levodopa induced vesicular release of glutamate and mechanisms of levodopa induced neurotoxicity in primary neuron cultures in rat striata
Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... LPS/IFN -induced NO production in VSMC The addition of LPS induced small, but significant NO production, but additions of both LPS and IFN induced detectably high levels of NO in VSMC As shown in Fig ... the enhancing effect of TS on LPS/IFN -induced NO production is caused by enhancement of iNOS protein induction Effects of a-T and its derivatives on the enhancement by TS of LPS/IFN -induced NO ... described in Fig In this study, to obtain information about the mode of actions of TS, we examined the effect of TS on LPS/IFNinduced NO production in VSMC We found that TS activated LPS/IFN-induced...
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Studies on the mechanisms of the beneficial effects of herba leonuri and leonurine on traumatic brain injury in rat
... impact, resulting in diffuse brain injury (Foda and Marmarou, 1994; Marmarou et al., 1994) Depending on the severity of injury, the induced brain injury results in hemorrhages, neuronal cell ... Pathophysiology of TBI Primary and Secondary Injury After TBI, the damage of brain tissue can be caused by primary and secondary injury mechanisms The primary injury refers to the direct effects of mechanical ... showing elimination rate of DPPH radicals against concentration of test compound used at different time points The graph for positive control VC in (a), pHL in (b) and Leo in (c) xix List of Publications...
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Báo cáo khoa học: Docosahexaenoic acid stabilizes soluble amyloid-b protofibrils and sustains amyloid-b-induced neurotoxicity in vitro ppt
... charges; in the case of Ab, the arginine at position 5, and the lysines at positions 16 and 28 Interestingly, the formation of fibrils by association of protofilaments has been proposed to involve ... cell toxicity To examine the effect of DHA on Ab -induced neurotoxicity in a neuronal cell model, we set up a kinetic toxicity study, using PC12 cells Ab42wt and Ab42Arc were incubated with or without ... peptides were incubated overnight with different concentrations of DHA, a concentration of DHA shown not to stabilize protofibrils (i.e lm) did not maintain Ab42wt -induced toxicity Ab42Arc -induced toxicity...
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Báo cáo y học: " Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages" docx
... propagation of various strains of HIV-1 The efficiency of the early steps of infection, including reverse transcription, nuclear import, and integration in macrophages and T cells of Sprague-Dawley rats ... Figure Infectivity of HIV-1 produced in rat and human cells Infectivity of HIV-1 produced in rat and human cells The medium [containing 50 or 500 pg of p24] from the various cell types electroporated ... the expression of the human p32 protein [23] In this study, we investigated the effect of human CyclinT1 and CRM1 expressed in rat T cells and macrophages, including primary cells, in order to identify...
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Báo cáo y học: "Release of extraction-resistant mRNA in stationary phase Saccharomyces cerevisiae produces a massive increase in transcript abundance in response to stress" ppt
... concentration of 40 µM, and used to print the slides During printing, the relative humidity was maintained between 50% and 52% and the ambient temperature was maintained between 21°C and 23°C ... including NTG1 [23], DNA2 [24], DIN7 [25], were also in this group Group (474 transcripts) increased by the first time point and began to decrease within two to To determine the rate of the initial ... results that there are coordinated changes in the abundance of transcripts encoding proteins with a variety of functions, including ribosome processing and biogenesis and response to stress, especially...
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An experimental study of temperatures in cloud from release of flashing liquid CO2 in 3m long channel
... time and vaporize into gas in atmospheric pressure Figure 10 Picture of formation of dry ice Temperature of CO2 cloud increases with increasing distance of release from the nozzle The reason behind ... be in increasing with increase of the distance from the nozzle The temperature of the cloud and dry ice is found to be constant at specific point and over time which also helped understanding ... scenarios of liquid CO2 The major goal of this paper is to ensure and include: • Released liquid CO2 includes phase transition into mixture of gas and solid with formation of dry ice • Froude Scaling...
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A proteomics study of chemically induced cirrhosis in rat liver revealed the mechanism of thioacelamide hepatotoxicity 3
... experimental rat livers (Figures 3-2 and 3-3) In fibrotic and cirrhotic livers, total collagen is increased up to eight fold, mainly because of collagen type I deposits (Rojkind et al., 1982) and the primary ... small uniform acinar or subacinar nodules in micronodular types and in lobular and plurilobular large nonuniform nodules in macronodular forms Regenerative nodules develop in the midst of scars but ... measured in optical densities (O.D.s) σx is the standard deviation of the Gaussian distribution of the spot in the direction of the x axis, and σy is the standard deviation in the direction of the...
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A proteomics study of chemically induced cirrhosis in rat liver revealed the mechanism of thioacelamide hepatotoxicity 4
... discussion Oral administration and intraperitoneal injection of TAA are both established methods in the generation of fibrosis and cirrhosis models of animals, particularly in the rats We adopted ... sweating, shedding of cells and bleeding Liver is the major storage site of iron and it is mainly stored in the forms of ferritin or hemosiderin (Ward et al., 1994; Crichton et al., 1992) Ferritin ... data in the differential expression of proteins in TAA -induced liver cirrhosis in rat livers, thus suggesting some important points regarding its mechanism, I think that there are certain aspects...
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A proteomics study of chemically induced cirrhosis in rat liver revealed the mechanism of thioacelamide hepatotoxicity 2
... during storage so just before injection, TAA was redissolved by stirring with a magnetic stirrer 2.2.3 Administration of TAA TAA was administered to the rats via intraperitoneal injection Each rat ... with 20 µl of solution containing 55 mM IAA/100 mM NH4HCO3 and incubated in the dark, at room temperature for 45 min, with occasional vortexing Then, the liquid phase was aspirated and the gel ... porcine trypsin auto-digest peptides (842.5090 Da and 2211.1040 Da [M+H+] ions) were set as internal calibration standards 2.8.8 Baseline correction, noise filtering, calibration and deisotoping...
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A proteomics study of chemically induced cirrhosis in rat liver revealed the mechanism of thioacelamide hepatotoxicity 1
... nature of proteomics approach, unexpected or novel findings can be obtained Table 1-1 Outline of our strategy in the study of global protein profiles of TAA administered Wister-Furth rat livers ... factors, transforming growth factor-β (TGF-β) and insulin growth factor (IGF)-binding proteins and synthesize other cytokines that interact with all types of neighbouring cells, including hepatocytes ... glycoproteins such as laminin, fibronectin, entactin and elastin Laminin, being produced by HSCs and the endothelial cells, is a glycoprotein that promotes cell adhesion, migration, differentiation, and...
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Báo cáo khoa học: "Alteration of nitrergic neuromuscular transmission as a result of acute experimental colitis in rat" pot
... fo erac lamina rof senilediug eht htiw ecnadrocca ni demrofrep saw yduts ehT o yrdnabsuh dna slaminA WB gk/gm 57 fo esod a ta stibbar elirbef dna yhtlaeh ot ylralucsumartni deretsinimda saw dna ... gurd eht gniretsinimda eb yletaidemmi dehgiew yllaudividni erew slamina ehT :1 esahP :sesahp gniwollof eht fo desirpmoc yduts ehT locotorp latnemirepxE skeew fo doirep tuohsaw muminim a gnivresbo ... raenil saw amsalp ni emipefec rof evruc dradnats ehT sisylana citenikocamrahP etis noitcejni eht ta trofmocsid laminim ylno dna niap dlim ot enon decneirepxe slamina tsoM yduts eht tuohguorht...
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A metabolomics approach to understand mechanism of heat stress response in rat
... heatstroke -induced cerebral ischemia and neuronal damage in rats The survival of such animals can be increased by inhibition of IL-1 receptors or monoamine system in brain as well as by induction of ... concentrations of insulin and cortisol, increased sera levels of insulin-like growth factor I and immunoglobulin G, and enhanced the lymphoproliferative response and phagocytic activity of peritoneal ... the cellular physiology of stress requires an integrative approach that includes understanding the function and interactions of all of the involved elements, proteins and others 2.1.6 Heat stress...
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Investigation of the pathogenesis caused by exposure to varying doses of VX nerve agent in rat with special reference to cardiotoxicity
... mononuclear cellular infiltration, myofibre degeneration and necrosis in all of the VX-challenged rats However, morphological changes in other organs were minimal In the group of rats that received ... distribution of acetylcholinesterase, at both nicotinic and muscarinic receptors throughout the PNS and CNS, can result in a variety of signs and symptoms of poisoning Inhibition of AChE may not ... manifestations of nerve agent poisoning are the nicotinic signs of intoxication However, concurrent nicotinic and muscarinic signs and symptoms are often present in both the PNS and CNS In the later...
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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot
... importance of STAT1 and IRF-1 in the inhibitory action of IFN-γ, the percentage of inhibition of the expression of GCP-2, RANKL and IL-6 mRNA induced by synergistic action of IL-17 and TNF-α was ... accelerated and more severe form of CIA [30] Events contributing to this protective effect of IFN-γ in CIA are inhibition of the CFA -induced myelopoiesis and osteoclastogenesis, inhibition of the ... cytokine by expanding myeloid progenitors and initiating proliferation of mature neutrophils [42] It has been described to induce the secretion of hematopoietic cytokines such as IL-6 and G-CSF in...
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báo cáo khoa học: " Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets" ppsx
... combined effects of sucrose and atrazine This strongly suggested important interactions of sucrose and xenobiotic signalling or of sucrose and ROS signalling, thus resulting in induction of specific ... of sucrose -induced tolerance was characterised by the lifting of atrazine repression, in the case of APX1 and sAPX, or by the induction by sucrose-atrazine combination, in the case of http://www.biomedcentral.com/1471-2229/9/28 ... family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin family protein Thioredoxin H-type (TRX-H-3) (GIF1) Thioredoxin family protein No classification...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
... importance of Fas and FasL [15], and that of TNF-R1 and TNF-α[16], in preeclampsia Thus, hypoxia -induced changes in the expression of both proapoptotic and antiapoptotic proteins, and 43 the balance of ... many proteins involved in apoptosis, including the expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis ... of protein changes for the experimental sample to control detected by using the Odyssey Infrared Imaging System (+) means an increase of signal intensity, and (-) means a decrease of signal intensity...
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Release of anti-cyanobacterial allelochemicals from aquatic and terrestrial plants applicable for artificial floating islands
... The state -of- the-art of the artificial floating islands Civil Engineering Journal, 41(7), 26-27 (in Japanese) Nakai, S., Y Inoue, M Hosomi, and A Murakami (1999) Growth inhibition of bluegreen ... anti-cyanobacterial activities of the plant extracts These findings indicates the possible release of anti-cyanobacterial compounds from vegetation in artificial floating islands, and such allelopathic ... elution using ml of methanol, 10 µL of the methanol eluent was added to 10 ml of CB medium (Watanabe and Satake, 1991) in a test tube, and after that M aeruginosa - 56 - Journal of Water and Environment...
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Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx
... gradient of 5–50% solvent B in 60 min, linear gradient of 50–100% solvent B in min, maintenance at 100% solvent B for min, and linear gradient of 100–5% solvent B in The column was maintained at ... PQGKAG containing a P1¢ Lys with the MMP-9 binding site (C) Interaction of the peptide substrate PQGKAG containing a P1¢ Lys with the MMP-12 binding site A aliphatic and ⁄ or hydrophobic amino acids ... tropoelastin isoform 2; Fig 1), PQGLAG, and PQGKAG were generated by taking the coordinates of the prodomain (YPFALAPT, residues 96–103) of the crystallized proform of MMP-9 (1lj6.pdb) and the coordinates...
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Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
... Akt and ERK insulin signaling pathways and inhibits distal effects of insulin on glycogen and DNA synthesis [6–9], and microinjection of Grb14 into Xenopus laevis oocytes inhibits insulin -induced ... livers of rats studied at the indicated time points after injection of 30 lg of insulin (four to six rats per time point) (A), or studied after injection of the indicated dose of insulin (two rats ... Desbuquois et al Insulin -induced translocation of Grb14 in rat liver A H N B M LP S PM GE –ins Grb14 – ins Grb14 + ins –ins + ins + ins – ins EEA1 + ins Na+K+ATPase Calnexin + ins number: 10 11...
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