drug products their role in the treatment of disease their quality and their status and feature as drug delivery systems
Báo cáo y học: "Pro/con debate: Octreotide has an important role in the treatment of gastrointestinal bleeding of unknown origin" pptx
... and, possibly, accelerates healing of bleeding lesions over the 72 hours following endoscopic hemostasis [16,17] Somatostatin and octreotide inhibit acid, and decrease both pepsin secretion and ... nonvariceal upper gastrointestinal bleeding J Clin Gastroenterol 2004, 38:243-247 24 Okan A, Simsek I, Akpinar H, Ellidokuz E, Sanul AR, Aksoz K: Somatostatin and ranitidine in the treatment of non-variceal ... bleeding and showed a trend toward efficacy for non-peptic ulcer bleeding (mostly caused by gastritis) However, the quality of some of the included studies has been questioned [9] In addition, the...
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Role of Corticosteroids in the Treatment of Tuberculosis: An Evidence-based Update potx
... treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases ... imaging of the brain was also performed in a subset of patients in this study.36 It was found that use of corticosteroids possibly reduced the risk of developing hydrocephalus and vasculitic infarcts; ... publication of this trial, Prasad and Singh12 updated their Cochrane systematic review on the efficacy of corticosteroids in TBM.12 The combined mortality in the control arms (anti-tuberculosis treatment...
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Managing Drug Interactions in the Treatment of HIV-Related Tuberculosis docx
... evaluated The rifamycin class upregulate (induce) the synthesis of several classes of drug transporting and drug metabolizing enzymes With increased synthesis, there is increased total activity of the ... the key role of the rifamycins in the success of tuberculosis treatment mandates that the drug- drug interactions between the rifamycins and antiretroviral drugs be managed, not avoided by using ... Predicting Drug Interactions Involving Rifamycins Knowledge of the mechanisms of drug interactions can help predict the likelihood of an interaction, if that specific combination of drugs has not...
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Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot
... treatment with either montelukast or salmeterol, but again, the protection was lost in the salmeterol group after weeks of treatment Protection was maintained in the montelukast group through the study’s ... effects of LTRAs include increased pulmonary function, decreased symptoms, and decreased use of rescue medication Montelukast has several advantages over other LTRAs, including formulation, onset of ... Holgate ST The anti-inflammatory effects of leukotrienemodifying drugs and their use in asthma Chest 2001;119:1533–46 Drazen JM, Israel E, O’Byrne PM Treatment of asthma with drugs modifying the leukotriene...
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Báo cáo y học: "Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries" ppsx
... such vitamin C and vitamin E, promoting their regeneration Therefore, a-LA has been proposed as a treatment for oxidative disorders of the nervous system characterized by an increase of free radicals ... after nerve injury [1] The activities of SOD and CAT were found to be high in sciatic tissue of rats indicating high production of superoxide anion radical Therefore, the increase of SOD and CAT ... suggested the importance of a-LA in the treatment of peripheral nerve injuries, but further studies are needed to explain the mechanisms of its neuroprotective effects and before the use of a-LA in...
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Báo cáo y học: "Role of vasopressin in the treatment of anaphylactic shock in a child undergoing surgery for congenital heart disease: a case report" docx
... demonstrated Vasopressin inhibits the synthesis of iNOS, blunts the increase in cGMP induced by NO and directly inactivates KATP channels in vascular smooth muscle [10] Moreover, vasopressin is able ... mechanisms and induce a relative deficiency in vasopressin plasma concentration further amplifying the vasoplegic scenario [5] Despite the presence of histamine receptors the heart is not the target ... be the standard medical therapy to reverse cardiovascular collapse in anaphylaxis Because of its α and β adrenergic effects, epinephrine inhibits further vasodilating mediator release from basophils...
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Báo cáo y học: "Role of pathophysiology of patellofemoral instability in the treatment of spontaneous medial patellofemoral subluxation: a case report" docx
... overdominancy of vastus medialis to vastus lateralis was probably playing a major role in the pathophysiology of medial subluxation as in our the case of our patient Because the pathophysiology of ... medial patellofemoral instability is mostly caused by the insufficiency of the lateral retinaculum following the release of the patellotibial and the epicondylopatellar ligaments The authors evaluated ... patellofemoral tracking during flexion and extension of the knee by pressing on the inferior lateral pole of his patella The achieved patellar stability was not sufficient and his patella was still...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... involves its interaction with receptors consisting of a heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation ... but can bind and antagonize the transactivating activity of the classic GCR-α Through these mechanisms, the autocrine production of IL-4 by TH2 cells in the asthmatic lung might render these cells ... the third section of the AQLQ (Asthma Quality of Life Questionnaire, showing a patient’s perception of general health and physical functioning) worsened in the placebo group and improved in the...
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Báo cáo y học: " Pro/Con Debate: Does recombinant factor VIIa have a role to play in the treatment of patients with acute nontraumatic hemorrhage" ppt
... from ongoing bleeding, even off-label use demands reasonable expectation of benefit Ongoing bleeding and reasonable expectation of benefit are mandatory even for compassionate off-label use of rFVIIa ... Recombinant activated factor VIIa in an unselected series of cases with upper gastrointestinal bleeding Thromb Res 2005, Epub ahead of print 18 Rizoli SB, Chughtai T: The emerging role of recombinant ... (upper gastrointestinal bleeding) without any evidence for the drug s efficacy and safety The first issue is the off-label use After a single successful report of off-label use of recombinant FVIIa...
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The role of hydrogen sulfide in the central nervous system implications in the treatment of alzheimers disease
... and Kimura in 1996 In their pioneering study, the novel neuromodulator role of H2S was transpired (Abe and Kimura, 1996) Since then its possible roles in all body systems were and are being investigated ... like tau is involved in microtubule assembly It serves as a binding for the tubulin Mutations in α-synuclein lead to loss of this binding ability, resulting in tubulin and α-synuclein aggregation ... that the action of H2S on [Ca2+]i can be suppressed by using inhibitors of PKA, phospholipase C 11 (PLC) and protein kinase C (PKC), suggesting the role of PKA and PLC/PKC pathways in the...
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Effects of anti malaria drug artesunate in the treatment of rhinovirus induced asthma exacerbation
... decreased the levels of cyclin D1, cyclin E, cyclin-dependent kinase 2, cyclindependent kinase 4, and E2F1, and increased the levels ofC ip1/p21 and Kip1/p27 They induced apoptosis, activated caspase-3, ... asthma Increased numbers of eosinophils in the bronchial mucosa as well as in the bronchoalveolar lavage (BAL) and sputum are consistent features of asthma, and BAL eosinophilia has been linked ... virus and the host cells (Kolatkar, Bella et al 1999, Casasnovas 2000, Xing, Casasnovas et al 2003) The following uncoating of the virus depends on the low pH inside the endosome However, the extent...
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Development and applications of novel solvent minimized techniques in the determination of chemical warfare agents and their degradation products
... 1.3 The imprinting efficiency is defined as the ratio of the binding ratio of the MIP to the NIP, where the binding ratio is the ratio of the adsorbed analyte to that remaining in solution The ... MIPs imprinted for 2-aminopyridine were compared in terms of specificity and selectivity Specificity was defined as the success of the imprinting process as seen from the difference in binding between ... of the template using caesium fluoride The binding affinity of the MIP was studied by colorimetric detection methods where the imprinting efficiency was determined to be 2.4 Another interesting...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"
... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free -drug levels; increase in volume of distribution ... affecting ALT levels Obtaining pretreatment baseline ALT levels in patients with HCV is recommended as well as monitoring of levels during treatment Discontinuation of valproate when aminotransferase ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained in the therapeutic range by intraperitoneal administration of lithium during continuous...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"
... the angles of the dural opening The most significant step involves constructing small supporting pillars on the bilateral sides of the vessels as they pass the edge of the dural window (the pillars ... et al.32 They separated the temporal deep fascia from the temporal muscle to the zygomatic arch, and then cut the fascia from the base backwards along the zygoma but left the fascia base 1-2 cm ... because of the limited space.15 The procedure of subtemporal craniectomy, which was introduced by Cushing,11 involves removing the part of the skull beneath the temporal muscle by opening the dura...
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Báo cáo y học: "Godoy & Godoy technique in the treatment of lymphedema for under-privileged populations."
... as brushing the floor, that involve the mobility of the limb and can be transformed into a form of treatment Several studies, both ongoing and in press, show that the association of these activities ... technique aims at draining lymph (already in the collectors) and stimulating the formation of lymph (the flow of interstice fluid to the lymphatic capillaries) Increases in interstice pressures, ... mechanisms maintain losses achieved during lymph drainage 8,9 First, the working pressures of the main muscle groups of the arms were assessed and then myolymphokinetic activities, common to the patient’s...
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Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... one month prior to study and during the study, other than multivitamin and mineral supplements containing vitamins and minerals as the sole medicinal ingredients Use of concomitant prohibited ... arthritis or other types of pain) or is unwilling to stop taking other medications for the treatment of OA Any other condition that, in the opinion of the investigator, would adversely affect the subject's ... acetaminophen and NSAIDs Although these drugs are effective for reducing pain associated with OA, they not reverse the disease In addition, there are considerable side effects associated with the use of these...
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Báo cáo y học: " Vacuum-assisted closure in the treatment of early hip joint infection"
... [16] and the possibility of costs minimization [8, 14] The disadvantage of lacking inspections of the sponges can be compensated by daily controlling of the canister fluid and monitoring of the inflammation ... haemodynamics, the surrounding tissue is decompressed and local microcirculation is re-established The increase of the oxygen gradient facilitates the transportation of toxins and inhibitors inducing thereby ... thereby the wound healing [16] As a result of the increased angiogenesis, the local antibiotic concentrations are increased, too [3, 11] Last but not least, the transport of cellular and humoral...
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Báo cáo y học: " Two-stage procedure in the treatment of late chronic hip infections spacer"
... safety The most commonly used antibiotics in ALC include tobramycin, gentamicin and vanco- 254 mycin [26] The combination of vancomycin and one of the aminoglycosides provides a broad spectrum of ... by the ratio in which the antibiotics are mixed into the cement and therefore, the total dose of antibiotics should not exceed 10% of the weight of the cement in order to avoid fracture of the ... an infection control rate over 90% Articulating spacers provide the advantages of maintaining limb length and joint mobility, minimising soft-tissue contracture and scarring, and facilitating...
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Báo cáo y học: "Complications after spacer implantation in the treatment of hip joint infections"
... implanted In 70 cases a “normal” spacer has been implanted, whereas in the remaining 18 cases a spacer head has been placed onto the in situ remained femoral stem In the latter cases, there was either ... remove the femoral stem For loading of the bone cement, the combination of gentamicin and vancomycin was most frequently used followed by the combination of gentamicin and teicoplanin Data about the ... reactions (rash and pruritus) against the intravenous antibiotics administered (in both cases combination of clindamycin and flucloxacillin) The symptoms were resolved after adjustment of the antibiotic...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008