... the study and helped with data analysis and drafting the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... between the vasodilator response to acetylcholine inthe brachial andcoronaryarteryin suspected coronaryarterydisease Int J Cardiol 2005, 105:58-66 Sandoo et al Arthritis Research & Therapy ... microvascular and macrovascular endothelial function requires further investigation using newer and more accurate assessments of endothelial function Accordingly, the aim of the present study was to examine...
... treatment with G-CSF for weeks was correlated with an increase of IL-10-secreting type Treg cells inthe peripheral blood andwiththe accumulation of plasmacytoid DC inthe gut lamina propria [34] In ... the experiments and participated inthe design of the study AM, AP and MC carried out the experiments AP and GS participated inthe design of the study and were responsible for patient care and ... (Th2) cytokine production [3] In humans, G-CSF increases interleukin (IL)-4 release and decreases interferon (IFN)-g production [4], induces immune modulatory genes in T cells, including the Th2...
... record pain during the next days of the baseline phase The diary consists of a single item with an 11-point numeric self-administered rating scale ranging from (no pain) to 10 (worst possible pain) ... sleep interference score andthe weekly mean pain score at baseline were used to define groups of patients differing in severity Since patients had to have pain at baseline to qualify for the present ... for patients classified as stable according to the change in mean sleep interference and mean pain scores These unexpected findings could be explained by the fact that as patients are being treated,...
... agreed that insulin causes weight gain, compared to 23% inthe insulin naïve The highest mean score for insulin-naïve patients was on the item pertaining to the belief that insulin signifies disease ... be demanding to administer 11 Insulin means I have to give up activities I enjoy 12 Insulin means my health will deteriorate 13 Injecting insulin is embarrassing 14 Injecting insulin is painful ... of the insulin-treated patients agree to the item that injecting insulin is painful, compared to 43% inthe insulin-naïve group This suggests that despite improved injection devices and thinner...
... agreed that insulin causes weight gain, compared to 23% inthe insulin naïve The highest mean score for insulin-naïve patients was on the item pertaining to the belief that insulin signifies disease ... be demanding to administer 11 Insulin means I have to give up activities I enjoy 12 Insulin means my health will deteriorate 13 Injecting insulin is embarrassing 14 Injecting insulin is painful ... of the insulin-treated patients agree to the item that injecting insulin is painful, compared to 43% inthe insulin-naïve group This suggests that despite improved injection devices and thinner...
... event occurring inthe CYC group compared withinthe non-CYC group Two of the three randomized clinical trials reported the FVC and DLCO value at baseline and after 12 months inthe CYC group ... value at baseline Inthe randomized controlled trials, both the FVC andthe DLCO were evaluated at baseline and after 12 months in CYC treatment groups andin non-CYC treatment groups Inthe observational ... SSc The greatest loss of lung volume occurs within the first years of the disease, and pulmonary-related deaths occur with greater frequency inthe second years from disease onset [5] Patients with...
... raters were investigators inthe study, with a background either as medical doctor or clinical psychologist The raters were trained in clinical interviews and assessments including video and case ... clozapine in monotherapy in subgroups of patients [27] The current study involved all psychiatric hospitals in Oslo and included both in- and outpatients The public health care service in Norway ... collecting data, analysis, drafting and revising the manuscript OAA: conception of the study, collecting data, analysis, drafting and revising the manuscript JIR: conception of the study and revising...
... after the institution of positive pressure ventilation Serum cytokine levels at three different time points – within the hours before intubation, within hours after intubation, and between 12 and ... biomarkers, including IL-6, IL-8, vWF, and ICAM-1 IL-8 and IL-6 are pro-inflammatory cytokines that are elevated inpatientswith ALI and are predictive of clinical outcomes, and their levels ... not increase In fact, the level of IL-8 was significantly lower at the later time point Thus, the institution of a low tidal volume strategy inpatientswith ALI may not worsen lung injury in these...
... scale The PGI memory scale [22] is part of the PGI battery of brain dysfunction, developed at PGIMER, Chandigarh, India The battery is administered in Hindi, the first language of most subjects, and ... correlate with occupational functioning [32] Addington et al found no association between cognitive measures and social functioning in 30 patientswith schizophrenia [35] The reason for these differences ... developing countries Families in India, play a major role in patient management They take up the responsibility for thepatient's compliance with medication and support them in times of crisis and...
... designed the protocol, monitored the patients, collected, analysed and interpreted the data, and wrote the manuscript CNG and JS recruited thepatientsand coordinated the study inthe other two ... The remaining of the intraperitoneal fluid was collected to determine intraabdominal viable tumor cells (in T1 and T4) The volume of the removed material was 30 ml in all measurements and standardized ... centres CM and WW monitored thepatientsand collected the data inthe study coordinating center Berlin JMM contributed to the idea and supported the study CAJ contributed to the idea, designed the...
... activity in RA, and may provide an insight into a new and interesting mechanism of action of anti-TNF-α mAbs inthe control of inflammatory arthritis Competing interests The author(s) declare that they ... Finland) inthe dark and allowed to equilibrate for at 37°C with intermittent shaking previously to record the background of the light output in mV PMA (final concentration ng/ml) was added with ... Following incubation at 37°C for 90 in a humidified atmosphere with 5% carbon dioxide, the filters were fixed with ethanol and stained with haematoxylin–eosin The chemotactic response was then...
... of the heart and used the data from Table to estimate the heart dose The same methods were used to examine the first 17 patientswith prostate cancer who were treated since the opening of the ... cm for patients with/ without serious heart diseaseInthe older patients these figures were 4.2 vs 5.6 cm Inthe prostate cancer patients, 4.8 vs 5.7 cm were calculated For all groups combined, ... protocols used in these patientsIn general, the highest doses to the heart were seen inthe anterior part of the left ventricle andthe interventricular septum (Figure 3) Up to 80% of the prescription...
... during the intervention period as an indicator for disease activity We concluded a rather stable disease during the intervention period since minimal changes in medication were recorded inthe ... during walking inthe previous week using a NRS, where indicates no pain and 10 indicates severe pain The Foot Function Index (FFI) was used to measure the impact of foot problems [23,24] The scale ... of the intervention) and at final follow up (directly after the end of the intervention period) The intervention period consisted of one or more appointments withthe podiatrist during which the...
... and more effective means of increasing the prescribing of proven therapies for CAD patients are needed The potential role of point-of-care reminders and opinion leaders in closing care gaps In ... evidence for patientswithcoronaryarterydisease would be conducted inthe near future On the survey form eliciting the opinion leaders, we gave all physicians the option to indicate if they did ... Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group: Prevention of cardiovascular events and death with pravastatin inpatientswithcoronary heart diseaseand a broad...
... mortality; and 2) these data were robust to the inclusion or exclusion of the TORCH and UPLIFT trials These findings are largely in keeping with previous observational studies, which have shown for the ... deaths and data from one of the studies overlapped substantially with another, leaving clinical trials for analysis (figure 6) In all, there were 431 deaths inthe tiotropium group and 453 deaths in ... was not determined as assigning causality to deaths in COPD is problematic and fraught with errors [11] The trials Page of 13 were stratified according to the study drug and to the main comparator...
... measurements split into quartiles depending on thepatients baseline FEV1 values The LOESS curves in each panel, again intended to highlight the main trends, are also displayed inthe right-hand plot, ... study) and treatment arm of each study, for both indacaterol (lefthand panel) and comparators (right-hand panel) Visual inspection of the indacaterol data points indicated that with increasing dose ... 6), the similar outcomes from the two analyses reinforce the overall conclusions while providing further insights into the impact of patient characteristics on dose response The key finding of the...
... to the register may bias the findings On the other hand, the precision of the estimates inthe present study are limited due to the small sample size Finally, there was no decrease inthe incidence ... confidence interval) arthroplasties In addition, thepatients were mostly Caucasians from a single urban area in southern Sweden, andthe findings may not apply to other settings In theory, the results ... trends inthe incidence of primary THA and TKA in a well defined sample of patientswith RA In order to this we studied the incidence of first hip and knee joint arthroplasty in a community setting,...
... protein (far upstream element-binding protein 2); LMNA: lamin A/C; PCBP2: poly(rC)-binding protein 2; PRDX2: peroxiredoxin 2; RB1: retinoblastoma-associated protein; RBBP4: retinoblastomabinding ... comparing the 2-D immunoblots withthe silver-stained reference gel and then extracted from another gel stained with Coomassie brilliant blue (Sigma-Aldrich) In- gel digestion involved the use ... staining withthe use of a densitometer, then analysed by using image analysis software, and finally compared withthe reference gel Selected protein spots were extracted from another gel stained...
... after the onset of diseaseinthepatientswith CFA, and 1–5 years after presentation inthe sarcoidosis patientsThe SLE patient had been diagnosed withthedisease for months Immunosuppressive therapy, ... multiple epitopes inthe protein [14] Interestingly, the authors of that study noted a correlation between the type of epitope andthedisease duration, supporting the hypothesis that the autoantibody ... described inPatientsand method Plaques were scored positive by visual inspection andin relation to the each of the other plaques on the membrane We screened sera from 11 other patientswith CFA, nine...
... and drafting the manuscript; BA was involved inthe conception and design of the study, analysis and interpretation of the data and critical revision of the manuscript; and JDF was involved in ... Competing interests The authors declare that they have no competing interests Authors' contributions ZM was involved inthe conception and design of the study, acquisition and interpretation of the ... collected included demographics, the results of the cosyntropin stimulation test, the use of etomidate, the time interval between the etomidate administration andthe cosyntropin stimulation test, the...