initiation and termination of seizure like activity in small world neural networks
Expression pattern and functions of dihydropyrimindase like 3 in the rodent microglia
... TNF-R1 contains the death domain and this domain is not present in TNF-R2 Binding of TNF-α to TNF-R1 is responsible for initiation of intracellular signaling namely (MAPK and NF-κB) and programmed ... knockdown in activated microglia altered the expression of proinflammatory cytokines such as TNF-α and IL-1β and inflammatory mediators including iNOS and NO and the migratory and phagocytic ability of ... protein-4 (CRMP4) - Gene Ontology predictions The molecular function of Dpysl3 includes SH3 binding domain, chondroitin sulfate binding domain (Franken et al., 2003), phosphoprotein binding domain...
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Báo cáo hóa học: " A survey and taxonomy of distributed certificate authorities in mobile ad hoc networks" doc
... can handle mobility of nodes It minimizes routing loads and enhances expandability of network by allowing participating nodes to authenticate each other without being interrupted by joining the ... bootstrapping, applying a DCA private key, joining a new CH, evicting an existing CH, refreshing CH shares In Bootstrapping operation, to construct the shared key and establish a (k,n) threshold sharing ... examining the proposed schemes in detail In Figure 1, we have classified all CAs from distribution perspective and it helps us to understand the degree of distribution in each kind of CA In this...
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Tài liệu Báo cáo khoa học: Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase pdf
... determined the N-terminus of P40 as it appears in protein extracts of M pneumoniae Determination of the N-terminus of P40 by Edman degradation failed due to the limited amount of starting material ... (CAF) [30]: during the first step of the labeling reaction the e-amino groups of lysine are specifically converted to homoarginine In a second step, the free amino terminal groups of the peptides ... labeled within the intact protein at its a-amino group and represents the amino terminal amino acid of P40 The efficiency of this reaction was quite high, as judged from the signal intensities of the...
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Báo cáo khoa học: Functional dissection of Escherichia coli phosphotransacetylase structural domains and analysis of key compounds involved in activity regulation potx
... containing the last 326 amino acids in the case of Pta-F1, the last 352 amino acids in the case of Pta-F2, and the last 470 amino acids in the case of Pta-F3 (Fig 2) PCR reactions performed in ... located in the C-terminal domain, the E coli Pta N-terminal domain is involved in stabilization of the hexameric native structure, in expression of the maximum catalytic activity, and in allosteric ... Results Expression and purification of E coli Pta and truncated Ptas containing the C-terminal end By analysis of the protein domain architecture of E coli Pta, three conserved domains can be detected...
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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf
... illustrated in Fig 2B (step 1) Interactions with small integrin-binding ligand N-linked glycoprotein (SIBLING) Individual members of the SIBLING family are known to bind strongly to both pro- and active ... immunoglobulin -like (Ig) domain other MMPs by lacking the HPX domain, which is replaced by a C-terminal cystein array region and an immunoglobulin G -like domain, and, instead of the N-terminal signal ... autocatalytic step of the activation by binding to the 64 kDa intermediate form of MMP-2 [52] Binding and activation of MMP-2 was abrogated in the presence of avb3 integrin-binding macromolecules...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf
... cells were maintained in RPMI1640 (HyClone, Logan, UT, USA) supplemented with 10% fetal bovine serum (Gibco, Grand Island, NY, USA) and 100 lgÆmL)1 each of penicillin and streptomycin GM-CSF (LG ... Activation of the GM-CSF receptor leads to the activation of multiple cytoplasmic signaling molecules, including MAPK The MAPKs are key regulators of cytokine and metalloproteinase production, and thus ... factor, interleukin-1b, TNF-a and interleukin-6 However, these factors are not sufficient to cover the active proliferation capacity of RA FLSs, thus indicating that other factors must be involved in...
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Báo cáo khoa học: Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF a-converting enzyme activity in airway epithelial cells doc
... determine HAT-induced tyrosine phosphorylation of EGFR Since EGFR is known to be phosphorylated by its intrinsic receptor kinase through homo- and heterodimerization following ligand binding (autophosphorylation) ... MEK inhibitor PD98059 and U0126 inhibited HAT-induced AR release; (b) activation of PAR-2 by PAR-2 AP induced ERK phosphorylation and desensitization of PAR-2 resulted in inhibition of HAT-induced ... PAR-2 induces AR protein production but not protein release into the culture supernatant Since HAT-induced initial ERK activation results in induction of AR gene expression, the effect of PAR-2...
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Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
... genes are shown in red, downregulated genes in blue in clusters III and IV, further underlining the importance of cell adhesion and cytoskeleton remodeling during the initiation phase of arthritis ... found in joints during the first week of transfer, and a second cell transfer was needed to induce a significant influx of lymphocytes into the joints and cause subsequent inflammation In this ... 'signature' genes in pre-inflamed joints Paws of naive BALB/cSCID mice and still non-inflamed (PA) paws were clinically normal with no sign of inflammation, and comparison of these two experimental...
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Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... kinds of different cytokines and growth factors in the RA joint microenvironments To identify factors having an effect on the growth of RA FLSs, we investigated the inflammatory cytokines and growth ... GM-CSF in the SF may be involved in RA pathogenesis in vivo To address the effects of GM-CSF in SF on the growth of RA FLSs, we cultured the RA FLSs in culture media containing SF Page of 11 (page ... of this manuscript, and also for interpretation and discussion of the data JJ, YEC and YJ performed most of the studies and were responsible for the execution of most of the experiments SAY and...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... for modulation of intracellular TLR signaling In addition to TLRs, a variety of other PRRs including the cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation For ... of lung interstitial and intra-alveolar fibrosis and ALI [93] The role of TLRs has been intensively studied in influenza infection TLR7 expression on pDCs plays a cell-specific role against influenza ... expression and activity of NADPH oxidase in structural cells In light of this finding, the free radicals and oxidant properties of tobacco smoke have been hypothesized to subvert innate immunity and...
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Báo cáo y học: "Early Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response" ppt
... expression of other TLRs and proteins involved in TLR signaling in SAEC In addition, we demonstrate that the expression of TLRs and their signaling proteins in SAEC is strongly regulated by type-1 and ... following TLR3 signaling (Fig 7A and 7B) Interleukin-1 receptor-associated kinases (IRAKs) are part of the TLR signaling cascade and are involved in the activation of NFκB and the MAP kinase ... Figure small- airway-epithelial in TLR signaling in stimulated primary Expression of proteins involvedcells (SAEC) Expression of proteins involved in TLR signaling in stimulated primary small- airway-epithelial...
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Báo cáo y học: " Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33 000 women from the general population" ppt
... intake of fish and risk of positive psychotic -like symptoms The risk of positive psychotic -like symptoms in relation to estimated dietary intake of fish is shown in Table The risk of belonging to ... levels of PUFAs in brain tissue, red blood cells and skin fibroblasts and with a low intake of fish and PUFAs [16,29-31] Finally, supplementation of PUFA, especially EPA, has been reported to be of ... acid and α-linolenic acid hAdjusted for age, total energy intake and dietary intake of vitamin B12, alcohol and dietary intake of other than omega-3 fatty acids ever, the mechanisms of action and...
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báo cáo khoa học: " Regulation of callose synthase activity in situ in alamethicin-permeabilized Arabidopsis and tobacco suspension cells" potx
... half-plasmodesmata of other cells [58] In filamentous cell suspensions of A thaliana, a wound -like response was induced by arabinogalactanbinding Yariv phenylglucosides, including the formation of plug -like ... synthase activity in Col-0 and BY-2 cells Each curve represents one independent experiment The maximum activity was 45 nmol min-1 g-1(FW) in Col-0 and 10 nmol min-1 g-1(FW) in BY-2 cells Omitting ... the mean of two to four independent experiments (B) Callose synthesis in the presence of digitonin Data points for digitonin are averages of two independent experiments and the average of maximum...
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Báo cáo y học: "Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive care units" pptx
... Decision-making process of AT In each center, the presence and number of empiric AT protocols were assessed The period of initiation of AT was defined by categorizing the week into day shifts and out -of- hours ... explaining the link between availability of guidelines and prognosis This point was clearly emphasized in the studies assessing the effects of implementation of the guidelines of the surviving ... admission to ICU and SOFA scores (7 ± vs ± 5) on initiation of AT The clinical features at the time of initiation of AT were assessed in these 261 patients (Table 3) Some organisms initially considered...
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Báo cáo sinh học: "Sources of variation and genetic profile of spontaneous, out-of-season ovulatory activity in the Chios sheep" potx
... keep inbreeding under control No hormonal, light or other treatment is involved during mating Lambing takes place between late October and April, with about 40% of all lambings occurring in November ... Number of ewes No activity Activity in Year only Activity in Year only Activity in both years 272 154 37 37 44 100% 56.6% 13.6% 13.6% 16.2% 71 Spontaneous out -of- season ovulatory activity in sheep ... with a study of the Mérinos d’Arles breed [11] reporting a 28% rate of spontaneous out -of- season ovulatory activity, determined in the same way The high proportion of ewes cycling out -of- season...
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the role of fgfr3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice
... extracellular domain (ligand binding domain) of each monomer consists of three immunoglobulin (Ig) -like domains (Ig I, Ig II and Ig III) (Wesche et al., 2011) The Ig II and III domains generally bind to ... role of FGFR3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice Mona Foth Submitted in fulfilment of the requirements for the Degree of PhD Beatson Institute ... composed of three immunoglobulin (Ig) -like domains that bind to FGF ligands The transmembrane domain comprises a single helix structure The intracellular domain is composed of two tyrosine kinase...
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Regulation of sla2p by activity in endocytosis and actin organization by the ark1 prk1 family of kinases
... NPFs in yeast and their domain structures The actin binding domains are highlighted in red (WH2 is Pan1p and Las17p, ADFH in Abp1p and TH2 in Myo3p and Myo5p) and the Arp2/3 binding acidic domain ... Abp1p contains an N-terminal ADF/cofilin homology domain that binds to actin, two acidic sequences and a C-terminal SH3 domain The actin binding activity 10 CHAPTER I INTRODUCTION of Abp1p is ... C-terminal domain (720-968 amino acids) sows significant homology to filamentous actin 24 CHAPTER I INTRODUCTION binding protein Talin and has been shown to bind actin via its I/LWEQ actin-binding...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... (25% in males and 36% in female) and Canadian Eskimos (43% in males and 40% in female) [21,22] According to the literature, the frequency of a bilateral absence of the frontal sinuses (Fig 3) in ... pneumatization results in the individual size and shape of the frontal sinus An absence of pneumatization in the frontal bone results in frontal sinus aplasia [1] This kind of variation should make ... frequency in our population and that in other populations may be due to the number of patients examined, the patient sample, and the difference in the examining techniques and equipment In addition,...
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Review and analysis of renewable energy perspectives in Serbia
... 2009 [17] Ministry of Energy and Mining Renewable Energy in Serbia Ministry of Energy and Mining, 2009 [18] Statistical Office of the Republic of Serbia Energy Balance of Electricity and Heat, ... Republic of Serbia Strategy of development of energy industry of Republic of Serbia until 2015, draft report, 2005 [6] EPS – Electric Power Industry of Serbia, Ministry of Energy and Mining of the ... involved in a number of research projects as a project manager/ senior energy expert in the fields of energy policy and modelling, development & administration of DSS and in lectures and seminars...
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Tài liệu Design and optimisation of conformal cooling channels in injection muolding tools docx
... on sizing and positioning of cooling channels With the same instrument, optimal processing conditions in the cooling operation was found, minimising functions linked to process quality and productivity ... software for prototyping and simulation The study is on going and hopefully would culminate in the suggestion of the level of proficiency required using virtual models in deciding moulding specifications ... mould and it is compensated by the incoming material; the remainder of the shrinkage takes place sometime following the production of the part [1] 1295 Fig Pressure history during injection moulding...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25