hypoxia inducible factors in acute kidney injury from pathophysiology to a novel approach of organ protection
Báo cáo y học: " Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study" ppt
... Nolph KD, Van Stone JC: The peak concentration hypothesis: a urea kinetic approach to comparing the adequacy of continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis Perit Dial Int 1989, ... validated in clinical practice, particularly in the acute setting [18] In designing the protocol, we recognized that combining continuous and intermittent modalities into a single treatment strategy ... continuous therapy and the values they calculated from the mean daily duration of treatment and the mean values for dialysate, replacement fluid and net ultrafiltration rates [6] This apparent inconsistency...
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Báo cáo khoa học: "Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury" doc
... is applicable to these patients (that is, whether a creatinine increase of more than 0.3 mg/dl from an elevated base- line represents AKI and has the same risks as a creatinine increase from a ... participating societies to represent both their area of expertise and their sponsoring organization AKIN is intended to facilitate international, interdisciplinary, and intersocietal collaborations ... kidney disease Sensitive and specific markers for kidney injury are not currently available in clinical practice Several groups are working on developing and validating biomarkers of kidney injury...
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Báo cáo y học: " Clinical review: Timing and dose of continuous renal replacement therapy in acute kidney injury" ppsx
... and clinical factors and stratification by site and initial modality of RRT in a multi- variate analysis, the relative risk of death associated with dialysis initiation with a higher degree of ... inadequate to answer the question of appropriate indications and timing of initiation of CRRT in AKI The vast majority of patients with AKI are never treated with RRT, yet have increased mortality rates ... azotemia (using the ‘early’ initiation group as the comparator) was 1.85 (95% confidence interval 1.16 to 2.96) Similarly, using a propensity score analysis to adjust for factors predicting initiation...
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Báo cáo y học: "Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study" ppt
... with American clinical practice, in that a continuum of care approach for AKI (that is, matching the appropriate therapy to the patient’s clinical status at different time points) was utilized In ... hemodynamic data are particularly important in light of the continuing belief by many experts that any episode of hypotension in an AKI patient, even if very transient, can cause further kidney injury ... both a predominantly male patient population and late renal replacement therapy initiation, may have contributed to the higher APACHE II score Finally, additional evidence supporting the overall...
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Báo cáo y học: "Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury" potx
... Shibata N, Inoue Y, Fukumoto K, Nishimura A, Fukushima K, Yshikawa Y, Spiteller G, Takada K: Evaluation of factors to decrease bioavailability of cyclosporin A in rats with gentamicin-induced acute ... Organic anion transporters OATs are predominantly found in the basolateral membrane of the renal tubules and facilitate the uptake of small organic anions from the peritubular plasma into renal ... function are all influential These factors change from minute to minute in the dynamic AKI patient Regular therapeutic drug monitoring should be a standard of care when treating patients with AKI...
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Báo cáo y học: "Acute kidney injury on admission to the intensive care unit: where to go from here" docx
... Molitoris BA, Warnock DG, Shah SV, Joannidis M, Ronco C, Acute Kidney Injury Network (AKIN): Development of a clinical research agenda for acute kidney injury using an international interdisciplinary ... Salvatori G, Dan M, Piccinni P: Practice patterns in the management of acute renal failure in the critically ill patient: an international survey Nephrol Dial Transplant 2006, 21:690-696 Rabindranath ... patients and prevent AKI This call for 'attention to basics' includes general measures like education and training of nursing and medical staff, emphasis on the importance of the clinical examination,...
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Báo cáo y học: "Late initiation of renal replacement therapy is associated with worse outcomes in acute kidney injury after major abdominal surgery" potx
... therapy (RRT) initiation in patients with AKI has been under debate for a long time From the view point of an early renal support strategy, the goal of early RRT is to maintain solute clearance and ... relevant covariates into the final Cox proportional hazards model Also, we did an additional analysis adjusting for three clinical relevant variables (namely, sepsis before RRT, mechanical ventilation, ... criteria Risk Increase plasma creatinine ×1.5 or GFR decrease > 25% < 0.5 ml/kg/h × h Injury Increase plasma creatinine ×2 or GFR decrease > 50% < 0.5 ml/kg/h × 12 h Failure Increase plasma creatinine...
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Báo cáo y học: " Recently published papers: Renal support in acute kidney injury is low dose the new high dose" doc
... Fotouhi A, Razavi SAH, Mansournia MA, Yamini-Sharif A, Amirzadegan A, Salarifar M, Sadeghian S, Davoodi G, Borumand MA, Esfehani FA, Darabian S: Sodium bicarbonate plus isotonic saline versus saline ... Bates DW: Acute kidney injury, mortality, length of stay, and costs in hospitalized patients J Am Soc Nephrol 2005, 16:3365-3370 Vasheghani-Farahni A, Sadigh G, Kassaian SE, Khatami SMR, Fotouhi ... data (Beginning and Ending Supportive Therapy for the Kidney) has examined the clinical Page of (page number not for citation purposes) parameters associated with successful cessation of continuous...
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Báo cáo y học: "The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data" pptx
... (black, Asian, American Indian/Alaska Native, white) Age categories employed in standardisation and calculation of age-specific rates and ratios were: less than year, to years, to 14 years, 15 to ... group AI/AN = American Indian/Alaska Native [1] The MCOD approach is particularly appropriate in the analysis of sepsis mortality because the vast majority of sepsis cases occur in elderly individuals ... a paucity of data on sepsis-associated mortality rates in Hispanics, American Indians/ Alaska Natives and Asians Earlier studies found that, relative to whites, blacks and other non-whites have...
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Tài liệu Báo cáo khoa học: N-Methyl-L-amino acid dehydrogenase from Pseudomonas putida A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily ppt
... of analytical grade from Nacalai Tesque (Kyoto, Japan) and Wako Pure Chemical Industries (Osaka, Japan) Culture and screening of bacteria Bacterial strains were cultivated for 1520 h at 30 C in ... N-Methyl-L-amino acid dehydrogenase from P putida H Mihara et al Table Substrate specicity of NMAADH in the forward reaction NMAADH activity was determined in reaction mixture containing 10 mM a- oxo acid, ... sequencing of the gene encoding NMAADH The NMAADH gene was inserted into pET2 1a( +) to yield the plasmid pDPKA NMAADH was puried to homogeneity by chromatography using a Green-Sepharose and a DEAE-Toyopearl...
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Báo cáo hóa học: " FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study" potx
... K, Nakanishi S, Kazama JJ, Gejyo F, Yamashita T, Fukagawa M: Total parathyroidectomy reduces elevated circulating fibroblast growth factor 23 in advanced secondary hyperparathyroidism Am J Kidney ... Intensive Care 2011, 1:21 http://www.annalsofintensivecare.com/content/1/1/21 Page of Table Baseline characteristics of patients with and without acute kidney injury No acute kidney injury Number Acute ... Ishimura E, Nishizawa Y: FGF-23 in patients with end-stage renal disease on hemodialysis Kidney Int 2004, 65:1943-1946 45 Sato T, Tominaga Y, Ueki T, Goto N, Matsuoka S, Katayama A, Haba T, Uchida...
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Bóa cáo y học: "RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis" pps
... analyses examining the impact of the different baseline characteristics on the appearance of acute kidney injury and maximum RIFLE class F are presented in Table Increasing age, greater severity of illness ... develop anemia Finally, acute kidney injury itself can lead to a non-infectious, proinflammatory response with activation of leukocytes, secretion of proinflammatory cytokines and recruitment of neutrophils ... hospital admission creatinine, the ICU admission creatinine or the CrMDRD creatinine as the baseline value Approximately one-half of patients were classified using the CrMDRD as a baseline None of...
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Báo cáo khoa học: "Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units" docx
... Society Adult Patient Database, 1996–2005 acute kidney injury and incidence from the Australia New Zealand Intensive Care Society Adult Patient Database, 1996–2005 ARF, acute renal failure Page of ... rates (95% confidence intervals) of acute kidney injury stratified by two-year intervals, and admission characteristics from the Australia New Zealand Intensive Care Society Adult Patient Database ... conducted a 10-year observational study of > 90,000 ICU admissions to 20 ICUs in Australia, using a high-quality clinical database, to evaluate trends in the incidence and mortality associated with AKI...
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Báo cáo y học: "Acute kidney injury in the intensive care unit: current trends in incidence and outcome" potx
... ANZICS Database Management Committee: Changes in the incidence and outcome for early acute injury in a cohort of Australian intensive care units Crit Care 2007, 11:R68 Ympa YP, Sakr Y, Reinhart ... creatinine and urine output Emerging biomarkers of AKI, such as neutrophil gelatinase-associated lipocalcin and cystatin C, give us a view of the biological clock, and the use of commercially available ... (Risk-InjuryFailure-Loss of renal function-Endstage renal disease) and AKIN (Acute Kidney Injury Network) criteria provides us a framework for identifying and staging AKI This will not only aid us in recruiting patients,...
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Báo cáo y học: "Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study" pot
... Mean uNGALa Peak uNGALa Values are expressed as mean ± standard deviation/median (interquartile range) aMean and peak urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations increased ... (1.1) Peak uNGALa Mean uNGALa,b aPeak Values are expressed as mean ± standard deviation/median (interquartile range) and mean urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations ... strata and Figure illustrates the data graphically There was a statistically significant association between worsening pRIFLEmax status and increasing mean and peak uNGAL concentrations (all...
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Báo cáo y học: "Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate" pot
... Levin A, Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury Crit Care 2007, 11:R31 Myers GL, Miller WG, Coresh J, Fleming ... Cockcroft–Gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients Am J Kidney Dis 2005, 46:242-252 Barrantes F, Tian J, Vazquez R, Amoateng-Adjepong ... Levey AS, Panteghini M, Welch M, Eckfeldt JH; National Kidney Disease Education Program Laboratory Working Group: Recommendations for improving serum creatinine measurement: a report from the Laboratory...
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Báo cáo y học: "Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury" potx
... overload, in particular in AKI, may be an important and underappreciated determinant of survival These data encourage speculation that one benefit of early RRT, when defined by the duration of time ... resuscitative management has been accomplished Few clinical investigations, until now, have evaluated the impact that fluid balance has on clinical outcomes in critically ill adults with AKI [1] In a ... Critical Care Vol 12 No Bagshaw et al septic patients with AKI, Van Biesen and colleagues [8] showed that additional fluid therapy (despite apparent optimal haemodynamics, restoration of intravascular...
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Báo cáo y học: "Acute kidney injury in intensive care unit patients: a comparison between the RIFLE and the Acute Kidney Injury Network classifications" potx
... Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A, Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury ... maximum AKIN in 64.1% and 67.4% of patients, respectively, whereas in almost 5% of patients it was the urine output criteria that led to a maximum RIFLE and a maximum AKIN Creatinine and urine output ... the criteria that lead to the worst classification are used Glomerular filtration rate (GFR) criteria are calculated as an increase of serum creatinine above the baseline serum creatinine level...
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Báo cáo y học: "Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study" ppsx
... for individual variations in hemodynamic variables, aiming at least for a mean Figure Algorithm showing selection of patients TBSA, percentage burned of patients total body surface area arterial ... dysfunction in burns The reason for AKI among patients with major burns may be multifactorial We found that the acute increase in plasma creatinine concentration was preceded by the initial inflammatory ... renal replacement therapy, plasma creatinine was within the reference range during the first day after injury in all cases but one, whose plasma creatinine was 126 μmol/L All four had multiple organ...
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Báo cáo y học: "Renal failure in the intensive care unit: acute kidney injury compared to end-stage renal failure" pptx
... patients admitted to intensive care units requiring chronic renal dialysis: a secondary analysis of the ICNARC Case Mix Programme Database Crit Care 2007, 11:R50 Dara SI, Afessa B, Bajwa AA, Albright ... R Chang is in charge of the Riyadh Intensive Care Program database Both authors extracted the data from the database and performed the analyses Dr Ostermann wrote the draft and Mr Chang provided ... Critical Care Vol 12 No Ostermann and Chang Figure Associated maximum organ failure and impact on outcome Shown are (a) incidence (%) and (b) ICU mortality (%) AKI, acute kidney injury; ESRF,...
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