novel clinical trial designs in clinical pharmacology and experimental medicine

MULTIPLE MEDICAL REALITIES Patients and Healers in Biomedical, Alternative and Traditional Medicine_2 pot

... sit here and see the patients for ten-minute intervals doing Western medicine and then switch for two minutes into Chinese medicine' Dr Deakin does manage to a bit of Western medicine, Chinese diagnosis ... around her and so are developed in interaction with those other people and their own established ways of behaving, thinking and feeling These are in turn linked to general cultural ideas and practices ... Jeffrey and A Lyon 1989 Labour Pains and Labour Power: Women and Childbearing in India London: Zed Books Jeffery, P.M., R Jeffery and A Lyon 2002 'Contaminating States: Midwifery, Childbearing and...

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MULTIPLE MEDICAL REALITIES Patients and Healers in Biomedical, Alternative and Traditional Medicine_1 pot

Danh mục: Sức khỏe giới tính

... 'Pluralism and Integration in the Indian and Chinese Medical Systems', in A Kleinman (ed.) Medicine in Chinese Cultures Washington D.C.: U S Government Printing Office, 401-417 1976 'Introduction', in ... within biomedicine and in late-capitalist production, and as a dominant organising principle in various forms of praxis in Western culture In spite of limitations in studies of elective affinity ... in China; and biomedicine, Ayurvedic medicine and Un ani medicine in India; and to the fact that all of these traditions include major medical texts, educational institutions, and professionalised...

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2012 Postgraduate Courses in Public Health and Preventive Medicine potx

Danh mục: Sức khỏe trẻ em

... working in the area of women’s and children’s health, with a focus on adolescent sexual and reproductive health and increasing investment in family planning in the Pacific • Research interest in ... understanding & interpretation of common accounting reports, budgeting & financial analysis An introduction to basic economic theory relevant to clinicians & clinical managers, including funding ... issues in clinical research; sampling & inference; selecting items, reducing items & creating aggregate scores; inter-rater & intro-rater reliability & interval consistency of responses; assessing...

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Update in Intensive Care and Emergency Medicine - part 1 pdf

Danh mục: Sức khỏe giới tính

... These include endotoxins and polysaccharide binding proteins, cytokines, leukotrienes, clotting factors, C-reactive protein, histamine, uric acid, catecholamines, and procalcetonin, to name but a ... tissue ischemic injury in patients presenting in shock and attempts to rescue patients in shock following the development of the ischemic insult Finally, applying protocolized care in the management ... electrocardiogram and, echocardiography, end-tidal CO2, and urine flow together with measurements of sublingual PCO2 and metabolic measurements in blood, including lactate Invasive measurements, including...

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Update in Intensive Care and Emergency Medicine - part 2 ppt

Danh mục: Sức khỏe giới tính

... mucosa and serosa This decrease was accompanied by an increase in the intestinal PCO2 gap Administering fluids alone or together with SIN-1 increased flow and mucosal µPO2 to baseline levels SIN-1 ... prostacyclin when no further increase in DO2 could be obtained by volume resuscitation and dobutamine infusion Gastric intramucosal pH (pHi) improved after starting prostacyclin, suggesting an increase ... sepsis and regional and microcirculatory oxygen transport in experimental animals and recently in humans The NO donor SIN-1 has been used in endotoxic dogs, where it increased cardiac index and...

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Update in Intensive Care and Emergency Medicine - part 3 potx

Danh mục: Sức khỏe giới tính

... the increased oxygen demand due to the dobutamine, suggesting both an inadequacy of hemodynamics and/ or an inadequacy of mitochondrial function In fact, considering the dobutamine test as an ‘increased ... frequently measured variables in medicine and is obviously of great importance in detecting patients with clinical hypertension and monitoring their subsequent treatment However, in critically ill unstable ... (1993) Effects of norepinephrine, epinephrine, and dopamine infusions on oxygen consumption in volunteers Crit Care Med 21:1502–1508 54 Uusaro A, Hartikainen J, Parviainen M, Takala J (1995)...

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Update in Intensive Care and Emergency Medicine - part 5 doc

Danh mục: Sức khỏe giới tính

... during 170 A B J Groeneveld and J Verheij ALI/ARDS, caused by indirect injury, including sepsis, than caused by direct/inhalational injury, in man Indeed, Holm et al observed no EVLW elevation in ... pressure (PAOP) [14–18] Based on these findings, volumetric parameters are increasingly implemented in clinical routine and decision making However, as summarized in recent reviews, those volumetric ... volume and cardiac output continuously Integrating such a monitoring tool into the existing and accepted concepts such as pressureand volume-monitoring seems to be a promising way for new, physiology-directed...

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Update in Intensive Care and Emergency Medicine - part 6 ppsx

Danh mục: Sức khỏe giới tính

... Messmer K, Fink MP (eds) Update in Intensive Care and Emergency Medicine Vol 33: Tissue Oxygenation in Acute Medicine Springer-Verlag, Berlin, pp 128–137 56 VanderMeer TJ, Wang H, Fink MP (1995) ... flow Interestingly, these alterations are more severe in septic than in other insults [12,13] Endotoxin administration induces severe microcirculatory alterations, including severe arteriolar and ... PEEP and hepatic metabolic performance in septic shock Intensive Care Med 22:1274–1275 23 De Backer D, Creteur J, Silva E, Vincent JL (2003) Effects of dopamine, norepinephrine and epinephrine...

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Update in Intensive Care and Emergency Medicine - part 7 docx

Danh mục: Sức khỏe giới tính

... than cm in normovolemia and may be more than 1.5 cm in hypovolemia In spontaneously breathing patients, the interatrial septum moves during inspiratory and expiratory phases During the inspiratory ... flow using pulsed Doppler and analyzing tricuspid annulus movement using Doppler tissue imaging (DTI) More interestingly, in spontaneously breathing patients, the collapsibility index, defined ... During atrial contraction, the septum bulges into the left atrium In contrast, during systole the interatrial septum moves into the right atrium and at end-systole into the left atrium During...

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Applications of prolyl hydroxylase inhibitors in tissue engineering and regenerative medicine

Danh mục: Kỹ thuật - Công nghệ

... Tissue Engineering Applications 33 3.1 Introduction As explained in chapter 1, inadequate vascularization is a major bottleneck limiting widespread clinical applications of tissue engineering, and ... bonds, and evaluated its efficacy in stimulating angiogenic signaling and vascular infiltration This study is described in detail in the following chapter 32 Chapter Incorporation of a PHI into ... artificial tissue and organ replacements This is the field of tissue engineering, which has been defined as "an interdisciplinary field that applies the principles of engineering and the life sciences...

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Annual update in intensive care and emergency medicine 2016

Danh mục: Y - Dược

... Update in Intensive Care and Emergency Medicine 2016 The series Annual Update in Intensive Care and Emergency Medicine is the continuation of the series entitled Yearbook of Intensive Care Medicine ... Medicine in Europe and Intensive Care Medicine: Annual Update in the United States Jean-Louis Vincent Editor Annual Update in Intensive Care and Emergency Medicine 2016 Editor Prof Jean-Louis Vincent ... consisting of recognizing organ dysfunction, identifying the possible source, following the clinical picture, and taking PCT and PCT-kinetics into account, is necessary in order to correctly interpret...

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Báo cáo y học: "Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: Potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity" docx

Danh mục: Báo cáo khoa học

... with formalin and paraffin embedded by standard histological examination To assess gross tissue morphology, sections were stained with hematoxylin and eosin A vaginal irritation grading system ... irritation, leucocytes infiltration, vascular congestion and edeme, and vaginal irritation index obtained in three groups of New Zealand White rabbits traited vaginally during 10 days by low (1 ... inhibit the entry of HIV-1 into T cells and may limit the reverse transcription step into macrophages and DC These findings indicate that C14 harbours potent HIV-1 entry inhibition activity and/ ...

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báo cáo khoa học:" Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer : a randomised, controlled clinical trial" pot

Danh mục: Báo cáo khoa học

... stress and lipid peroxidation [38] Iron is also required for collagen synthesis by enzymes in hydroxylation of proline and lysine This hydroxylation of proline and lysine is catalyzed by proline ... peroxidase, type I iodothyronine deiodinase, metalloprotein, fatty acid binding protein and selenoprotein P therefore selenium is considered as an antioxidant nutrient and the diseases where low ... concept and design, Clinical sample and data collection, Analysis and interpretation of data, Drafting of manuscript 21 22 Dr Freny Karjodkar-Critical revision of manuscript, Administrative and material...

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Báo cáo y học: "Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case" docx

Danh mục: Báo cáo khoa học

... isoleucine or valine in the YMDD motif results in a sterical hindrance, preventing lamivudine from appropriately configuring into the nucleotide binding site of the reverse transcriptase [12], and ... performed parts of the cloning and analyzed the sequencing data SZ established and performed PCRs and was involved in sequencing RLT was involved in cloning and sequencing OS supervised the study, ... both termini and in silico translated into their amino acid sequences (figure 3) The patient had virus variants containing a mutation resulting in a substitution of leucine to methionine at position...

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Báo cáo y học: " Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection" ppt

Danh mục: Báo cáo khoa học

... neuroprotective in in vitro and in vivo brain injury models [40] Following the discovery that xenon inhibits NMDA receptors, it was shown that xenon could protect neuronal cell cultures against injury induced ... for the binding of the co-agonist glycine at the glycine site on the NMDA receptor (Figure 2a) Based on protein crystallographic data, the binding of glycine is proposed to result in domain closure ... general anesthetics to proteins increases at lower temperatures due to favorable enthalpic interactions, and this increase in binding correlates with the increase in general anesthetic potency...

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Tài liệu Clinical Physiology and Pharmacology The Essentials ppt

Danh mục: Sức khỏe giới tính

... important topics and improve both your skills and conﬁdence in problem-solving Since the information is placed in a realistic setting, your recall of key facts and concepts in physiology and pharmacology ... • continue to develop your problem-solving skills Using This Book Clinical Physiology and Pharmacology is written primarily for undergraduate students studying modules in physiology and pharmacology ... understanding of many types of biological and clinical factors They are intended to help you prepare for problems associated with clinical physiology and pharmacology that you may meet both in formal...

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Tài liệu NEW ADVANCES IN THE BASIC AND CLINICAL GASTROENTEROLOGY docx

Danh mục: Sức khỏe giới tính

... tract infections (RTI) Two studies have examined the effect in adults of a combined multi-strain probiotic and multivitamin/mineral supplement containing L gasseri, B longum and B bifidum on the incidence, ... factors Nonetheless, clinical trials with products containing both lactobacilli and bifidobacteria have demonstrated the safety of these probiotics in infants and children, and in a recent study, ... can alter the intestinal microflora and reduce the growth of pathogenic microorganisms in the intestines of preterm infants, decreasing the incidence of necrotizing enterocolitis and sepsis Moreover,...

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Tài liệu Clinical presentation and outcome of patients diagnosed with active pulmonary tuberculosis in a large critical care unit docx

Danh mục: Sức khỏe giới tính

... observed to be more sensitive than staining in 69% of total aspirates, including cases that were found negative with gram staining Cultures are more specific in diagnosing early stage tuberculosis (21) ... were clinically assessed by the physician present in the ICU at the time of admission Symptoms are summarized in Table Treatment was initiated on the basis of the clinical diagnosis made during ... diagnosed on the bases of clinical judgement only Using our standard ICU database, microbiology laboratory records and other referenced documents, patient related information and relevant data were...

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Tài liệu Clinical Physiology and Pharmacology The Essentials docx

Danh mục: Sức khỏe giới tính

... important topics and improve both your skills and conﬁdence in problem-solving Since the information is placed in a realistic setting, your recall of key facts and concepts in physiology and pharmacology ... • continue to develop your problem-solving skills Using This Book Clinical Physiology and Pharmacology is written primarily for undergraduate students studying modules in physiology and pharmacology ... understanding of many types of biological and clinical factors They are intended to help you prepare for problems associated with clinical physiology and pharmacology that you may meet both in formal...

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Toxicology and Clinical Pharmacology of Herbal Products pdf

Danh mục: Sức khỏe giới tính

... Page i Toxicology and Clinical Pharmacology of Herbal Products Page ii Forensic Science and Medicine Steven B Karch, MD, SERIES EDITOR TOXICOLOGY AND CLINICAL PHARMACOLOGY OF HERBAL PRODUCTS, ... Cataloging in Publication Data Toxicology and clinical pharmacology of herbal products / edited by Melanie Johns Cupp p ; cm.—(Forensic science and medicine) Includes bibliographical references and ... accurate and in accord with the standards accepted at the time of publication Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to...

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