gpiib iiia integrin receptor antagonists in the rapid diagnosis of thromboembolic events
Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot
... action of a single mediator (An in- depth discussion of the mediators involved in EIB and their cellular sources are beyond the scope of this review.) 61 activity in individuals with underlying airway ... hyperresponsiveness.4 The occurrence of EIB in asthmatic persons is common and often signifies suboptimal control of asthma.8 The diagnosis of EIB is confirmed in the laboratory by a drop of 15% or more in forced ... demonstrated the protective effect of CysLT1 receptor antagonists against EIB, providing strong evidence of an important role of cysteinyl leukotrienes in regard to EIB.10 Treatment of Exercise-Induced...
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Báo cáo sinh học: " Shell Vial culture Assay for the rapid diagnosis of Japanese encephalitis, West Nile and Dengue-2 viral encephalitis" pdf
... blind passaged in suckling mice by intracerebral inoculation Subsequently the strains were adapted to porcine kidney cell line in the laboratory by serial blind passage Porcine kidney cell line ... in outbreaks of WN virus infection in the United States[30,31] Among the 50 patients included in the study, (8%) patients left against medical advice, so the clinical outcome of these cases is ... *Four out of fifty patients included in the study left the hospital against medical advice, the clinical outcome of whom is not known Hence, these cases were excluded from the analysis of clinical...
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báo cáo hóa học:" Shell Vial culture Assay for the rapid diagnosis of Japanese encephalitis, West Nile and Dengue-2 viral encephalitis" pdf
... blind passaged in suckling mice by intracerebral inoculation Subsequently the strains were adapted to porcine kidney cell line in the laboratory by serial blind passage Porcine kidney cell line ... in outbreaks of WN virus infection in the United States[30,31] Among the 50 patients included in the study, (8%) patients left against medical advice, so the clinical outcome of these cases is ... *Four out of fifty patients included in the study left the hospital against medical advice, the clinical outcome of whom is not known Hence, these cases were excluded from the analysis of clinical...
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Báo cáo y học: "ncreased serum HO-1 in hemophagocytic syndrome and adult-onset Still''''s disease: use in the differential diagnosis of hyperferritinemia" docx
... for the work reported in the manuscript, and no other financial interests that any of the authors may have could create a potential conflict of interest or the appearance of a conflict of interest ... Sports, and Technology of Japan (to M Takeno) The sources of funding had no role in the writing of the report and did not participate in the decision to publish the results The authors would like ... characterized by the proliferation of macrophages that phagocytose hematopoietic cells in the bone marrow and their subsequent infiltration into other organs, accounting in part for the systemic clinical...
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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... off-state The unique ability of arginyl to fulfil this constraining function in the N-terminus of the V1aR is similar to the unique constraining role of alanyl previously reported for Ala293 in the ... stabilize the G-protein interaction of the active receptor [28] In summary, Arg46 of the V1aR is required for high affinity agonist binding and signalling It is one of the constraining residues ... role suggests that binding of the agonist releases the Arg46-mediated constraint on the ground state of the receptor, thereby promoting agonistinduced activation Interestingly, Ôdual-roleÕ residues...
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Báo cáo hóa học: " Adenoviruses with an avb integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases" pdf
... with adenoviruses with RGD moieties in the HI loop of the fiber or in the KKTK domain of the fiber [30] Furthermore, mutation of the KKTK domain ablated binding to HSPGs and led to reduced liver ... HI loop of the fiber knob (Ad5lucRGD) or into the fiber shaft KKTK domain (AdTLRGDK) increased the expression of transgene in all tested cell lines in comparison with AdTL Interestingly, the optimal ... Replicating viruses WT -Replicating wild type virus WT-RGD -RGD insertion in HI loop of fiber knob for avb integrin targeting [43] WT-RGDK -Fiber shaft’s KKTK domain mutated to RGDK for avb integrin...
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Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt
... neurogenesis The list of these genes is reported in additional file These results support the hypothesis of a possible role of E6 and E7 in the induction of neuroendocrine differentiation of SCLC ... Evaluation of the results obtained in the two systems showed deregulation of the same pathways in human SCLC and in that induced experimentally by the E6/E7 oncoproteins of HPV16 To further highlight the ... release the E2F transcription factor, subsequently leading to progression of the cell into the S-phase [14] Furthermore, E7 binds to inhibitors of cyclin-dependent kinases (p16, p21), increasing the...
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Báo cáo y học: "Antigen receptor signaling in the rheumatic diseases" doc
... dephosphorylates the inhibitory tyrosine of Lck [54] Pep cooperatively inhibits TCR signaling by binding Csk and this association in turn is mediated by a proline-rich sequence in the C-terminal region of ... signaling in the periphery is also critical in the maintenance of immune homeostasis and tolerance to self These antigen receptor- dependent events are likely relevant for the interpretation of disease ... confirm the gain-offunction hypothesis but not all are in agreement In our laboratory, we revisited the question of the functional significance of the R620W risk allele Functional studies of the...
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Báo cáo y học: "Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice." ppt
... blocking of the muscarinic receptor Consequently, a reduced blocking effect by L-NAME in NOD mice can at least in part be explained by changes in muscarinic receptor signalling If this is the ... the first time the possible existence of M3R located in the blood vessel wall of the salivary gland in NOD mice When the parasympathetic nerve innervating the gland is stimulated, acetylcholine ... infused intravenously over a period of minute Electrical stimulation was repeated to minutes after the end of infusion In Group pilocarpine (0.10 mg/100 g BW dissolved in 0.01 ml of 0.9% saline)...
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Báo cáo y học: "Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndrome" ppsx
... intracellular domain of TNFR1 A definitive list of all the TRAPS mutations can be found on the INFEVERS website [43] Many of the mutations involve cysteine residues involved in intramolecular disulphide ... mutations in TNF receptor (TNFR1) illustrating the extreme clustering of mutations towards cysteine-rich domains CRD1 and CRD2 (a) The preligand assembly domain (PLAD), ligand binding domain, and other ... significantly interfere with the trafficking or function of the wild-type allele [56] Figure These findings suggest that inflammation in TRAPS results from either haploinsufficiency of wild-type receptors...
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Hypoglycemia induced changes in cholinergic receptor expression in the cerebellum of diabetic rats ppt
... consequence of insulin therapy in diabetes altered the binding parameters of Muscarinic M1, M3 receptors and gene expression of α7nAchR, AchE, ChAT and GLUT3 in the cerebellum and AchE activity in the ... Muscarinic M1 and M3 Receptor Binding Studies in the Cerebellum Muscarinic M1 and M3 receptor binding assays were done using specific antagonists [3H]QNB and [3H]DAMP in the cerebellum of rat ... the role of cholinergic receptors during recurrent hypoglycemia in diabetic rats Experimental evidence indicate the involvement of the cerebellum in variety of human mental activities including...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... whether P63+ basal/stem cells were activated under the influence of Hedgehog overexpression, we examined the pCX-shh-IG-injected prostates during the progression of PIN toward CaP to gain further ... bars: 50 μm in upper (d) of panel A; 10 μm in lower (d) of panel A and in (d) of panel C CaP: prostate cancer; HE: hematoxylin-eosin stain; PIN: prostatic intraepithelial neoplasia; HGPIN: high ... pictures Hedgehog signalling members were expressed in the PIN (F-J) and CaP (K-O) of the pCX-shh-IG-injected prostates, in contrast to the absence of evident signal in the pCX-IG-injected vehicle controls...
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Báo cáo y học: "Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation" pot
... linear regression analysis by plotting the specific binding of the radioligand on X-axis and bound/free on Y-axis The maximal binding is a measure of the total number of receptors present in the ... half the specific binding was defined as EC50, which is same as IC50 The affinity of the receptor for the competing drug is designated as Ki and is defined as the concentration of the competing ... in the tissue and the equilibrium dissociation constant is the measure of the affinity of the receptors for the radioligand The Kd is inversely related to receptor affinity Nonlinear regression...
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Báo cáo y học: "The rapid growth of a pleomorphic adenoma of the parotid gland in the third trimester of pregnancy" pdf
... monitoring of tumors of the salivary glands diagnosed during pregnancy Indications for early surgical intervention should be discussed on a individual patient basis in a multidisciplinary setting ... Written informed consent was obtained from the patient for publication of the manuscript and accompanying images A copy of the written consent is available for review by the Editor -in- Chief of this ... his part of the manuscript TU helped to revise the manuscript, HS performed the gland surgery and performed the final reading of the manuscript All authors have read and approved the final manuscript...
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báo cáo khoa học: " Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor d from Peroxisome proliferatoractivated receptor g in the ob/ob mouse" ppt
... Within the treated skeletal muscle the concentrations of adenine were decreased and those of adenosines and ribose sugars from the adenosines were increased Therefore, the decrease in amino acids ... concurrent increase in the pathways product 4,7,10,13,16,19-docosahexaenoic acid Two steps in the pathway are again catalyzed by the ∆ 6desaturase Also, the final step in the pathway, the formation of ... gluconeogenesis), glycine, glutamate, glutamine, alanine, proline and valine, and the amino acids that are glucogenic and ketogenic, threonine, tyrosine and phenylalanine, were increased in the PPARδ agonist...
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báo cáo khoa học: " Evidence for the rapid expansion of microRNA-mediated regulation in early land plant evolution" docx
... considering the unfinished character of the Physcomitrella genome sequence In regards to the maturation pathways of miRNAs, the prediction of genomic precursors revealed some interesting aspects of the ... differs in plants and animals In animals, the pri-miRNAs are processed in the nucleus by the microprocessor complex containing the enzyme Drosha and its cofactor, the protein DGCR8 (in humans), ... was based on the presence of their putative binding sites in conserved target genes [36-38] Furthermore, the presence of miR160 was shown in the moss Polytrichum juniperinum [37] In this study,...
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Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma" potx
... for LPA receptors in linking lung injury in the murine bleomycin model of pulmonary fibrosis Asthma is a chronic inflammatory disease of the airways involving T-lymphocytes and eosinophils infiltration, ... cytokines play a key role in orchestrating inflammatory and structural changes of the airway in asthma by recruiting, activating and promoting inflammatory cells into the airway [38-40] In addition ... cells in the airways Very little is known on the physiological consequences of increased LPA levels and role of LPA receptors in asthma To address the role of LPA receptors in Th2-mediated inflammation,...
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Báo cáo khoa học: " Ruminal acidosis and the rapid onset of ruminal parakeratosis in a mature dairy cow: a case report" doc
... sloughing of the stratum corneum and demarcation of cells through the epithelial layers (arrow) inent, considering the short duration of the induced acidosis Compromised integrity of the ruminal ... Figure The HF diet resulted in a mean ruminal pH of 6.58 ± 0.02 with a daily minimum of 6.42 and a maximum of 6.85 In contrast, the average ruminal pH during the HG was 5.41 ± 0.09 with a minimum of ... observed increases in lymphocyte-like cell infiltration into the upper layer of the ruminal epithelium during the feeding of the HG diet is a systemic immune response to this invasion Several experiments...
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Báo cáo y học: " Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody" ppsx
... of the virus -receptor interaction may not simply be a modulation of binding affinity, rather it could represent a shift in the way the Env and receptor interact The two modes of interaction may ... further for sensitivity to antagonists of the virusreceptor interaction (Fig 4) Variant B32 was identical to the parent strain GL8 and therefore served as the reference strain If the nature of the ... that the Env-sFcCD134 interaction itself determines the degree of inhibition and that within the range examined, the level of surface CD134 expression on the target cell does not influence the...
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Báo cáo y học: " A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction" ppt
... strains of HIV and SIV are capable of by-passing the primary receptor and interacting directly with the coreceptor [11-15] In these "CD4-independent" strains of virus, the chemokine receptor binding ... determinants in CRD2 of CD134 for receptor binding is lost These data would suggest that the specificity of receptor binding of the GL8 Env may be dependent on intermolecular interactions in the ... subsequently permitting chemokine receptor binding Thus modifications to the structure of the V1V2 loop may mimic CD4-binding and facilitate chemokine receptor binding The T271I mutation in FIV Env may...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25