imgt ® tools for the nucleotide analysis of immunoglobulin ig and t cell receptor tr v d j repertoires polymorphisms and ig mutations imgt v quest and imgt highv quest for ngs
... associated with the introduction of foods likely to significantly alter nutritional status, to determine their human health impact 21 Specific tools may be needed to facilitate the implementation and ... provisions ofthe SPS and TBT Agreements The application of product tracing to the areas covered by both Agreements was considered by the Codex Committee on Food Import and Export Inspection and ... assessment should take into account all available scientific data and information derived from different testing procedures, provided that the procedures are scientifically sound andthe parameters...
... proposition with the clue was not the contrastive statement ofthe argument So, it is not straightforward to expand our simplified recording of contrast statements to add a "counter" label Another ... node at the top ofthe tree, for are evidence Consider L to De a the tree, representing the lowest that can receive more evidence to dummy) For every node NEN on thethe following: Another use of ... the tree is quite different (claim, e v i d e n c e ) , a l t h o u g h t h e description forthe restricted set turns out to be the same - nawely, the right border ofthe tree 2) Expanding the...
... Genome 2D promoters of genesbacteria A Genome 2D input (tab-delimited text) file within the weight lactis Additionalfor cre-boxes andfoundshowing the cre-box genome ofofthe identified additional data ... transcriptome analyses The dataset used is from Hamoen and colleagues [24] The strength of up- or downregulation is depicted by the intensity ofthe color Stem-loop structures indicate annotated terminators ... publicly available We therefore developed Genome 2D, a software tool that enables visualization of transcriptome data onto a linear map of an annotated bacterial genome and at the same time highlights...
... the imatinib data), and not by the others, then the distributional deviations must fall within the detection spectra of that method but outside the detection spectra ofthe other methods In the ... control the types of categories modeled: the number of genes in the category (N); the proportion of modulated genes (π); andthe mean and standard deviation ofthe modulated gene scores (μ and ... BCR/ABL1-mediated leukemogenesis, supporting the validity ofthe methodology (see main text) (4) The table illustrates the use of indicator functions to determine the direction of transcriptional deviation...
... study A simulation study was used to validate the CT model andthe utility ofthe DIC andthe PBF for model choice between CP and CT Three replicated datasets were generated from each of two different ... in design compared to the calving ease dataset, any attempt to infer upon v would prove even more difficult To provide a stark contrast to the CP model, v was then held constant to in the CT model ... different populations as characterized by the distribution ofthe liability residuals Population I had a residual density that was standard Student -t distributed with scale parameter σe = and degrees...
... identified, quantified, and valued the costs and benefits ofthe project alternatives, the next step is to identify the least-cost or most cost-effective alternative to achieve the purpose ofthe project ... produced and used in the domestic economy, the effects on the domestic markets of extra output and extra demand may be significant In each case, the effect on the price ofthe nontraded good and ... be adjusted by adding such costs to the project site Outputs that substitute for imports should be adjusted by the difference in transport, distribution, and handling costs between the existing...
... effect of fading at both the remote andthe base station, without additional power or bandwidth One effective technique to mitigate effect of fading is time and frequency diversity Beside that, in ... less attenuated replica ofthe transmitted signal to the receiver, which makes it easier forthe receiver to reliably determine the correct signal transmitted Diversity can be provided using temporal, ... we often encounter the evaluation of probability distribution of a generic quadratic form of CGRV Here, we give the mathematical derivation ofthe probability distribution of this quadratic form...
... other end ofthe electronic medium is truly the patient; likewise, the patient may not be able to verify that a physician is on the other end ofthe communication For that reason, the standards ... not to accept the request, but eventually did so for fear that rejecting the request would damage the former patient’s self-esteem The former patient never posted anything inappropriate, and ... social networking to protect themselves from unintended consequences of such practices and to maintain the public trust by: Protecting the privacy and confidentiality of their patients Avoiding...
... protein on the T4 derived RNA target; however, the positions ofthe footprints relative to the respective initiator AUG and 5' terminal boundary ofthe pseudoknot structure appeared to be identical ... (cleavage) ofthe same RNA to treatment with these chemical agents In Panel B, the V1 lanes denote the amount of RNase V1 (×10-5 units) used to digest the RNA substrate consistent with the prediction that ... protect RNA targets from cleavage with these enzymes These RNA footprinting studies also extended the information we obtained from treatments with DMS and DEPC about intrinsic structure of the...
... relative to the marker placed on the metatarsale V provided the information forthe up- and down movement andthe forward-backward movement ofthe feet The data ofthe metatarsale V got transformed ... could be made for step length, step height, the toe off andthe initial contact inclination angles ofthe feet For a perfect match ofthe listed trajectory settings, the patient was fixed in the ... vertical and horizontal directions andthe relative position ofthe suspension point with respect to the foot plates The PC memorized the treatment conditions of each individual patient The dimensions...
... protein on the T4 derived RNA target; however, the positions ofthe footprints relative to the respective initiator AUG and 5' terminal boundary ofthe pseudoknot structure appeared to be identical ... (cleavage) ofthe same RNA to treatment with these chemical agents In Panel B, the V1 lanes denote the amount of RNase V1 (×10-5 units) used to digest the RNA substrate consistent with the prediction that ... protect RNA targets from cleavage with these enzymes These RNA footprinting studies also extended the information we obtained from treatments with DMS and DEPC about intrinsic structure of the...
... predict if a peptide had a signal peptide attached or not To compare this method with the more traditional weight matrix method, they started with a recalculation ofthe matrix weights using the ... associated with the distance between the real andthe predicted cleavage site For every predicted position, the error d2 was added to the fitness If the program tagged several positions, it would receive ... if the program tried to move the head ofthe virtual machine outside the peptide sequence This was needed to avoid cheating where the program otherwise could locate the end ofthe sequence and...
... participated in conceiving the study JV participated in the conception ofthe project and provided the germplasm DJB participated in SSR, STS and SNP development and analysis, carried out the synteny ... synteny analysisand participated in drafting the manuscript MAG participated in conceiving the study, coordinated the SSR and STS markers development and analysis, and participated in drafting the ... participated in the development andanalysisof SSR and STS markers and drafting the manuscript DMTAF carried out the identification andanalysisof SNP markers CT and MMC participated in SSR and STS mark-...
... as alteration of protease substrate specificity by DSB binding to the viral protease Our data further demonstrate that the differential sensitivity of HIV-1 and SIV to DSB is not due to intrinsic ... determine the sensitivity of HIV-1 and SIV to DSB In additional experiments, we tested whether the two substitutions at the P2 and P1 positions were sufficient to confer DSB sensitivity The SIVm2 mutant ... between these sequences may underlie the differential sensitivity ofthe two viruses to DSB To test this hypothesis, we designed and constructed HIV-1 and SIV mutants containing the corresponding...
... restored activity to wild-type levels while the same treatment resulted in only partial restoration of activity ofthe Q240E mutant (Table 1) These results reveal that both mutations weaken the ... (Figure 15) with diminished endothelium-dependent vasorelaxation Taken together, their finding provided direct evidence that CSE is an important regulator of vasodilation and blood pressure Figure ... production but also reduce the severity ofthe disease state Albeit carried out in animals, these studies serve to highlight the potential importance of CSE-mediated production of H2S in regulating...
... Signal transducer and activator of transcription T- bet T- box expressed in T cells TCR Tcellreceptor Thy1.1 Thymus cell antigen 1, theta Thy1.2 Thymus cell antigen 2, theta TIMP Tissue inhibitor of ... suggesting the presence of intracellular MMP substrates that may indirectly regulate cytokine and chemokine activity The plethora of potential substrates andthe diversity ofcell types that express ... changes and progression ofthe disease However, there may be another important idea that has been overlooked COPD and asthma are both diseases that involve Tcell infiltration and have elevated levels...
... Identification of further selective peptides, together with the investigation and understanding of their structure-activity relationships, may start to provide a rational way to develop additional ... valuable basis for structure-activity studies The high higher than that determined on native receptors This result selectivity ofthe a-conotoxins, together with the possibility suggests that ... probability and conductivity indicated a far greater contribution (92%) ofthe 40 pS event to the a3*-mediated membrane current than the 20 pS event (8%), it was concluded that the b2 subunit strongly...
... produced, with the codes themselves, and their symbolic definition The first level output can be considered as the kernel of an "uncoded d i c t i o n a r ~ The conventional translation of a text ... THAM system works with four types of objects : source text (S), translated text (T) , revised text (R) and uncoded dictionary (D) In the actual system, each of these objects corresponds to one ... The translator is provided with a text editing system, as well as an uncoded dictionary which may be directly accessed on the screen But the translation is always done by the translator This data...