the example of hereditary persistence of fetal hemoglobin with sickle cell anemia and beta thalassemia
Báo cáo khoa học: The association of viral proteins with host cell dynein components during virus infection pdf
... HIV enters the cells following virus binding to CD4 and co-receptors and the fusion of the viral membrane with the plasma membrane of the cell During passage through the cytosol, the viral RNA ... constituted the interacting polypeptide stretch The P phosphoprotein of rhabdovirus is a cofactor of the RNA polymerase complex and, in fact, facilitates the binding of the polymerase to the N-RNA ... double-stranded DNA viruses that infect the stratified epithelia of skin and mucous membranes The icosaedric capsid contains 360 copies of the major capsid protein L1 and up to 72 molecules of the minor...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... ligand are cross-linked to domains I and III, respectively, of the receptor [19,22] The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ligand binds to domain III of ... contributions of the four extracellular domains of ErbB-4 to the specific binding for the cognate ligand, NRG1-b1, were then examined on the basis of the competition of unlabeled NRG1-b1 with 125I-labeled ... expression of the receptors was confirmed by immunoblotting of the cell lysates (Fig 1B) As often observed for membrane proteins, the bands were rather broad in the blots, due to the heterogeneity of the...
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Báo cáo y học: "A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome" ppsx
... whether the variation of the aclarubicin dosage could have played any role in the outcomes among the different groups of AML (new vs R/R) and MDS /t-AML There was no randomized study among the ... over the decade The toxicity data from this analysis may therefore overestimate the adverse events of the regimens under current health care system Majority of the studies were small (only of the ... standards Therefore, the relapsed and refractory AML was still sensitive to alternative chemotherapy The CR rate of CAG (56.7%) for new AML appears to be slightly lower than the CR rate of standard...
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The interplay of collaborative technology with learner characteristics conceptual and empirical examinations
... assumptions and values) These are the typical processes that have been examined by past research Lastly, the outputs of the framework are the result of the interplay of the process factors with the input ... learning, the relevant knowledge and skills has not been acquired before the launch of the problem The problem questions provide the starting point for the learning activity and the analysis of the ... (Please see Anderman et al.(2006), Leidner and Jarvenpaa (1995), and Mayes and de Frietas (2004) for further details of learning theories and pedagogies) Before discussing the details of the theoretical...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 2
... 25μM to test the potential cytotoxic effects of six compounds generated in this study and compared with the effects of the same amount of and DMS The ratio of dead cells versus total cells from ... to the samples, mixed and left to stand at room temperature for 5-10 minutes The organic and aqueous phases were separated by adding 240μl of chloroform and 240 μl of 2N KCl The mixture was then ... in the concentrations tested (10μM, 25μM, 50μM, 75μM, and 100μM), none of the six compounds inhibited DAGK and human PKC alpha (Figure 2.8 and Figure 2.10) On the other hand, and in agreement with...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 3
... for SPHK1 Among these synthetic compounds, CP6 showed to be the best inhibitor candidate, in terms of the ability to penetrate into the cells and inhibit the endogenous SPHK1 and the good yield ... samples without DMS treatment due to the large variations The only comparable results were from 1μM of CP6 at the 14 days culture, and 5μM of CP6 at the 14 and 28 days of culture, where in the cell ... days, P
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 4
... placing the 6-well plates on ice and the cells were scraped out and collected by centrifugation Cell pellets were lysed and the protein concentrations in the cell lysates were quantified The same ... samples were counted The percentages of the expressed cell surface markers in the cells are summarized in Table 4.1, and plots of receptor expression of the last passage cells cultured in two ... of iκBα would cause the release and the activation of NF-κB The activated NF-κB can then translocate into the nucleus and trigger gene expression Due to the limited number of the MSCs, in this...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 5
... to further confirm our conclusions Finally, the study could be expanded to study other stem cells and other differentiations pathways, to further validate and confirm the potential usage of SPHK ... applicable in other types of stem cells Also, it should be noticed that both human BMand AD- MSCs are primary cells, and thus they may possess certain variations between different donor cells Therefore, ... source of MSCs recently established (Zuk et al 2002), with very little studies on their expansion being reported in the literature The benefit of using this type of MSC is quite obvious, as the cells...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation 6
... directing the differentiation of stem cells into the osteogenic lineage in vitro.” J Bone Miner Res 19:1379–1394 Hentze, H, Graichen R, et al (2007) Cell therapy and the safety of embryonic stem cellderived ... platelet-derived growth factor in the maintenance of human embryonic stem cells." Stem Cells 23(10): 1541-8 Peng, H and J Huard (2003) "Stem cells in the treatment of muscle and connective tissue diseases." ... susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan." Hum Mol Genet 6(8): 1349-56 Nirmalanandhan, V S., M Rao, et al (2007) "Effect of length of the engineered...
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Development of sphingosine kinase (SPHK) inhibitors and the role of sphingolipids in adult stem cell proliferation and differentiation
... On the one hand, it could act as an intracellular mediator and trigger numerous cellular events, including intracellular calcium release, and promote cell survival and cell growth On the other ... stem cells and the strategies used for stem cell expansion and differentiation, are discussed below 1.4 HUMAN STEM CELLS 1.4.1 Brief Introduction of Human Stem Cells Diverse stem cells and their ... Ugarte et al (2003) compared the cell surface markers expression of culture-expanded cells, isolated from BM and adipose tissue, of the same donors and of same passages, and found that both populations...
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The role of microRNAs in embryonic stem cell development and differentiation
... locus are the pre-microRNA hairpins and the putative minimal promoter The number and precise sequences of the pre-microRNAs, their distance from the promoter and the polyadenylation sites, the regions ... are first plated, either intact or after immunosurgical isolation of the inner cell mass (ICM), onto a layer of feeder cells (Smith, 2001) The mass of cells is dissociated and replated onto a ... miR-134 in the coding region of Sox2 Considered together, the results show that miR-296 and miR-134 repress the translation of Nanog and Sox2 mRNAs respectively via their interactions with specific...
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Between fathers and fetuses - the social construction of male reproduction and the politics of fetal harm
... reXected the association of maternity with vulnerability The cultural associations of paternity with virility and maternity with vulnerability formed the context within which the symbols of the ‘crack ... explore the range of complex questions about biological gender diVerence generated by the politics of fetal risks, and the problematic nature of the idea of individual causality in discussions of fetal ... culpability for fetal health problems (A more detailed discussion of the rise of the concept of fetal rights and fetal protectionism can be found in Daniels, 1993.) After a brief discussion of the social...
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Images of Power in Hollywood Films: The Example of Star Wars ppt
... concentration of power in the person of the Chancellor and a reduction in the power of the Senate The Chancellor proceeds to disband the Senate and rule by fiat Shades of Hitler The Jedi are part of a ... contrasted with the damned The recognition that even the agents of the Church could be corrupt was evidenced in the inclusion of priests, monks and nuns in the numbers of the damned These types of contrasting ... houses as a proof of their superior breeding By the eighteenth century, they began to include images of their estates and the houses themselves on those same walls In the age of the absolute monarchies,...
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báo cáo hóa học:" Response shift masks the treatment impact on patient reported outcomes (PROs): the example of individual quality of life in edentulous patients" pdf
... when comparing the preand then-test scores anterior mandible on radiographic assessment of at least cm, have the cognitive ability to understand the purpose of the study, and they had to provide ... first asked to nominate and describe the areas of their lives (cues) that they consider to be the most important for their QOL They were then asked to rate their current level of satisfaction/functioning ... CAO, DH and FH designed the study LR and SH monitored the study CAO, LR and SH conducted the literature search SH and LR performed the statistical analyses LR wrote the first draft of the paper...
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Báo cáo nghiên cứu nông nghiệp " Provenance Variation the example of Eucalyptus camaldulensis " pdf
... Tolerant of seasonal waterlogging Frost tolerant/frost sensitive Moderately salt tolerance Easily propagated E camaldulensis - important characteristics Versatile timber, suitable for - pulp and paper ... Benstead Ck NT L Indoon E camaldulensis provenances from tropical regions (with summer rainfall) perform poorly in temperate areas with Mediterranean type climates provenances from temperate regions ... always well defined Provenances may have different genetic adaptation Eucalyptus camaldulensis Katherine Petford/Wrothham Park Gibb River de Grey River 20º Wiluna 30º Silverton Lake Albacutya Lake...
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Báo cáo y học: "What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs" pot
... http://arthritis-research.com/content/10/1/R20 A series of examples follow, using a vertical form of the Paling Perspective Scale, populated with numerical and verbal descriptors of risk, together with information on the risk of death from ... [34]), and not all risks are directly connected with the epidural Childbirth is common, women may have experienced an epidural themselves or be familiar with the experience of others, and all these ... help professionals understand their patients' risk, and patients to understand their own risk Broadly these can be aggregated under the headings of perception (influences on how individuals and...
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Báo cáo y học: "Construction of predictive promoter models on the example of antibacterial response of human epithelial cells" pdf
... of the TFs included in the model and the frequencies of all possible pairs (F), constructed of these sites If the frequencies of single sites and the pairs of them satisfy the equation Fij = fi ... where N is the number of all sequences of the (-)-training set, mi is the number of sequences possessing the i-th site, and Mij is the number of sequences possessing pairs of the i-th and j-th ... AP-1 and C/EBP Nevertheless, these factors were included in the model, because not the binding sites themselves, but their combinations may be overrepresented On the other hand, some of the factors,...
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Currency crisis on the example of russia currency crisis 1998 and 2014
... at the end of 2014 - 2015, devaluation of the other currencies of the CIS countries was only a matter of time At the end of 2014, the rate of the Armenian dram has fallen sharply against other ... abolishment of the raw model of the economy and development of the other sectors of economy, which were replaced by imports before the currency crisis 3.4 Recovery process and lessons from the crisis The ... effect, on the other hand was undermining the stability of the economy The result was a decline in the profitability of investing in securities and, accordingly, increasing the attractiveness of investments...
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Báo cáo y học: "HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
... than the level of HLA-DR in the cell lysates (5ul of a in 10 dilution, from x 106 PBMC) The shed HLA-DR therefore seemed to represent a small fraction of the total HLA-DR of the cell, however the ... Figures 3a-d show the intracellular and surface staining of PBMC in a healthy control and from a septic patient These images illustrated a high intracellular expression of HLA-DR within the PBMC in ... expression of HLA-DR in PBMC of healthy controls and septic patients Intracellular HLA-DR was measured in permeabilised cells to investigate the presence of HLA-DR retained within the PBMC population...
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Báo cáo y học: "The Syndrome of Frontonasal Dysplasia, Callosal Agenesis, Basal Encephalocele, and Eye Anomalies – Phenotypic and Aetiologica"
... etiology of any reported condition within the FND spectrum One of the patients here described was previously evaluated within a sample of patients purportedly presenting holoprosencephaly (HPE) [3] and ... index cases were isolated with no recurrence in relatives There were no antecedents of neural tube defect in the families There was no parental consanguinity The sex ratio of the sample was 1:1 Age ... always present Facial and ocular anomalies are variable The former ranges from mild hypertelorism with a median upper lip notch to median cleft involving the lip and the nose, and the later includes...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25