structural and functional aspects of viroporins in human respiratory viruses respiratory syncyt
Báo cáo khoa học: Structural and functional aspects of unique type IV secretory components in the Helicobacter pylori cag-pathogenicity island potx
... H pylori strains harbouring a functional cagPAI, is the activation of nuclear transcription factor-jB and the induction of pro -in ammatory production of cytokines, mainly interleukin (IL)-8 [12] ... the first and last turns of helices E and F, and the C-terminus helices I and J In addition, there is a lysine-rich N- and C-terminus, in accordance with the basic isoelectric point of CagS However, ... components of H pylori cag PAI L Cendron and G Zanotti host tyrosine kinases The phosphorylation triggers a series of interactions between CagA and human proteins that interfere with the signalling...
- 9
- 496
- 0
Báo cáo y học: "Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review" ppsx
... activates myosin light chain kinase, and as a result phosphorylation of the 20-kd light chain of myosin occurs, resulting in an increased actin-activated myosin ATPase activity, which finally initiates ... Roles of plasma membrane Ca++ – ATPase in the relaxation and contraction of hepatic sinusoidal endothelial fenestrae – effects of prostaglandin E1 and endothelin In: Cells of the Hepatic Sinusoid ... by ballooning and fusion of these invaginations; (III) As a consequence, the cytosol located among plasmalemmal invaginations becomes thinner and remains as anastomosing trabeculae in trabecular...
- 17
- 360
- 0
structural and functional features of fronting in english versus vietnamese equivalents = đặc điểm cấu trúc và chức năng của khởi ngữ trong tiếng anh và tương đương trong tiếng việt
... containing Fronting and Khởi ngữ were categorized into functional and structural groups In the functional group, samples containing fronting were categorized into four minor groups: Linking with ... - Identify and point out the structural and functional features of Fronting in English and “Khởi ngữ” in Vietnamese - Find out the similarities and differences in the structural and functional ... functions and structures of fronting in English and khởi ngữ in Vietnamese 2.3 Data collection 50 sentences in English containing the fronting structure and 50 sentences in Vietnamese containing khởi...
- 64
- 1,077
- 5
EXPRESSION ANALYSIS AND FUNCTIONAL STUDY OF HS3ST3B1 IN HUMAN PROSTATE CANCER
... structure consisting of repeating galactose and N-acetylglucosamine ! "*! Introduction units Studies have shown its importance in maintaining the structure and arrangement of collagen fibrils in the corneal ... 2001) This is in support of previous studies illustrating the requirement of heparan sulphate chains for sequestering and binding of FGF-2 to its receptor within the ECM (Bernfield and Hooper, ... Histopathology of the Prostate Gland 1.1.4.1 Normal histology of the prostate Columnar secretory cells line the ducts and acini of the prostate gland These ducts and acini are regularly spaced and are...
- 136
- 411
- 0
Báo cáo y học: "Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments" pot
... their charge [43] In these experiments, the interaction of VLDL and apoE proteins increased the charge of VLDL particles, resulting in the migration of VLDL band (lane vs lane 3-4 in Figure 4) Remarkably, ... modulating the in vivo metabolism of apolipoprotein Bcontaining lipoproteins in humans Clin Chem 1988, 34:B28 Greenow K, Pearce NJ, Ramji DP: The key role of apolipoprotein E in atherosclerosis ... 2005, 83:329 Weisgraber KH, Innerarity TL, Mahley RW: Abnormal lipoprotein receptorbinding activity of the human E apoprotein due to cysteine-arginine interchange at a single site J Biol Chem 1982,...
- 9
- 333
- 0
Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
... However, a tight binding of N7 of the purine base and Asp137 was observed in HPRT in complex with ImmGP, indicating a role in transition state stabilization during catalysis [17] A series of mutations ... activity of PRTFDC1 towards hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remains unclear and it is uncertain ... main chain carbonyl Binding of a xanthine base from XMP in the same position, would lead to the loss of a hydrogen bond and a less favorable interaction To investigate this further, the protein...
- 11
- 770
- 0
Tài liệu Báo cáo khoa học: Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1b mRNA doc
... E185, D226, D244) in PIN domains involved in binding Mg2+ ions are conserved in all three sequences Other conserved residues are R263, V139 and N144 Determination of the MCPIP domain architecture ... proteins interacting with MCPIP will clarify the dynamics and features of this protein Role of MCPIP in regulation of the endogenous IL-1b transcript level After identification of a PIN domain in the ... amino acids located within the PIN domain (D141A and D226A) Transcription was inhibited by addition of actinomycin D, and RNA was collected after 3, and h The mRNA level for IL-1b (top panel) and...
- 14
- 598
- 0
Báo cáo khoa học: Structural and functional characterization of human Iba proteins ppt
... shown in the presence of the actin crosslinking protein neurabin-2 (D) and an actin binding decient truncation mutant of neurabin-2 (E) in the lament cross-linking efciency of Iba1 and Iba2 or in ... phagocytosis [3] and to enhance the interaction of Iba1 with F-actin to a certain degree [11] In this study F-actin binding and cross-linking by Iba proteins was calcium independent, conrming previous ... morphology of the generated lament bundles Calcium afnity of Iba1 and Iba2 Homodimerization and actin binding of Iba1 and Iba2 were similar in the absence or presence of calcium ions Calcium binding in...
- 14
- 546
- 0
Báo cáo khoa học: Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase pdf
... structures of CMP and UMP, and interactions between the cytosine moiety of nucleotide and various side chains of wild-type CMP kinase (Upper) Chemical differences between CMP and UMP are indicated in ... Calculating proton uptake release and binding free energy taking into account ionization and conformation changes induced by proteininhibitor association: application to plasmepsin, cathepsin D and ... with enzyme binding and substrate catalysis Kinetic and nucleotide-binding properties of E coli CMP kinase variants with ATP as variable substrate Determination of the reaction rates of different...
- 11
- 437
- 0
Báo cáo hóa học: " In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics" doc
... mode of action of the antibiotics Ampicillin inhibits the cell wall biosynthesis by inhibiting the cross-linking reaction mediated by transpeptidase, while both streptomycin and kanamycin bind ... delocalization of the electron in the carbonyl group of the b-lactam ring in ampicillin at elevated temperature Elevation in temperature might induce breakage in the b-lactam ring of the free ampicillin, ... seeding of Gnps was done in presence of the antibiotics (Ampicillin, Streptomycin and Kanamycin, Fig 1) individually and thus Gnps conjugated antibiotics were formed [27] Dynamic Light Scattering...
- 9
- 332
- 0
Báo cáo hóa học: " In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics" pdf
... mode of action of the antibiotics Ampicillin inhibits the cell wall biosynthesis by inhibiting the cross-linking reaction mediated by transpeptidase, while both streptomycin and kanamycin bind ... delocalization of the electron in the carbonyl group of the b-lactam ring in ampicillin at elevated temperature Elevation in temperature might induce breakage in the b-lactam ring of the free ampicillin, ... seeding of Gnps was done in presence of the antibiotics (Ampicillin, Streptomycin and Kanamycin, Fig 1) individually and thus Gnps conjugated antibiotics were formed [27] Dynamic Light Scattering...
- 9
- 285
- 0
Báo cáo y học: "Summary The claudin multigene family encodes tetraspan membrane proteins that are crucial structural and functional components of tight junctions, which have important roles in regulating para cellular" pdf
... claudins ‘Non-classic’ claudins Claudin-10b Claudin-15 Claudin-9 Claudin-11 Claudin-6 Claudin-4 Claudin-18a Claudin-3 Claudin-18b Claudin-20 Claudin-12 Claudin-14 Claudin-2 Claudin-19b Claudin-19a ... Claudin-16 Claudin-7 Claudin-1 Claudin-21 Claudin-24 Claudin-22 Claudin-23 Figure A phylogenetic tree of full-length human claudin proteins, indicating the relationships between them Claudin-10, ... are just emerging and will probably become a major focus of research in the field of claudins and TJs From a practical point of view, a better under tanding of TJ s formation and regulation...
- 7
- 348
- 0
Design, structural and functional characterization of human beta defensin analogs
... Examples: Cecropins (A), andropin, moricin, ceratotoxin and melittin from insects, Cecropin P1 from Ascaris nematodes148, Magainin (2), dermaseptin, bombinin, brevinin-1, esculentins and buforin II from ... coils Examples; Bactenecins (cattle) and PR-39 (pigs); both are rich in proline and arginine, Prophenin (pigs); rich in proline and phenylalanine, Indolicidin (cattle); rich in tryptophan 1.1.2.4 ... into the same category Examples; Antimicrobial domains from bovine -lactalbumin, human haemoglobin, lysozyme and ovalbumin Lactoferricin from lactoferrin 1.1.3 The family of defensins Defensins...
- 143
- 424
- 0
Structural and functional analysis of critical proteins involved in mRNA decay
... by interacting with Upf3 (Lykke-Andersen et al., 2000) The crystal structure of the interacting domains of hUpf2 and hUpf3b shows that the RNA-binding domain (RBD) of Upf3 is involved in the interaction ... include the poly(A)-binding protein (Pab1) and the cap-binding protein (eIF4E) Pab1 couples decapping with deadenylation and inhibits decapping by promoting the formation of the translation initiation ... thereby linking the two domains together ix Electrostatic potential mapping combined with mutagenesis reveals that motifs I, V, and VI are involved in RNA binding In addition, trypsin digestion of...
- 191
- 313
- 0
Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf
... in place of the flavoprotein, and then redox cycles within NOS; and (d) heme–NO binding is an intrinsic feature of catalysis that constrains the rate of heme reduction by the flavoprotein domain ... complicated in dual-flavin enzymes because of a number of factors, including the k1 and k2 of KeqA possibly being in uenced by changes in the FAD and FMN reduction state or by changes in NADP(H)-binding ... The kinetics of interflavin electron transfer (FAD and FMN) in dual-flavin enzymes has been studied using a T-jump method [79] and by observing rates of flavin semiquinone formation (FADH• and ⁄...
- 16
- 639
- 0
Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling pptx
... the role of dynamics in interprotein [65–68] and intraprotein [69] ET reactions and protein rearrangement after carbon monoxide dissociation from myoglobin [64] In general, the rates of ET reactions ... KIE for proton tunnelling during the RHR of the quinoprotein methylamine dehydrogenase are unchanged following the addition of 30% glycerol – an increase in solvent viscosity of approximately two- ... used in place of MR NADH4 and NADPH4 are prepared by maintaining a slight pressure ($1.2 bar) of hydrogen (> 99%) over a solution of NAD(P)H (500 mg) and palladium-activated charcoal (30 mg) in...
- 12
- 595
- 0
Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc
... 1gjr), in which Y303 prevents stacking of the flavin and nicotinamide rings The figure also shows several positions determined by docking of Fld onto FNR (Fld in green, light orange and pink correspond ... binding, they show low catalytic efficiency [59,117,118] All the data indicate a fine-tuning of the FNR efficiency produced by minor structural changes in the regions involved in coenzyme binding ... hydride transfer and the relative conformation and orientation of FNR and NADP+ ⁄ H during the interaction are critical [121] Hydride transfer in systems involving flavins and pyridine nucleotides...
- 17
- 634
- 0
Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt
... tight main-chain and medium side-chain restraints Model building was carried out in o [29] and coot [30] In chain A, residues and 169–176 are missing; in chain B, residues 167–172 are missing; in ... in chain C, residues 1, and 169–174are missing; in chain D, residues 168–174 are missing; in chain F, residues and 168–175 are missing All amino acid residues were present in the E chain, and part ... usually found in nucleotide binding enzymes is not present in UpUMPK [19] UpUMPK contains instead a glycine-rich motif within amino acids 44–54 that is responsible for binding of the phosphate...
- 12
- 656
- 0
Báo cáo khoa học: Structural and functional analysis of the interaction of the AAA-peroxins Pex1p and Pex6p pptx
... in uence of the binding and ⁄ or hydrolysis of ATP on the interaction of the AAA-peroxins, Pex1p and Pex6p carrying mutated ATP-binding sites were tested for interaction with the binding partner in ... biogenesis remains unknown In this study we mapped the mutual binding sites and assayed the effects of deletion and point mutations in Pex1p and Pex6p for the interaction of the proteins and for their ... demonstrate the inverse importance of D1 and D2 in Pex1p and Pex6p for the interaction of these two proteins While a fragment of Pex6p consisting of N and D1 alone exhibits significant binding properties...
- 12
- 584
- 0
Báo cáo khoa học: Identification and functional expression of a second human b-galactoside a2,6-sialyltransferase, ST6Gal II docx
... were obtained and subcloned in the Topo TA cloning vector (Invitrogen, USA) The inserted fragments were cut out by digestion with BamHI and EcoRI and inserted into BamHI and EcoRI sites of the ... Zeiss-instrument (Model LSM 510) Construction of recombinant baculoviruses and production of soluble ST6Gal I and ST3Gal III in Sf9 In order to express soluble and His6-tagged enzymatic forms of human ... follitropin, and thyrotropin I Structural elucidation of the sulfated and sialylated oligosaccharides on bovine, ovine, and human pituitary glycoprotein hormones J Biol Chem 263, 25–35 12 Harduin-Lepers,...
- 12
- 584
- 0
Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25