... Specificity = 23% Sensitivity = 90% Predictive value NPV = 68% PPV = 55% Threshold = -0.35 Biomarker modela (n = 308) True/Predicted NR R Accuracy NR R 62 16 88 142 Specificity = 41% Sensitivity = ... Specificity = 48% Sensitivity = 80% R 17 67 Predictive Value NPV = 86% PPV = 36% Threshold = -1.3 Biomarker modela (n = 308) True/Predicted NR R Accuracy NR 137 87 Specificity = 61% Sensitivity = ... markers were unable to achieve high enough specificity and sensitivity to be routinely useful predictors Thus, additional testing of serum and other types of markers from other studies will be needed...
... association with typical and atypical antipsychotic treatment J Clin Psychiatry 2004, 65:1491-1498 Kapur S, Langlois X, Vinken P, Megens AA, De Coster R, Andrews JS: The differential effects of atypical ... haloperidol, perphenazine (each coded individually), and all other typical antipsychotics grouped into a single category Among the typicals, haloperidol and perphenazine were given individual attention ... oligomenorrhea, amenorrhea, dysmenorrhea, hypogonadism, hypothyroidism, infertility-male-hypospermatogenesis, infertility-female-pituitary/hypothalamic, impotence-organic, psychosexual http://www.annals-general-psychiatry.com/content/8/1/5...
... Stohl W, Metyas S, Tan SM, Cheema GS, Oamar B, Roschke V, Wu Y, Baker KP, Hilbert DM: Inverse association between circulating APRIL levels and serological and clinical disease activity in patients ... repopulation occurred All patients showed a clinical response measured as SLAM (systemic lupus activity measure) score (Table and [18]) or in histopathological analysis of kidney biopsies (I Gunnarsson, ... presented in Table All patients were recruited from the Rheumatology Clinic at the Karolinska University Hospital, Stockholm, Sweden Thirteen non-treated healthy subjects, median age 60 years (range...
... Safeguarding of CD4+ lymphocytes viability Figure Safeguarding of CD4+ lymphocytes viability Representative flow cytometry histograms (patient no 9) characterizing viability of CD4+ T cell subset at the ... death CD4+ T cells viability was analyzed by flow cytometry after two days of preincubation and five days of culture For patients nos 8, 9, 15, and 23, cell viability analysis using the 7AAD ... reservoir and its capacity to induce a rescuable virus production in untreated and HAART-treated patients Our approach permitted to enumerate HIV-1-SCs and to assess the functionality of unintegrated...
... of the twenty-one non-responders had an increased EGFR-GCN (p < 0.0001) However, there is no consensus on the predictive role of increased EGFR-GCN due to difficulty in reproducibility of the ... weeks Toxicity was graded according to the National Cancer Institute Common Toxicity Criteria (version 2.0) Pretreatment and Follow-Up Studies History, physical examinations, and a safety assessment ... Cetuximab and Panitumumab is limited to patients with a wild-type k-ras status, because benefits in RR PFS and OS are limited only to k-ras wild-type patients Page of The aim of the present study was...
... 114.7 (46.4) 5 2 Abbreviations: CABG, coronary artery bypass graft; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MI, myocardial infarction; SAP, stable angina pectoris; USAP, unstable ... angiographic rather than clinical end points, clinical trials comparing the safety and efficacy between these DES types and BMSs have yielded inconsistent results In the ENDEAVOR I, II,II Continued ... and PES in unselected patients treated in daily practice remains controversial The long-term safety of DESs remains in question (10-11) Despite the results of meta-analyses of randomized studies...
... in practice styles and of outcomes for chronically ill adults treated in staff-model and independent practice HMOs vs FFS care in large multispecialty groups, small, single-specialty groups, and ... majority (54%) were female About 22% were at or below 200% of the poverty line; 16% of those reported being covered by Medicaid Three of 10 eligible for Medicare were also in the poverty group ... scores estimated using the internal-consistency reliability method The construction of summary measures, score reliability and validity, and normative and other interpretation guidelines are...
... No Yes Drug regularity Regular Irregular Drug sensitivity profile—0 months Sensitive Resistant to H and/or HR Smear conversion at months Yes No Initial smear grading Scanty, 1ϩ 2ϩ, 3ϩ Initial ... and sensitivity testing London, UK: Butterworth, 1968 Canetti G, Fox W, Khomenko A, et al Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in ... smear results), the relapse rate was 10% Drug susceptibility pattern at the time of relapse Of the 487 patients for whom drug susceptibility results were available at the start of treatment, 455...
... account for the differential VAD chemosensitivity As chemosensitivity is an important risk factor for survival, we postulated that the higher chemosensitivity might indeed translate into superior EFS ... chemosensitive patients severity of sensory neuropathy associated with the subsequent use of VTD Our approach was based on risk-stratification by initial VAD-chemosensitivity Therefore, we studied ... prognostic factors OS 0.081 0.211 Age (median) 0.828 0.770 Paraprotein subtype ISS 0.382 0.026 0.393 0.645 VAD chemosensitivity 0.887 0.974 VGPR after induction 0.722 0.406 VGPR after auto-HSCT 0.181...
... value with highest accuracy × table was constructed yielding sensitivity, specificity, positive and Patient characteristics Eighty patients from January 2005 and July 2009 were retrospectively analyzed ... relatively low in gastric cancer, due to subjectivity, the error of IHC counting could be bigger, which may influence the sensitivity and specificity when predicting treatment response, so more accurate ... exact tests Results Polh expression correlates with oxaliplatin sensitivity of gastric cancer cell lines Oxaliplatin sensitivity of four gastric cell lines (SGC7901, AGS, MKN45, and MGC803) were...
... size Histological type 334 (77%) 142 (74%) 192 (79%) endometrioid clear cell serous 22 (5%) 15 (3%) (4%) (2%) 14 (6%) 11 (4%) undifferentiated 33 (8%) 20 (11%) 13 (5%) other types 31 (7%) 17 (9%) ... multivariate Cox’s proportional hazard models Tumour response to chemotherapy (probability of CR, probability of PS or HPS) was evaluated using a multivariate logistic regression model Statistical ... proliferation-stimulating survivin activity TP53 may play a part in negative survivin regulation Studies on cancer cell lines have shown that the wildtype TP53 repressed survivin at both mRNA...
... Prasad VR: The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type reverse transcriptase Nucleic Acids Res 1998, 26:3066-3072 Abstract ... RT was limited to positions 38249 due to the type of assay performed Sequencing of both the RT and PR genes was also employed to determine the subtypes of these viral isolates in concert with ... http://hivdb.stanford.edu/ Nucleotide genomic diversity in the RT and PR regions of the various viral isolates was compared with a consensus subtype B reference virus, LAV-1 (http://www.hiv.lanl.gov;...
... tumour activity by measuring parameters that primarily reflect osteoblastic activity (i.e ALP and 18 F-fluoride uptake) is a temporal discordance in changes with intrinsic tumour activity Although ... may subside at a different rate than the metabolic activity of the malignant tumour tissue, or an initial increase in osteoblastic activity may occur as part of a healing response in the surrounding ... in bone clearance of tracer, is also limited in practicality These results are from a small pilot study, and the conclusions on the ability of 18F-fluoride PET to measure early response in bone...
... opportunity to compare the types of providers was made possible by several practice and policy innovations at the Columbia Presbyterian Center of New York Presbyterian Hospital in New York City In ... individual providers or small group practices The providers were faculty from a university medical center, hence were not necessarily typical of those in nonacademic practice settings The patients were ... physicians were able to function equally as primary care providers The ability to this type of study, even in a setting atypical for some patients, adds significant weight to the results from prior...
... completed this study Of the 14 bipolar patients taking lithium, were Type I and were Type II In the valproate group, were Type I and were Type II These groups were studied both separately and together, ... ratio method, and both Bipolar Type I and Bipolar Type II patients were included who could also be taking other medications In the second part of this study only Bipolar Type I patients on valproate ... sodium valproate on choline concentrations or activity An in-vitro study suggested that valproate may inhibit choline acetyltransferase activity [34] In one study patients taking either lithium...
... Reumatism, the Crafoord Foundation, the Nanna Svartz foundation, and the Medical Faculty of Lund University The skilful technical assistance of Mrs Mette Lindell is appreciated References Welsing ... Swinkels HL, Kiemeney LA, van Riel PL: The relationship between disease activity, joint destruction, and functional capacity over the course of rheumatoid arthritis Arthritis Rheum 2001, 44:2009-2017 ... criteria; CRP = C-reactive protein; COMP = cartilage oligomeric matrix protein; DAS = disease activity score; HAQ = health assessment questionnaire The most marked reduction in serum COMP was seen...
... assessment of pain, patient's global assessment of disease activity, physician's global assessment of disease activity, the Disability Index of the Health Assessment Questionnaire, serum levels ... are summarized in Table Bioassay for circulating TNF-α bioactivity A functional assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to ... bioactivity and clinical response Using the ability of TNF-α to stimulate rheumatoid arthritis synoviocytes, TNF-α (5 ng/ml) was combined with 20 µl plasma per well in order to increase the sensitivity...
... genotype [31] Several authors have also proposed the use of Table IL-10 and TNFα genotypes of systemic lupus erythematosus patients stratified by treatment Treatment TNFα genotype IL-10 genotype ... producer genotype and good response to antimalarial drugs (OR 2.25, 95%CI 1.11–4.58, p = 0.024), whereas the IL-10 genotype did not show any significant association However, when combined genotypes ... producer genotypes with the most common low producers A combined two-loci model was developed, including both cytokine polymorphisms to estimate individual effects of each combined genotype, using...
... Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 2Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and 3Department of Statistics, Faculty ... intractable bleeding The severity of acute bowel toxicity may predetermine the degree of chronic bowel changes [9] Therefore early intervention to prevent or reduce acute toxicity may also have long term ... ratio The study protocol was submitted to the ethical review board of Faculty of Medicine, Chiang Mai Page of University and written informed consent was obtained from each patient Patients Patients...
... tissue complication probability (NTCP) [8,12,13] value and relative volume of lung receiving more than a threshold dose (Vdose) [7,10,14-19] Technology such as intensity-modulated radiotherapy (IMRT) ... concurrent chemotherapy and IMRT in the Department of Radiation Oncology at the Peking University School of Oncology, Beijing Cancer Hospital & Institute Patients were included if they had pathologically ... fixation device (Pelvicast Base Plate, 35781-N1, Orfit industries) to improve the setup reproducibility during CT simulation and delivery of treatment Treatment-planning CT scan was performed using...