... through the opera, and after the opera. But they talked very quietly, and they looked behind them before they spoke. When theopera finished, the girls went back to their The directors oftheOpera ... &apos ;The ghost killed him!' The directors oftheOpera House The Opera House was famous, and the directors oftheOpera House were very important men. It was the first week of work for the ... he has the head of a dead man, with a yellow face and no nose. People hear a voice in another room, but the room is empty. It is thePhantomoftheOpera . . . 12 ThePhantomofthe Opera...
... ofthe anemia with bloodtransfusions. The contribution of plasma NTBI to the toxicity associated with Fe overload in these disorders isuncertain, as is the form of NTBI. Significant levels of NTBI ... is limited by the size of an intracellular chelatable Fe pool or permeability of the Fe–chelator complex.In view ofthe similar efficacy ofthe multidentatepyridinones to DFO, further experiments ... itis of interest to investigate the uptake and metabolism of NTBI in normal and cancer cells, and the effect of Fechelators on these processes.In the present study we have characterized these...
... with theiron metal at the active site. The presence of iron is therefore a prerequisite for its effect and suggeststhat the absence of reactivity with the MnSOD mutants isdue to the lack of ... under these conditions which favour the insertion of iron into the active site of SODs [3] (results not shown).Hydrogen peroxide inhibits MnSOD as it is the product of the enzymatic dismutation of ... was the extremely high thermostability of Mn[G77Q] and the very low thermostability of Fe[A141Q](Fig. 5). Each of these mutants has two glutamine residuesin their active sites; one from the...
... 1-substitutedimidazole on theironof 13G10±Fe(ToCPP) is even moredif®cult than the binding of two 1-substituted imidazoles on the ironof free Fe(ToCPP). In addition, the in¯uence of the nature ofthe substituent ... distortion ofthe porphyrin ring anda shift oftheiron atom outside the plane ofthe porphyrin.Binding of imidazole to the iron( III) of Fe(ToCPP),a,a-1,2- a,b-1,2-Fe(DoCPP), Fe(MoCPP)and to their ... (Table 1). The bind-ing ofthe ®rst CN±ligand to theiron was thus more easy in the hydrophobic binding pocket ofthe antibody than the binding ofthe second one, most probably because of the steric...
... below.Instability ofthe mutant enzymeFurther analysis ofthe kinetic parameters ofthe G167Emutant was hindered by rapid inhibition ofthe activity of the bc1complex during the assay, which ... concentrations of > 40 lM(Fig. 4A) may be aresult ofthe weakly chaotropic nature ofthe substrateand the inherent partioning of quinol into the Qosite. The Fig. 3. Steady-state level oftheiron sulfur ... Studies ofthe mechanism of assembly of the bc1complex suggest that the ISP is one ofthe lastsubunits to be integrated within the membrane-boundsubcomplex [2]. The integration ofthe ISP...
... interesting that the )10 sequence islocated inside theiron box of desA (nucleotides 7–12 of theiron box), explaining the regulation of desAexpression by binding of DmdR1 to theiron box. The same ... mediated by binding of the regulatory protein DmdR1 to theiron box located in the promoter region ofthe desABCD cluster. Elec-trophoretic mobility-shift assays ofthe desA promoters of both S. coelicolor ... awild-type copy ofthe desA gene to complement the mutation in trans suggests that the DdesA mutationaffects expression ofthe downstream genes desBCD in the des cluster and that the presence of wild-type...
... the earlier inter-pretation that these two lines form the gzand the gxyregion of the g ¼ 1.92 signal, whereas the gz¼ 2.078 and the trough at g ¼ 1.887 form the gzand gxylines of the g ... in the titrations in the presence of redoxdyes was comparable to the titration in the absence of these dyes (Fig. 9). The g ¼ 2.01 signal found in the absence of dyes was not detectable in the ... Quantification of the EPR signal to obtain the total concentration of Fe–Sclusters was performed with the samples obtained under100% H2at pH 8 in the absence of redox mediators. The Nicontent of the...
... ong theo th t tng dn v trng lngnguyên t. Khi cái ng ong c a ra thì 16 n v khi lng có th ln lt c vit lên,nhng nguyên t liên quan cht ch vi nhau c vit theo ... biu rng bt c nguyên tã cho nào cng sth hin tính tng t v tính cht vi 8 nguyên t theo sau nó trong bng HTTH hóa hc.Ai là cha ca bng HTTH?ã có nhiu ý kin không tán thành ... loi các nguyên t. Bn tho này ã cp n khong mt nacác nguyên tã bit c sp sp theo trng lng nguyên t và trình bày nhng thay i tunhoàn v hóa tr nh là mt hàm s ca...
... ispresent. In other words, the length ofthe signal limits the frequencyresolution. This is distinct from the first factor, because the length of the input signal does not have to be the same as the length ... displacement of the water, and so on. The shape ofthe time domain waveform is not importantin these signals; the key information is in the frequency, phase andamplitude ofthe component sinusoids. The ... jargon, windows provide a trade-off between resolution (the width ofthe peak) and spectral leakage (the amplitude ofthe tails).To explore the theoretical aspects of this in more detail, imagine...