... by a sulfur ligand in all zinc- containing MtaA proteins [i.e 2.0 (N/O) plus (S)] We interpret these results as indicating the binding ofthe thiol sulfur of HS-CoM to thezinc atom of MtaA ina ... Ala mutant at a zinc- sulfur distance of % 2.7 AIn Cys239 Ala and His237 Ala, the pronounced changes inthe EXAFS spectra resulting from HS-CoM addition are indicative of an increase inthe ... (antisense); inthe second mutant, Cys239 was exchanged for Ala using the primers 5ÂCGTGACTGT ACTCCACATCgcTGGTAAGGTTAACGC (sense) and 5ÂGCGTTAACCTTACCAgcGATGTGGAGTACAGTC ACG (antisense) The mutated bases...
... Hayakawa A, Suzuki H, Miyata T, Kurokawa K, Hotta Y, Ishikawa N, Nakashima I: 4-hydroxynonenal induces a cellular redox status-related activation ofthe caspase cascade for apoptotic cell death ... protected against HNE-induced DNA fragmentation PARP activation and AIF translocation to the nuclei during apoptosis are implicated on a large scale in DNA fragmentation and peripheral chromatin condensation ... Second, in investigating the classi- cal markers of apoptosis, we obtained data showing that HNE induced caspase-8, -9, and -3 activities and cleavage, AIF and cytochrome c release from mitochondria,...
... aggregated micro-data The macroeconomic data on revenues were taken from national accounts data in Statistik Austria (200 1a) and data from the Association of Austrian Social Insurance Institutions ... Fiscal data that are only available at the household level inthe ECHP (that is, in our case, housing and social assistance benefits), are allocated to individuals by assuming that the total amount ... sustainable inter-temporally c Annual additional average tax payment per capita of native population balancing the inter-temporal budget constraint Note: Generational accounts for natives Base...
... arguments; (iii) if an EP has three arguments, then one of them is a state -of- affairs, and another is an undergoer coindexed with an argument ofthe embedded stateof-affairs Finally, as far as ... which the achievement of such a goal can be based realistically A presentation ofthe technical details ofthe LKB implementation ofthe grammar fragment that we have described above, which practically ... approaches to verbal alternations in particular and to development of (the lexicon of) large-scale computational grammars of natural language based on HPSG in general As an dmtc stands for directed_motion_to_contact...
... world, have a lot to gain as well from maintaining a certain image and attracting foreign capital An interesting aspect of this diplomatic game is the theory and practice of city branding – the notion ... autonomously in engaging in international political activities, a city in another country can be hindered by national law in its international aspirations At the same time, cities operate inthe international ... countries such as Canada, Spain and Sweden; and that they are growing (Hawksworth, 2007: 15) Given the economic gains that come with such an image and position and the importance of maintaining them,...
... conserved aspartate in human prolidase by asparagine causes skin abnormalities, recurrent infections, and mental retardation [45] On the basis of ICP-AES analyses, both D9 7A EcMetAP-I and D8 2A PfMetAP-II ... origin software package This software package uses a nonlinear least-square algorithm that allows the concentrations ofthe titrant and the sample to be tted to the heat-ow-per-injection to an ... leads to the growth and proliferation of carcinoma cells In comparison to conventional chemotherapy, antiangiogenic therapy has a number of advantages, including low cellular toxicity and a lack...
... be labeled as aesthetic emotional states of pleasure The consideration ofthe aesthetic emotional state as a result of an appraisal process implies a dynamic organizational linkage ofthe aesthetic ... it appears that not only brain areas dominant in aesthetic judgments are engaged, but there is also the specific engagement of another area, which has a fundamental roleinthe processing of more ... pleasure in certain pure sensations and combinations of them Inthe primary layer a secondary layer can be added The secondary layer of pleasure offers the elegance in aesthetic taste However, James...
... impose the same condition on any acquirer British Library Cataloguing in Publication Data Data available Library of Congress Cataloging in Publication Data Data available Typeset by Newgen Imaging ... and the set of tRNAs charged with the appropriate amino acids to the ribosomes, discovered earlier as the protein-making apparatus inthe cytoplasm The guiding roleof Francis Crick in bringing ... proposed in 1963 that cellular aging involves the accumulation of defective proteins as a result of an inherent inaccuracy ofthe translational machinery This is generally known as the error catastrophe...
... factors Inthe case of HTLV-I, Tax has been shown not to associate with a CTD kinase [11] and a dominant negative mutant of cdk9 (the catalytic subunit of pTEFb) was found to increase Tax transactivation ... elongation, there is a switch in CTD phosphorylation to serine phosphorylation resulting inthe loss ofthe capping machinery and the association of splicing, elongation and chromatin remodeling ... transactivators have been shown to have arole at initiation and downstream events, such as elongation The most notable of these has been Tat, the viral transactivator of HIV-1 Without cellular...
... malignant glioma would show an increase inthe choline peak and a decrease inthe N-acetyl aspartate peak as compared to unaffected areas ofthe brain (Fig 1. 4A) These metabolites level changes have ... onset in patients at the time of diagnosis is 64 years of age inthe case of GBM and 45 years of age inthe case of anaplastic gliomas (Fisher et al., 2007) About 5% of patients with malignant ... remains to be elucidated 1.10.3 Structure and Function of Parkin Structurally, the 465 amino acid-containing parkin protein is composed of several modular domains At the N-terminal of parkin, there...
... 2004) Interestingly, activation of caspases can be achieved via a signaling cascade in which certain caspases are cleaved by the upstream caspases to gain the proteolytic activity towards their ... domain (DED) or the caspase recruitment domain (CARD) The DED or CARD domain can direct the interaction ofthe initiator caspases with the upstream adaptor molecules, whereby the initiator caspases ... carried out by the Atg1 complex, consisting of Atg1, Atg13, and Atg17, downstream ofthe target of rapamycin (TOR) and cAMP-dependent kinase (PKA) pathways (Matsuura et al., 1997) The Atg1 kinase...
... survival estimation of female patients with relapsed ovarian carcinoma In multivariate analysis only the variation of blood levels of CA125 and the free disease interval from the finalization ofthe ... Mano A, Falcao A, Godinho I, Santos J, Leitao F, de Oliveira C, Caramona M: CA-125 AUC as a predictor for epithelial ovarian cancer relapse Cancer Biomark 2008, 4:73-81 Mano A, Falcao A, Godinho ... paclitaxel/cisplatin as primary treatment for advanced epithelial ovarian cancer: a National Cancer Institute of Canada Clinical Trials Group Study J Clin Oncol 2000, 18:4038-4044 Jacobs IJ, Skates SJ, MacDonald...
... strengthen the technical learning ability ofthe economy ina period of radical technical change They concluded that the capability of national economies to learn abou, adapt and change their instiutional ... innovation are increasingly being framed within an international arena The links between sub-regional, regional, national and international systems of innovations imply hat analyses should include ... the Faculty of Arts and the Faculty of Medicine in 1935, the Faculty of Economics and Law in 1936, the Faculty of Theology in 1942 and, finally, the Faculty of Science in 1954 The main reason...
... higher in fractions and than in fraction (Table 1) These results indicate that fraction contains a significant number of mitochondria, and that fraction is the main lysosomal fraction The DNAcleavage ... mitochondria in this process [19] In mammalian apoptosis, caspase-8 and caspase-9 are known to be associated with the mitochondrial pathway Active caspase-8 induces the release of mitochondrial apoptosis ... by Lu and Wolfe [23], who used a combination strategy of 4,6-diamino-2-phenylindole (DAPI) staining for the detection of DNA and Azo dye staining for the identification of acid phosphatase activity,...
... study of 3260 enrollees ina national managed care organization inthe United States, that 23% ofthe English-speaking and 34% ofthe Spanish-speaking respondents could not adequately read and ... than words alone However, words are still important in explaining the implications ofthe pictures and in explaining what is happening inthe pictures This hypothesis includes the same qualification ... Koplan JP Health literacy among medicare enrollees ina managed care organization JAMA 1999; 281:545–51 [10] International Reading Association, Special Interest group on reading and readability...
... is involved in these pathways Since adenine is a substrate of ADPRT, the elevation of ATP inthe absence of adenosine kinase shows that adenine must be released inthe process before being incorporated ... mentioned inthe Introduction that patients deficient in ADPRT are accumulating adenine [8–11] The modes of adenosine salvage (Table 3) all require AK, so that they are not operative inthe case of AK ... predict that there is redundancy both in adenine salvage and in adenosine salvage in that parallel pathways producing ATP from each of these substrates exist While the metabolism of many cells...
... this time the valency hybrid tetramers As a result, the b chain was found to acquire a noticeable resistance against the acidic autoxidation ina manner of contacting with thea chain, no matter ... state the partner a chains may take, the oxy-form or the ferric met-form Unlike separated b chains, the spontaneous formation of hemichrome was at variance with separated a chains inthe pH range ... isolated a chain In contrast to this, the heme pocket ofthe b chain still obstructs easy access ofa water molecule as well as a proton, so that the b chains can keep a constant resistance against...