from cultured cell and animal model studies to human application
From Investment funds and Asset Management Companies to questions about Africa’s farmers pptx
... agricultural activities towards horticulture, animal production and other agricultural sub-sectors * Asset management and agricultural engineering companies’ model Sector integration can also ... such a model compared to the previous model seems to be the agricultural specialization of the management company and the proximity in the relationship between the latter and the main actors of ... hesitate to commit to fresh produce production, biofuels or livestock As with the bank integration model, asset management companies and agricultural engineering models can also directly acquire land...
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Báo cáo sinh học: " A reduced animal model approach to predicting total additive genetic merit for marker-assisted selection" ppsx
... appropriate submatrices of A A and A respec, au , v p v is the vector corresponding to animali of T, q is the matrix corresponding i to animali of B, is the vector ( )! and stands for the direct product ... QTL not linked to the ML, v is the 2q x random vector with the additive effects of the MQTL alleles, e is the n x random vector of residual effects, and X, Z and P are n x f, n x q and q x 2q known ... effects due to QTL unlinked to the ML and the additive effects due to the MQTL On the other hand, van Arendonk et al (1994) discussed an AM method to reduce the number of equations per animal to one...
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Báo cáo y học: "A simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studies" pptx
... These n models were then trained using Monte-Carlo cross-validation process and random sub-sampling to create 50 sub-models for each n model The objective of using such cross-validation and random ... GANN and stepwise ANN for feature selection and classification GA and ANN are two widely used methods for handling noisy and complex data We applied MCCV and random sampling techniques to minimise ... Low High and low refer to the quantity of stem cells in cord blood ANN output is computed based on the average performance from 50 random samplings Std err with 95% CI refers to the standard error...
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Báo cáo y học: "Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to human" pptx
... 8y and human H1CIRMF and H2CIRMF are seropositive Only mandrills Mnd2DCDP, MndNB and Mnd5D3B were negative in PCR The mandrill Mnd17D7CDP, M 4y and the human H3CIRMF are indeterminate; and mandrills ... Furthermore, recent studies showed that interspecies transmission of SFV from mandrills to humans is possible [15,16,34] The aim of our study was to evaluate the natural history of mandrill SFV in ... viruses from wild northern animals Cytochrome b phylogenetic analysis also confirmed the geographical separation of the wild mandrills (Figure 3) Transmission of SFV from mandrills to humans We...
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báo cáo hóa học:" Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF" ppt
... until only the cells cultured from the post-debridement edge – those that have the ability to respond to growth factors or cellular therapy – remain Obviously, growing primary cells from each debrided ... freezing and one did not grow Of these 13, 11 cultures were shown to be viable and uncontaminated To assure viability and sterility, a vial was recovered from the freezer and passaged times and then ... growth factors to see which stimulate mitogenic response and found that combinations of PDGF-AB-IGFI, bFGF-PDGF-AB and EGF-PDGF-AB elicited the highest response [26] Taken together, these studies...
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Báo cáo Y học: Modelling of simple and complex calcium oscillations From single-cell responses to intercellular signalling pdf
... relatively easily from it The influx into the cell is assumed to be constant The transport of Ca2+ both out of the cell and into the store is modelled by functions linear in the cytosolic Ca2+ concentration, ... (1998) Model of b -cell mitochondrial calcium handling and electrical activity I Cytoplasmic variables Am J Physiol 274 (Cell Physiol 43), C1158–C1173 165 Magnus, G & Keizer, J (1998) Model of b -cell ... suggested to explain bursting in Ca2+ oscillations Shen & Larter [189] demonstrated regular bursting and transition to chaos in a model involving Cacyt, Caer and IP3 Both the activatory and inhibitory...
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Báo cáo hóa học: " Open Access Cell and gene therapies: moving from research to clinic" pptx
... Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration Cytotherapy 2009, 11:377-391 doi:10.1186/1479-5876-8-31 Cite this article as: Stroncek and Puri: Cell and gene ... information, ideas and hypothesis We welcome contributions from all those participating in this field; clinicians, scientists, and engineers from academia, industry and the regulatory community Author ... essential The goal the JTM Cell and Gene Therapy Section is to advance this field by reporting the results of translational medicine studies and by being a forum for the exchange and discussion of new...
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Báo cáo sinh học: "The combined transduction of copper, zincsuperoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury" ppt
... the apoptosis of cells were indicators of hypoxiareoxygenation injury [25,26] Our previous studies have shown that application of PEP-1-SOD1 or PEP-1-CAT can tranduced into myocardium and protected ... medium was changed to DMEM containing g/L glucose and 1% FBS Cells were cultured in a humidified hypoxia chamber (Stem Cell Technology, USA) and flushed with 95% N2 + 5% CO to achieve 0.1% oxygen ... supernatants and cells were collected respectively after treatment Annexin V and propidium iodide (PI) binding assay To measure H9c2 cell apoptosis after hypoxia-reoxygenation treatment, we labeled the cells...
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founding and evaluating efficiency of training model to transfer technology from polyclinic hospital of hoa binh province to district hospitals
... fell from 0.23 to 0.3 day, other indicators such as total number of inpatient days, total number of tests, total surgeries, tips, total imaging tests increased from 1.03 times (lowest) to 2.86 ... reaching level A from 87.0 -100%, the level B from 0- 13.0%, and level C was 0% Thus, the level A increased from 0% to 87-100%, level B decreased from 13.0 - 0% and levels C decreased to 0% Table ... execution time longer (4-5 years), to have the basis to evaluate the effectiveness, the impact of the model, from which lessons could be learned to expanded model to all of the district HOs of Hoa...
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Báo cáo khoa hoc:" An expression of mixed animal model means equations to account for different and variances in the base" pps
... vector of records; b is the vector of fixed effects; a is the random b vector of breeding values of base animals; a is the random vector of breeding r values of non-base animals; e is the random ... fixed and an additive genetic animal model with groups and relationships, respectively Cantet and Fernando [1] extended these rules to allow for heterogeneous additive genetic variances and segregation ... Quaas and Pollak [12] for a model with genetic groups was exploited in Graser et al [4] and in Quaas [11] They gave easy rules to set up the equations corresponding to an animal model with base animals...
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Báo cáo y học: " Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy" pptx
... PMPA and FTC suppressed viral replication to undetectable levels in nonhuman primates and restored CD4 counts As expected from results in human clinical trials, therapy was well-tolerated from ... guidelines as set forth in the Animal Welfare Act and The Guide for the Care and Use of Page 14 of 19 Laboratory Animals, as well as according to animal care standards deemed acceptable by the ... latency and eliminating reservoirs in attempts to eradicate the virus from the body Methods Cells We used the human MT-4 cells (T-CD4 + cell line derived from cord lymphocytes transformed with HTLV-I...
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Tài liệu Banks’ exposure to interest rate risk, their earnings from term transformation, and the dynamics of the term structure pptx
... predictors: an application to New Zealand Sandra Eickmeier Tim Ng 12 2009 Opting out of the great inflation: German monetary policy after the breakdown of Bretton Woods Andreas Beyer, Vitor Gaspar ... exposure to interest rate risk to derive the following statements about their exposure to this risk and their earnings from term transformation The systematic factor for the exposure to interest ... bank’s earnings from term transformation As stated above, we can use data on the banks’ exposure to interest rate risk, derived from the banks’ internal models, and, therefore, not have to estimate...
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Tài liệu Thermodynamic Models for Industrial Applications: From Classical and Advanced Mixing Rules to Association Theories pptx
... Margules equations 4.4 From the van der Waals and van Laar equation to the regular solution theory 4.4.1 From the van der Waals EoS to the van Laar model 4.4.2 From the van Laar model to the Regular ... 1990s and are suitable for industrial applications While many of the principles and applications are common to a large family of these models, we have focused on two of the models (the CPA and ... Cataloging-in-Publication Data Kontogeorgis, Georgios M Thermodynamic models for industrial applications : from classical and advanced mixing rules to association theories / Georgios M Kontogeorgis, Georgios...
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Tài liệu Báo cáo khoa học: "Bilingual Terminology Acquisition from Comparable Corpora and Phrasal Translation to Cross-Language Information Retrieval" pptx
... similarity vectors SIMT →S - Merge the first and second models to yield a twostages translation model, based on bi-directional comparable corpora and represented by similarity vectors SIM(S↔T ... 1999) for the first and second models and propose a merging and disambiguation process for the two-stages translation model Therefore, context vectors of each term in source and target languages ... Next, context vectors related to source words are translated using a preliminary bilingual seed lexicon Similarity vectors SIMS→T and SIMT →S related to the first and second models respectively,...
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Tài liệu Báo cáo khoa học: Three-dimensional structures of thermophilic b-1,4-xylanases from Chaetomium thermophilum and Nonomuraea flexuosa Comparison of twelve xylanases in relation to their thermal stability pdf
... right hand: two b-sheets and the a-helix form fingers and a palm, a long loop between the B7 and B8 strands forms a thumb, and a loop between the B6 and B9 strands forms a cord (Fig 1A) The final model ... Asp and Arg (Table 5) In NFX, the additional Arg160 is located on the protein surface, and Asp156 makes a double salt bridge with Arg58 (Oc1 and Oc2 atoms of aspartic acid and Ng1 and Ng2 atoms ... hydrogen bonding with b-strand A5 and the extension of b-strand B3 interacts with a b-strand B4 BAX also has a longer C-terminal b-strand A4 and a short additional b-strand after that When the three-dimensional...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... was observed for all cell lines (Fig 2A) In order to minimize cell handling prior to FACS analysis, no ®xation step was included Avoiding cell ®xation and working on living cells eliminates potential ... This work was supported by grants from the Association pour la Recherche sur le Cancer to B L and E V and from MURST and Istituto Superiore di Sanita¢, Rome, Italy to M G REFERENCES Allinquant, B., ... heparinase-treated cells compared to untreated cells (Fig 6B, bold line) DISCUSSION Intracellular vectorization after chemical coupling or genetic fusion to the CPP derived from the HIV-1 Tat...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... terminus and SR at the C terminus of the protein belong to different subunits and condense to form an intersubunit disulfide bond; in atypical 2-Cys Prxs, Sp and SR belong to the same subunit and establish ... solfataricus cells in response to H2O2 (A), paraquat (B) and tert-butyl hydroperoxide (C) Twenty micrograms of cytoplasmic proteins extracted from nonexposed and exposed culture for 30, 60 and 120 ... terminus and SR at the C terminus belong to different subunits and condense to form an intersubunit disulfide bond; in atypical 2-Cys, Sp at the N terminus and SR at C terminus, originate from the...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... 3899 and 4516 SPC molecules for the agonist and the antagonist in water, respectively, and 817 and 927 Me2SO molecules for the agonist and the antagonist, respectively, corresponding to a total ... for residues P5 and P8 (exposed) and P4, P6 and P9 (buried) according to the X-ray structure of the MBP(86–102) epitope complexed to MHC II Figure 9C,D illustrates the structure and sequence alignment ... normal human tissue give rise to multiple sclerosis, in which the immune response (T cells or antibodies), directed primarily against the virus, cross-reacts with the human tissue to cause autoimmune...
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Báo cáo khoa học: The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles Ser195 and Cys145 are predicted to be the active site nucleophiles pot
... positioned to perform catalysis with the Oc ˚ atom of Ser171 at about 2.8 A from the Oc atom of ˚ Ser195 and about 2.7 A from the amino group of Lys96 4718 The analysis of the structural model reveals ... about 2.6 A from the Oc atom of Ser171 ˚ and 2.5 A from the thiol group of Cys145 4720 Even taking into account all of the limitations of molecular models of proteins with respect to experimental ... containing a second CX3C motif From top to bottom (with database accession numbers in parentheses): Sulfolobus solfataricus (P95896); Pseudomonas syringae pv tomato str DC3000 (AAO55930); Pseudomonas...
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