... sequence ofthe rat IL-13 mRNA 217 Appendix 2.2 Setup of Polymerase Chain Reaction (PCR) 218 Appendix 2.3 TA Cloning, transformation and amplification of plasmid DNA 220 Appendix 2.4 Gel extraction and ... ii SUMMARY ix LIST OF ABBREVIATIONS xi UNITS OF MEASUREMENT xvi LIST OF TABLES xix LIST OF FIGURES xxi LIST OF APPENDICES xxiv LIST OF PUBLICATIONS AND CONFERENCE ABSTRACTS xxvi CHAPTER 1.1 INTRODUCTION ... subunits associate with tyrosine kinases ofthe Janus family Activation of JAKs initiates a series of downstream signal transduction events which leads to phosphorylation of STAT6, a transcription factor...
... ofthe subjects in the same manner In the NF “no force–feedback” model, kC had the same value as MED except that the force–feedback was disabled Fifth Model NF–HINT The fifth model was somewhat ... obtained using the same model structure and applying b = α = 17 We found informally that it was generally easy to increase the amplitude ofthe oscillation, and it was often relatively easy ... was the skill level ofthe nth subject, D(c) was the intrinsic difficulty ofthemodel c, and Ns was a random noise variable By taking the natural logarithm of both sides of (9), we arrived at a...
... Compared to the macaque models, the marmoset modelof CIA shows several advantages First of all, common marmosets are smaller and reach their adult age earlier than macaques, which saves capacity ... [11], allows the evaluation ofthe efficacy of therapeutics using a small number of animals Finally, in contrast to macaques, half ofthe common marmosets developed chronic arthritis This chronic arthritis ... type II collagen an experimental modelof arthritis J Exp Med 1977, 146:857-868 Cathcart ES, Hayes KC, Gonnerman WA, Lazzari AA, Franzblau C: Experimental arthritis in a nonhuman primate I Induction...
... capacity ofthe heterozygous animals, SC formation and the behaviour ofthe trivalent 5/15; ;15 was studied at the pachytene stage of meiosis = MATERIALS AND METHODS Two Saanen male goats (Capra ... Luciani JM, Guichaoua MR, Mattei A, Morazzani MR (1984) Pachytene analysis ofa man with a 13q;14q translocation and infertility: behaviour ofthe trivalent and nonrandom association with the sex ... probability of variable pairing faces and leads to the conclusion that a single pairing face on the translocated chromosome determines the plane of SC assembly The cis configuration was also found in the...
... biased upwards, but the bias was larger for BLUE in all cases This apparent paradox can be explained by the fact that BLUE is an unbiased estimator of: and not exp(p + H Empirical biases forthe ... assess the sampling performance of Poisson MML in terms of empirical bias and square root MSE Relative bias was empirical bias asa percentage ofthe true variance component Coefficients of variation ... ’baseline’ value can then be interpreted asthe expected value ofthe Poisson parameter of an observation made under the conditions of an ’average’ level ofthe fixed effects and in the absence of random...
... clinical practice Asa corollary example of an empirical 'treatment-based' diagnostic strategy, a presumptive diagnosis of gastroesophageal reflux disease (GERD) may be pragmatically validated ... nature ofthe referral (e.g., amount and type of information accompanying the referral) may depend on the nature ofthe condition, whether the referral is for reasons of diagnosis and/or treatment, ... medical participants both noted lack of formal clinical studies examining effectiveness of manual/manipulative approaches to manage (diagnose and treat) musculoskeletal chest pain, and lack of...
... PlatiniumÒ Taq DNA High Fidelity Polymerase (Invitrogen) and the primers: PDZ-1-2, forward: 5¢-CCGAATTCGAAGAAATCACACTTGAAAGG-3¢, and reverse: 5¢GGATCCCCATCATTCATATACATACTTGT GGGTT-3¢; PDZ3, forward: ... least one MAPK implicated in ERK activation to facilitate a functional interaction and regulate the localization and the duration ofthe signal For example, the MEK partner directs the ERK cascade ... 5¢-GTGGGGAAATATGCTCTTGAGGAGGT-3¢; primers 2, forward: 5¢-GTGACTTCAGAGACACTGCCA-3¢, and reverse: 5¢-CCCTTTCAAGTGTGATTTCTTC3¢; primers 3, forward: 5¢-ACCAGATGGTGAGAGCGAT-3¢, and reverse: 5¢-CTGTCTTTCATAGGTCCCAAT-3¢...
... selectivity Tomatsu H, Takano J, Takahashi H, Watanabe-Takahashi A, Shibagaki N & Fujiwara T (2007) An Arabidopsis thaliana high-affinity molybdate transporter required for efficient uptake of molybdate from ... -MASSPTKILCDAGESDLCRDDAAAFLLKFVAIASIL 1:MFFIDVLWKLFPLYLFGSERDYLSETESILKIVPETMAAASSLSILCDAGEPDLCRDDSAAFLLKLVAIASIF TjZNT1 TjZNT2 37:LAGVAGVAIPLIGKNRRFLQTEGNLFVAAKAFAAGVILATGFVHMLAGGTEALTNPCLPDYPWSKFPFPGFFA ... in YNB medium at 30 °C, and imaged with a laser scanning confocal microscope (FV 1000; Olympus, Tokyo, Japan) Metal accumulation assay The Cd2+ accumulation assay was performed as described in...
... interpretation of data MR carried out the ELISA experiments and participated in analysis of data CA performed the statistical analysis and the clinical associations AS participated in the analysis and ... G, Alessandri C, Capoano R, Profumo E, Siracusano A, Salvati B, Rigano R, et al.: Screening ofa HUAEC cDNA library identifies actin asa candidate autoantigen associated with carotid atherosclerosis ... interpretation of data and in the revision ofthe manuscript RR participated in the design ofthe study and in the revision ofthe manuscript EP participated in analysis of data GV participated in the...
... subsequently the proximal by partial clamping ofthe aorta (for the cases with more than one graft) After completion ofthe proximal anastomoses the extracorporeal circulation is interrupted and hemostasis ... beat empty of volume The last part ofthe operation is carried out using an off pump coronary artery bypass (OPCAB) stabilizer in order to perform the necessary distal coronary anastomoses and ... routinely place surgical gauze beneath the heart in order to appropriately elevate the apex and expose the site of rupture, as much as needed to avoid possible distortion of aortic valve and sequent...
... analysis with the change in behavior from third to fifth grade For each of these two analyses we used the cases available in the ECLS for that particular analysis Thus the sample sizes, and the ... behavior measured on a scale of to (the average of all ofthe items), the largest deviation from zero for either the upper or lower bound ofa confidence interval was about a fifth ofa point The ... have revealed at least a tiny visible effect, given the more than adequate sample size and given the reliability ofthe behavior rating variable The claims of martial arts studios and the expectations...
... where m = for Case and m = for Case The interval enclosures for all state variables and the initial approximations xapp,1 (t) and xapp,2 (t) are shown in Fig In the considered time span, the improved ... solution a set of linear ODEs xapp (t) = flin (xapp (t)) ˙ (9) with the same dimension asthe original system is solved analytically for xapp = xapp (0) = x0 + x0 Usually, the original state equations ... to the case of uncertain initial states to present the solver VAL E NC IA-IVP It aims at calculating tight enclosures [xencl (t)] forthe unknown exact range [x (t)] of all reachable states for...
... Street Journal distributed with the Penn Treebank II, and the definition of baseNP is the same as Ramshaw’s, Table summarizes the average performance on both baseNP tagging and POS tagging, each section ... identifiers assigned to POS tags We used the approach of Katz (Katz.1987) for parameter smoothing, and build a trigram model to predict the probabilities of parameter (1) and (3) In the case that unknown ... pruning may be regarded asthe special case of our statistical model, since the maximum-matching algorithm of baseNP rules is only a simplified processing version of our statistical model Compared...
... Recapitalization Planning: Toward a Fleet Management Modelforthe HMMWV Table 4.1 Fleet Management Model Assumptions in Sensitivity Analyses and Base Case Replace Earlier Base Case Replace Later ... rather than separate location variables and coefficients, and we treated the variant’s annual mileage-by-age figures as usage values in the equations After calculating EDA-based repair costs by age, ... Finally, asthe availability and quality of Army data continue to increase, so, too, will the precision ofmodel outputs For example, additional data on the failure rates of older vehicles and of...
... a trained agent, the 50/50 arrangement doesn’t change as drastically as it can in the residential arena ߜ You construct your own database Commercial real estate is a database business For example, ... be available at the drop ofa hat largely because agents have trained them to expect service 24 hours a day, days a week The National Association of Realtors ran a huge marketing campaign a few ... in office leasing you have to create a database of all the buildings in the marketplace and all the information about the buildings: Tenant lists, when leases are up, building features and amenities,...
... viability of diaspora bonds asa development financing instrument The rise of various diasporas and their economic status in their adopted countries are fast becoming a source of pride as well as financial ... e.g., Korean and Chinese diaspora in Japan; Indian and Pakistani diaspora in the United Kingdom; Turkish, Croatian and Serbian diasporas in Germany; Algerians and 11 National Jewish Population Survey ... choose the law and the forum governing bond contracts Finally, factors that facilitate—or constrain the issuance of diaspora bonds include having a sizeable and wealthy diaspora abroad, and a strong...
... coeruleus area, the principle sensory nucleus and the lateral parabrachial nucleus ofthe brainstem A small number of scattered NPS-positive cells were found in other brain areas, such as amygdala and ... recent example forthe impact of orphan receptor research on neuroscience and our understanding of brain functions The identification of NPS asa modulator of arousal and anxiety represents a first ... profile that was independent ofthe motor-activating effects ofthe peptide [11] NPS increased the time the animals spent exploringthe less protected or brighter areas ofthe different test chambers...
... configuration is that the aperture array can serve asthe front contact forthe solar cell Silver is selected forthe metal apertures and the top metal layer because of its low losses at optical frequencies ... This has led to the widespread use of wafer-based crystalline silicon solar cells1,2 where the wafers contribute a substantial portion ofthe expense ofthe module.2 The electrical and manufacturing ... absorbed in the silicon generates a single carrier pair which has the energy ofthe band gap (1.11 eV) Figure 4 (a) shows the results of this calculation fora = 750 nm as well asthe bare silicon...
... configuration is that the aperture array can serve asthe front contact forthe solar cell Silver is selected forthe metal apertures and the top metal layer because of its low losses at optical frequencies ... This has led to the widespread use of wafer-based crystalline silicon solar cells1,2 where the wafers contribute a substantial portion ofthe expense ofthe module.2 The electrical and manufacturing ... absorbed in the silicon generates a single carrier pair which has the energy ofthe band gap (1.11 eV) Figure 4 (a) shows the results of this calculation fora = 750 nm as well asthe bare silicon...
... evidence of brain metastasis; history of autoimmune disease; history of other malignancies except basal cell carcinoma ofthe skin; and pregnancy The study protocol was approved by the Institutional ... EA participated in the patients care RI carried out the immunoassays AT carried out the immunoassays BG participated in the patients care VEH participated in the patients care WML analyzed the ... sequences The patients had different HLA alleles, as shown in Table Ofthe six patients enrolled in the trial, five were male and one was female (patient 2) Patients had an average age of 62 years,...