release activation and the invasive ability of cells in co culture of human monocytes thp 1 cells and fibroblasts
Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
... Mankin score of 5 .1 (3 11 ) and a safraninO score of (0–4) Specimens from licofelone-treated groups had a Mankin score of 3.5 (0 10 ) and a safranin-O score of 0.4 (0–3) with the 2.5 mg dosage and ... focuses on the in situ effect of licofelone on the gene expression and protein synthesis of the major collagenolytic enzymes (MMP -13 and cathepsin K) and aggrecandegrading proteases (ADAMTS-4 and ADAMTS-5) ... reducing the synthesis of LTB4 and IL -1 by the OA synovium [6] These findings are in strong support of the in situ role played by LTB4 in the structural changes that occur in OA The progression of the...
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Senescence and Cell Cycle Control
... understanding of the role of p21Cip1 in senescence of mouse cells Role of the Rb Pathway in Senescence The Rb-family pocket binding proteins, i.e., Rb, p107 and p130, also play critical roles in ... maintenance of the proliferative capacity in stem cells Overexpression of Bmi -1 abrogates the induction of both p16INK4a and p19ARF in MEFs, slowing down the senescence process In HDFs, Bmi -1 ... (Noda et al 19 94) During induction of senescence, p53 transactivates the p21Cip1 gene (el Deiry et al 19 93), and p21Cip1 protein binds to and inhibits G1-regulatory cyclin-dependent kinases (Cdk),...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... determining the structures of both Inhibition of choline-binding proteins the ligated and unligated forms of C-LytA, due to the insolubility of the protein at the required concentrations The recently ... to the column is favored entropically, as binding of the first DEAE group brings the C-LytA protein in close proximity to the resin and promotes the subsequent cooperative binding of the rest of ... Journal compilation ª 2006 FEBS 369 Inhibition of choline-binding proteins B Maestro et al Thermal unfolding transition in the absence and in the presence of the different ligands The in uence of...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... on human Th1 and Th2 cell lines DPIV family in cancer and cell biology 11 4 11 5 11 6 11 7 11 8 11 9 12 0 12 1 12 2 12 3 12 4 12 5 12 6 as detected with living cell cytochemistry J Histochem Cytochem 50, 11 69 11 77 ... involved in FEBS Journal 277 (2 010 ) 11 26 11 44 ª 2 010 The Authors Journal compilation ª 2 010 FEBS Denise M T Yu et al 10 3 10 4 10 5 10 6 10 7 10 8 10 9 11 0 11 1 11 2 11 3 helper function of CD4 cells J ... 11 26 11 44 ª 2 010 The Authors Journal compilation ª 2 010 FEBS 11 41 DPIV family in cancer and cell biology 12 7 12 8 12 9 13 0 13 1 13 2 13 3 13 4 13 5 13 6 13 7 Denise M T Yu et al pharmacological blockade of dipeptidyl...
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Understanding the participatory news consumer - How internet and cell phone users have turned news into a social experience pdf
... where they go for most of their news, in other words, is increasingly obsolete Six in ten Americans (59%) get news from a combination of online and offline sources on a typical day, and the internet ... online? The act of sharing of news and conversation about news is an integral part of email exchanges and social media activity Of the 71% of the adult population who get news online, 75% of them ... stories in their Tweets, and haggle over the meaning of events in discussion threads For instance, more than in 10 online news consumers get or share links in emails The rise of the internet as...
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Báo cáo khoa học: Linking pseudouridine synthases to growth, development and cell competition potx
... displacement of the dying D cells by the faster-growing V cells Considering that correct formation of the D–V boundary normally prevents mingling of D and V cells, it seems reasonable to conclude that in ... Compartments and the control of growth in the Drosophila wing imaginal disc Development 13 3, 44 21 4426 Klein T (20 01) Wing disc development in the fly: the early stages Curr Opin Genet Dev 11 , 470–475 ... and human proteins within the two TruB motifs and the pseudouridine synthase and archaeosine transglycosylase RNA-binding domain, which are involved in the 3250 pseudouridine synthase activity In...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... 80 10 0 B 12 0 20 40 60 Time (min) 10 0 C 60 40 D 60 40 0 20 40 60 22 10 12 14 16 12 14 16 [ GST - IB ] ( àM) 20 E 20 [ATP] (àM) F 18 16 14 12 10 16 14 nM min -1 Initial velocity (v) 18 nM min -1 120 ... buffer and 2.5 1. 2 lm, 6 .1 1. 3 lm, 2 .15 ã 10 )3 s )1 and 16 .2 nmặmin )1 in the kinase assay using Hepes MgCl2 MnCl2 buffer These ndings conrmed the importance of kinase conditions used for determining ... kcat and Vmax were 2.3 0.6 lM, 3.7 0.9 lM, 1. 51 ã 10 )3 s )1 and 18 .7 nMặmin )1, respectively, in kinase buffer Tris HCl MgCl2 MnCl2 and 2.5 1. 2 lM, 6 .1 1. 3 lM, 2 .15 ã 10 )3 s )1 and 16 .2 nMặmin)1...
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
... Dzs contain 15 deoxynucleotides for the core catalytic domain and nine for each of the hybridizing arms They have the ability to bind specific uPAR mRNA by complementary base-pairing between the ... degradation Importantly, the uPAR–b1 integrin complex was also disrupted in the antisense cell clone, with this interaction important in maintaining the invasive phenotype of colon cancer cells [24] It ... Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells...
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Anatomy, Histology, and Cell Biology PreTestTM Self-Assessment and Review pptx
... portion: Clefts 1: Clefts → 4: Epithelial lining of middle ear canals and tympanic membrane Epithelial lining of palatine tonsils Epithelial components of thymus gland Epithelial cells of inferior parathyroid ... (nephron) and collecting portions (i.e., collecting ducts, calyces, and pelves) of the developing kidney The epithelial lining (transitional epithelium) of the ureters, as well as their muscular and connective ... sex cords and their ducts The endoderm of the urogenital sinus gives rise to the epithelia of distal organs of the reproductive system and the external genitalia As in the urinary system, connective...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
... antagonistic conformation by displacing the H12 of the receptor by 4OHTAM’s bulky sidechain, thus preventing the binding of the coactivators (Shiau et al 19 98) The absence of the alkyaminoethoxy sidechain ... fragment encompassing the active apoptotic protein, which is released into the cytosol and triggers the apoptosis of the cells (Figure 1) Unless processed inside the cells, these recombinant proteins ... endocytosis; the translocation domain mediates the processing of the fusion protein in the endosome or lysosome by furin to release into the cyotsol a C-terminal moiety; the released moiety containing the...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
... of LC3 and conversion of LC3-I to LC3-II [48,49 ,11 8], induction of beclin [48], induction of BNIP-3 [66] and activation of G-interacting protein (GAIP) by phosphorylation on serine 15 1 [11 4] p53 ... adenocarcinoma HCT -15 , lindane [11 7] in the mouse Sertoli cell line, dihydrocapsaicin [11 8] in WI38 lung fibroblasts, cadmium in mesengial MES -13 cells [69 ,11 3] and TNFa treatment in MCF-7 [49] and ... pathway-controlled activation of caspases and nucleases leading to the death of the injured cells without affecting neighboring cells The intrinsic pathway of apoptosis regulates the activity of the...
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Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx
... often linked to an activation of the ERK1 ⁄ pathway ROS-induced ERK1 ⁄ activation has been demonstrated in a wide variety of cells, including neurons [22] Oxidants induce neuronal death and in ... phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons Brain Res 837, 12 7 14 2 31 Kamakura S, Moriguchi T & Nishida E (19 99) Activation of the protein kinase ERK5 ⁄ BMK1 by receptor ... requires the sustained p38 pathway to induce CGN cell death [26] These studies have strengthened the notion that both the magnitude and the duration of ERK1 ⁄ activation determine the cellular outcomes,...
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Báo cáo khoa học: ERK and cell death: ERK location and T cell selection pdf
... ligands induce a slow and sustained activation of ERK originating from the Golgi and leading to pERK being distributed throughout the cell (Fig 1) [16 ,38,39] The differences in the kinetics of ... subunits and TCRf This allows for the recruitment of the kinase Zap-70 to the TCR and induces its activation (reviewed in [18 ]) The TCRf chain contains six ITAMs Initially, studies comparing variants ... the nature of the selecting ligand In addition, the kinetics of the other MAPK important for negative selection are the same independent of the ligand Given their opposing function and downstream...
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Báo cáo khoa học: ERK and cell death: cadmium toxicity, sustained ERK activation and cell death pot
... kinase C in a cultured cell line of fetal rat skin keratinocytes J Biol Chem 2 61, 13 013 13 018 52 Alessi DR (19 97) The protein kinase C inhibitors Ro 318 220 and GF 10 9203X are equally potent inhibitors ... cascade leading to ERK activation, and in the inactivation of MKP3, which would stabilize ERK activation These two mechanisms could act together to induce the delayed and sustained activation of ERK, ... been linked to the kinetics of activation [12 ], subcellular localization [13 ] and scaffolding proteins [14 ] A Cadmium poisoning and sustained ERK activation Cadmium is a nonessential metal, recognized...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... A2058 cells were transiently transfected with each of the dominant negative forms (N17Rac1, N17Cdc42 and N19RhoA) and the corresponding control vectors, and the cells were incubated in the absence ... assembly of focal adhesions [15 ] Activated FAK in turn recruits other proteins, including paxillin, p130Cas, vinculin and talin in focal adhesions These protein complexes anchor the actin cytoskeleton ... autotaxin, can increase the levels of Cdc42-GTP and Rac1-GTP via the activation of PI3Kc [ 21] In the present study, direct pulldown assay confirmed that LPA increased the levels of GTP-Rac1 and GTP-Cdc42...
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Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx
... allele be insufficient in maintaining its own expression in the intestinal nonendocrine cells, and in preventing the formation of intestinal polyps for the nonendocrine intestinal epithelia? We ... of Cdx-2 [3–7, 10 –25], including the genes that encode proglucagon and insulin in pancreatic islets and intestinal endocrine cells [4–6] Within the intestinal polyps in the Cdx-2+ ⁄ – mice, the ... analysis The hamster pancreatic islet cell line InR1-G9, the mouse intestinal proglucagon producing endocrine cell lines GLUTag and STC -1, and the human colon cancer cell lines HT29, Caco-2 and SW480,...
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schaum's easy outline molecular and cell biology - william stansfield, raul j cano, jaime s. colome
... Figure 1- 4 Eukaryotic cell cycle 11 Figure 1- 5 Mitosis in animal cells 12 Figure 1- 5 Mitosis in animal cells, continued CHAPTER 1: Cells 13 The nuclear membrane dissolves, and a spindle of microtubules ... allows the helicase to unwind the DNA The unwinding produces positive superhelical turns in the rest of the DNA, making it energetically favorable to continue unwinding the strands To unwind the ... as the lagging strand The leading and lagging strands are synthesized halfway around the bacterial chromosome until they encounter the lagging and leading strands synthesized at the other replication...
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apoptosis and cell proliferation
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose