rational design of oral modified release drug delivery systems
Báo cáo khoa học: Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor pptx
... amount of enzyme was added to release 15 nmol of MCA in the enzyme reaction For determination of the inhibitory activity, a fixed amount of enzyme was first incubated with different amounts of the ... ideal template for the design of potent, specific and stable furin inhibitors Here we report the design and synthesis of various peptide analogs derived from the Lys fragment of MBTI and their functional ... inhibitory activity of the Lys domain was higher than that of the Arg domain, this study focused on the former The Lys domain consists of two peptide chains, which are composed of 26 and nine residues,...
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Chemical Aspects of Drug Delivery Systems pptx
... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS (e.g tablets, ... Aspects of Drug Delivery Systems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG RELEASE ... development of alternative drug delivery systems, which attempt to address the requirements of rate and extent of drug release, and thereby absorption Delivery systems include oral sustained release...
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THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)
... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled -release drug delivery systems: preprogramed drug release By the route of delivery: ... A4: series of multiple doses of a conventional drug delivery system B: ideal drug concentration profile PRODRUG What is a prodrug? Prodrug is an inactive precursor of a drug Prodrug reconversion ... Society of Chemistry, American Chemical Society, Wiley InterScience journals… CONTENTS Generalities of drug delivery Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery...
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Báo cáo hóa học: " Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference" pptx
... inactivation of the catalytic sites not integrate Transduction of both dividing and non-dividing cells results in transcription of episomal forms of the vector and a strong expression of the gene of interest ... delivery systems in vivo Mucosal adjuvants The talk on mucosal adjuvants for the genital tract by Ali Harandi from the University of Göteborg highlighted the significance of the development of ... levels of cross-reactive neutralising activity and correlated with the length of time the patients remained free of disease Broadly neutralising antibodies were present in the sera of 23 of the...
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Báo cáo sinh học: "Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010" potx
... trial of a Tenofovir gel by the Centre for the AIDS Program of Research in South Africa (CAPRISA) [3], have given hope for the development of an effective product directed towards women The use of ... induction of tolerance A deeper understanding of the properties of vaccineinduced antibodies, as well as the potential role of complement in eliciting immunity against HIV, will contribute to the design ... gp160 are now inspiring the design of novel vaccine candidates Particular aspects of the strategy have been the removal or masking of immunodominant and variable parts of the viral surface in order...
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báo cáo hóa học:" Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010" pptx
... trial of a Tenofovir gel by the Centre for the AIDS Program of Research in South Africa (CAPRISA) [3], have given hope for the development of an effective product directed towards women The use of ... induction of tolerance A deeper understanding of the properties of vaccineinduced antibodies, as well as the potential role of complement in eliciting immunity against HIV, will contribute to the design ... gp160 are now inspiring the design of novel vaccine candidates Particular aspects of the strategy have been the removal or masking of immunodominant and variable parts of the viral surface in order...
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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
... construction of drug delivery systems in not too long a time The functionalization of CNTs used in the construction of drug delivery systems will be discussed in later sections In vivo behavior of functionalized ... application of CNTs as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems ... schematic illustration of the strategy for the preparation of the CNT-based drug delivery systems Figure The modification of CNTs Schematic illustration of modification of CNTs with various molecules...
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Báo cáo y học: "Clinical use of a modified release methylphenidate in the treatment of childhood attention deficit hyperactivity disorder" pps
... efficacies over different periods of the day, depending on the release profile [21-23] Having different MPH-MR proportions with differing release profiles allows tailoring of treatment to each patient, ... formulation of MPH contains a 30:70 ratio of IR to DR MPH by weight [17] It uses a multiparticulate bead delivery system in a capsule, in which each bead acts as a drug reservoir; a distinct advantage of ... absorption of sustained -release methylphenidate formulations compared to an immediate -release formulation Biopharm Drug Dispos 1989, 10:165-171 15 Elia J, Ambrosini PJ, Rapoport JL: Treatment of attention-deficit-hyperactivity...
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Development of controlled drug delivery systems using uniform nanoporous materials as matrices
... sustained release of the large protein model drug of bovine serum albumin (BSA) on SBA-15 Chapter covers the factors affecting stability of the released BSA in fabrication of drug delivery systems, ... surface of the polymer, resulting in a release rate that is proportional to the surface area of the drug delivery system (See Figure 2.5b) a Drug Drug Drug- loaded biodegradable particles b Drug Drug ... application of SBA-15 in the delivery of the small molecule model drug of ibuprofen (IBU), with emphasis on the influence of the different functional methods on the adsorption and release of IBU Chapter...
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Drug Delivery Systems
... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... terms of duration of clinical use and Table 15.1 Use of a drug delivery system for kinetic control Dissolution of drug is too slow Drug and/or formulation is physically removed from the site of ... loading of up to 20% w/w of protein in the polymer with full retention of the protein enzymatic activity The addition of PEG to the formulation eliminated the burst release of drug and drug release...
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fluid dynamics of packed columns principles of the fluid dynamic design of columns for gasliquid and liquidliquid systems
... 295 Part Principles of the Fluid Dynamic Design of Packed Columns for Liquid/Liquid Systems Basic Principles of Packed Column Design for Liquid/Liquid Systems 7.1 Introduction ... number Froude number of liquid Froude number of liquid Froude number of liquid Reynolds number of liquid Reynolds number of liquid Reynolds number of droplet modified Reynolds number of vapour or gas ... hydraulic behaviour of packed columns for the development of a new method for the standard presentation of the fluid dynamics of columns with any type of packing design The basic principles of the method...
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nanoparticulate drug delivery systems, 2007, p.382
... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... nanoparticulate drug- delivery systems The first chapter covers a complete overview of the nanoparticulate drugdelivery system, covering wide applications and evaluation of the nanoparticulate drug- delivery ... polymer therapeutics for drug and gene delivery J Control Release 2002; 82:189 58 Torchilin VP Structure and design of polymeric surfactant-based drug delivery systems J Control Release 2001; 23:137...
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Báo cáo hóa học: " Nanotechnology-based drug delivery systems" pdf
... application of nanodelivery systems in medicine Design of nanotechnology – based drug delivery Systems Nanoparticles can be used in targeted drug delivery at the site of disease to improve the uptake of ... therapy The effectiveness of drug delivery systems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and ... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drug delivery systems is shown in Figure...
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Báo cáo hóa học: " Research Article Optimal Design of Nonuniform Linear Arrays in Cellular Systems by Out-of-Cell Interference Minimization" ppt
... tackled the problem of optimal design of linear arrays in a cellular systems under the assumption of Gaussian interference Two design problems are considered: maximization of the ergodic capacity ... localization of transmitters based on the estimation of direction of arrivals REFERENCES [1] J H Winters, J Salz, and R D Gitlin, “The impact of antenna diversity on the capacity of wireless communication ... minimization of the interference power at the output of the matched filter (by developing a closed form approximation of the performance criterion), for fixed and variable positions of user and...
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Báo cáo hóa học: " Research Article Analysis and Design of Timing Recovery Schemes for DMT Systems over Indoor Power-Line Channels" pdf
... has a twofold origin: the short-term variations of the channel response and the jitter of the sampling process [8] Uncompensated cyclic shortterm variations of the channel, with harmonics of 50 ... the shortcomings of the conventional strategies designed for DMT systems that operate in LTI channels are firstly revisited [8] This analysis suggests two direct improvements: to design a phase ... values of 20 picoseconds, 10 picoseconds and picosecond This model is sometimes simplified, for example, when modeling the phase noise of the oscillators employed in the downconversion of OFDM signals,...
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Ophthalmic Drug Delivery Systems - part 1 pptx
... Preface A major goal of pharmacotherapeutics is the attainment of an effective drug concentration at the intended site of action for a desired length of time Efficient delivery of a drug while minimizing ... edited by James W Munson 12 Techniques of Solubilization of Drugs, edited by Samuel H Yalkowsky 13 Orphan Drugs, edited by Fred E Karch 14 Novel Drug Delivery Systems: Fundamentals, Developmental ... concentration of a drug at its intended site of action and the resulting pharmacological effect The specific aim of designing a therapeutic system is to achieve an optimal concentration of a drug at...
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Ophthalmic Drug Delivery Systems - part 2 pdf
... loss of efficacy, the development of prodrugs takes advantage of the increased corneal permeability of the prodrug and the subsequent hydrolysis of the prodrug to active compound (16, 99,100) Prodrugs ... advantages of direct topical drug administration include targeted drug delivery to the anterior segment of the eye and avoidance of systemic drug toxicity Many of the disadvantages of eyedrops, ... is the study of the biological effects of drugs (112) More specifically, it is the study of how the concentration of drug in the biophase (site of action) relates to the magnitude of biological...
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Ophthalmic Drug Delivery Systems - part 4 doc
... increased utility of the microdialysis approach in the study of ocular drug delivery and disposition Unique applications of the microdialysis approach in the examination of drug ocular disposition ... pathophysiology of the posterior eye segment affects the distribution and elimination of drug from the vitreous (29) In particular, the effect of three conditions were examined: changes in the diffusivity of drugs ... weight of the diffusing species, and CP represents the concentration of polymer (collagen and hyaluronic acid) in the hydrogel in units of grams of polymer per gram of hydrogel Using the sum of the...
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