... side effects [22]. One ofthe reasons could be ascribed to the composition ofthe formulation and the poor control ofthe drug release rate. Therefore, thedevelopmentof compatible polymer-based ... L: The role of taxanes in the treatment of breast cancer. Semin Oncol 1996, 23:68-75. [4] Rowinsky EK: Thedevelopment and clinical utility ofthe taxane class of antimicrotubule chemotherapy ... participated in the design ofthe study and coordination ofthe work as lead investigator. All authors contributed to the interpretation ofthe results and the drafting ofthe manuscript, and they read...
... in thedevelopmentof oral can-cer [28], esophageal cancer [29] and colorectal cancer [30]. Furthermore the association between the presence of HPV 16 and thedevelopmentof head and neck cancer has ... toneurogenesis. The list of these genes is reported in addi-tional file 2. These results support the hypothesis of apossible role of E6 and E7 in the induction of neuroen-docrine differentiation of SCLC. ... andspecificity for HPVs identification [32]. The reasons for having false-negative detection of HPVs are the use of inappropriate primers or loss ofthe HPV L1 and E2genes during integration. The aim of...
... forbreastcancer in the United States is often multimodal, requiring a combination of therapies including surgery, chemotherapy, hormonal therapy, and radiation. The contemporary view ofbreast ... Family history ofbreast and ovarian cancer are strong risk determinants however, with the number of relatives, closeness ofthe degree of relationships, and ages of diagnosis of affected family ... individual risks forbreastcancer 60-85% and may be identified in 5-10% of all breastcancer cases.28 Personal history of noninvasive breastcancer or previous abnormal breast biopsy containing...
... 'all the present of earth vanished into the future of Heaven, and the Kingdom ofthe Infinite arose upon the ruins ofthe finite.' The beauty of earth was looked upon as an enchantment ofthe ... attitude ofthe Fathers ofthe Church, Basil and Gregory, or for Augustine's deep faithand devout admiration ofthe works of creation: even the tone of Ausonius and Fortunatus, in their charmingdescriptions ... you ofthe sweet exhalations from the earth or the breezes from the river? Other persons mightadmire the multitude ofthe flowers, or ofthe lyric birds, but I have no time to attend to them....
... (either forthe company or forthe customer). It includes all activities from thedevelopmentof an idea or a concept for a product, to the realization ofthe product during the production stage ... feedback, the purpose ofthe conceptual model, some background of the research that lead to thedevelopmentofthe model, and key 11852 Afr. J. Bus. Manage. Figure 5. Trend of project ... development New product development (NPD) is a business process for developing new products for a company, whether it is an upgrade of an existing product or a new concept (either for the...
... cover the entire world of knowl- edge. as generic resource (see figure 2). Before starting the development, the set of field labels relevant for the application must be identified. Then the ... requirement. Unfortunately one ofthe cur- rent trends in IE is the progressive reduction of the size of training corpora: e.g., from the 1,000 texts ofthe MUC-5 (MUC-5, 1993) to the 100 texts in MUC-6 ... those. The presence of all the relevant terms should guarantee that the information in the text is never lost; inserting just the relevant terms allows to limit thedevelopment effort, and...
... calledCHEMFET of BIOFET. In all of these devices, the surface poten-tial developed at the surface ofthe semiconductor is based on the direct interaction ofthe ligand with the exposed atoms of the semiconductor, ... maturation with the commercialization of these pH sensors in the mid-80’s, while they were the platform for thedevelopmentof other ion-selective FETs and bio-FETsup to date. When SiO2, or other metal ... used forthe oxidation of ferrocyanide, or the reduction of methyl viologen, and the simultaneous spec-troscopic monitoring ofthe products through the disc. In the same year, the construction of...
... wholeconversation or forthe most part of it). These twoknowledges inform the rest ofthe modules about the situation ofthe conversation and which one is the goalexpressed by the user. Then, the Dialogue ... of the Kernel. The Linguistic Kernel contains the independent knowledge ofthe system, related to the dialogue management. The rest of the configurable modules are adjusted to the design of the ... allows the user to change the topic ofthe conversation at any particularmoment ofthe dialogue as well as moving fromone service to another just by asking to do so in acolloquial way. Therefore,...
... all the branches of a single-bank, but all the banks have some standardization in them. This is because ofthe rules they are subject to. Besides this, each ofthe banks has its standard forms, ... trap” of other competitors. On the other hand, a significant amount of individual clients works in corporate, once they are met their needs, the bank have more chance to be introduced to their ... service is both the object of both the banking market. Meanwhile the bank's operations and market relationships and the impact of organic influence each other directly. Therefore, to understand...
... [81-85]. Most likely the observedeffect depends on the nature ofthecancer cells, the characteristics ofthe used MSC, on the integrity of the immune system and on the timing and site of injection.Two ... administration (i.e. the local environ-ment ofthe stem cell in the recipient) and the need for in vitro culturing. The manipulation ofthe cells mayalso contribute to the tumourigenic potential.Recently ... spontaneoustransformation of human MSC [62,63]. However, several of these authors have reported that the occurrence of transformed cells in their human MSC culture was dueto cross cont amination of the...