neuropathology of brain injury in cardiac surgery
Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot
... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... focused on those molecular markers of brain injury which were positively associated with a decrease in neuroserpin levels
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báo cáo hóa học:" Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pdf
... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... focused on those molecular markers of brain injury which were positively associated with a decrease in neuroserpin levels
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Báo cáo khoa học: "Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury" potx
... pre-existing lung injury in most patients with ALI 10 11 12 Key messages • Biological markers of lung injury are elevated in spontaneously ventilating patients with ALI 13 • Intubation and institution ... not increase In fact, the level of IL-8 was significantly lower at the later time point Thus, the institution of a low tidal volume strategy in patients with ALI may not worsen lung injury in ... acceptance of the null hypothesis, namely that the institution of positive pressure ventilation is not associated with an increase in biomarkers of lung injury The total number of patients in this...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"
... prognosis of severe traumatic brain injury, part 1: Guidelines for the management of severe traumatic brain injury J Neurotrauma 2000;17:451-533 Piek J Decompressive surgery in the treatment of traumatic ... References 10 11 12 13 14 15 16 17 18 Timofeev I., Hutchinson PJ Outcome after surgical decompression of severe traumatic brain injury Injury 2006;37:1125-1132 Coplin WM Intracranial pressure and surgical ... in ischemic necrosis of the portion of the herniated brain Coskay et al introduced an interesting method called the “vascular tunnel” to avoid this complication.33 Following removal of part of...
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awareness of deficit after brain injury clinical and theoretical issues jan 1991
... AWARENESS OF DEFICIT AFTER BRAIN INJURY Figure 1-7 Edwin A Weinstein, (Courtesy of Dr Edwin Weinstein.) M.D obtained—material which is new to the self-observer—it is possible to achieve the interpretation ... Awareness of Deficit After Brain Injury This page intentionally left blank Awareness of Deficit After Brain Injury Clinical and Theoretical Issues Edited by GEORGE P PRIGATANO Barrow Neurological Institute ... discussion of propositional attitudes in Dennett (1986) 34 AWARENESS OF DEFICIT AFTER BRAIN INJURY phrenia are something that the simplistic model outlined in the preceding section is insufficiently...
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Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt
... only in the field of motor domain [47] but also in those processes involving perceptual learning [48] and cognitive recovery [49] According to these principles, the greatest effects of training in ... a mean chronicity of 570.9 ± 313.2 days Etiology of acquired brain injury in this group of patients included severe traumatic brain injury (TBI) (n = 3), ischemic or hemorrhagic stroke (n = 11), ... ± 283.11 478.00 ± 324.77 Time since injury (days) NS (p = 0.204) The table shows the information of the patients Age and time since injury are defined in terms of mean and standard deviation...
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báo cáo hóa học: "Usability of a virtual reality environment simulating an automated teller machine for assessing and training persons with acquired brain injury" pdf
... validity of the Cantonese version of Mini-Mental State Examination: A preliminary study J Hong Kong College of Psychiatry 2004, 4:25-28 Brain Injury Association of America: Facts about traumatic brain ... functioning in problem-solving in clients with ABI, which might then be incorporated into the various stages of problem-solving skills training and then transferred to problem-solving performance in ... RC, Lofgren E, Wallergard M, Linden A, Boschian K, Minor U, Sonesson B, Johansson G: Three applications of virtual reality for brain injury rehabilitation of daily tasks In Proceedings of the...
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báo cáo hóa học: " Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice" pot
... protein y, IgG1-linked murine recombinant fusion protein; MBP, mannose-binding protein; rVCP, recombinant Vaccinia virus complement control protein; sCR1, soluble complement receptor type Page of ... stainings of serial coronal cryosections (8 µm) of brain tissue were performed using a biotin/avidin/peroxidase technique with diaminobenzidine tetrahydrochloride as chromogen (Vector, Burlingame, ... traumatic brain injury The assessment of intracerebral cell death by TUNEL histochemistry revealed a dramatic increase in TUNEL-positive neurons in the injured left hemispheres of PBSinjected...
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báo cáo hóa học: " Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease" pdf
... address the degree of sensitivity of the midbrain to air pollution, we measured the effects of DE inhalation on multiple other pro-inflammatory factors, including cytokines and chemokines Data reveal ... Synuclein protein levels were measured in the midbrain by western blot An * indicates significant difference (p < 0.05) from control animals DE elevated a synuclein protein levels in the midbrain ... hypothesized point of entry of PM in the brain) ; the frontal lobe (damaged in AD and Frontaltemporal lobe dementia); the temporal lobe (damaged in AD and Frontaltemporal lobe dementia); the midbrain (damaged...
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báo cáo hóa học: " Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation" doc
... contribute to the loss of BBB integrity [2] One important common determinant of increased paracellular permeability is brain inflammation Because brain inflammation occurs in a phasic manner, water ... using the VectaShield mounting medium (Vector Laboratories) For all immunostaining experiments, the staining specificity was examined by omitting the primary antibody during the corresponding incubation ... internal capsule of LPC rats (nor in the sham group), consistent with a previous focal infectious/inflammatory model of brain abscess that displayed AQP4 modification only in a ring surrounding...
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báo cáo hóa học: " Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression" docx
... the brain (A) Brain levels of the pro-inflammatory prostaglandin PGE2 (B), the anti-inflammatory one 15d-PGJ2 (C), and interleukin-1b (IL-1b) mRNA levels in control and after CMS in the brain ... of LPS and can activate brain TLR-4 inducing a neuroinflammatory response In order to clarify the origin of stress-induced activation of the TLR-4 pathway in CMS, we studied LPS and its binding ... loss and number of fecal boli were increased in CMS (Figure 7B&7C) However, in spite of the anti-inflammatory effects demonstrated in the brain by the antibiotic intestinal decontamination protocol...
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báo cáo hóa học: " Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues" pdf
... surrounding the infarct (Figure 2B) IgG cannot cross an intact blood brain barrier (BBB) and its presence in the brain parenchyma indicates BBB disruption and injury [9] Staining of coronal brain ... mediator of the sterile inflammatory response Findings Inflammation is recognised as a major contributor to the worsening of acute brain injury [1] In particular two pro-inflammatory members of the ... IL-1 isoform in mediating the early inflammatory period following ischemic brain injury This is consistent with recent discoveries highlighting the earlier appearance of IL-1α in sterile inflammatory...
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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx
... alternative of treatment in stroke-induced brain edema remains to be elucidated The lack of efficacious treatment so far for stroke-induced brain edema makes our hypothesis Int J Med Sci 2008, worthy of ... for us In conclusion, our work adds something new to the understanding of the elevation of CRP and NT-PBNP in the acute phase of stroke both CRP and NT-PBNP are markers of brain edema in stroke ... role of ANP in regulating blood flow in the infarcted area was studied in stroke patients and a statistically significant increase in the number of ANP-immunoreactive astrocytes was found in the...
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Theory of Brain Function quantum mechanics and superstrings - part 4 ppt
... basically of two cylinders of nine triplets of MTs each, forming a kind of separated T At some point, each of the two cylinders in the centriole grows another, each apparently dragging a bundle of MTs ... their eyes, neurons in their visual cortex begin producing vast quantities of tubulin [67] Selective dysfunction of animal brain MTs by the drug colchicine causes defects in learning and memory which ... β tubulins are rather complex, providing a varying primary tubulin structure, e.g., at least 17 different β-tubulins can exist in mammalian brain MTs, one easily sees that the number of different...
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Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus ppt
... the injuryinduced decrease in expression (M = 74.93) [F(3,9) = 14.907, p < 01], indicating DZ decreased α3 expression, regardless of injury condition DZ normalized γ2 injuryinduced decreases in ... phosphorylation of subunit proteins Increases in glutamate after injury trigger VGCC and NMDA receptors, increasing [Ca2+]i, and resulting in activation of CaMKII A single dose of DZ can downregulate ... subunits in the brain typically form a limited number of receptor combinations [23] Reportedly, the following subunits combine to form nearly 80% of the GABAAR combinations in the rat brain: α1-3,...
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Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc
... PiT1-binding immunoadhesin generated by fusing the aminoterminal residues of the GALV (SEATO strain) Env, comprising the signal peptide, the RBD and the proline-rich region, to the rFc tag, herein, ... detection of GLUT1 by immunoblotting performed in rats has previously shown that GLUT1 is expressed in all brain regions but in less abundance in the striatum, the thalamus and the brainstem [24] In ... any PiT2 staining The arrow points at a characteristic stained nigral cell as shown in the inset (magnification x300) D: PiT2 immunostaining in the cerebellum of a normal mouse Purkinje cells...
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Textbook of Traumatic Brain Injury - part 1 ppt
... high of 618 per 100,000 population in a United States national survey (Sosin et al 1996) Caution must be taken TEXTBOOK OF TRAUMATIC BRAIN INJURY in interpreting these findings because brain injury ... literature is inconclusive with regard to the long-term effects in patients with short-time 28 TABLE 2–1 brain injury TEXTBOOK OF TRAUMATIC BRAIN INJURY Classification of traumatic TABLE 2–3 brain injury ... result of brain injury, and Pilz (1980), who described the occurrence of axonal swellings in human brain injuries of vary- 36 ing severity Further support for the concept of varying degrees of TAI...
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Textbook of Traumatic Brain Injury - part 2 potx
... lightning-related injuries Another important and increasingly common kind of brain injury occurs as a complication of coronary artery bypass surgery This kind of diffuse brain injury is believed to result, in ... hemorrhage in traumatic brain injury: preliminary findings Brain Inj 8:489–500, 1994 35 Levine B, Cabeza R, McIntosh AR, et al: Functional reorganisation of memory after traumatic brain injury: a ... helpful in assessment of extent of brain injury and in following the medical sequelae of traumatic brain injury (TBI), such as edema, intracranial bleeding, and degeneration With improvements in technology,...
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Textbook of Traumatic Brain Injury - part 3 pot
... “Depression Following Traumatic Brain Injury: A year Longitudinal Study.” Journal of Affective Disorders 27:233–243, 1993 lower socioeconomic classes in their 30s The principal cause of brain injury was ... with 175 176 TEXTBOOK OF TRAUMATIC BRAIN INJURY F I G U R E – Comparing physiatric and neuropsychiatric terminology for post–traumatic brain injury (TBI) changes in level of consciousness and ... that ongoing EP assessments in the acute and postacute injury period TEXTBOOK OF TRAUMATIC BRAIN INJURY may improve early recognition of worsening cerebral dysfunction, thereby facilitating the...
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