involvement of hypoxia inducible factor 1 in physiological and pathological responses to continuous and intermittent hypoxia role of reactive oxygen species
Báo cáo y học: "Understanding the roles of the transcription factors nuclear κ α factor-κB and hypoxia-inducible factor-1α in lung injury" pptx
... Hypoxia- inducible factor- 1 : role in hypoxaemia-initiated lung injury The master regulatory element of hypoxic conditions and adapting oxidative stresses to gene expression is HIF -1 [8 10 ] HIF -1 consists ... transcription factors in the regulation of oxidant-mediated α lung injury: role for hypoxia- inducible factor- 1 Crit Care 2003, 7 :in press Fein AM, Calalang-Colucci MG Acute lung injury and acute respiratory ... transcription factors in the regulation of oxidant-mediated κ lung injury: role for nuclear factor- κB Crit Care 2002, 6:4 814 90 10 11 12 13 Haddad JJ: Basic science review: Redox and oxygen- sensitive...
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báo cáo hóa học: " Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" pdf
... http://www.jneuroinflammation.com/content/4 /1/ 12 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Semenza GL: Hypoxia- inducible factor and the molecular physiology of oxygen homeostasis J Lab Clin Med 19 98, 13 1:207- 214 ... that hypoxia- stimulated IL -1 expression in astrocytes is mediated by hypoxia- inducible factor- 1 (HIF -1 ) [11 ] Hypoxia- inducible factor- 1 (HIF -1) is a transcription factor that plays a central role ... Characterization of hypoxia- inducible factor and regulation of DNA binding activity by hypoxia J Biol Chem 19 93, 268: 513 - 518 Wang GL, Semenza GL: Purification and characterization of hypoxia- inducible factor...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... sensing Curr Opin Cell Biol 20 01, 13 :16 7 -17 1 Semenza GL: HIF -1 and human disease: one highly involved factor Genes Dev 2000, 14 :19 83 -19 91 Semenza GL: Involvement of hypoxia- inducible factor in ... Normoxic α induction of the hypoxia- inducible factor 1 by insulin and β interleukin -1 involves the phosphatidylinositol 3-kinase pathway FEBS Lett 2002, 512 :15 7 -16 2 Haddad JJ, Land SC: A non-hypoxic, ... overview of the potential signaling pathways involved in cytokine-mediated regulation of hypoxia- induced hypoxia- inducible factor- 1 (HIF -1 ) translocation and activation Hypoxia and inflammatory...
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Báo cáo khoa học: Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions docx
... Immunofluorescence 10 CTL Echinomycin concentration (nM) normoxia B echinomycin (nM) 10 hypoxia 10 Sp1 -tubulin Fig Effect of echinomycin on Sp1 activity and protein level HepG2 cells were incubated for 16 h ... S & Harris AL (2002) 14 15 16 17 18 19 20 Hypoxia- inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected ... drug targeting hypoxia- inducible factor J Natl Cancer Inst 95, 516 –525 Formica JV & Waring MJ (19 83) Effect of phosphate and amino acids on echinomycin biosynthesis by Streptomyces echinatus Antimicrob...
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Báo cáo khoa học: Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1a ppt
... number of proinflammatory cytokines, such as TNF-a, interleukins, lipopolysaccharide, and reactive oxygen ⁄ nitrogen species [15 ] In terms of mechanisms underlying HIF1a induction by in ammatory ... Semenza GL (19 95) Purification and characterization of hypoxia- inducible factor J Biol Chem 270, 12 30 12 37 Ke Q & Costa M (2006) Hypoxia- inducible factor- 1 (HIF -1) Mol Pharmacol 70, 14 69 14 80 Schofield ... hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia- inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) Proc Natl Acad Sci USA 10 3, 14 767 14 772 11 Pouysse¢gur...
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Báo cáo y học: "α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis" pps
... 5±7 58 ± 10 73 ± 18 0. 01 68 ± 23 66 ± 11 % bcl-2 – Osteoarthritis Standard MVD 0. 71 Activated MVD 15 ± 18 ± 0. 01 16 ± 17 ± 0.46 % PD-ECGF lin cells 51 ± 14 68 ± 21 0. 01 55 ± 18 66 ± 21 0 .14 % PD-ECGF ... C/activator protein -1 complex-dependent and hypoxia- inducible factor 1- independent signaling pathway J Biol Chem 2000, 275:27874-2782 43 Matsumoto K, Kanmatsuse K: Interleukin -18 and interleukin -12 ... HIF -1 Negative 16 0 Low 10 13 High 12 21 Negative 18 0 Low 14 High 14 20
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Báo cáo y học: "Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture" ppsx
... (post-normalization to β-actin) in 20% oxygen in monolayer culture of meniscus cells in the presence and absence of the hypoxia inducible factor- 1 inhibitor YC -1 Data are expressed as mean ± standard deviation ... Hypoxia- inducible factor 1: oxygen homeostasis and disease pathophysiology Trends Mol Med 20 01, 7:345-350 47 Semenza GL: HIF -1 and mechanisms of hypoxia sensing Curr Opin Cell Biol 20 01, 13 :16 7 -17 1 ... objective of the current investigation was to determine whether hypoxia inducible factor (HIF) -1 and downstream target genes that are involved in the adaptive response of cells and tissues to low oxygen...
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Báo cáo y học: "Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints" potx
... Debatin KM: Role of hypoxia inducible factor- 1 alpha in modulation of apoptosis resistance Oncogene 2007, 26:2027-2038 Loor G, Schumacker PT: Role of hypoxia- inducible factor in cell survival during ... Obberghen E: Regulation of hypoxia- inducible factor (HIF) -1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I Mol Endocrinol 2005, 19 :13 04 -13 17 Yudoh K, Nakamura ... of inflammatory cytokines (a) to (d) Administration of 2ME2 (10 μM) or of dimethyloxaloylglycine (DMOG) (1 mM) did not induce inflammation or fibrosis of synovial tissue A slight thickening of...
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Báo cáo y học: "Hypoxia-inducible factor-1 a/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling" pps
... et al Respiratory Research 2 011 , 12 :10 3 http://respiratory-research.com/content /12 /1/ 103 Page 10 of 14 Figure Involvement of oxidative stress in gp -12 0 mediated PDGF-BB induction in pulmonary ... lesions in SHIV-nef-infected macaques Am J Respir Crit Care Med 2006, 17 4(4):437-445 Mermis et al Respiratory Research 2 011 , 12 :10 3 http://respiratory-research.com/content /12 /1/ 103 10 11 12 13 14 15 ... Am J Hypertens 19 97, 10 (10 Pt 1) :11 17 -11 24 Ghofrani HA, Seeger W, Grimminger F: Imatinib for the treatment of pulmonary arterial hypertension N Engl J Med 2005, 353 (13 ) :14 12 -14 13 Patterson KC,...
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Báo cáo khoa học: Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1⁄TSC2 in C2C12 myotubes pptx
... 3, 10 09 10 13 Jacinto E & Hall MN (2003) Tor signalling in bugs, brain and brawn Nat Rev Mol Cell Biol 4, 11 7 12 6 Frost RA & Lang CH (2007) Protein kinase B ⁄ Akt: a nexus of growth factor and ... Plasmids pcDNA3 .1- myc-TSC1 (12 133), pcDNA3-Flag-TSC2 (14 129), pcDNA3-Flag-TSC2-S939A (14 132), pcDNA3Flag-TSC2-T1462A (14 130) and pGEX-2TK -14 -3-3 beta FEBS Journal 277 (2 010 ) 218 0– 219 1 ª 2 010 The Authors ... activity of the TSC1 ⁄ TSC2 complex and Rheb Results and Discussion IGF -1- induced activation of mTOR signaling is prevented by PI3K inhibitor wortmannin and mTOR inhibitor rapamycin In the present...
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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc
... http://www.jnanobiotechnology.com/content/9 /1/ 36 Page of 14 Kim JH, Cho YH, Park YL, Sohn JH, Kim HS: Prognostic significance of insulin growth factor- I receptor and insulin growth factor binding protein-3 expression in primary ... Group: Insulin-like growth factor (IGF1), IGF binding protein (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies Lancet Oncol 2 010 , 11 :530-542 Henningson ... doi :10 .11 86 /14 77- 315 5-9-36 Cite this article as: Jones et al.: Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring InsulinLike Growth Factor- 1 in a Preclinical...
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Báo cáo y học: "RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro" pps
... models of inflammation-induced arthritis [11 -14 ] and to preserve joint architecture in a recent clinical trial [15 ] However, the effectiveness of BPs at preventing joint destruction in other clinical ... tibiae and femorae of adult male C57BL/6 mice and cultured in -MEM containing 10 0 U/mL penicillin, 10 0 g/mL streptomycin, mM glutamine, 10 % FCS, and 10 0 ng/mL murine M-CSF (R&D Systems, Inc.) ... in osteoclasts for continual protein synthesis to prevent apoptosis [ 41, 45] Together, these observations indicate that Mcl -1 plays an important role in maintaining osteoclast survival Mcl -1 inhibits...
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Báo cáo y học: " Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo" pptx
... WR1065 5000 4000 3000 2000 10 00 11 13 15 17 19 Days in culture SIV p27 (pg/ml) B - 642 45000 40000 35000 30000 25000 20000 15 000 10 000 5000 No WR1065 9.5 uM WR1065 18 .7 uM WR1065 11 13 15 17 19 ... challenge of finding a cure for HIV infection Science 2009, 323(5 919 ) :13 04 -13 07 Page of 10 (page number not for citation purposes) AIDS Research and Therapy 2009, 6:24 10 11 12 13 14 15 16 17 18 19 ... were assayed using the p27 Antigen Assay kit (Beckman Coulter, Fullerton, CA) on days 3, 7, 10 , 14 and 17 Results Anti-HIV -1 activity and cytotoxicity of WR1065 in human TCBs In HIV -1- infected human...
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Báo cáo y học: " Expression and function of human hemokinin-1 in human and guinea pig airways" pdf
... mainly through NK1 receptor stimulation and to a minor extent Grassin-Delyle et al Respiratory Research 2 010 , 11 :13 9 http://respiratory-research.com/content /11 /1/ 139 Page of 12 A SR 14 0333 10 -9 ... http://respiratory-research.com/content /11 /1/ 139 Page of 12 A Trachea 10 0 Hemokinin -1 Endokinin A/B Endokinin C Endokinin D Substance P Neurokinin A 80 60 Contraction (% ACh mM) Contraction (% ACh mM) 10 0 ... mM) 10 0 B Main bronchi [Sar ,Met(O2 )11 ] SP 40 [ -Ala8 ]-NKA (4 -10 ) 20 Hemokinin -1 Endokinin A/B 80 Endokinin C 60 Substance P [Sar9,Met(O2 )11 ] SP 40 20 0 11 10 - log [Agonist] (M) 11 10 - log...
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Báo cáo khoa học: "Insulin-like growth factor-1 in myocardial tissue: interaction with tumor necrosis factor" pptx
... mitochondrial integrity [1] IGF -1 mediated protection of cardiac contractility may be involved in the PI3 kinase pathway and in activation of protein kinase C [16 ] IGF -1 induces increases in intracellular ... binding protein -1 by anti-TNF antibody Shock 19 95, 4: 21- 26 Anwar A, Zahid AA, Scheidegger KJ, Brink M, Delafontaine P: Tumor necrosis factor- alpha regulates insulin-like growth factor- 1 and insulin-like ... MEKK, mitogen-activated protein kinase kinase kinase; NFκB, nuclear factor- κB; PI3, phosphoinositol-3; PIP, phosphoinositol-4-phosphate; TNF, tumor necrosis factor decrease IGF -1 concentration in...
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ROLES OF AUXIN RESPONSE FACTOR TRANSCRIPTION FACTOR (GmARF) IN SOYBEAN AND STRIGOLACTONE IN ARABIDOPSIS IN RESPONSE TO DROUGHT AND SALT STRESSES
... Introduction of the auxin response factor transcription factor family in plant 1. 3 .1 Concept and classification of transcription factor 1. 3 .1. 1 Concept Transcription factor is a specific DNA binding protein ... strigolactone in response to drought and salt stress conditions Contents 3 .1 Roles of auxin response factor transcription factor in soybean in response to drought stress 3.2 Roles of strigolactone in ... 2 011 ) 1. 3.3 The research situation of transcription factor in response to enviroinmental stresses 1. 3.4 The auxin response factor transcription factor 1. 3.4 .1 Concept and structure The phytohormone...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... 4.6 LPS (1 lgÆmL )1) 10 0 ± 1. 5 10 2 ± 12 .3 98 ± 7.6 98.27 ± 8.2 10 0 10 1 10 2 10 3 Annex-FITC 10 4 10 0 10 1 10 2 10 3 Annex-FITC In order to investigate the mechanism of action of MDP on the mitochondrial ... reactive oxygen species in mitochondria FEBS Lett 416 , 15 18 Ulevitch RJ & Tobias PS (19 99) Recognition of gramnegative bacteria and endotoxin by the innate immune system Curr Opin Immunol 11 , 19 –22 ... mean of three independent experiments each performed in triplicate Percentage unstimulated cells State State FCCP rate B 10 0 10 1 PI 10 2 10 3 A 10 4 MB (10 0 lgÆmL )1) 10 0 ± 11 2 ± 14 .2 10 7 ± 10 .8...
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Báo cáo khoa học: Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines pot
... J Biochem 2 71) 3653 Ó FEBS 2004 ρ+ 10 3 10 4 10 1 10 2 FL1-H 10 3 10 4 10 1 10 2 10 3 10 4 10 3 10 4 10 1 10 2 FL1-H 10 3 10 4 10 1 10 2 FL1-H 10 3 10 4 60 40 Counts 20 80 10 0 60 40 20 0 10 0 10 2 FL1-H 10 0 Counts ... [17 ,18 ] Analysis of q0 cells has provided insights into oxygen metabolism [13 ,17 ,19 – 21] and the role of mitochondria in redox signalling during apoptosis [22,23] Redox-sensitive signalling and ... 60 40 20 Counts Lung 10 1 80 10 0 10 0 80 10 0 10 0 60 80 10 0 20 0 Counts 10 2 FL1-H Muscle 10 1 30 60 90 12 0 15 0 18 0 10 0 40 Counts 60 20 Bone 40 Counts 80 10 0 ρ0 FL1-H Blank Standard growth condition...
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báo cáo hóa học:" Airborne particulate matter PM2.5 from Mexico City affects the generation of reactive oxygen species by blood neutrophils from asthmatics: an in vitro approach" docx
... Element Min Max Min Max Min Max C 26.5 68.6 17 .2 60.0 14 .2 59 .1 O 25.6 45.0 25.7 44.8 11 .9 49.4 S nd nd 0.8 4 .1 3.8 12 .0 Fe 0.4 1. 9 0.3 12 .0 0.4 11 .8 Cu 0.4 1. 0 0.7 1. 5 0.4 3.6 PM10 fine fraction ... Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons BMJ 19 95, 311 :11 45 -11 48 Page 10 of 11 (page number not for citation purposes) Journal of ... sucrose, 10 ml of 1. 4 mM tetramethylbenzidine dissolved in dimethyl sulfoxide and 10 0 ml of 3.0 mM hydrogen peroxide After incubation at 37°C for 10 min, 10 ml of catalase (13 00 U/ ml) and 10 0 ml of...
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báo cáo khoa học: " Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets" ppsx
... reduction of oxygen at the PSI site [52] Atrazine binding to D1 protein of PSII and inhibition of electron feeding to PSI were indeed likely to decrease superoxide radical production by blocking the ... sucrose-induced tolerance to singlet oxygen In contrast with non-induction of H2O2-scavenging systems, atrazine-treated plantlets seemed to be able to sense the increase of 1O2 levels and induce ... 2009, 9:28 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 meneghiniana (Bacillariophyta) Aquat Toxicol 19 87, 10 (4):239-249 Hersh CM, Crumpton WG: Atrazine tolerance of algae isolated...
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