oxidative stress in the pathogenesis of diabetic nephropathy
Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt
... stabilization of HIF [39] Our results of catabolic stress- induced expression of HIF-1α in chondrocytes are consistent with these findings These findings suggest that HIF-1α may, at least in part, ... maintain chondrocyte viability in the face of catabolic changes in articular cartilage Many molecular aspects of HIF-1 signaling should be also studied to further clarify the role of HIF-1 in the ... Germany) was used The assay is based on the light-emitting oxidation of luciferin by luciferase in the presence of extremely low levels of ATP After collecting the chondrocytes by scraping, cells were...
- 11
- 385
- 0
Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... Oxidative stress after status epilepticus in rats inefficiency of the electron-carrying components of the mitochondrial transport chain, monoamine degradation, xanthine oxidase reaction, ... determined by analysis of variance markedly increased in this model compared with corresponding values for the control group After pilocarpine-induced SE, there was a significant (77%) increase in ... activity only changes during the initiation of seizures [14] When studying this epilepsy model, we found increased catalase activity in the hippocampus, indicating that this enzyme, in association with...
- 6
- 480
- 0
Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... increment in the protein level of GM-CSF-induced MLN51 (Fig 2E) These data indicate that GM-CSF not only induces the expression of MLN51, but also blocks the proteasome-mediated degradation of ... blocking of the proteasome degradation pathway GM-CSF-induced MLN51 is involved in the hyperproliferation and anti-apoptosis of MH7A cells via the upregulation of FLIP Next, we investigated the ... of RA FLSs, thus indicating that other factors must be involved in this proliferation In our previous studies, we have determined that GM-CSF in the synovial fluid plays an important role in the...
- 10
- 433
- 0
báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... Immunolocalization of VEGF, Flt-1 and Flk-1 in GCT samples We initially analyzed the expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing...
- 8
- 445
- 0
báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... expression and the clinical stage of GCTs at presentation To determine the status of pY-Flt-1 and pY-FAK in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining; less ... Immunolocalization of VEGF, Flt-1 and Flk-1 in GCT samples We initially analyzed the expression profiles of VEGF and the VEGF receptors in GCT specimens TRAP Page of staining demonstrated the presence of bone-resorbing...
- 8
- 244
- 0
Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... the pathogenesis of EoE by enhancing activation of eosinophils through synergy with eotaxin via the ERK signaling pathway The data may be used in the possible diagnosis and prognosis of EoE In ... together with eotaxin, FGF enhances activation of eosinophils in EoE specifically Page of The increased global expression of bFGF led to the investigation of the local expression bFGF of the esophageal ... this increase is also reflected systemically In addition, the extent of increase in FGF and ERK pathways was closely associated with the severity of the disease and endoscopic findings in the...
- 9
- 243
- 0
Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
... binds directly to the ODDD of HIF-1α in the cytoplasm and acetylates a single lysine residue at position 532 Acetylation of this specific lysine residue favours the interaction of HIF-1α and the ... part of the E3 ubiquitin ligase complex Interaction of prolinehydroxylated HIF-1α with pVHL/E3 ubiquitin ligase complex activates the ubiquitination machinery, thereby promoting degradation of ... HIF-1α is not ubiquitinated Thus, degradation of HIF-1α in the proteasome is inhibited and HIF-1α protein accumulates Binding of HIF-1 to HIF binding sites, formation of the transcriptional complex...
- 9
- 439
- 0
Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx
... protein; matrilin-1) Matrilin-3 CILP (cartilage intermediate layer protein) Fibronectin PRELP (proline/arginine-rich and leucine-rich repeat protein) Chondroadherin Fibrillin Tenascin-C Elastin MGP (matrix ... [23], linkage analysis of 14 candidate genes in OA kindreds resulted in the exclusion of 10 important cartilage genes, including COL2A1 [40] Analysis of 47 families with the phenotype of earlyonset ... epiphyseal dysplasia of several joints during childhood, and OA of the knees in adulthood A complex splicing defect of exon and/or exon 10 in the COL9A1 gene has been identified in other families [59]...
- 9
- 403
- 0
Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
... arthritis dylarginine deiminase of involvement of hyaluronic of rheumatoid Proposed mechanism (PADI4) in the pathogenesis acid (HA) and peptidylarginine deiminase (PADI4) in the pathogenesis of rheumatoid ... antithrombin However, such binding did not stimulate the activity of antithrombin as did heparin and heparan; in fact, it blocked the ability of antithrombin to inhibit thrombin In the present study, the ... proteinase binding loop on the protein surface [19,20] Because the molecular structure of HA is analogous to that of heparin, HA might exert its effect by binding to the heparin-binding region of...
- 6
- 437
- 0
Báo cáo y học: "Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis" potx
... passages in vitro before being exposed to the immunoglobulins Consequently, the data suggest that the local stromal environment in the joint (and based on previous data from the group other organs ... determines the disease specific immune response Given the variety of signaling pathways initiated by IGF-1 in fibroblasts, it may be speculated, as the authors mention briefly, that binding of antibodies ... trigger the release of IL-16 in RASFs, the present research from Smith and Cruikshank extends the panel of signals involved in the regulation of IL-16 at least under pathologic conditions Although the...
- 3
- 222
- 0
Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf
... result in an increase in the gene expression of the aggrecanase ADAMTS4 in cells derived from degenerate NP In vivo, the NP contains the highest concentration of aggrecan in the IVD The response of ... observed on the other cell types (Fig 6d) Discussion In this study, we investigated whether in IVD degeneration there is local production of the cytokine IL-1 and whether IL-1 could induce the cellular ... immunopositivity was observed in the matrix of the IVDs or in blood vessels, with the exception of immunopositivity for ICE, which showed some staining in the matrix and blood vessels of the most degenerate...
- 14
- 403
- 0
Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... suggesting a more general mechanism of these receptors in inflammatory diseases Maintaining autoantibody titers through FcRn-mediated recycling One of the most striking characteristics of the K/B ... through the regulation of FcRs much like the instructive role of the innate immune system for the adaptive response [56] The production of autoantibodies as a result of the failure of the immune ... anaphylatoxin, acting through the C5aR, is a major regulator of the transcription of activating and inhibitory FcγRs in IC-induced lung disease C5a increased the expression of activating FcγRIII and...
- 7
- 476
- 0
Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc
... extravasate into the extracellular space Once in the vicinity of the synovium, the DPPIV activity would be able to initiate amino-terminal degradation of the increased levels of proinflammatory ... levels in SF may represent an increase in the presence of attractin Certainly, analysis of serum reveals an increase in attractin in RA patients with erosive disease, which is not observed in individuals ... presence of systemic activated T cells will lead to their continuous influx into the inflamed synovium, maintaining the inflammatory state This will lead to a continuous activation of synovial...
- 17
- 395
- 0
Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... adjacent to the developing joint space The arrowhead indicates the area from which the high-magnification micrograph was taken (inset) The arrowhead in the inset indicates COMP staining (f) At ... in the pericellular space (Figure 4a) In OA cartilage taken from the area adjacent to the main defect from patients in the late stages of OA, an increase in staining intensity was found in the ... especially in the pericellular matrix of cell clusters (Figure 3b, inset) With the help of light microscopic in situ hybridization, the mRNA for COMP was detected in the cytoplasm of chondrocytes of the...
- 10
- 480
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25