polyphenol rich cocoa and chocolate potential role in the prevention of diabetes
Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... increase the amount of complex containing MT1MMP and furin, and the expression of a catalytically inactive dominant negative furin construct affected the processing of pro-MT1-MMP Taken together, these ... sequence for the interaction with the PDZ proteins: Mint-3, AMPA binding protein and glutamate receptor interacting protein (GRIP) It would therefore be interesting to determine whether this motif ... the nature of the GRASP55 binding site in the MT1-MMP ICD pACT plasmids driving the expression of MT1-MMP ICDs containing single-, double- and triple-point mutations were generated (Fig 4A) and...
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báo cáo hóa học:" Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study" potx
... data, interpreted the findings and wrote the manuscript OM was involved in developing the study proposal, supervising the data collection and reviewing the manuscript SGH was involved in developing ... developing the study proposal and reviewing the manuscript MMS was involved in supervising the data collection and reviewing the manuscript KMM was involved in developing the study proposal and reviewing ... two mothers had live birth of twins (Figure 1) Table shows the demographic and obstetric characteristics of the mothers enrolled in the study The median age of the mothers was 25 years and the...
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Báo cáo y học: "Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis" pdf
... Arthritis Research & Therapy Vol 11 No Chabane et al (MMP-1, -8, and -13), the gelatinases (MMP-2 and -9), the stromelysins (MMP-3, -10, and -11), the matrilysins (MMP-7 and -26), and the membrane-bound-type ... our understanding the pathogenesis of OA and may lead to the development of new therapeutic targets for the treatment of the disease Lipoxygenases (LOXs) are a family of enzymes that incorporate ... activation inhibits the expression of a number of genes involved in the pathogenesis of OA, including IL-1β, TNF-α, MMP-1, MMP-13, inducible nitric oxide synthase, and microsomal prostaglandin E synthase-1...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in the far UV To prepare proteins without Cu2+, part of each protein ... understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders Copper binds ... copper binding could still allow domain swapping to occur It is of interest that a N-terminally truncated prion protein, lacking the copper binding domain is capable of domain swapping and forms...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... stranded sequence was determined for a region of this construct containing galA and some of the flanking regions, resulting in the genomic sequence of A niger galA The presence of one putative intron ... control of the xylanolytic activator protein [32,41] The increase in expression levels of galA in the CREA mutant, indicates that at least one of the detected putative CREA binding sites in the promoter ... proteins The three arabinogalactans were incubated with GALA for 15 min, 30 min, h and 20 h to determine the substrate specificity of the enzyme The degradation of the polymer Ó FEBS 2002 and subsequent...
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Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc
... unknown, and the specific roles of the various members of the DIM family, e.g DIM A and DIM B, in these functions have never been investigated The recent developments in our understanding of the biosynthetic ... group in the a position of the fatty acyl residues The signals that correspond to the resonance of the methine proton of the a carbon (d) and that of the carbon bearing the methyl group near the ... obtained for four mice, indicating that fewer than 50 bacteria of the PMM56 mutant strain were present in the spleen of these mice For the determination of the number of PMM56 bacteria present in...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... mislocalization of all three enzymes in these cells clearly shows the involvement of PEX14 in the targeting of PTS-1, PTS-2 and I-PTS proteins to the glycosome To further analyse the effect of the destruction ... with a binding constant Kd of 2.75 lM, and that the amino-terminal domains of the two peroxins were responsible for this interaction The role of TbPEX14 in glycosome biogenesis received further ... N-terminal domain of the polypeptide of each of these organisms is followed by a stretch of hydrophobic amino acids that is presumably involved in the protein’s anchoring to the membrane Also in...
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Báo cáo hóa học: " Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment" pptx
... (TIRdomain-containing adapter-inducing interferon-b) joining the RIG-I/MDA5 pathway In the other pathway, TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1 These kinases stimulate ... synergistically inhibited the growth of HepG2 cells without affecting the growth of normal human hepatocytes and increased the expression of RARb and p21(CIP1), while inhibiting the phosphorylation of RXRa ... toll-interleukin-1 receptor domain-containing adaptor inducing IFN (TRIF) TRIF is an adaptor protein that is a critical component of the TLR3 signaling pathway By cleaving IPS-1 and inactivating TRIF,...
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Play and it’s role in the mental development of the child
... dominating to a subordinate position 17 Thus, in play the child creates the structure meaning/object, in which the semantic aspect – the meaning of the word, the meaning of the thing – dominates ... in the form of other things But the moment the stick – i.e., the thing – becomes the pivot for severing the meaning of “horse” from a real horse, the child makes one thing influence another in ... examining a piece of candy, putting it in one’s mouth, chewing it, and then spitting it out In play the object, to win, is recognized in advance At the end of play development, rules emerge; and...
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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx
... viability These findings provide a basic rationale for the use of taxol in DC immunotherapy and insights into the development of combinational DC therapies with other anticancer drugs that not harm the ... survival and maturation of DCs [11,17,20] To investigate further the mechanisms of taxol-induced changes, the viablity of TPCK, an inhibitor of the serine protease that inhibit NF-κB signaling pathway ... major cytokines involved in immune responses Importantly, taxol increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit molecules into the DC...
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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc
... activity We further investigated a putative role for MAPKs in the TNFα-induced increase in Cyp7b activity by using the MEK1 inhibitor PD98059 and the p38 inhibitor SB203580 The p38 inhibitor (SB203580) ... understanding of the role played by Cyp7b in the arthritic process The inhibitory effect of PSI on the TNF-α-induced upregulation of Cyp7b activity is also in accordance with a role for NF-κB in ... with the findings in this report that NF-κB and AP-1 are involved in the TNF-α-enhanced Cyp7b activity Figure NF-κB and AP-1 binding sites within the Cyp7b promoter Putative promoter binding sites...
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báo cáo khoa học: " Field transcriptome revealed critical developmental and physiological transitions involved in the expression of growth potential in japonica rice" potx
... overexpression of AtHAP2 delays flowering via down-regulation of FT [34] In SD-flowering rice plants, the CCT-domain containing proteins Hd1 and Ghd7 regulate flowering by repressing expression of the florigen ... (24:00) Sampling for different stages of development of inflorescence and anther was based on the length of the inflorescence and the anther itself, respectively, whereas sampling for pistil and lemma/palea ... as anther, pistil, and entire inflorescence; and the endosperm (Figure 1B) The profiles of lemma and palea clustered together with the reproductive organs in earlier stages of development and...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... involves its interaction with receptors consisting of a heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation ... phosphorylation of signal transduction molecules including motifs similar to those involved in insulin signaling, the insulin receptor substrate (IRS)-1, IRS2 and signal transducer and activator of transcription ... high-affinity α chain (IL-4Rα) and a second chain that can be either the common γ chain or the α chain of the IL-13 receptor (IL-13Rα) [23] The common γ chain is found in multiple cytokine receptors...
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HUMAN CARBOXYLESTERASE 2 SPLICE VARIANTS: EXPRESSION, ACTIVITY, AND ROLE IN THE METABOLISM OF IRINOTECAN AND CAPECITABINE
... benzamidine and 10% ethylene glycol The amount of protein was quantified using the Protein the BioRad Protein Assay with bovine serum albumin used for a standard curve The purity of the protein, ... Bob and Linda Reiff and John and Cheryl Jugovic; and my cousins Erin Dunivan and Kristin and Scott Petherick Your love and support throughout my life and education has been and continues to be incredible ... key sequences defining splice sites are contained within the introns These sequences are the 5’ and 3’ splice sites, the branch point region, and the polypyrimidine tract (Matlin et al., 2005;...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... role in the pathogenesis of both types of diabetes mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased ... diabetic complications (11-13) The combination of the low levels of antioxidants and raised levels of free radical play a major role in delaying wound healing in aged rate and diabetic rats (14) It ... and diseases such as type diabetes mellitus, obesity and the metabolic syndrome (30) In these conditions there is an elevation of both glucose and free fatty acid levels in the blood and an increase...
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focuses on expressions of criticizing in American and Vietnamese e-newspapers in the light of Directness/Indirectness
... style They give the main points and state the criticism at the top in the headline and the lead paragraph(s) The body of the articles then adds details, statements, and comments from people involved ... together at the beginning of the sentence, but in other case, they are separated or the writer delays the appearance of the verb Thus, one of the reason people sometimes misunderstand the information ... well as the language used 4.2 4.2.1 Data analysis and findings Structure of the articles Each of the three main part of an article (the headline, the lead and the body) has its own distinctive...
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Factors influencing borrower’s behavior and decision making patterns in the success of a micro finance model
... influence on the behavior of borrowers If the income and savings of the individual is high then he/she is least attracted to debt financing On the other hand, the individual with low income and ... evaluate the level of knowledge and interest about micro financing prevailing in the lower income groups The awareness of micro financing may encourage the poor people to empower themselves and contribute ... and savings is more attracted towards debt financing The selection of income group and the means of income are very important The main function of the MFIs is to enhance the capacity of the borrowers...
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Tài liệu PLEASE GIVE NORBERT WEINER (AND OTHER CURIOUS DEVELOPMENTS IN THE WORK OF JANET ZWEIG) doc
... documents the pattern of shifting individual actions, roles, and responsibilities in public space In all of these works, Arendt’s insistent appeal for thinking and seeing participation in the world ... chooses to participate? Does the potential interactivity of individuals operating independently in public space and the unpredictability of their random initiatives or abstinences— produce a conceptually ... visitors to the site, individual decisions of these members of the public, and the recycling of tiles placed in the grid, to determine possible life spans of Limited Edition If not incal- Sculpture...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... that the RPEL domain of MRTF-A binds actin more strongly than the RPEL domain of myocardin, and that the RPEL motif itself is an actin-binding element RPEL1 and RPEL2 of myocardin bind actin weakly ... ABPs in transcription regulation B Zheng et al Table Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding ... and perinuclear areas of the cell via its N-terminal ABD In the absence of ligand, AR is localized predominantly in the cytoplasm, and its hinge domain and the LBD are tethered to the C-terminal...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... lL of the enzyme/inhibitor mixture to 180 lL of substrate (4NPGlc), incubating for 30 at 37 °C, and measuring the release of 4NP Protein assays and protein sequencing Total protein in crude and ... combination of XhoI and BamHI, and subsequently the cDNA insert was puri®ed using the Qiaquick PCR puri®cation kit and ligated into the XhoI and BamHI sites of the pHIL-S1 vector, in phase with the PHO1 ... following gradients were used: incubations containing arbutin or salicin as substrate; 100% C initial, increasing D to 20% (10 min), 50% (15 min), 100% (5 min), held at 100% (5 min); cyanodin glycosides;...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25