their brand attitude, may suggest an interesting implication for the new brand advertising strategy. Instead of focusing on the content ofthe message which only emphasizes the benefits of ... This finding is just reverse ofthe finding of Belk (1973). Ruth, Brunel, Otnes (1999) classified categories of gift-giving into public occasion (i.e., Christmas, Chinese New Year), individual ... to be aware ofthe new product and has initial favorable emotion with its brand after receiving the gift. REFERENCE 1. Annamma Joy, “Gift giving in Hongkong andthe continuum of social ties”,...
... control of glycolysis and glycogen synthesis by glucokinase overexpres-sion. The validity of S4048 for testing theroleof Glc6P was supported byits lack of effect on glucokinase binding and its ... beexplained by sequestration of Glc6P derived from glu-cokinase and hexokinase I in distinct pools [3,24], orby the involvement of mechanisms, additional toGlc6P, in mediating the effects of glucokinase ... vs. 1.5 ± 0.1). These resultssuggest that the increase of Glc6P inthe presence of S4048 was caused by the inhibition of Glc6P hydro-lysis inthe absence of detectable changes in glucosephosphorylation.S4048...
... documents and find that the fea-ture vectors corresponding to some of these docu-ments (particularly the short ones) have all zeroes in them. In other words, none ofthe bigrams from the training ... one in which the author himself likes the movie, andinthe other, the author’s cousin likes the movie. The over-generalization resulting from these “stemmed” re-lations renders dependency information ... extracting objective materials and re-moving them from the reviews is not effective in terms of improving performance. To determine the reason, we examine the n-grams andthe depen-dency relations...
... located in a gene cluster and three of them areP450 enzymes. The FUM6 protein (CYP505B1) inter-venes in one ofthe first steps in fumonisin synthesis byhydroxylation ofthe polyketide-amino acid ... required forbreaking the plant’s defence but, on the other hand,alkanes serve as nutritional input during the initial col-onization steps. Insect cuticle consists of protein and chitin, and is covered ... tightbinding affinity was demonstrated towards lauric acid,resulting inthe synthesis of mainly x-1 hydroxylatedlauric acid, suggesting a roleinthe lipid oxidativemetabolism. Interestingly, the...
... the transaction from the vantage point of firm A, the floating-rate payer. The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net cost of ... to the desire on the part of firms to hedge cash flows against the effects of interest rate volatility. The timing ofthe appearance of interest rate swaps, coming as it did during a pe-riod of ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk. The Role for Hedging inthe Theory of Corporate...
... bridging the A’ and G b-strands ofthe I27 protein during the main unfold-ing barrier.[39]To further validate this view and gain insight into the roleof solvent hydrogen bonds in protein unfolding, ... rapidly, causing the unfolding of one of the I27 modules inthe chain. Unfolding then extends the over-all length ofthe protein, relaxing the pulling force to a lowvalue. As the slack inthe length ... Snapshot ofthe b-strands A’ and G ofthe I27 proteinshowing the protein backbone only for simplicity. C) Snapshot ofthe b-strands A’ and G ofthe I27 protein showing 4 D2O molecules bridging the protein...
... absurdities, often raise the imagination, and move the heart: when made the materials of poetry, and adorned by the skill andthe eloquence of an ardent and superior mind, they instruct the understanding, ... prostitutions, andthe standard of theiropinions on the subject of good andof evil. Under this influence, they would enter, if not restrained by the laws ofcivil society, on a scene of violence ... the preservation ofthe individual, while they continue to operate inthe manner of instinctive desires; are nearly the same in man that they are inthe other animals; but in him they are sooneror...
... (glycero-)sphingolipids. In addition the fatty acid chains ofthe phospholipids composingthese rigid domains are generally more saturated thanthose inthe lipids ofthe surrounding membrane. In fact, this ... cluster in response to extracellular stimuli andthe size of the domains containing those clusters has been estimated. In summary, multiple lines of evidence have helped toargue in favour ofthe ... carefully.Isolation of lipid rafts ⁄ caveolae is very often the firststep inthe biochemical analysis oftheroleof thesedomains in cellular signalling. After disruption of cells,lipid rafts...
... 484–487.23. Brines, R.D. & Brock, J.H. (1983) The effect of trypsin and chy-motrypsin on thein vitro antimicrobial and iron-binding proper-ties of lactoferrin in human milk and bovine colostrum. ... Berkel* and Jan H. NuijensPharming, Archimedesweg, Leiden, the NetherlandsLactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate theroleof N-linkedglycosylation ... 2004 Tryptic susceptibility of lactoferrin variants (Eur. J. Biochem. 271) 683 Theroleof N-linked glycosylation inthe protection of human and bovine lactoferrin against tryptic proteolysisHarrie...
... Director ofthe Prosperity Institute of Scandinavia, Jönköping International Business School (charlotta.mellander@jibs.se). Kevin Stolarick Research Director ofthe Martin Prosperity Institute in ... % within CS % within Income Total % within CS % within Income Count % within CS % within Income Count % within CS % within Income Count % within CS % within Income ... Director ofthe Martin Prosperity Institute and Professor of Business and Creativity at the Rotman School of Management, University of Toronto, (florida@rotman.utoronto.ca). Charlotta Mellander*...
... consumers may be unaware ofthe information on the label, they may not know the region/area of origin or they may fail to interpret what they mean. Furthermore, many other brands and trademarks, owned ... During the interviews 46% ofthe total sample selected the Mortadella with the PGI mark, 43% the one without the PGI mark andthe remaining 11% stated no preference. The Mortadella with the ... improve the information environment by either supplying missing information or by increasing the flow of information between suppliers and consumers. A label is intended to help consumers distinguish...
... M, Wolff MH: Roleofthe protein kinase PKR in the inhibition of varicella-zoster virus replication by betainterferon and gamma interferon. J Gen Virol 2005, 86(Pt1):1-6.61. Sainz BJ, Halford ... KOS-GFP spread inthe eyes or periocularskin of scid mice during the first 6 days p.i. (Fig. 6A). In contrast, CyP treatment enhanced the spread of KOS-GFPinto the periocular skin of scid mice ... impair the capacity of ascid mouse to limit HSV-1 spread from the site of inoculation. Role of peripheral WBCs in innate resistance to HSV-1 The lack of effect of NK cell depletion on innate...