strengths and weaknesses of nested case control study
The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust pptx
... exposures. Study designA nested case control study of lung cancer and DE in a cohort of 12 315 workers in eight non-metal mining facilities included 198 lung cancer deaths and 562 control subjects. ... quantitative estimates of average intensity and cumulative REC exposure for subjects in both this and the cohort study (12).A small percentage of subjects in the nested case control study worked at ... truncated at the date of death of the matched case subject. We identified 650 eligible control subjects and interviewed 611 (94.0%) of them or their next of kin (if the control subject was deceased...
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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... large nested case- control study. Materials and methodsThis nested case- control study was performed within the gov-ernment-initiated healthcare region of the city of Enschede inThe Netherlands. ... many cases weremissed. However, one weakness of this study is that underes-timation of the number of events might still have occurred.Another weakness of this study, as in any case- control study, is ... the article. HEV and RWF also contributed to the selection and inclusion of cases and controls. JvdP also contributed to the statisticalanalysis of the data. All authors read and approved the...
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Conclusions on Strengths and Weaknesses of Rang Dong Plastic Company
... theorganization’s strengths and weaknesses; (4) the selection of strategies that build on theorganization’s strengths and correct its weaknesses in order to take advantage of externalopportunities and counter ... an evaluation of current performance and ending with the review and possible revision of mission and objectives.The second is the process of generation, evaluation, and selection of the best alternativestrategy.In ... Chandlerdefined strategy as “the determination of the basic long-term goals and objectives of anenterprise, and the adoption of courses of action and the allocation of resources necessary forcarrying...
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Associated factors for treatment delay in pulmonary tuberculosis in HIV-infected individuals: a nested case-control study docx
... period of study. Of these, 274 had the pulmonary form of the disease and constituted the study population. Of these, 32 wereexcluded according to the algorithm of Figure 1. Twohundred and forty-two ... the treatment of HIV, and to identify the factors associated with this delay.Methods Study design and populationA nested case- control study was undertaken within acohort of HIV-infected individuals ... infections and use of ART poten-tially modify the course and the clinical and radiologicalfeatures of pulmonary TB [10], and could be associatedwith diagnostic and treatment delay of TB. However,...
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Báo cáo khoa học: "Breast cancer risk factors in Turkish women – a University Hospital based nested case control study" pps
... Hyperinsulinemia and increased risk of breast cancer: findings from the Britishwomen's hearth and health study. Cancer Causes and Control 2004, 15:267-275.51. Pike MC, Krailo MD, Henderson BE, Casagrande ... smoking and breastcancer risk. However, duration or intensity of smoking wasnot investigated in the current report that might be one of the weaknesses of this study. On the other hand, this ... contributionsVO carried out study conception and design, drafting of the manuscript. BO helped to draft the manuscript and acquisition of data, analysis and interpretation of data,she has been involved...
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Báo cáo y học: "Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study" pot
... in excess of standard recommendations (31.2% of celecoxib and 8.8% of rofecoxib prescriptions). Therewas a strong correlation between dosage and age. For allproducts, the proportion of low dosages ... formulary of reimbursed medications.A population-based case control study was conducted inwhich the prevalence of risk factors and the medical histories of patients prescribed COX-2 inhibitors and ... compared. The study populationconsisted of a random sample of members of the Quebec drugplan (age 18 years or older) who received at least onedispensation of celecoxib (n = 42,422; cases), rofecoxib...
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Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study" docx
... AllPsA probands were Caucasians. Information was collectedsystematically and included age at onset of psoriasis and PsA, and disease pattern. The control individuals (controls) were of similar ... total of 238 Newfoundland PsA patients and 149 healthyNewfoundland control individuals were studied. With respectto the Newfoundland PsA patients, 53% were male and theirmean age at onset of ... participated in study design, and drafted the initial manuscript. LP assisted in gen-otyping some of the control individuals. SH aided in recruit-ment and clinical phenotyping of PsA patients. PR and DGconceived...
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Báo cáo y học: " A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab" docx
... historical control study, with controlsbeing active RA patients followed before the advent of TNF-αblocker therapy and who were treated with methotrexatealone. Such a historical control group is of ... effect of cofactors (continu-ous variables and discrete variables) on that of infliximab. Allanalyses were performed with SPSS (SPSS Institute, Cary,NC, USA) software.Results Control and infliximab ... biological and BMD characteristics of the 189 RA patients enrolled in the study are summarized inTable 1. Patients exhibited typical clinical and biological fea-tures of RA. The study included...
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Báo cáo y học: "Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study" ppt
... The study was approvedby the Institutional Review Board of the National Institute of Diabetes and Digestive and Kidney Diseases and the NationalInstitute of Arthritis and Musculoskeletal and ... ng/ml, with intra- and inter-assay CVs of 6% and 12%, and those for the IGFBP-3 assay were 0.8mg/l, with intra- and inter-assay CVs of 13% and 17%, respec-tively. Serum levels of DHEA were measured ... independent of the use of exogenous glucocorticoids. Most reports indicate that cir-culating levels of cortisol and dehydroepiandrosterone(DHEA) are normal, and not elevated, in the setting of increased...
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Báo cáo y học: "Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study" pps
... genomewide study. N Engl J Med 2007, 357:1199-1209.32. Wellcome Trust Case Control Consortium: Genome-wide asso-ciation study of 14,000 cases of seven common diseases and 3,000 shared controls. ... helped to perform analysis and interpretation of the data. DHa and PA helped to perform anal-ysis and interpretation of the data and to draft the manuscript.VHT and UW (and the European Consortium ... all case- control indi-viduals, accounting for HLA-DRB1 risk alleles. HLA-DRB1classification according to du Montcel and colleagues [7] asdescribed above was applied. Cases of the case- control cohort...
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báo cáo khoa học: " RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study" ppt
... mechanism of LV-COX-2siRNA-1-mediated downregulation of invasion and migration, theexpression of genes associated with angiogenesis wereexamined. The mRNA levels of vegf, egf and bfgf of SaOS2cells ... LV -control and parental SaOS2 cells.bP < 0.001 comparedwith the LV -control and parental SaOS2 cells.Figure 4 Measurement of invasion and migration of SaOS2 cells. (A) Invading and migrating ... osteosarcoma.Cyclooxygenasesarekeyenzymesintheconversion of arachidonic acid into prostaglandin (PG) and othereicosanoids including PGD2, PGE2, PGF2, PGI2 and thromboxane A2 [6]. There are two isoforms of cyclooxygenase, designated COX-1 and COX-2....
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Báo cáo y học: " Histology of adipose tissue inflammation in Dercum’s disease, obesity and normal weight controls: a case control study" doc
... design of the study, carried out the histological judgement and contributed to thewriting of the manuscript. HB initiated and designed the study, took allbiopsies and contributed to the writing of ... 8:24http://www.journal-inflammation.com/content/8/1/24Page 6 of 6 RESEARCH Open AccessHistology of adipose tissue inflammation inDercum’s disease, obesity and normal weightcontrols: a case control study Emma Hansson1*, Henry ... a larger series of patients, and compare them withhealthy, obese, body mass index (BMI)-matched controls and controls with normal BMI.Patients and MethodsPatientsA total of 53 women with...
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