if the lvef drops by 10 percentage ejection points or more from baseline and to below 50 then trastuzumab treatment should be suspended restart trastuzumab therapy
Early and locally advanced breast cancer - Diagnosis and treatment pdf
... treatment If the LVEF drops by 10 percentage (ejection) points or more from baseline and to below 50% then trastuzumab treatment should be suspended Restart trastuzumab therapy only after further cardiac ... considered to be at low risk 10 should be offered an aromatase inhibitor, either anastrozole or letrozole, as their initial adjuvant therapy Offer tamoxifen if an aromatase inhibitor is not tolerated or ... sensory or learning disabilities, and to people who not speak or read English If the patient agrees, families and carers should have the opportunity to be involved in decisions about treatment and...
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Báo cáo y học: " Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis" ppsx
... relevant text words in the title, keywords or abstract We then combined the results from the searches with the studies identified and included in the previous review [3] Inclusion and exclusion ... cross-sectional studies were rated out of a total of eight points and case-control and cohort studies out of a total of nine points A score of seven or more was chosen a priori to indicate high methodological ... respiratory infection; or [d] there were insufficient or unusable data presented in the paper We thus identified a total of 29 papers published between 1997 and the end of November 2 010 which...
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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot
... in the AD group A number of actions of MMPs and TIMPs, apart from the inflammatory response, have been closely linked to AD pathology For example, MMP-9 has been shown to be able to cleave and ... risk for future AD’ The group difference in the CSF analysis method should therefore not influence the findings of the study Moreover, it should be stated that the present data not suggest MMP and ... obtained from the L3/L4 or L4/L5 interspaces and collected in polypropylene tubes The samples were centrifuged at 2,000 g at 4°C for 10 minutes to eliminate cells and other insoluble material, and...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... content may be maintained by a compensatory mechanism, or the changes in heme content may be below the detectable limit of the assay method used Accordingly, we treated HeLa and HepG2 cells for 12 ... HeLa and YN-1 cells were treated with 50 lm SnPP or mm SA for up to 48 h SnPP was freshly prepared and added immediately to the culture medium The culture dishes were placed in the incubator Northern ... (A and B) and HepG2 cells (C and D) were left untreated or treated with SA (5 mM) for the indicated time and harvested The upper panels in (A) and (C) show the northern blot analysis of HO-1 and...
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Báo cáo khoa học: "Increased expression of osteopontin in the spinal cords of Lewis rats with experimental autoimmune neuritis" doc
... migration into the spinal cord in the early stages of EAN Further study of the functional role of OPN will be required to determine whether it acts as a pro- or anti-inflammatory mediator, or both ... EAN-affected spinal cords may facilitate the migration of inflammatory cells, including both Th1 and Th2 cells, into the spinal cord parenchyma if needed The population of inflammatory cells in the subarachnoid ... generation in an autocrine or a paracrine manner OPN requires the presence of its receptor on the cell surface for internalization into brain cells CD44 has been shown to be a receptor of OPN [2]...
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Báo cáo khoa học: "Increased phosphorylation of c-Jun NH (2)-terminal protein kinase in the sciatic nerves of Lewis rats with experimental autoimmune neuritis" ppt
... etilE( sexelpmoc esadixorep nitoib-nidiva gnisu dezilausiv erew snoitcaeronummi ehT ]9[ yduts suoiverp ruo morf snoitacifidom thgils htiw ,)KU ,cetoreS ;1DE( seidobitna egahporcam tar-itna lanolconom ... sisotpopa fo gniniats elbuoD )sworra ,C3 giF( IP 42 yad ta sevren citaics detceffa-NAE ni )sworra ,A3 giF( KNJ -p sserpxe segahporcam taht gnitseggus ,)sworra ,B3 giF( 1DE htiw dezilacol-oc erew ... sisylana tolb nretseW 4.7 Hp ta )SBP( enilas dereffub -etahpsohp ni edyhedlamrofarap %4 ni noitaxif retfa niffarap ni deddebme erew evren citaics eht fo seceiP sisylana nietorp rof Co07− ta nezorf...
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Báo cáo y học: " Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis" ppsx
... COPD and that the inflammatory process involves both the lung (airways and parenchyma) and the systemic circulation [32-34] The intensity of the inflammatory process in the airways and in the ... smoking-inflammation pathway may be an important contributor to the increased risk observed in women in the peri and post-menopausal periods Further research is needed to confirm this hypothesis Another potential ... data for this study as well as all the other authors of the primary studies who contributed their time and data to this project Page of (page number not for citation purposes) Respiratory Research...
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Báo cáo y học: "High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study" pps
... serum cortisol level The normal range of morning serum cortisol concentration in our hospital laboratory is 138 to 690 nmol/L, which is broadly the same as that of other laboratories [54] For the ... training and standardization, eligible patients were randomly selected and each patient was independently evaluated by the investigator (according to CAM-ICU) and the psychiatrist (according to DSM-IV) ... as follows: (a) previous cardiothoracic surgery, (b) history of schizophrenia, (c) history of adrenal gland disease, (d) history of glucocorticoid therapy for more than consecutive days within...
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Báo cáo y học: " Endothelial Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery: a prospective observational stud" pptx
... factors and complement, improved tissue oxygen delivery and, therefore, decreased ischemia-reperfusion injury to the bowel, and shortened exposure time to the CPB circuit Finally, the timing and ... extracorporeal pumps, and LPS receptor inhibitors have been tried in patients without success [10- 12] In addition, the estimated prevalence of endotoxemia during cardiopulmonary bypass may be unreliable ... of the inflammatory cascade We did not specifically measure left ventricular ejection fraction prior to surgery in our study Further support to the validity of the observed levels of endotoxin...
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Báo cáo y học: "No increased risk of infant hypospadias after maternal use of loratadine in early pregnancy"
... finding may be random and the reason for publishing is of course to ask other researchers to look for the presence or absence of that specific association It is often thought that if there is a ... or not to publish and also how such a finding should be handled by authorities If such a “signal” is published it is imperative to stress that in spite of formal statistical significance, the finding ... Sci 2006, 107 after July 1, 1995 and searched the registers for all known cases of hypospadias The total number of loratadineexposed infants is then 2780 and 25 had hypospadias identified (0.9%)...
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Báo cáo y học: "An Increased Risk of Osteoporosis during Acquired Immunodeficiency Syndrome"
... soluble member of the tumor necrosis factor receptor superfamily (TNFR), also known as osteoclastogenesis inhibitory factor (OCIF) [54,55] It has specificity for OPG/OCIF function for inhibiting ... mammals such as the mouse [43] will be of major assistance for human studies The identification of susceptibile genes for osteoporosis is expected to be a major contributing factor toward the long-term ... possible to diagnose and treat osteoporosis (bone density levels more than 2.5 standard deviations (SD) below the young normal mean) prior to the occurrence of fractures (established osteoporosis)...
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Tài liệu Báo cáo " The extreme value of local dimension of convolution of the cantor measure" docx
... Notations and Primary Results Let ν be the standard Cantor measure and µ = ν ∗ ∗ ν (m−fold) Then, by similar proof as the Lemma 4.4 in [5], we have Proposition Let ν be the standard Cantor measure, ... (s3) are the values in Corollary From Lemma 2, Corollary and Proposition 2, we have Theorem Let µ is the 5−fold convolution of the standard Cantor measure, then the lower extreme value of the local ... (x′ , x′ ) = {(2, 2), (1, 5)} Therefore, 110 10 10 10 µ2 (s2 ) = + = 10 ; 2 2 10 10 105 µ2 (s′ ) = + = 10 2 2 2 ii) By Proposition 3, we have a) If n is even then (x1 , , xn) = (x1 , , xn−1,...
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Tài liệu Báo cáo khoa học: "THE BY RESOLUTION OF LOCAL SYNTACTIC AMBIGUITY THE HUMAN SENTENCE PROCESSING MECHANISM" doc
... one or other of the two versions of their examples the with the to NP) In the case of the n o n - m i n i m a l l y attached version, the correct a t t a c h m e n t (to the NP) w o u l d be attempted ... which purport either to investigate syntactic processing empirically, or to model it computationally, should not ignore the role or the r e q u i r e m e n t s of these processes To so is to study ... o l a t i o n We refer to "the oil tycoon" and "the off-shore oil tracts", but we've never m e n t i o n e d them before To control for this, we should really present these t a r g e t s e n...
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Báo cáo Y học: Subsite mapping of the binding region of a-amylases with a computer program ppt
... a-NP-maltooligosaccharides [10] , the CNP-maltooligosaccharides, which are b-glycosides, are unique as their preparation and use in the mapping of the active centre of a-amylases were reported by our laboratory for the ... enough to span the entire binding region of PPA and BLA met the requirements of getting the best subsite map The results confirm that the nine subsites for BLA and the five subsites for PPA, originally ... %calculated, the bond cleavage frequency calculated according to the subsite map; Difference, the sum of the difference between the measured and calculated data During the iteration we look for the smallest...
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A study in the growth mechanism of silicon nanowires with or without metal catalyst
... sketch of the CVD system sample collector The ZnS or S powder was put in one side and would be flowed to the wafer The reaction temperature was set at about 1100 °C The samples were analyzed by scanning ... uration of the formed liquid alloy with silicon atoms, which leads to nucleation and growth of a SiNW [19] Therefore, the diameter and location of the SiNW are determined by the features of the catalyst ... precursor of SiH4 (Eq (1)) When dropping Si atoms come to contact with the metal particle located on the substrate (Fig 2B a), a liquid metal–Si alloy will be formed With more and more Si atoms...
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Báo cáo khoa học: "THE RECOGNITION CAPACITY OF LOCAL SYNTACTIC CONSTRAINTS" ppt
... truly short contexts should be used >$ This graph, or more conveniently the table of "valid neighbors" below, define the LCA(I) automaton The table is actually the union of the SCr(t,l) sets for all ... PP There is no simple analytic answer to tiffs question Contradictory forces play here: the nature of the language c.g a rigid word order and constituent order yield stronger constraints; the ... use the term cohort to refer to the set of lcxicaUy valid readings of a given word We use the term path to refer to a sequence of M tags ( M ~ N) which is a tagimage corresponding to the words...
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Đề tài " On the K-theory of local fields " ppt
... convenient to work in a more general setting ON THE K-THEORY OF LOCAL FIELDS 15 Let Φ be a functor from a category of categories with cofibrations and weak equivalences to the category of pointed ... Moreover, the composite of the maps in the lower row is equal to the map of the statement, and the upper left-hand and upper righthand terms are contractible Hence the theorem is equivalent to ... is the category with one object and one morphism, and includes this category as (n) the full subcategory on the object We let Gk (C; X) be the functor from (I (n) )k+1 to the category of pointed...
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Báo cáo khoa học: The specificity of alcohol dehydrogenase with cis-retinoids Activity with 11-cis-retinol and localization in retina docx
... inner plexiform and ganglion cell layers The signal was absent in the choroid and outer plexiform layer, and in the outer and inner segments of the photoreceptor cells Discussion We have here presented ... [33], and it was used to prepare 11-cis-retinal by oxidation with MnO2 [34] For the synthesized retinoids, the retinals were the forms of storage Synthesis of 7-cis-retinol, 9-cis-retinol and 11-cisretinol ... could be stored there as retinyl esters, isomerized to 11-cis-retinol, and finally oxidized to 11-cis-retinal [18] In addition, 11-cisretinal has to be produced in the retina to generate the photopigments...
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