... leading toincreased concentrations inthe water inthe domestic system.3.18 Flushing ofthe mains distribution system to remove the contaminated water resulted inthe disturbance of old mains ... chapterdescribes the structure ofthe works, the distribution of contaminated water, thenatureof the contamination ofthe water supply, water quality data on the concentrations ofthe contaminants from131. ... indication ofthe water inthe mains) (Buckingham,personal communication, June 2003). Inthe case ofthe 2 minute flush sample, most ofthe contaminantsfrom the domestic pipework (copper, lead or zinc)...
... determine the affixes in Part I, the addition ofthe admissible final-consonant string QUE does not influence the results of that paper. However, the generalized letter QU should replace the ... letter string under examination is listed, and those admissible classes containing the given letter string are shown together with the number of words they contain. Since only admissible classes ... modifi- cations ofthe definitions above, and applying them to the corpus K, certain new classes are joined to the col- lection of admissible classes in Tables 1 and 2. Only suffix classes will...
... interactions of papain with loop L6 of chagasin and loop L2 of cysta-tin B. (C) Zoom -in view ofthe interactions of papain with loop L4 of chagasin and the N-terminal segment of cystatin B. (D) Zoom -in ... (loop L2). The s angle in the chagasin–papain complex is 5.8°, indicating that the chagasin molecule is slanting towards the R domain. The angle of approach of cystatin B is )12.7°, and the inhibitor ... and inhibitionmode of chagasin should be valuable in guiding the development of drugs for the prevention and treat-ment of Chagas disease.ResultsFunction of chagasin as an inhibitor of papainChagasin...
... anaerobically cultivated in phosphateFig. 2. The mechanisms ofthe ring contraction process inthe biosynthesis of vitamin B12postulated on the basis ofthe isolation of factor IVfrom the anaerobe P. ... [5–7].One was based on the results of our anaerobic[1-13C,1,1,4-18O3]ALA feeding experiment in P. sher-manii [5], shown inthe top row of Fig. 1. The otherwas based on the isolation of factor ... at C1 of 13C,18O-precorrin-3x [8–10] as shown inthe lower row of Fig. 1.We were interested inthe mechanism of cor-rin formation by the anaerobe P. shermanii in anoxygen-containing atmosphere....
... investigation into the regulation of protein synthesis in mammalian cells, we have investigated the e ffects of inhibition ofthe p roteasome o n the localiza-tion and integrity of eIF4G in C2C12 myoblasts. ... prepared as d escribed abovefollowing a period of labelling as described inthe figurelegends. Incorporation of radioactivity into aliquots con-taining equal amounts of protein was determined byprecipitation ... hsp25 staining was d iffuse, b einglocalized,inparttotheperinuclearregionandtoareas of more intense s taining at the cell p eriphery (Fig. 4C).Similarly, aB-crystallin was detectable in resting...
... assembly ofthe enzyme and is increasedby the binding of PLP and substrates. Indeed, the two helices that form the cluster interact with the N-terminal a-helix ofthe other subunit inthe dimerand ... coincide with the drop of catalytic activity attribut-able to urea inhibition. The further increase of fluores-cence matches the complete loss of catalytic activityand the release ofthe cofactor, ... that the last folding event may correspond to the formation ofthe third cluster of CHCs. The for-mation ofthe cluster presumably fastens together all the structural components ofthe protein...
... (HPFs) in hematoxylin and eosin stainedparaffin sections. In each HPF, the number of eosinophilsor H-RS cells was determined and the sum of ten HPF wascalculated. The biopsies were then classified ... consecutive HPFs. In each HPF, the number of eosinophils and H-RS cells was determined and the sum of ten HPFwas calculated. The biopsies were then classified as low eosinophilia (< 50 eosinophils ... the orientation ofthe enzyme inthe membrane of L1236 cells and the exogenous addition of arachidonicacid reaching the active site ofthe cytosolic enzyme toa greater extent than that of the...
... prospectivestudies indicated the inadequate sensitivity of CA125 in the setting of ovarian cancer screening in asymptomaticpopulations [32-34]. Despite the well- characterized limi-tations inthe interpretation ... almostroutinely during the course of chemotherapy. Decreasinglevels of CA125 after cytoreductive surgery and during ini-tial chemotherapy courses have been used as an indicator of clinical outcome ... bloodlevels of CA125 and the free disease interval from the finalization ofthe first line chemotherapy were predictive of survival, while the other variables, including the RECIST criteria, had...
... denote the number of vertices, and (G) denote the number of edges. In thispaper, we construct a graph G having no two cycles with the same length which leads to the following result.Theorem. ... +32t − 1.Then f(n) ≥ n +32t − 1, for n ≥ nt. This completes the proof ofthe theorem.From the above theorem, we havelim infn→∞f(n) − n√n≥2+25626911,which is better than the previous ... Chunhui Lai, On the size of graphs with all cycle having distinct length, DiscreteMath. 122(1993) 363-364.[6] Chunhui Lai, The edges in a graph in which no two cycles have the same length,...
... projects. As Indian companies enter the maturing cycle, and the overload of outsourcing construction there, the outsourcing costs in India are most likely to increase inthe coming years. Outsourcing ... ofthe spending on software ofthe world and the trend of moving software outsourcing to developing countries like India, China and Eastern Europe, and more recently, to Association of Southeast ... outsourcing development inthe world, in India and China. Chapter two investigates the development of software outsourcing in Vietnam and focuses on some ofthe key factors for development, as well...
... activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury inthe upper gastrointestinal tract leading to increase in ... (100 mM) induced the expression of genes involved inthe metabolism of ethanol [16]. In addition, the metabolism of ethanol results in an increased production of toxic metabolites such as free ... considering the reported high expression ofthe ankyrin-repeat oncoprotein (gankyrin) in human hepatocellular carcinoma . Gankyrin binds to the cell-cycle regulator CDK4 and the S6b ATPase subunit of...
... weeks,or by their CIDI at 9 months. To determine whether therewere changes inthe other measures independent of the changes inthe CESD, the 6-week change in each measurewas regressed on the 6-week ... regression to the mean wasnot a major factor inthe lack of relationship. The PCS was the least sensitive physical health measure. The PCS has the feature that if a person has no change on7 ofthe SF-36 ... importanttask for the investigator is to examine the domains cov-ered by the instruments, to ensure that they are likely tobe affected by the intervention of interest. Other impor-tant issues in instrument...